- Amy Jo Johnson - Tina Sharp
- James Blunt - Self
- Beau Garrett - Lynnet
- Katy Perry - Herself
- Alex Carter - Tim
- John Terry - Uncle Jesse
- Eric Winter - R.J. Blake
- Scott William Winters - Hal Berney
- Stacy Haiduk - Barb Furillo
- Ignacio Serricchio - Jace Furillo
- Joe Lando - Pete Ritter
- Kieren Hutchison - Kerry Connelly
- Jason London - Bobby
- Charlotte Salt - Gillian Parsons
- Arye Gross - Charlie Hewitt
- Amanda Seyfried - Rebecca
- Debrah Farentino - Isabelle Matia-Paris
- Shanna Collins - Amber
- Esodie Geiger - Officer Barcley
- Kit Gwin - Judge
- Kit Gwin - Lenny Kellman
- Mercedes Connor - Sasha
- Doris Hargrave - Phyllis Esposito
- Ross Kelly - Wayne
- Hugo Perez - Stefan Sartino
- Nicholas Ballas - Ray
- Nicholas Ballas - Daryl
- Nicholas Ballas - Wayne
- Bruce McIntosh - Walter
- Jeremiah Bitsui - Ricky Sanchez
- Fredrick Lopez - Carlos Sanchez
- Robert Douglas Washington - Evan Garvey
- Kristy Vaughan - Molly Blitzer
- J.D. Hawkins - Leon Garvey
- Paul Blott - Mitchell Harrison
- Debrianna Mansini - Anna Rodriguez
- Scarlett McAlister - Wendy Levy
- Chris Browning - Greg
- Chris Browning - Ely
- William Sterchi - Mr. Happy
- Josh Berry - Sheriff Blitzer
- Josh Berry - Deputy
- J.D. Garfield - Mr. Kalata
- Judy Herrera - Leanne Diaz
- Loren Haynes - D.J. Tim
- Boots Southerland - Jake Smith
- David Garver - John Zack
- Ivan Brutsche - Ruben
- David Lee Garver - John Zack
- Steven Michael Quezada - Ernie Kent
- Gregory Chase - Stanley Klein
- Gary L. Stevens - Augie French
- Kent Kirkpatrick - Del Graves
- Mary Sue Evans - Dr. Schuler
- Rachel Reynolds - Lucy Carmichael
- Mike Hatfield - Kyle
- Tom Schuch - Len Baxter
- Jem - Herself
- Brian Keith Gamble - Dr. Kramer
- Hector Hugo - Rusty
- Kevin Wiggins - Vet
- Forrest Fyre - Andrew Roys
- Forrest Fyre - Lenox Pauling
- Joe Peracchio - Kel
- Johnnie Hector - Mikey
- Chad Brummett - Greg
- Maurizio Rasti - Sheik Omar Al Sayed
- Gerald Brodin - Fred Hamilton
- Sewell Whitney - Rick DuMont
- Lindsay Price - Herself
- Vivian Nesbitt - Alice
- William Russ - Congressman Dean Nichols
- Alicia Ziegler - Laura Nichols
- David Ramsey - Dr. Noah Gleason
- Joshua Bryant - Dr. Ronald
- Pab Schwendimann - Glen
- Sheila Ivy Traister - Wanda
- Dennis E. Garber - Jeffrey
- Jonathan Murphy - Calvin Handley
- Patrick Labyorteaux - Derek Polk
- Chris Freihofer - Smith
- Angelique Midthunder - Ricki
- Sean Hennigan - Mr. Fielding
- David F. Maxwell - R. Sidley
- Timothy Nolen - Roy
- Price Hall - Zack Wright
- Joe Coyle - Wade Dickerson
- Marya Beauvais - Shelby Dickerson
- Casey Messer - Monica
- Joanna Lipari - Rosie
- Bob Jesser - Freddy
- Chris Bruno - Dr. Elliot
- Marjorie David
William Russ hace el papel de Congressman Dean Nichols.
Genevieve Padalecki interpreta a Kris Furillo en la serie.
Micah Alberti interpreta a Matt Ritter en la serie.
Ryan Sypek hace el papel de Junior Davis.
Nicole Tubiola hace el papel de Danielle Davis.
Nana Visitor hace el papel de Jean Ritter.
Greg Serano interpreta a Pablo Betart en la serie.
James Read interpreta a Ken Davis en la serie.
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