- Ronnie Schell - Mel (voice)
- B.J. Ward - Female Computer / Stanley (voice)
- Harvey Korman - O. Ratz / Restaurant Owner (voice)
- Marvin Kaplan - Dave D. Fly (voice)
- Nancy Dussault - Woman (voice)
- Elizabeth Daily - Buttercup (voice)
- Cathy Cavadini - Blossom (voice)
- Paul Mercier - Dad / Dog (voice)
- Allison Moore - Dee-Dee (voice)
- Bill Kopp - Yuckie Duck (voice)
- Marsha Clark - Dora (voice)
- Victor Love - Restaurant Manager (voice)
- Earl Kress - Diner Guy (voice)
- Henry Corden - Fred (voice)
- Jean Vander Pyl - Wilma (voice)
- Soleil Moon Frye - Mary (voice)
- Maurice LaMarche - Big Fat Boy (voice)
- Mae Whitman - Little Girl (voice)
- Pat Musick - Grandma (voice)
- Faizon Love - Sledgehammer O'Possum (voice)
- Larry B. Scott - Dogg (voice)
- John Rubinow - George (voice)
- Tony Pope - Junior (voice)
- Brad Garrett - Harley (voice)
- Richard Dumont - Captain Buzz (voice)
- Rick Jones - Slide (voice)
- Paul Zakaib - Blubnoids (voice)
- George Morris - Announcer (voice)
- Roberto Frattini - Jof (voice)
- Patrick Pinney - Johnny / Human (voice)
- Mary Gross - Sally (voice)
- Seth MacFarlane - Larry / Steve (voice)
- Lori Alan - Cindy / Loudspeaker Voice (voice)
- Hank Azaria - Elmo (voice)
- Ken Hudson Campbell - Louie (voice)
- Doug James - President (voice)
- Pat Fraley - Mad Bomber (voice)
- Butch Hartman - Chip (voice)
- Russi Taylor - Hard Luck Duck (voice)
- Russi Taylor - Baby (voice)
- Robert Picardo - Pfish (voice)
- Steven A. Calabro - D. Z. (voice)
- Nancy Linari - (voice)
- Denver Pyle - Podunk Possum (voice)
- Mayf Nutter - Major Portions (voice)
- Christine Cavanaugh - Dexter (voice)
- Christine Cavanaugh - Boy / Alien Kid #2 (voice)
- Jim Cummings - Fuzzy / Mayor (voice)
- Jim Cummings - Fox (voice)
- Jim Cummings - Trucker / French Chef / Fat Guy / Colonel (voice)
- Jim Cummings - Sheriff (voice)
- Jim Cummings - (voice)
- Jim Cummings - Tad / General / Narrator / Dog (voice)
- Kath Soucie - Bubbles / News Reporter / Baby (voice)
- Kath Soucie - Bubbles / Teacher (voice)
- Kath Soucie - Mom (voice)
- Kath Soucie - Scarlet / Winona (voice)
- Kath Soucie - Mom / Ms. Physics (voice)
- Kath Soucie - Girl / Alien Kid #1 (voice)
- Carlos Alazraqui - Casanova (voice)
- Mary Kay Bergman - Doris (voice)
- Gary Owens - Announcer / Commander (voice)
- Roger Rose - Gorilla (voice)
- Roger Rose - Reilly (voice)
- Rob Paulsen - Noof / Yoink / Sgt. Farflung (voice)
- Rob Paulsen - Zeek / Plunger Boy / Executive (voice)
- Rob Paulsen - Pigeon (voice)
- Rob Paulsen - Cop (voice)
- Rob Paulsen - Cook / Cop / Health Inspector / Woman (voice)
- Rob Paulsen - Gramps / Alien Co-Pilot / Mule (voice)
- Tress MacNeille - Sharon / Wife (voice)
- Frank Welker - Pudge (voice)
- Frank Welker - Dino / Saber Tooth Cat (voice)
- Frank Welker - President / General Guy / Man #2 / Einstein (voice)
- Frank Welker - Dino / Older Baby / Cat Siren (voice)
- Frank Welker - Stinky / Elmo / Bloo's Owner (voice)
- Nick Jameson - (voice)
- Nick Jameson - Scientist / Guard Bird / Cop / Dinosaur (voice)
- Nick Jameson - Simon / Cat #1 / Truck Driver (voice)
- Michael Bell - Dad (voice)
- Mark Hamill - Count (voice)
- Ashley Johnson - Mina (voice)
- Jeff Bennett - Johnny Bravo (voice)
- Jeff Bennett - Professor / Cop / Anchor Man / Man #1 (voice)
- Jeff Bennett - Igor (voice)
- Jeff Bennett - Chief / Paperboy (voice)
- Jeff Bennett - Al (voice)
- Jeff Bennett - Anchor Man / Police Chief / Judge / Guard (voice)
- Jeff Bennett - (voice)
- Jeff Bennett - Eustice / Elvis / Man #1 (voice)
- Jeff Bennett - Chief (voice)
- Jess Harnell - Cerberus (voice)
- Miles Thompson - Boid (voice)
- Tom Fahn - Woim (voice)
- Charlie Adler - Mortichae / Waiter / Man #2 (voice)
- Charlie Adler - Ward Zesty Relish / Alien (voice)
- Charlie Adler - Swamp / King / Newt / Man (voice)
- Charlie Adler - (voice)
- Charlie Adler - Cow / Chicken / The Devil (voice)
- Charlie Adler - Wimpy Alien / Alien Dad / Terrified Man / Alien Grandpa (voice)
- Charlie Adler - Captain / Soldier / Porcupine (voice)
- Chuck McCann - Bossman / Tiny / Skinny Slim (voice)
- Candi Milo - Mom (voice)
- Candi Milo - Stewardess / Female Eskimo (voice)
- Candi Milo - Teacher / Timmy (voice)
- Candi Milo - Poopsie (voice)
- Gregg Berger - Alien #1 / Alien #2 / Fed / Cop (voice)
- Gregg Berger - Bear / Dog / Priest (voice)
- Gregg Berger - Man / Cat #2 (voice)
- Jeannie Elias - Pig #1 / Pig #3 / Cooking Show Host (voice)
- T.K. Carter - Steve / Santa (voice)
- T.K. Carter - Sledgehammer O'Possum (voice)
- T.K. Carter - Lion (voice)
- Howard Hoffman - Courage / Farmer / Muriel / Mouse / Chicken (voice)
- Dee Bradley Baker - Dad (voice)
- Dee Bradley Baker - Wind-Up Wolf / Big Bad Wolf / Pig #2 (voice)
- Dee Bradley Baker - (voice)
- Gary Imhoff - Pizza Boy (voice)
- Brian Cummings - Male Eskimo / Guard / Gater (voice)
- Neil Dickson - Alien Leader / Sphinx (voice)
- Julienne Davis - President (voice)
- Tom Kenny - Godfrey / Lab Geek (voice)
- Tom Kenny - (voice)
- Tom Kenny - Rolo (voice)
- Philip Maurice Hayes - Tumbleweed Tex (voice)
- Philip Maurice Hayes - Dad (voice)
- Mike Milo - Bloo / Scully (voice)
- Greg Eagles - Fix (voice)
- Kevin Michael Richardson - Flinch / Thugs (voice)
- Lala Sloatman - Sophie (voice)
- Jeret H. Ochi - Snoot (voice)
- Glenn Shaddix - Doctor (voice)
- Derek Webster - Commander (voice)
- Kevyn Brackett - Ethel (voice)
- James Giordano - (voice)
- Paul Parducci - (voice)
- R.J. Reiley - (voice)
- Ernie Anderson - Narrator (voice)
- Rhoda Gemignani - Mamma Mia
- Ryan Stiles - Vivian
- Phil LaMarr - Captain Americlean / Commercial Announcer / X-19 (voice)
- John DiMaggio - Mish Rotten / Shine Guard / Ali Bubble (voice)
- Roz Baker - Misty Pure / C-Flo / Apple (voice)
- Frank Gorshin - Captain King Crab (voice)
- Billy West - Lieutenant / Rock Shrimp / Jackie Android (voice)
- Liane Schirmer - Dr. Deli (voice)
- Ralph Bakshi
- Andy Bialk
- Eugene Mattos
- Davis Doi
- Joseph Barbera
- William Hanna
- Tex Avery
- Elliot Blake
- Stewart St. John
- Cynthia Parker
- George Johnson
- Michael Rann
- Jill Ziegenhagen
- Fred Seibert
- Dan Smith
- Kris Zimmerman
- Buzz Potamkin
- Michael Warner
- Bodie Chandler
- Preston Oliver
- Pete Houser
- Ed Collins
James Giordano interpreta a (voice) en la serie.
Seth MacFarlane interpreta a Larry / Steve (voice) en la serie.
Paul Parducci interpreta a (voice) en la serie.
Ronnie Schell hace el papel de Mel (voice).
B.J. Ward hace el papel de Female Computer / Stanley (voice).
Harvey Korman hace el papel de O. Ratz / Restaurant Owner (voice).
Marvin Kaplan hace el papel de Dave D. Fly (voice).
Nancy Dussault interpreta a Woman (voice) en la serie.
Elizabeth Daily interpreta a Buttercup (voice) en la serie.
Cathy Cavadini interpreta a Blossom (voice) en la serie.
Capítulo disponible en las siguientes plataformas:
