- Robert Fuller - Cooper Smith
- Robert Fuller - James Fitzpatrick
- Jay North - Tom Blake
- Peter Falk - Gus Morgan
- Harlan Warde - Dr. Haines
- Ken Mayer - Jesse
- Harry Swoger - Ben
- Tim Graham - Walters
- Claire Carleton - Depot Clerk
- Cap Somers - Townsman
- Mike Steen - Hunting Party Member
- Dan Duryea - Amos
- Regis Toomey - Mr. Hunter
- John Rodney - Major Groff
- Kevin O'Neal - Efraim
- Bette Davis - Ella Lindstrom
- Cynthia Chenault - Inga Lindstrom
- Alex Gerry - Dr. Vincent Monroe
- Harold Daye - Stig Lindstrom
- Paul Birch - Gen. Ulysses Simpson 'Sam' Grant
- Paul Birch - Sam Benson
- Terry Burnham - Marguerite Lindstrom
- Herman Hack - Gambler
- Susan Henning - Britt Lindstrom
- Terry Kelman - Lennart Lindstrom
- Jamie Matt - Margit Lindstrom
- Sid Troy - Barfly
- Claire Trevor - C.L. Harding
- Johnny Cash - Frank Hoag
- Amzie Strickland - Arletta Hoag
- Theodore Newton - Buzz
- John Holland - Ellington
- William Benedict - Wagon Train Member
- Gail Bonney - Wagon Train Member
- Lloyd Ford - Wagon Train Member
- Chick Hannan - Wagon Train Member
- Jean Ingram - Estrabella
- David McMahon - Wagon Train Member
- Lillian O'Malley - Wagon Train Member
- Carleton Young - Dr. Colter Craven
- Anna Lee - Mrs. Allyris Craven
- Cliff Lyons - Creel Weatherby
- Chuck Hayward - Quentin Cleatus
- Willis Bouchey - Mr. Grant
- John Carradine - Park Cleatus
- John Wayne - Gen. William Tecumseh Sherman
- Danny Borzage - Soldier
- Richard H. Cutting - Col. Lollier
- Annelle Hayes - Mrs. Grant
- Tex Holden - Wagon Train Member
- Mae Marsh - Mrs. Jesse Grant
- Kermit Maynard - Wagon Train Member
- Jack Pennick - Drill Sergeant Tim Molloy
- Chuck Roberson - Junior
- George Sowards - Wagon Train Member
- Arthur Tovey - Townsman
- Hank Worden - Hank
- Don Grady - George
- Berkeley Harris - Sgt. Kincaid
- Berkeley Harris - Cpl. Reese
- Wally Cox - Vincent Eaglewood
- Dennis Rush - Robbie
- Dennis Rush - Jamie
- Gail Kobe - Erika Hennepin
- Guinn "Big Boy" Williams - Calvin Bryngelson
- Warren Oates - Private Silas Carpenter
- Lynette Bernay - Lynn
- Ron Harper - Lt. Bevins
- Cloris Leachman - Loretta
- Marshall Reed - The Sheriff
- Marshall Reed - Tom
- Chuck Hicks - Court Martial Officer
- Herbert Lytton - Dr. Jenner
- Herbert Lytton - Doctor
- Herbert Lytton - Dr. Porter
- Phyllis Thaxter - Christine Elliot
- Donald Woods - Philip Ayers
- Melinda Casey - Eileen
- Melinda Casey - Priscilla Walker (as Melinda Plowman)
- Tony Maxwell - Kenny
- Jane Wyman - Dr. Carol Ames Willoughby
- Jane Wyman - Hannah Barber
- Gary Hunley - Nat Conners
- Henry Daniell - Morton W. Snipple
- Kathryn Card - Mrs. Mercer
- Kathryn Card - Abby
- Scotty Morrow - Professor
- Brandon De Wilde - Mark Miner
- Brandon De Wilde - Daniel Morgan Benedict III
- Lee Van Cleef - Rufe Beal
- Raymond Bailey - Jim Brenton
- Randy Boone - David Garner
- Harry Harvey - Vern Orton
- Harry Harvey - Sheriff Matt
- Harry Harvey - Deputy Marshall Clancy (uncredited)
- Harry Harvey - Mayor Ives
- Harry Harvey - Mr. Parsons
- Larry Pennell - Marshal Trace McCloud
- John Lupton - Ernie Weaver
- Charles Seel - Mort
- Charles Seel - Wagon Train Member
- Rudy Doucette - Wagon Train Member (uncredited)
- Ross Martin - Sam Pulaski
- Annette Funicello - Rose Pulaski
- Richard Bakalyan - Muscles
- Ken Curtis - Pappy Lightfoot
- Ken Curtis - Kyle Cleatus
- Seymour Cassel - Ed
- Arthur Shields - Judge Tremayne
- Agnes Moorehead - Mary Halstead
- Robert Patten - Kermit
- Paul Sorensen - Posse Member
- John Daheim - Wilkins
- John Daheim - Corey
- William Demarest - Mr. Hennessey
- L.Q. Jones - Lenny
- Wesley Lau - Stevens
- Dale Van Sickel - Hamilton
- William Bendix - Capt. Matthew Cobb
- Marc Lawrence - First Mate Ferris
- Frank Hagney - Jail Prisoner
- Russell Johnson - Craig Manson
- Rachel Ames - Nora Courtney
- Rachel Ames - Florence Yeager
- Fred Graham - The Bartender
- Grant Withers - Mark Hammond
- Dick Rich - Bartender
- Lovyss Bradley - Wagon Train Member
- Lovyss Bradley - Mrs. Olsen (uncredited)
- Lovyss Bradley - Wagon Train Member (uncredited)
- Jane Wyatt - Heather Mahoney
- Cyril Delevanti - Jamieson
- Richard Eyer - Matthew Brant
- Jean Hagen - Sarah Proctor
- Jean Hagen - Maidie Brant
- Edward Platt - Spinoza de Costa
- Lee Marvin - Jose Morales
- Lee Marvin - Jud Benedict
- Chris Robinson - Brad Proctor
- Jim Bannon - Ben Graham
- Joe Dominguez - Manuel Sandoval
- Joe Dominguez - Old Indian
- Abel Fernandez - Tonino (uncredited)
- Jean Allison - Angela Kingdom
- Shelley Winters - Ruth Owens
- Kent Smith - Prof. Paul Owens
- Russell Simpson - Mr. Carr
- Emerson Treacy - George Hankes
- Harry Carey, Jr. - John Jay Burroughs
- Harry Carey, Jr. - Charlie Hankins
- John Larch - John Ramsey
- Rand Brooks - Thomas Pope
- Tom McKee - Vinson
- Tom McKee - Archibald McAdoo
- Susan Silo - Betty Whittaker
- Susan Silo - Susan
- Lon Chaney Jr. - Louis Roque
- Lon Chaney Jr. - Carstairs
- Richard Jaeckel - Barker
- William Challee - Homeowner
- William Challee - Freighter (uncredited)
- Alan Marshal - Bart Grover
- Edgar Buchanan - Ben Mattox
- Sherwood Price - Jesse
- Myrna Fahey - Melanie Craig
- Myrna Fahey - Jane Hawkins
- Dick Wessel - Biff
- Ed Wynn - Cappy Darrin
- Gary Clarke - Lonnie Fallon
- Lynn Loring - Kathy Jennings
- Norman Leavitt - Cory (uncredited)
- Norman Leavitt - Sam the Bartender
- Norman Leavitt - Slim
- Norman Leavitt - Wagon Train Member
- Norman Leavitt - Mr. Kelsey
- Alan Hale Jr. - Kirby
- Frank Overton - The Doctor
- Frank Overton - Martin Jennings
- Verna Felton - Gran Jennings
- Richard Reeves - The Trapper
- Richard Reeves - Pop Harmon
- Richard Reeves - Patrick McClure
- Richard Reeves - Walls
- Richard Reeves - Sam Hulsey
- Richard Reeves - Roberts
- Richard Reeves - Orv Bassett
- Anne Helm - Ruth Cain
- George Gobel - Horace Best
- Joe Flynn - Edwin Crook
- Allen Jenkins - Mr. Gillespie
- Mary Field - Mrs. Gillespie
- Jim McMullan - Arnie Swenson
- Carolyn Jones - Molly Kincaid
- Brenda Scott - Martha Kincaid
- Pamela Austin - Merrybell Freeman
- Noah Beery Jr. - Stump Beasley
- Rory Calhoun - Jarbo Pierce
- Tom Simcox - Adam Pierce
- Art Linkletter - Sam Darland
- Bill Mumy - Toddy
- Tommy Sands - Ethan Morgan
- Tommy Sands - Keith Lance
- Tommy Sands - Larry Hanify
- Ray Teal - Ray Tarback
- Ernest Borgnine - Willy Moran
- Ernest Borgnine - Indian Brave (uncredited)
- Ernest Borgnine - Earl Packer
- Ernest Borgnine - Estaban Zamora
- Keith Richards - Major Hunt
- Keith Richards - Lace Andrews
- Peter Fonda - Orly French
- Vera Miles - Sister Rita
- Vera Miles - Janice Stuart
- Sharon Farrell - Pearlie Garnet
- Sharon Farrell - Judy Wilson
- Hugh Beaumont - Jed Halick
- Walter Reed - Major Harrison
- Walter Reed - Sheriff Miller (uncredited)
