- Hayes MacArthur - Lance
- Ken Marino - Brian
- Lisa Lampanelli - Mrs. Janks
- Chelsea Handler - Dr. Price
- Kathy Griffin - Lindsay
- June Diane Raphael - Chloe
- Kellee Stewart - Valerie
- John Cleese - Dr. Grant
- Peter Gallagher - Vince
- Kevin Christy - Craig
- Johnny Sneed - Roger
- Jane Kaczmarek - Candi
- Jane Kaczmarek - Patti Morris
- Eddie Pepitone - Older Man
- Carrie Wiita - Carrie
- Anna Diop - Waitress
- Allan Murray - Announcer
- Natalie Cohen - Busty Girl
- Jennifer Birmingham Lee - Sarah
- Loni Love - Nurse
- Julia Cho - Employee
- Michelle Buteau - Girlfriend
- Angela Relucio - Bridesmaid
- Daniel Escobar - Waiter
- Keri Safran - Barista
- Matt Cook - Clerk
- Cici Lau - Flower Lady
- Ben Bliss - Tenor
- Kulap Vilaysack - Waitress
- Tiffany Elle - Woman
- Cameron Bender - Rob
- Sunil Narkar - Indian Restaurant Owner
- Beth Dover - Madeline
- Wesley Thompson - Ronald
- Annie Korzen - Edith
- Diane Sellers - Female Attendant
- Alex Stamm - Young Guy
- Jacob Davich - Young Guy
- Megan Stevenson - Jenn
- Joy Lofton - Waitress
- Vincent M. Ward - Ira
- Jeff Lorch - Jeremy
- Jackie Seiden - Katie
- Moshe Kasher - Waiter
- Michael James - Doctor holder
- Stephane Nicoli - Bartender
- Patrick Hume - Mugger
- Bianca Lopez - Waitress
- Eve - Britnee
- Dov Davidoff - The Manager
- Yves Bright - Guy
- Haley Strode - Cute Girl
- Courtney Parks - Stripper
- Nicole Sullivan - Alicia
- Rueben Grundy - ER Doctor
- Dan Levy - Guy
- Julian McCullough - Nick
- Oscar Magana Jr. - Bar Patron
- Jeremy Timmins - Husband
- Matthew Godbey - Patron
- Matthew Godbey - Patient (voice)
- Marie Del Marco - Ramona
- Lauren Burns - Lorraine
- Leslie Thurston - Bank Lady
- Phillip Garcia - Student
- Lili Fuller - Student
- John Ross Bowie - Eddie
- Maz Jobrani - Dr. West
- Lance Barber - Nate
- Sydney Mikayla - Maggie
- Leslie Grossman - Michelle
- Natasha Leggero - Danielle
- Page Leong - Dr. Cohen
- Dean Norris - Wayne
- Mary Grill - Rebecca
- Wayne Bastrup - Bryan
- Jacqueline Lovell - Susie
- Brent Bailey - Matt
- Paul Scheer - Phillip
- Ginger Gonzaga - Lulu
- Jahmela Biggs - Lauren
- Whitney Cummings
- Susie Farris
- Ed Alton
Chris D'Elia hace el papel de Alex Green.
Zoe Lister-Jones interpreta a Lily en la serie.
Rhea Seehorn hace el papel de Roxanne.
Dan O'Brien interpreta a Mark en la serie.
Tone Bell hace el papel de RJ.
Maulik Pancholy hace el papel de Neal.
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