- Robert Fuller - Cooper Smith
- Robert Fuller - James Fitzpatrick
- Jay North - Tom Blake
- Peter Falk - Gus Morgan
- Harlan Warde - Dr. Haines
- Ken Mayer - Jesse
- Harry Swoger - Ben
- Tim Graham - Walters
- Claire Carleton - Depot Clerk
- Cap Somers - Townsman
- Mike Steen - Hunting Party Member
- Dan Duryea - Amos
- Regis Toomey - Mr. Hunter
- John Rodney - Major Groff
- Kevin O'Neal - Efraim
- Bette Davis - Ella Lindstrom
- Cynthia Chenault - Inga Lindstrom
- Alex Gerry - Dr. Vincent Monroe
- Harold Daye - Stig Lindstrom
- Paul Birch - Gen. Ulysses Simpson 'Sam' Grant
- Paul Birch - Sam Benson
- Terry Burnham - Marguerite Lindstrom
- Herman Hack - Gambler
- Susan Henning - Britt Lindstrom
- Terry Kelman - Lennart Lindstrom
- Jamie Matt - Margit Lindstrom
- Sid Troy - Barfly
- Claire Trevor - C.L. Harding
- Johnny Cash - Frank Hoag
- Amzie Strickland - Arletta Hoag
- Theodore Newton - Buzz
- John Holland - Ellington
- William Benedict - Wagon Train Member
- Gail Bonney - Wagon Train Member
- Lloyd Ford - Wagon Train Member
- Chick Hannan - Wagon Train Member
- Jean Ingram - Estrabella
- David McMahon - Wagon Train Member
- Lillian O'Malley - Wagon Train Member
- Carleton Young - Dr. Colter Craven
- Anna Lee - Mrs. Allyris Craven
- Cliff Lyons - Creel Weatherby
- Chuck Hayward - Quentin Cleatus
- Willis Bouchey - Mr. Grant
- John Carradine - Park Cleatus
- John Wayne - Gen. William Tecumseh Sherman
- Danny Borzage - Soldier
- Richard H. Cutting - Col. Lollier
- Annelle Hayes - Mrs. Grant
- Tex Holden - Wagon Train Member
- Mae Marsh - Mrs. Jesse Grant
- Kermit Maynard - Wagon Train Member
- Jack Pennick - Drill Sergeant Tim Molloy
- Chuck Roberson - Junior
- George Sowards - Wagon Train Member
- Arthur Tovey - Townsman
- Hank Worden - Hank
- Don Grady - George
- Berkeley Harris - Sgt. Kincaid
- Berkeley Harris - Cpl. Reese
- Wally Cox - Vincent Eaglewood
- Dennis Rush - Robbie
- Dennis Rush - Jamie
- Gail Kobe - Erika Hennepin
- Guinn "Big Boy" Williams - Calvin Bryngelson
- Warren Oates - Private Silas Carpenter
- Lynette Bernay - Lynn
- Ron Harper - Lt. Bevins
- Cloris Leachman - Loretta
- Marshall Reed - The Sheriff
- Marshall Reed - Tom
- Chuck Hicks - Court Martial Officer
- Herbert Lytton - Dr. Jenner
- Herbert Lytton - Doctor
- Herbert Lytton - Dr. Porter
- Phyllis Thaxter - Christine Elliot
- Donald Woods - Philip Ayers
- Melinda Casey - Eileen
- Melinda Casey - Priscilla Walker (as Melinda Plowman)
- Tony Maxwell - Kenny
- Jane Wyman - Dr. Carol Ames Willoughby
- Jane Wyman - Hannah Barber
- Gary Hunley - Nat Conners
- Henry Daniell - Morton W. Snipple
- Kathryn Card - Mrs. Mercer
- Kathryn Card - Abby
- Scotty Morrow - Professor
- Brandon De Wilde - Mark Miner
- Brandon De Wilde - Daniel Morgan Benedict III
- Lee Van Cleef - Rufe Beal
- Raymond Bailey - Jim Brenton
- Randy Boone - David Garner
- Harry Harvey - Vern Orton
- Harry Harvey - Sheriff Matt
- Harry Harvey - Deputy Marshall Clancy (uncredited)
- Harry Harvey - Mayor Ives
- Harry Harvey - Mr. Parsons
- Larry Pennell - Marshal Trace McCloud
- John Lupton - Ernie Weaver
- Charles Seel - Mort
- Charles Seel - Wagon Train Member
- Rudy Doucette - Wagon Train Member (uncredited)
- Ross Martin - Sam Pulaski
- Annette Funicello - Rose Pulaski
- Richard Bakalyan - Muscles
- Ken Curtis - Pappy Lightfoot
- Ken Curtis - Kyle Cleatus
- Seymour Cassel - Ed
- Arthur Shields - Judge Tremayne
- Agnes Moorehead - Mary Halstead
- Robert Patten - Kermit
- Paul Sorensen - Posse Member
- John Daheim - Wilkins
- John Daheim - Corey
- William Demarest - Mr. Hennessey
- L.Q. Jones - Lenny
- Wesley Lau - Stevens
- Dale Van Sickel - Hamilton
- William Bendix - Capt. Matthew Cobb
- Marc Lawrence - First Mate Ferris
- Frank Hagney - Jail Prisoner
- Russell Johnson - Craig Manson
- Rachel Ames - Nora Courtney
- Rachel Ames - Florence Yeager
- Fred Graham - The Bartender
- Grant Withers - Mark Hammond
- Dick Rich - Bartender
- Lovyss Bradley - Wagon Train Member
- Lovyss Bradley - Mrs. Olsen (uncredited)
- Lovyss Bradley - Wagon Train Member (uncredited)
- Jane Wyatt - Heather Mahoney
- Cyril Delevanti - Jamieson
- Richard Eyer - Matthew Brant
- Jean Hagen - Sarah Proctor
- Jean Hagen - Maidie Brant
- Edward Platt - Spinoza de Costa
- Lee Marvin - Jose Morales
- Lee Marvin - Jud Benedict
- Chris Robinson - Brad Proctor
- Jim Bannon - Ben Graham
- Joe Dominguez - Manuel Sandoval
- Joe Dominguez - Old Indian
- Abel Fernandez - Tonino (uncredited)
- Jean Allison - Angela Kingdom
- Shelley Winters - Ruth Owens
- Kent Smith - Prof. Paul Owens
- Russell Simpson - Mr. Carr
- Emerson Treacy - George Hankes
- Harry Carey, Jr. - John Jay Burroughs
- Harry Carey, Jr. - Charlie Hankins
- John Larch - John Ramsey
- Rand Brooks - Thomas Pope
- Tom McKee - Vinson
- Tom McKee - Archibald McAdoo
- Susan Silo - Betty Whittaker
- Susan Silo - Susan
- Lon Chaney Jr. - Louis Roque
- Lon Chaney Jr. - Carstairs
- Richard Jaeckel - Barker
- William Challee - Homeowner
- William Challee - Freighter (uncredited)
- Alan Marshal - Bart Grover
- Edgar Buchanan - Ben Mattox
- Sherwood Price - Jesse
- Myrna Fahey - Melanie Craig
- Myrna Fahey - Jane Hawkins
- Dick Wessel - Biff
- Ed Wynn - Cappy Darrin
- Gary Clarke - Lonnie Fallon
- Lynn Loring - Kathy Jennings
- Norman Leavitt - Cory (uncredited)
- Norman Leavitt - Sam the Bartender
- Norman Leavitt - Slim
- Norman Leavitt - Wagon Train Member
- Norman Leavitt - Mr. Kelsey
- Alan Hale Jr. - Kirby
- Frank Overton - The Doctor
- Frank Overton - Martin Jennings
- Verna Felton - Gran Jennings
- Richard Reeves - The Trapper
- Richard Reeves - Pop Harmon
- Richard Reeves - Patrick McClure
- Richard Reeves - Walls
- Richard Reeves - Sam Hulsey
- Richard Reeves - Roberts
- Richard Reeves - Orv Bassett
- Anne Helm - Ruth Cain
- George Gobel - Horace Best
- Joe Flynn - Edwin Crook
- Allen Jenkins - Mr. Gillespie
- Mary Field - Mrs. Gillespie
- Jim McMullan - Arnie Swenson
- Carolyn Jones - Molly Kincaid
- Brenda Scott - Martha Kincaid
- Pamela Austin - Merrybell Freeman
- Noah Beery Jr. - Stump Beasley
- Rory Calhoun - Jarbo Pierce
- Tom Simcox - Adam Pierce
- Art Linkletter - Sam Darland
- Bill Mumy - Toddy
- Tommy Sands - Ethan Morgan
- Tommy Sands - Keith Lance
- Tommy Sands - Larry Hanify
- Ray Teal - Ray Tarback
- Ernest Borgnine - Willy Moran
- Ernest Borgnine - Indian Brave (uncredited)
- Ernest Borgnine - Earl Packer
- Ernest Borgnine - Estaban Zamora
- Keith Richards - Major Hunt
- Keith Richards - Lace Andrews
- Peter Fonda - Orly French
- Vera Miles - Sister Rita
- Vera Miles - Janice Stuart
- Sharon Farrell - Pearlie Garnet
- Sharon Farrell - Judy Wilson
- Hugh Beaumont - Jed Halick
- Walter Reed - Major Harrison
- Walter Reed - Sheriff Miller (uncredited)
- Sol Gorss - Townsman (uncredited)
- Robert Blake - Johnny Kamen
- H.M. Wynant - Clay Boudreau
- H.M. Wynant - Bart Haskell
- Tris Coffin - Whittaker
- Jay Novello - Carlotti
- Onslow Stevens - Col. Daniel Morgan Benedict II
- Onslow Stevens - Jack Hanford
- Janis Paige - Nellie Jefferson
- Don C. Harvey - Jim Collins
- Don C. Harvey - Jason Arnold (uncredited)
- Don C. Harvey - Marshal
- Stacy Harris - The Sheriff
- Stacy Harris - Sheriff
- Stacy Harris - Sheriff Francher
- Robert Colbert - Blane Wessels
- Douglas Fowley - Ed Graham
- Jean Hale - Susan Durfee
- Hari Rhodes - Jefferson Washington Freeman
- Dick Cherney - Townsman (uncredited)
- Frank De Kova - Isaiah Quickfox
- Frank De Kova - Obuki
- Frank De Kova - Ocheo
- Forrest Tucker - Rex Montana
- Kristine Miller - Milly Clark
- Joseph Vitale - Chenwakee
- Frank J. Scannell - Griff
- Audrey Dalton - Lola Medina
- Audrey Dalton - Danna Bannon
- Ray Montgomery - George
- John Doucette - Col. Wayne Lathrop
- John Doucette - Gen. Jameson
- John Doucette - Boone Gilla
- John Doucette - Chandler Ames
- John Doucette - Marshal Jason Hartman
- John Doucette - Michael McGoo
- John Doucette - Burt Enders
- John Doucette - Ben Engel
- Clu Gulager - Harry Diel
- Dal McKennon - Lee
- Dal McKennon - Alex
- Dal McKennon - The Horsetrader
- Darby Hinton - Benjie Diel
- Frank Ferguson - Judge Hiram Larkin
- Russ Conway - Mr. Freeman (uncredited)
- Russ Conway - Mr. McCrea
- Herschel Graham - Party Guest (uncredited)
- Herschel Graham - Townsman (uncredited)
- Jeanette Nolan - Chottsie Gubenheimer
- Buck Taylor - Skeeter Ames
- Andrew Duggan - Dan Brady
- Beverly Washburn - Susan Palmer
- John Harmon - Fabor
- Kevin Hagen - Lansing
- Richard Devon - Saloon Hoodlum
- Phillip Pine - Manuel Zamora
- Marshall Thompson - Will Stebbins
- Marshall Thompson - Bradley Mason
- Robert Armstrong - Roy Daniels
- Dean Stockwell - Jimmy Drew
- Dean Stockwell - Juan Ortega
- Dean Stockwell - Rodney Lawrence
- Dean Stockwell - Will Santee
- Leonard Nimoy - Bernabe Zamora
- Stuart Randall - Sheriff Hixon
- Andrew Prine - Eric Camden
- Andrew Prine - Felix Colton
- Virginia Christine - Minna Collins
- Virginia Christine - Amanda Santee
- Byron Foulger - Jervis Clinton
- Byron Foulger - Humphrey Pumphret
- Byron Foulger - George Duskin
- Byron Foulger - Hibbs
- Rex Holman - Joe Abbot
- Rex Holman - Harry
- Robert Pine - Jonathan Olsen
- Ann Blyth - Nancy Winters
- Ann Blyth - Eve Newhope
- Ann Blyth - Martha Barham
- Aline Towne - Meg
- Dorothy Neumann - Wagon Train Member (uncredited)
- Damian O'Flynn - Mr. Emerson
- John Wilder - Stanley Blower
- Edward Binns - Jud Steele
- Edward Binns - Sheriff Bill Strode
- Marjorie Bennett - Sylvester's Wife
- Marjorie Bennett - Maud Wilks
- J. Pat O'Malley - Colin Dunn
- J. Pat O'Malley - Earl Caulkins
- William Smith - Thomas Lance
- Laurie Mitchell - Annie Tolleson
- Laurie Mitchell - June
- Martin Milner - Matt Trumbell
- King Donovan - Henry Bennett
- Johnny Crawford - Jimmy Bennett
- Steven Ritch - Red Cloud
- Steven Ritch - Running Bear
- Joe Turkel - Eddie
- Arthur Franz - Nathan Forge
- Arthur Franz - Dan Highet
- Fred Sherman - Attendant
- Russell Thorson - Simon Landis
- Russell Thorson - Major
- Russell Thorson - Warden
- Robert F. Simon - Jay Thorton
- Larry J. Blake - Booley Herbert
- Larry J. Blake - Chief White Cloud
- Larry J. Blake - Sheriff (uncredited)
- Morgan Jones - Jason Elliott
- Janice Rule - Maggie Thomas
- Harold J. Stone - Mayor Tucker
- Denver Pyle - Bragg
- Naomi Stevens - Hannah Moses
- Bruce Dern - Wilkins
- Bruce Dern - Jud Fisher
- Tom Skerritt - Hamish Browne
- Lane Bradford - Kenny Stark (uncredited)
- Eddy Waller - Ned
- Dawn Wells - Mrs. Murray
- Mauritz Hugo - Haines
- Mauritz Hugo - Frankie Palmer
- Robert J. Wilke - Sgt. Wick
- Robert J. Wilke - Jabez Moore
- Robert J. Wilke - Wesley Thomas
- Robert J. Wilke - Col. Thomas Stone
- Walter Baldwin - Eddie Blake (uncredited)
- Rhonda Fleming - Jennifer Churchill
- Rhonda Fleming - Patience Miller
- Mary Treen - Bessie Treymore (uncredited)
- Joseph Mell - Storekeeper
- Joseph Mell - Proprietor (uncredited)
- Joseph Mell - Wheelman
- Charles Cooper - Lieutenant Quincy Abbott
- Milton Frome - Tom Yates
- Milton Frome - Sheriff
- John Dennis - Police Sergeant
- Robert Osterloh - Ransome Jarvis
- Robert Osterloh - Wilbur Martin
- Michael Ansara - Chief North Star
- Michael Ansara - Adam MacKenzie
- Penny Santon - Carlota Perez
- Mickey Rooney - Samuel T. Evans
- Lillian Bronson - Miss Phoebe
- Lillian Bronson - Alicia Thorton
- Ellen Corby - Aunt Em
- Olive Sturgess - Melanie Evans
- Peter Mamakos - Chief (uncredited)
- Lee Patrick - Mrs. Elliot Swinbourne Steele
- Dan Tobin - Mr. Bill Dashwood
- John Baer - Clay Willis
- Peter Brown - Benedict O'Brien
- Peter Brown - Ben Campbell
- Nancy Reagan - Mrs. Baxter
- Dan Riss - Kelleher
- Louis Quinn - Trinket Seller
- Alvy Moore - Private Bledsoe
- Harry Hickox - Capt. Albert Sanborn
- Lola Albright - Leonora Parkman
- Dayton Lummis - Major P.S. Barham
- Dayton Lummis - Rev. Philip Marshall
- Dayton Lummis - Dr. Baldwin
- Marjorie Main - Cassie Tanner
- Margaret O'Brien - Julie Revere
- Reed Hadley - Mort Galvin
- George Chandler - Cleveland 'Clee' McMasters
- Michael Forest - Julio
- Harvey Stephens - Maxwell Revere
- Harvey Stephens - Bank Manager
- Nancy Gates - Della
- Henry Brandon - Chief Dark Eagle
- Henry Brandon - Black Panther
- Henry Brandon - Ute Indian Chief
- Paul E. Burns - Fred Elkins
- Paul Fix - Amos Billings
- Paul Fix - Jake
- Paul Fix - Sean Bannon
- Dennis Patrick - Josh Anders
- Jean Engstrom - Loan
- Leslie Nielsen - Brian Conlin
- Dick Miller - Michel
- Polly Bergen - Kitty Allbright
- Read Morgan - Ben Denike
- Read Morgan - Curly Horse
- Read Morgan - Jake
- Suzanne Pleshette - Myra Marshall
- Charles Drake - Marshal Vern Rothman
- Perry Cook - The Sheriff
- Joby Baker - Nathan May
- Robert Emhardt - Papa Kling
- Robert Emhardt - Roger Crowell
- Katharine Ross - Bonnie Brooke
- Richard Donner
- John Ford
- Virgil W. Vogel
- Herschel Daugherty
- Allen H. Miner
- Sidney Lanfield
- John McGreevey
- David Swift
- Tony Paulson
- Dwight Newton
- Jean Holloway
- Norman Jolley
- Frederick Shorr
- Howard Christie
- Cyril J. Mockridge
Naomi Stevens interpreta a Hannah Moses en la serie.
Peter Falk interpreta a Gus Morgan en la serie.
Tom Skerritt hace el papel de Hamish Browne.
Robert J. Wilke hace el papel de Wesley Thomas.
Carleton Young interpreta a Dr. Colter Craven en la serie.
Bette Davis interpreta a Ella Lindstrom en la serie.
Marc Lawrence interpreta a First Mate Ferris en la serie.
John Wayne interpreta a Gen. William Tecumseh Sherman en la serie.
Joe Turkel interpreta a Eddie en la serie.
Edward Platt interpreta a Spinoza de Costa en la serie.
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