- Scott Bryce - Stan
- Rue McClanahan - Marian
- Enrico Colantoni - Victor
- Patrick Swayze - Tony
- Josh Flitter - Cub Scout
- Bryan Hearne - Kid
- Krysten Ritter - Bryn
- Ned Eisenberg - Judge
- Mary Testa - Sophia
- Charles Borland - Officer Reid
- Rock Kohli - Farzad
- Tom Nelis - Hotel Guest
- Steven Schub - Guest
- Chip Chinery - Guest
- Derrick Williams - Canadian Tourist
- Ron Nakahara - Tourist
- James Shanklin - Tourist
- Chris Kies - Considerate Guest
- Novella Nelson - Nurse
- Kate Blumberg - Dr. Bonata
- Graeme Malcolm - Doctor
- Christopher Swift - Technician
- Asa Somers - Paramedic
- Ruben Santiago-Hudson - Marshall
- MaryAnn Hu - Soo Lin
- MaryAnn Hu - Saleswoman
- Julie White - Press Secretary
- Steve Bridges - President George W. Bush
- Henry Strozier - Hal Stevens
- Kim Brockington - Woman
- Frank Rivers - Man
- Ed Moran - Secret Service Agent
- Sheryl Lee Ralph - Florence
- J.R. Horne - Minister
- Leah Hocking - Diane
- Christopher Wynkoop - Greenfield
- Belinda Sinclair - Rita's Hand Double
- Keith Richards - Self
- Phil Collins - Self
- Dana Vance - Dr. Michelle Shack
- Tony Cucci - Security Guard
- J.D. Jackson - Security Guard
- Michael Paternostro - Brad
- Matthew Del Negro - Daryl
- Diahann Carroll - Viveca Rae
- Carl Gordon - Lawrence Rae
- Christopher W. Holmes - Nightclub Dancer
- Christopher W. Holmes - Hockey Fan
- Michael Emerson - F. Thomas Erickson
- Ralphie May - Sammy
- Thea Vidale - Arbitrator
- Philippe Hartmann - Futon Delivery Man
- Tony Devon - Agent Marco
- Eli Wallach - Norman
- Christopher Evan Welch - Pilot
- Amie Farrell - Sheila
- Wally Dunn - Leon
- Rob Leo Roy - Eddie
- Deborah Collins - Pamela
- Sam Kitchin - Trucker
- Peter Killy - Naked Man
- Hannah Dalton - Waitress
- Robert T. Bogue - Carl
- Tania Deighton - Leah
- Mitchell Green - Bouncer
- Ed Wheeler - Wayne
- Ruth Zhang - Soo Lin's Mother
- Jeremy Beazlie - Surfer Dude
- Teddy Sears - Waiter
- Craig Syracusa - Pedestrian
- Bryse Gregory - Bartender
- Vinny DeGennaro - Bartender
- Thomas Sharkey - Danny
- Mackenzie Milone - Little Girl
- Heather Simms - Bobbi
- Portia - Cassandra
- Robert M. Koch - Mike
- Reuben Jackson - Demetrius
- Sarah Knowlton - Kathy
- Gerry McIntyre - Chris
- Charles Parnell - Minister
- Thom Sesma - Wedding Guest
- Celeste Holm - Diana
- Mark Capri - Andrew
- Orlando Pabotoy - Nurse
- Annie Campbell - Janice
- Ken Leung - Terrence
- Gloria Irizarry - Inez
- Caitlin O'Connell - Olenka
- Joe Morton - Martin James
- Bobb'e J. Thompson - Dante
- Joel Hurt Jones - Agent
- Tom Werner
- Whoopi Goldberg
- Terry Hughes
- Larry Wilmore
Whoopi Goldberg interpreta a Mavis Rae en la serie.
Wren T. Brown hace el papel de Courtney Rae.
Elizabeth Regen interpreta a Rita Nash en la serie.
Omid Djalili hace el papel de Nasim Khatenjami.
Gordana Rashovich hace el papel de Jadwiga.
Capítulo disponible en las siguientes plataformas:
