- Andrew Fromer - Bike Guy
- Quincy Oshiro - Orchestra Student
- Markus Jorgensen - Boris Koslov
- Gilberto Ortiz - Alex Gomez
- Kikey Castillo - Christina Harrison
- Nancy J. Lee - Nail Tech
- Rebecca Knowles - Leslie
- Anjul Nigam - Pandit Raj
- Wallace Langham - Ron Hansen-Bhattacharyya
- Aarti Mann - Jaya Kuyavar
- Chelly - Parvesh
- Alice Amter - Auntie #1
- Chriselle Almeida - Auntie #2
- Sohm Kapila - Auntie #3
- Sarah Ripard - Auntie #4
- Viji Nathan - Older Auntie #5
- Eric Evans - Ira the Cashier
- Gable Swanlund - Little Girl
- Jodie Bentley - Knowing Mom
- Kevin Gardner - Concerned Man
- Atticus Shaffer - Russia
- Alex Skinner - Dudley
- Joe Toro - Victor
- David Theune - Rick
- Jae Suh Park - Joyce Wong
- Dee Rogers - Student
- Chris Schleicher - Mr. Schleicher
- Sheldon White - Photographer
- Iqbal Theba - Aravind
- Peter James Smith - Mr. Chan
- Angela Kinsey - Vivian
- Siri Hiremath - Tween Devi
- Siri Hiremath - 10-year-old Devi
- Ruth Williamson - Arlene Stringer
- Mark Collier - Andy
- Dylan Thai - Eddie Tan
- Donna Pieroni - Patty Shevchenko
- Madison Rojas - Tween Paxton
- Rachel Zimmermann - Beth
- Rachel Zimmermann - Belgium
- Skyler Cox - Tween Fabiola
- ChaCha Shen - Young Eleanor
- K.T. Thangavelu - Amma
- Rashmi Rustagi - Older Indian Woman
- Rashmi Rustagi - Prashant's Mother
- Gokul - Gokul
- Gigi Hadid - Gigi Hadid (voice)
- Lily D. Moore - Rebecca
- Andy Samberg - Andy Samberg (voice)
- Kelly Sullivan - June Hall-Yoshida
- Carol Mack - Cheryl
- Martin Martinez - Oliver Martinez
- Gwyn LaRee - Pat
- Tembi Locke - Elise Torres
- Amy Tolsky - Mrs. Paloma
- Avery Kristen Pohl - Cross Country Girl
- Cocoa Brown - Principal Grubbs
- Michael Badalucco - Howard Gross
- Michael Badalucco - Howard Gross (voice)
- John Mawson - Dr. Elgin Peters
- Dia La Ren Nash - Olivia
- Margarita Franco - Dr. Morales
- P.J. Byrne - Evan Safstrom
- Pooja Kumar - Noor
- Niecy Nash-Betts - Dr. Jamie Ryan
- Common - Dr. Chris Jackson
- Andrew Tinpo Lee - Paul Wong
- Tyler Alvarez - Malcolm Stone
- Clyde Kusatsu - Ted Yoshida
- Tohoru Masamune - Kevin Hall-Yoshida
- Helen Hong - Sharon
- Billy Crystal - Himself
- Abbey DiGregorio - Gail
- Dino Petrera - Jonah Sharpe
- Sendhil Ramamurthy - Mohan Vishwakumar
- Benjamin Norris - Trent Harrison
- Adam Shapiro - Mr. Shapiro
- Hanna Stein - Shira
- Jack Seavor McDonald - Eric Perkins
- Aitana Rinab Perez - Zoe Maytag
- Rushi Kota - Prashant
- Ranjita Chakravarty - Nirmala
- William B. Simmons II - Jordan
- Alexandra Billings - Jennifer Warner
- Utkarsh Ambudkar - Manish Kulkarni
- Megan Suri - Aneesa Qureshi
- Paul Krugman - Jerry
- Alex Felix - Haley Garcia
- Anirudh Pisharody - Des
- Jamison McDermott - Brianne
- Cree Kawa - Aaron
- Sarayu Blue - Rhyah
- Chrisanne Eastwood - Janitor Stacey
- Jeremiah Caleb - Suitor 1
- Lisa Yamada - Meghan
- Melissa Dawn Johnson - Jenny Smith
- Jeff Elam - Delivery Guy
- Lex Medlin - Captain Joe
- Gita Reddy - Smita
- London Thor - Stella
- Kaliayh Rhambo - Kayley
- David Banks - Mr. Warburton
- Bottara Angele - Stella's Friend
- Brandon Firla - Mr. Brighton
- Irene White - Math Teacher
- Deacon Phillippe - Parker
- Victoria Moroles - Margot
- Terry Hu - Addison
- Andrea Rosen - Ms. Nuni
- Jill Basey - Mrs. Peppers
- Fernando Rivera - Leo Ferris
- Gabe Liedman - Cyril
- Eliza Blair - Erica
- Dwight Howard - Dwight Howard
- Michael Cimino - Ethan
- Jenny O'Hara - Dr. Keyes
- Micah McNeil - Dylan
- Alexander G. Eckert - Worried Nerd
- Yelena Friedman - Pretty Girl
- Jeff Garlin - Len
- Cooper Roth - Shrimp
- Steve Agee - Skeeter
- Stephanie Escajeda - Señora Diaz
- Isabella Day - Michelle
- Genneya Walton - Ms. Thompson
- Janina Gavankar - Akshara
- Jade Bender - Blair Quan
- Paul Schackman - Diedrich Fenton
- Claudia O'Doherty - Baby
- Claudia O'Doherty - Baby (voice)
- Sam Li - Anton
- Paula Andrea Placido - Ava
- Dwayne Standridge - Mr. Martel
- Danielle Lima - Princeton Student
- Pete Gardner - Coach Noble
- Tia Carrere - Dr. Logan
- Daniel David Stewart - Kade Andrews
- Capri-Antoine Vaillancourt - Kyle
- Marina Cockenberg - 2nd AD
- Lyn Alicia Henderson - Dr. Leela Tye
- Ken Marino - Stoo
- Austin Kane - Pete
- Indrajit Sarkar - Ram
- DeShawn Cavanaugh - Douche Bro
- Quinn McPherson - Seth
- Marcy Avila - Hot Pocket
- Marina Cockenberg
- Christina Elisa Hjelm
- Asmita Paranjape
- Brett Greenstein
- Eric Koljan
- Erica Oyama
- Lang Fisher
- Collin Daniel
- Howard Klein
- Joseph Stephens
Jenny O'Hara interpreta a Dr. Keyes en la serie.
Common interpreta a Dr. Chris Jackson en la serie.
Clyde Kusatsu hace el papel de Ted Yoshida.
Michael Badalucco hace el papel de Howard Gross (voice).
Maitreyi Ramakrishnan interpreta a Devi Vishwakumar en la serie.
Poorna Jagannathan interpreta a Dr. Nalini Vishwakumar en la serie.
Jaren Lewison interpreta a Ben Gross en la serie.
Darren Barnet interpreta a Paxton Hall-Yoshida en la serie.
Lee Rodriguez interpreta a Fabiola Torres en la serie.
Ramona Young hace el papel de Eleanor Wong.
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