- Spencer Breslin - Peter Johnson
- Carrie Preston - Sister Katrina
- Colin Fox - Fred Bradley
- Eddie Kaye Thomas - Fat Pat
- Sarah Drew - Bianca Knowles
- Louise Fletcher - Vivian Caldwell
- Kari Matchett - Beth
- Boyd Banks - Janitor
- Rue McClanahan - Millie Marcus
- Chelan Simmons - Gretchen Speck-Horowitz
- Mike Beaver - Border Patrol Officer #1
- Kellie Waymire - Penelope
- Alex Rice - Deanna Littlefoot
- Beth Grant - Marianne Marie Beattle
- Kimberly Scott - Officer Hale
- Glenn Fitzgerald - Bank Robber
- Jewel Staite - Heidi Gotts
- Dov Tiefenbach - Rufus
- Melissa Grelo - Native Princess
- Michael Buie - Chuck Aronson
- Aron Tager - Gwen
- Tim Minear - Muse (voice) (uncredited)
- Demetrius Joyette - Shoplift Kid
- Matt Gordon - Conservative Patron
- Kathryn Greenwood - Ronnie
- Magdalena Alexander - Katya
- Scotch Ellis Loring - Muse (voice)
- Scotch Ellis Loring - Dr. Ron Campbell / Muse (voice)
- Scotch Ellis Loring - Dr. Ron Campbell
- Ted Whittall - Dick Johnson
- Sandi Ross - Glory
- Gabriel Hogan - Thomas
- Jeff Clarke - Savage
- Mark Aiken - Dr. Frank Chambers
- Quancetia Hamilton - Minister
- Lisa Messinger - Mother in Commercial
- Patricia Zentilli - Angie Olsen
- Bill Lake - Detective Sloan
- Nora Sheehan - Customer
- Steve Arbuckle - Busboy
- Alex Rice - Deanna Littlefoot
- Ryan Rajendra Black - Bill Hooton
- Billy Merasty - Jerry
- Audrey Wasilewski - Cindy Bradley
- Kim Roberts - Peggy
- Steven Taylor - Ronnie's Daughter
- Lisa Marcos - Attractive Nurse
- Kathryn Haggis - Annoyed Customer
- Morgan Karam - Customer #2
- Brandon Oakes - Native Chief
- Tim Minear
- Bryan Fuller
- Todd Holland
Kim Roberts interpreta a Peggy en la serie.
Kimberly Scott interpreta a Officer Hale en la serie.
Caroline Dhavernas interpreta a Jaye Tyler en la serie.
Tyron Leitso hace el papel de Eric Gotts.
Tracie Thoms hace el papel de Mahandra McGinty.
Katie Finneran interpreta a Sharon Tyler en la serie.
Lee Pace hace el papel de Aaron Tyler.
Diana Scarwid hace el papel de Karen Tyler.
William Sadler hace el papel de Darrin Tyler.
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