- Michael Angarano - Elliot
- Jet Jurgensmeyer - Skip
- Andrew Rannells - Reggie
- Jane Lynch - Roberta
- Adam Rippon - Timothy
- Evan O'Toole - Smitty
- Patricia Belcher - Ellie
- Carrie Aizley - Ivy
- Katie O'Rourke - Erica
- Karen Y. McClain - Ruth
- Samira Wiley - Nikki
- Carlos Antonio - Manny
- Charles Emmett - Luke
- Alice Hirson - Justice Ginsburg (voice)
- Nicola Lambo - Angela (voice)
- Andrea Martin - Zusanna
- Aly Mawji - Liam
- Amari O'Neil - Felix
- Aya Cash - Olivia Walker
- Adwin Brown - James
- Tucker Smallwood - Henry Rice
- Winston Story - Rex
- Chelsea Handler - Donna Zimmer
- Devere Rogers - Owen
- Jeff Blumenkrantz - Piano Player
- Carlie Craig - Jill
- Gabrielle Sanalitro - Loretta
- Barry Karas - Barry
- Jeffrey Cade Ross Brown - Reuben
- Cleo Fraser - Katie
- A.J. Castro - Elias
- Connie Shin - Student
- Connie Shin - Olivie
- Iyad Hajjaj - Machmud
- Deborah Levin - Dana
- Mike Park - Todd Fung
- Brad Grunberg - Ralph
- Irene Roseen - Doris
- Dan Warner - Doug
- David Schwimmer - Noah
- Steve Paymer - Delivery Man
- Steve Paymer - Steve
- Jon Cryer - Jon Cryer
- Martha Kelly - Patty
- Samuel Faraci - Skip
- Yelyna De Leon - Blanca
- Bruno Amato - Randy
- Rachel Quaintance - Vicky
- Scott Beehner - Donald
- Joy Osmanski - Trish Yashida
- David Douglas - Edward
- Jake Green - Tour Announcer (voice)
- Ruben Pla - Estefan's Father (voice)
- Brian Jordan Alvarez - Estefan
- Mary McCormack - Janet
- Sara Rue - Joyce
- Alec Baldwin - Malcolm
- Cheyenne Jackson - Michael
- Ian Harvie - Bud
- Dyana Ortelli - Fernanda
- Zack Weinstein - Ryan
- Gregor Manns - Customer
- Ken Luckey - Man
- Jennifer Lopez - Jennifer Lopez
- Leigh-Allyn Baker - Ellen
- Danielle Weeks - Morgan
- Carly Dutcher - Ilana
- Katarina Demetriades - Brianna
- Emily Churchill - Rosemary
- Rasika Mathur - Trish
- Doc Farrow - Parent
- Barry Bostwick - Jerry Wise
- Dan Bucatinsky - Neil
- Andy Favreau - JJ Wise
- Victor Turpin - Elias
- Geovanni Gopradi - Alejandro
- Lauren Weedman - Cheryl
- Andy Buckley - Hank
- Dana DeLorenzo - Karen's Mom
- Alexa Nisenson - Young Karen
- Bobby Cannavale - Vince
- Ryan Pinkston - Drew
- Sterling Sulieman - Ryan
- Rose Abdoo - Rita
- Jack McGee - Officer Murphy
- Mackenzie Marsh - Angela
- Jason Sims-Prewitt - Officer Connelly
- Jerry Levine - Joe
- Jay Brian Winnick - Officer Rizzo
- Robert Klein - Martin Adler
- Emilio Borelli - Mario
- E.J. Callahan - Janitor
- Nick Offerman - Jackson Boudreaux
- Sharon Sachs - Debbie
- Brian Posehn - Pete
- Mitch Silpa - Maitre D'
- Jett Wilder - Mary
- Lidia Porto - Nurse Jill
- Edward Padilla - Priest
- Max Greenfield - Eli Wolff
- Buz Kohan - Buz
- Robert Towers - Partner
- Justin Shaw - Benji
- Natalie Dreyfuss - Emma
- Harry Connick Jr. - Leo Markus
- Laura Kightlinger - Sheila
- Chris Redd - Alvin
- Ramone Hamilton - Jordan
- Ben Platt - Blake
- Michael Galante - Lincoln
- Mary Pat Gleason - Bridget
- Colette Whitaker - Smart Shower (voice)
- Davi Santos - Twenty-Something
- Anthony Ramos - Tony
- Kyle Bornheimer - Lenny
- Eddie Matos - Steve Sandoval
- Kate Micucci - Page
- Fred Cross - Curtis
- Reid Scott - Marcus
- Derek Gaines - Theodore
- Paul Ben-Victor - Mario
- Dylan Riley Snyder - DJ
- Eva La Dare - Dr. Welch
- Karan Soni - Mike
- Livia Treviño - Mrs. Timmer
- Drew Lipson - Baseball Player
- Jaime Moyer - Janae
- Earl T. Kim - Guard
- Ali Wentworth - Dr. Superstein
- Meredith Salenger - Lucy
- Ben Giroux - Grief Panda
- Ryan Phillippe - Ryan Phillippe
- Billie Lourd - Fiona
- Peter Graham - Trevor
- Chris Parnell - Dr. DiLorenzo
- Allison Smith - Molly
- Rebecca Corry - Pam
- Seth Rudetsky - Jerry Sussman
- Aileen Quinn - Ramona Delaney
- Theresa Ireland - Miss Hannigan
- Eddie Pepitone - Walt
- Vanessa Bayer - Friday
- Vanessa Bayer - Amy
- Navaris Darson - Julian
- Tim Bagley - Larry
- Christopher Thornton - Luke
- Jocelyn Ayanna - Ceecee
- Aryan Simhadri - Farhan
- Randy Vasquez - Ron
- Blythe Danner - Marilyn Truman
- Christian Ochoa - Hector
- Wayne Wilderson - Ellis Palmer-Payne
- Persia White - Katie Palmer-Payne
- Charles C. Stevenson Jr. - Smitty
- Matt Letscher - James Wise
- Karina Bonnefil - Genevieve
- Nicole Sullivan - Ruth
- Gus Kenworthy - Steve
- Miss Coco Peru - Miss Coco Peru
- Joel McHale - Phil
- T.R. Knight - Dexter Murphy
- Frankie A. Rodriguez - Christopher
- Tip Scarry - Owen
- Molly Shannon - Val Bassett
- Anna Suzuki - Anna
- Jill Basey - Margot
- Demi Lovato - Jenny
- Hollis W. Chambers - Chase
- Leslie Jordan - Beverley Leslie
- Lucie Arnaz - Factory Boss
- Brian Michael Jones - Joe
- Matt Cook - Ross
- Patton Oswalt - Danley Walker
- Yvette Nicole Brown - Ru
- Sarah Baker - Cathy
- Gracen Newton - Grace's Son
- Minnie Driver - Lorraine Finster
- Matt Bomer - McCoy Whitman
- Adam Barr - Rabbit (voice)
- Seth Rudetsky - Jerry Sussman
- Tabitha Brown - Female Officer
- Pej Vahdat - Steve (voice)
- Antonio D. Charity - Male Officer
- Aleksei Archer - Flight Attendant
- Tony Amendola - Priest
- Erik Betts - Dancer
Mary McCormack hace el papel de Janet.
Eric McCormack interpreta a Will Truman en la serie.
Debra Messing hace el papel de Grace Adler.
Sean Hayes interpreta a Jack McFarland en la serie.
Megan Mullally interpreta a Karen Walker en la serie.
Capítulo disponible en las siguientes plataformas:
