- Roger Lodge - John
- Richard Speight Jr. - Frank
- Diana Maria Riva - Miss McKenzie
- Billy Gibbons - Billy Gibbons
- Christopher Massey - Boy #2
- Kevin Smith - Self / Silent Bob
- Lou Wagner - Mike Werle
- Deborah Theaker - Joanne
- Joe Cipriano - TV Announcer
- Robert Klein - Self
- Fernanda Motta - Attractive Woman
- Mike "Boogie" Malin - Marvin
- Jack Riley - Mr. Shipley
- Pat Harrington, Jr. - Self
- Jeff Doucette - Gino
- Craig Kilborn - Craig Kilborn (uncredited)
- Leigh-Allyn Baker - Stacey
- Vicki Lawrence - Natalie Warner
- Tone Loc - Dave
- Duane Martin - Alan
- Ian Buchanan - Paul
- Michael Manasseri - Dr. Trabert
- Heidi Klum - Self
- Alley Mills - Jenny Ludke
- Dan Castellaneta - Walt
- Fabio - Self
- Bob Barker - Bob Barker
- Jodie Sweetin - Maryanne
- Jillian Warry Barberie - Lisa
- Steve Burns - Self
- Kane Ritchotte - Chad
- Lisa Donahue - Self
- Bill Fagerbakke - Cop
- Gregory Jbara - Lloyd
- Bill Cobbs - Counterman
- Jim Turner - Leonard
- Jeff Garlin - Howie
- Jillian Bach - Tammy
- Billy Gardell - Billy
- Alison Irwin - Self
- Phill Lewis - Roy
- Jay Kleckner - Rabbi
- Jun Song - Self
- Will Kirby - Self
- David DeLuise - Dan
- Brian Doyle-Murray - Mr. Savitsky
- Brian Doyle-Murray - George Savitsky
- Robb Derringer - Rob
- Tom Williams - Baby
- John Mendoza - Dealer
- Melody Kay - Bridesmaid
- Susan Diol - Andrea
- Jerry Van Dyke - Big Jimmy Hughes
- Amy Farrington - Pam
- Cody Klop - Young Kevin Gallagher
- Nathan Marlow - Self
- Phil LaMarr - Steve
- Julio Oscar Mechoso - Chuck
- Bret Michaels - Bret Michaels
- Tamia Richmond - Young Woman
- Heather Tindell - Woman #2
- Shauna Duggins - Linda
- Stacy Francis - Maureen
- Trace Adkins - Curtis
- Sharon Brathwaite-Sanders - Secretary
- Shane Edelman - Stewart
- Bruno Gunn - Prison Guard
- Heather McPhaul - Pam Yesner
- Travis Tritt - Hank
- Waddy Wachtel - 'Jailhouse Rock' Guitarist (uncredited)
- Todd Kimsey - Earl
- Michael Pennie
- Chris Sheridan
- Linda Videtti Figueiredo
- Greg Garcia
Dan Castellaneta interpreta a Walt en la serie.
Brian Doyle-Murray hace el papel de George Savitsky.
Anthony Clark hace el papel de Greg Warner.
Jean Louisa Kelly hace el papel de Kim Warner.
Mike O'Malley hace el papel de Jimmy Hughes.
Liza Snyder interpreta a Christine Hughes en la serie.
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