- Ivan Gonzalez - Jerry Guildencrantz
- Ophelia Lovibond - Izzy Gould
- Max Olesker - Ben Rosenstern
- Rufus Jones - David Wilkes
- David Tennant - Narrator (voice)
- Simon Greenall - Nigel Trescott
- Karen Ascoe - Sally Wingate
- Salman Rushdie - Self
- Clare Balding - Self
- Jenni Murray - Self
- Carol Vorderman - Self
- Nyasha Hatendi - Reporter
- Nadia Kamil - Woman's Hour B.A.
- Adrian Der Gregorian - Office Guy
- Olivia Colman - Sally Owen
- Matt Addis - Journalist
- Elizabeth Berrington - Elaine Pearson
- Justin Edwards - Mark Stephenson
- Andrew Brooke - Dave Green
- Asim Chaudhry - Security Guard 1
- Sophie Fletcher - Alice
- Dan Mersh - Man in Broadcasting House
- Marcus Onilude - Security Guard 2
- Samuel West - Richard Cartwright
- Clare Wille - Camilla
- Tom Basden - Dan Shepherd
- Sarah Hadland - Pilates Instructor
- Mary Beard - Self
- Simon Bubb - Benedict Cartwright
- Evan Davis - Self
- Alan Yentob - Self
- Shelley Conn - Azia Zamani
- Amit Shah - Sadiq Iqbal
- Kåre Conradi - Jens Smit
- Maggie Service - Hotel Receptionist
- Gary Lineker - Self
- Alan Shearer - Self
- Ben Batt - Ryan Chelford
- Derek Riddell - Clive Cook
- Lenny Henry - Self
- Laurence Howarth - Adam Brady
- Jeffery Kissoon - Ray Fredericks
- Emily Lloyd-Saini - Fiona's P.A.
- Louise Minchin - Self
- Jeremy Paxman - Self
- Will Sharpe - Michael Chung
- Shauna Shim - Donna Fredericks
- Dan Walker - Self
- Ben Ashenden - Assistant Floor Manager
- Priyanga Burford - Faiza Rajah
- Laura Checkley - Paramedic
- Chris Cowlin - Paramedic
- Brian Cox - Self
- Sophie Raworth - Self
- Daniel Ings - Matt Taverner
- Raquel Cassidy - Tasmin Howard
- Hugh Grant - Self
- Dominic Mafham - Tony Dixon
- Claudia Winkleman - Self
- Sara Pascoe - Coco Lomax
- Alex Beckett - Barney Lumsden
- Joel Fry - Karl Marx
- Kae Alexander - Receptionist
- Rose Matafeo - Chloe
- Pooky Quesnel - Fiona Craig
- Emma Sidi - Zoe
- John Morton
Hugh Grant interpreta a Self en la serie.
Hugh Bonneville interpreta a Ian Fletcher en la serie.
Monica Dolan interpreta a Tracey Pritchard en la serie.
Jessica Hynes hace el papel de Siobhan Sharpe.
Sarah Parish interpreta a Anna Rampton en la serie.
Jason Watkins interpreta a Simon Harwood en la serie.
Hugh Skinner interpreta a Will Humphries en la serie.
David Westhead hace el papel de Neil Reid.
Nina Sosanya hace el papel de Lucy Freeman.
Jonathan Bailey interpreta a Jack Patterson en la serie.
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