- James Cameron - Self - Filmmaker, Inventor, Explorer
- Lady Gaga - Self - Artist, Philanthropist and Businesswoman
- Bernie Sanders - Self - I-VT
- Mitt Romney - Self - R-UT
- Kevin Roose - Self - Tech Columnist, The New York Times
- Tim Urban - Self - Author, "Wait Buy Why"
- Sal Khan - Self - Founder and CEO, Khan Academy
- Eugenia Kuyda - Self - Founder and CEO, Replika
- Danah Boyd - Self - Founder, Data and Society
- Edward R. Murrow - Self (archive footage)
- Jordan Klepper - Self - Podcast Host and Comedian
- Donald Trump - Self (archive footage)
- Ike Sriskandarajah - Self - Investigative Reporter
- Kara Swisher - Self - Tech Journalist
- Mark Zuckerberg - Self (archive footage)
- Bill Clinton - Self (archive footage)
- Anthony Fauci - Self - Distinguished University Professor, Georgetown University
- Larry Cohen - Self - CEO, Gates Ventures
- Elon Musk - Self (archive footage)
- Renée DiResta - Self - Research Manager, Stanford Internet Observatory
- Josh Hawley - Self (archive footage)
- Tucker Carlson - Self (archive footage)
- Jonathan Ross - Self (archive footage)
- Anderson Cooper - Self (archive footage)
- Connie Chung - Self (archive footage)
- Jacob Chansley - Self (archive footage)
- Christiane Amanpour - Self (archive footage)
- Thomas L. Friedman - Self - New York Times Columnist and Author
- Robert Reich - Self - Former U.S. Secretary of Labor, Co-Founder, Inequality Media
- Rutger Bregman - Self - Historian and Author, "Utopia for Realists" and "Humankind"
- Mark Cuban - Self - Co-Founder, Cost Plus Drugs
- John D. Rockefeller - Self - Founder of Standard Oil (archive footage)
- Andrew Carnegie - Self - Founder of Carnegie Steel (archive footage)
- Jelani Cobb - Self - Dean and Professor of Journalism, Columbia Journalism School
- Bono - Self - Musician and Activist
- Kevin Esvelt - Self - MIT, Inventor of CRISPR Gene Drive
- Miranda Soto
- Caitrin Rogers
- Morgan Neville
- Eve Marson
- Jen Krajicek
- Clarisse Guevarra
- Adam Carl
- Berke Gülbakan
- Miguel Araujo
- Dan Deacon
- Jon Plane
Bill Gates hace el papel de Self.
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