- Amy Jo Johnson - Tina Sharp
- James Blunt - Self
- Beau Garrett - Lynnet
- Katy Perry - Herself
- Alex Carter - Tim
- John Terry - Uncle Jesse
- Eric Winter - R.J. Blake
- Scott William Winters - Hal Berney
- Stacy Haiduk - Barb Furillo
- Ignacio Serricchio - Jace Furillo
- Joe Lando - Pete Ritter
- Kieren Hutchison - Kerry Connelly
- Jason London - Bobby
- Charlotte Salt - Gillian Parsons
- Arye Gross - Charlie Hewitt
- Amanda Seyfried - Rebecca
- Debrah Farentino - Isabelle Matia-Paris
- Shanna Collins - Amber
- Esodie Geiger - Officer Barcley
- Kit Gwin - Judge
- Kit Gwin - Lenny Kellman
- Mercedes Connor - Sasha
- Doris Hargrave - Phyllis Esposito
- Ross Kelly - Wayne
- Hugo Perez - Stefan Sartino
- Nicholas Ballas - Ray
- Nicholas Ballas - Daryl
- Nicholas Ballas - Wayne
- Bruce McIntosh - Walter
- Jeremiah Bitsui - Ricky Sanchez
- Fredrick Lopez - Carlos Sanchez
- Robert Douglas Washington - Evan Garvey
- Kristy Vaughan - Molly Blitzer
- J.D. Hawkins - Leon Garvey
- Paul Blott - Mitchell Harrison
- Debrianna Mansini - Anna Rodriguez
- Scarlett McAlister - Wendy Levy
- Chris Browning - Greg
- Chris Browning - Ely
- William Sterchi - Mr. Happy
- Josh Berry - Sheriff Blitzer
- Josh Berry - Deputy
- J.D. Garfield - Mr. Kalata
- Judy Herrera - Leanne Diaz
- Loren Haynes - D.J. Tim
- Boots Southerland - Jake Smith
- David Garver - John Zack
- Ivan Brutsche - Ruben
- David Lee Garver - John Zack
- Steven Michael Quezada - Ernie Kent
- Gregory Chase - Stanley Klein
- Gary L. Stevens - Augie French
- Kent Kirkpatrick - Del Graves
- Mary Sue Evans - Dr. Schuler
- Rachel Reynolds - Lucy Carmichael
- Mike Hatfield - Kyle
- Tom Schuch - Len Baxter
- Jem - Herself
- Brian Keith Gamble - Dr. Kramer
- Hector Hugo - Rusty
- Kevin Wiggins - Vet
- Forrest Fyre - Andrew Roys
- Forrest Fyre - Lenox Pauling
- Joe Peracchio - Kel
- Johnnie Hector - Mikey
- Chad Brummett - Greg
- Maurizio Rasti - Sheik Omar Al Sayed
- Gerald Brodin - Fred Hamilton
- Sewell Whitney - Rick DuMont
- Lindsay Price - Herself
- Vivian Nesbitt - Alice
- William Russ - Congressman Dean Nichols
- Alicia Ziegler - Laura Nichols
- David Ramsey - Dr. Noah Gleason
- Joshua Bryant - Dr. Ronald
- Pab Schwendimann - Glen
- Sheila Ivy Traister - Wanda
- Dennis E. Garber - Jeffrey
- Jonathan Murphy - Calvin Handley
- Patrick Labyorteaux - Derek Polk
- Chris Freihofer - Smith
- Angelique Midthunder - Ricki
- Sean Hennigan - Mr. Fielding
- David F. Maxwell - R. Sidley
- Timothy Nolen - Roy
- Price Hall - Zack Wright
- Joe Coyle - Wade Dickerson
- Marya Beauvais - Shelby Dickerson
- Casey Messer - Monica
- Joanna Lipari - Rosie
- Bob Jesser - Freddy
- Chris Bruno - Dr. Elliot
- Marjorie David
William Russ interpreta a Congressman Dean Nichols en la serie.
Genevieve Padalecki interpreta a Kris Furillo en la serie.
Micah Alberti interpreta a Matt Ritter en la serie.
Ryan Sypek hace el papel de Junior Davis.
Nicole Tubiola interpreta a Danielle Davis en la serie.
Nana Visitor interpreta a Jean Ritter en la serie.
Greg Serano interpreta a Pablo Betart en la serie.
James Read interpreta a Ken Davis en la serie.
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