- Sol Gorss - Townsman (uncredited)
- Robert Blake - Johnny Kamen
- H.M. Wynant - Clay Boudreau
- H.M. Wynant - Bart Haskell
- Tris Coffin - Whittaker
- Jay Novello - Carlotti
- Onslow Stevens - Col. Daniel Morgan Benedict II
- Onslow Stevens - Jack Hanford
- Janis Paige - Nellie Jefferson
- Don C. Harvey - Jim Collins
- Don C. Harvey - Jason Arnold (uncredited)
- Don C. Harvey - Marshal
- Stacy Harris - The Sheriff
- Stacy Harris - Sheriff
- Stacy Harris - Sheriff Francher
- Robert Colbert - Blane Wessels
- Douglas Fowley - Ed Graham
- Jean Hale - Susan Durfee
- Hari Rhodes - Jefferson Washington Freeman
- Dick Cherney - Townsman (uncredited)
- Frank De Kova - Isaiah Quickfox
- Frank De Kova - Obuki
- Frank De Kova - Ocheo
- Forrest Tucker - Rex Montana
- Kristine Miller - Milly Clark
- Joseph Vitale - Chenwakee
- Frank J. Scannell - Griff
- Audrey Dalton - Lola Medina
- Audrey Dalton - Danna Bannon
- Ray Montgomery - George
- John Doucette - Col. Wayne Lathrop
- John Doucette - Gen. Jameson
- John Doucette - Boone Gilla
- John Doucette - Chandler Ames
- John Doucette - Marshal Jason Hartman
- John Doucette - Michael McGoo
- John Doucette - Burt Enders
- John Doucette - Ben Engel
- Clu Gulager - Harry Diel
- Dal McKennon - Lee
- Dal McKennon - Alex
- Dal McKennon - The Horsetrader
- Darby Hinton - Benjie Diel
- Frank Ferguson - Judge Hiram Larkin
- Russ Conway - Mr. Freeman (uncredited)
- Russ Conway - Mr. McCrea
- Herschel Graham - Party Guest (uncredited)
- Herschel Graham - Townsman (uncredited)
- Jeanette Nolan - Chottsie Gubenheimer
- Buck Taylor - Skeeter Ames
- Andrew Duggan - Dan Brady
- Beverly Washburn - Susan Palmer
- John Harmon - Fabor
- Kevin Hagen - Lansing
- Richard Devon - Saloon Hoodlum
- Phillip Pine - Manuel Zamora
- Marshall Thompson - Will Stebbins
- Marshall Thompson - Bradley Mason
- Robert Armstrong - Roy Daniels
- Dean Stockwell - Jimmy Drew
- Dean Stockwell - Juan Ortega
- Dean Stockwell - Rodney Lawrence
- Dean Stockwell - Will Santee
- Leonard Nimoy - Bernabe Zamora
- Stuart Randall - Sheriff Hixon
- Andrew Prine - Eric Camden
- Andrew Prine - Felix Colton
- Virginia Christine - Minna Collins
- Virginia Christine - Amanda Santee
- Byron Foulger - Jervis Clinton
- Byron Foulger - Humphrey Pumphret
- Byron Foulger - George Duskin
- Byron Foulger - Hibbs
- Rex Holman - Joe Abbot
- Rex Holman - Harry
- Robert Pine - Jonathan Olsen
- Ann Blyth - Nancy Winters
- Ann Blyth - Eve Newhope
- Ann Blyth - Martha Barham
- Aline Towne - Meg
- Dorothy Neumann - Wagon Train Member (uncredited)
- Damian O'Flynn - Mr. Emerson
- John Wilder - Stanley Blower
- Edward Binns - Jud Steele
- Edward Binns - Sheriff Bill Strode
- Marjorie Bennett - Sylvester's Wife
- Marjorie Bennett - Maud Wilks
- J. Pat O'Malley - Colin Dunn
- J. Pat O'Malley - Earl Caulkins
- William Smith - Thomas Lance
- Laurie Mitchell - Annie Tolleson
- Laurie Mitchell - June
- Martin Milner - Matt Trumbell
- King Donovan - Henry Bennett
- Johnny Crawford - Jimmy Bennett
- Steven Ritch - Red Cloud
- Steven Ritch - Running Bear
- Joe Turkel - Eddie
- Arthur Franz - Nathan Forge
- Arthur Franz - Dan Highet
- Fred Sherman - Attendant
- Russell Thorson - Simon Landis
- Russell Thorson - Major
- Russell Thorson - Warden
- Robert F. Simon - Jay Thorton
- Larry J. Blake - Booley Herbert
- Larry J. Blake - Chief White Cloud
- Larry J. Blake - Sheriff (uncredited)
- Morgan Jones - Jason Elliott
- Janice Rule - Maggie Thomas
- Harold J. Stone - Mayor Tucker
- Denver Pyle - Bragg
- Naomi Stevens - Hannah Moses
- Bruce Dern - Wilkins
- Bruce Dern - Jud Fisher
- Tom Skerritt - Hamish Browne
- Lane Bradford - Kenny Stark (uncredited)
- Eddy Waller - Ned
- Dawn Wells - Mrs. Murray
- Mauritz Hugo - Haines
- Mauritz Hugo - Frankie Palmer
- Robert J. Wilke - Sgt. Wick
- Robert J. Wilke - Jabez Moore
- Robert J. Wilke - Wesley Thomas
- Robert J. Wilke - Col. Thomas Stone
- Walter Baldwin - Eddie Blake (uncredited)
- Rhonda Fleming - Jennifer Churchill
- Rhonda Fleming - Patience Miller
- Mary Treen - Bessie Treymore (uncredited)
- Joseph Mell - Storekeeper
- Joseph Mell - Proprietor (uncredited)
- Joseph Mell - Wheelman
- Charles Cooper - Lieutenant Quincy Abbott
- Milton Frome - Tom Yates
- Milton Frome - Sheriff
- John Dennis - Police Sergeant
- Robert Osterloh - Ransome Jarvis
- Robert Osterloh - Wilbur Martin
- Michael Ansara - Chief North Star
- Michael Ansara - Adam MacKenzie
- Penny Santon - Carlota Perez
- Mickey Rooney - Samuel T. Evans
- Lillian Bronson - Miss Phoebe
- Lillian Bronson - Alicia Thorton
- Ellen Corby - Aunt Em
- Olive Sturgess - Melanie Evans
- Peter Mamakos - Chief (uncredited)
- Lee Patrick - Mrs. Elliot Swinbourne Steele
- Dan Tobin - Mr. Bill Dashwood
- John Baer - Clay Willis
- Peter Brown - Benedict O'Brien
- Peter Brown - Ben Campbell
- Nancy Reagan - Mrs. Baxter
- Dan Riss - Kelleher
- Louis Quinn - Trinket Seller
- Alvy Moore - Private Bledsoe
- Harry Hickox - Capt. Albert Sanborn
- Lola Albright - Leonora Parkman
- Dayton Lummis - Major P.S. Barham
- Dayton Lummis - Rev. Philip Marshall
- Dayton Lummis - Dr. Baldwin
- Marjorie Main - Cassie Tanner
- Margaret O'Brien - Julie Revere
- Reed Hadley - Mort Galvin
- George Chandler - Cleveland 'Clee' McMasters
- Michael Forest - Julio
- Harvey Stephens - Maxwell Revere
- Harvey Stephens - Bank Manager
- Nancy Gates - Della
- Henry Brandon - Chief Dark Eagle
- Henry Brandon - Black Panther
- Henry Brandon - Ute Indian Chief
- Paul E. Burns - Fred Elkins
- Paul Fix - Amos Billings
- Paul Fix - Jake
- Paul Fix - Sean Bannon
- Dennis Patrick - Josh Anders
- Jean Engstrom - Loan
- Leslie Nielsen - Brian Conlin
- Dick Miller - Michel
- Polly Bergen - Kitty Allbright
- Read Morgan - Ben Denike
- Read Morgan - Curly Horse
- Read Morgan - Jake
- Suzanne Pleshette - Myra Marshall
- Charles Drake - Marshal Vern Rothman
- Perry Cook - The Sheriff
- Joby Baker - Nathan May
- Robert Emhardt - Papa Kling
- Robert Emhardt - Roger Crowell
- Katharine Ross - Bonnie Brooke
- Richard Donner
- John Ford
- Virgil W. Vogel
- Herschel Daugherty
- Allen H. Miner
- Sidney Lanfield
- John McGreevey
- David Swift
- Tony Paulson
- Dwight Newton
- Jean Holloway
- Norman Jolley
- Frederick Shorr
- Howard Christie
- Cyril J. Mockridge
Naomi Stevens hace el papel de Hannah Moses.
Peter Falk hace el papel de Gus Morgan.
Tom Skerritt hace el papel de Hamish Browne.
Robert J. Wilke hace el papel de Wesley Thomas.
Carleton Young hace el papel de Dr. Colter Craven.
Bette Davis interpreta a Ella Lindstrom en la serie.
Marc Lawrence hace el papel de First Mate Ferris.
John Wayne hace el papel de Gen. William Tecumseh Sherman.
Joe Turkel hace el papel de Eddie.
Edward Platt hace el papel de Spinoza de Costa.
Capítulo disponible en las siguientes plataformas:
