- Arnold Pinnock - Walt Forbes
- Olivia Cheng - Dr. Grace Lee
- David James Lewis - Major Gleason
- Kyra Zagorsky - Dr. Delaney
- Karin Konoval - Mrs. Bloom
- Kevin McNulty - Earl
- Eileen Pedde - Mom
- Chilton Crane - Cathy Whiteman
- Adrian Hough - Allan
- Alyson Bath - Mindy
- Laura Mennell - ADA Peckham
- Jason Gray-Stanford - Aaron Donner
- Gerard Plunkett - Ted Bishop
- Tom McBeath - Ellis
- Matthew Kevin Anderson - D13 / Derek
- Yasmeene Ball - Charlotte
- Danielle Kremeniuk - Secretary
- Lisa MacFadden - Doctor #3
- Link Baker - Agent Morton
- Carolyn Anderson - Agent Paulson
- Robert Moloney - Oliver
- Elysia Rotaru - Irene
- Jazmine Campanale - Dr. Chen
- Howie Lai - Traveler 2150
- Michael Karl Richards - Dale
- Bradley Duffy - Dale
- Barry W. Levy - Dr. Calloway
- Jennifer Copping - Sylvie Ward
- Sandy Robson - Jacob Ward
- Lee Majdoub - Dr. Barker
- Sunita Prasad - Blair
- Paloma Kwiatkowski - Abigail Paris
- Dakota Guppy - Chloe
- Todd Thomson - Dr. Higgins
- Brandyn Eddy - Doctor #2
- Brandyn Eddy - Mark
- Brandy Le - Helix
- Stephanie Bennett - Jenny
- Cameron McDonald - Graham
- Gwenda Lorenzetti - Colleen
- Fiona Hogan - Nurse Jane
- Trevor Roberts - Dad
- Xantha Radley - Vera
- James Rha - Xiao
- Michael Cha - Young Shanghai Man
- Pricilla Mudaliar - Annie Kapoor
- Jeremy Lacombe - Runner 1
- Nina Winkler - Runner 2
- Heath Affolter - Heath
- Bob Frazer - Traveler 3224
- Pat Smith - Mr. Morrissy
- Sonia Sunger - Reporter
- James R. Baylis - Bob
- Tristan Jensen - Guard
- Alison Araya - Captain Garcia
- Anesha Bailey - Ensign Jackson
- Brenden Sunderland - Young Boy
- Melissa Roxburgh - Carrie
- Benjamin Charles Watson - Lars
- Andrew Dunbar - Wayne
- Noah Beggs - Trucker
- Vincent Gale - Traveler 0029
- Kurt Evans - Programmer 0017
- Ronald Patrick Thompson - First Guardsman / Traveler 5401
- Debs Howard - Stacey
- Zoey Siewert - Young Girl
- Winslow Holmes - Terminal Patient #1
- Robin T. Rose - Terminal Patient #3
- John Tierney - Terminal Patient #4
- Lillian Lim - Terminal Patient #5
- Mel Tuck - Terminal Patient #6
- Glenn Beck - Terminal Patient #7
- Rukiya Bernard - Dr. Carroll
- Babak Haleky - Volunteer
- Darcey Johnson - Terry
- Jesse Carroll - Tall Driver
- Jerry Trimble - Coach Perry
- Yee Jee Tso - Jervis
- Lissa Neptuno - Joanne
- Colby Wilson - Mike
- Greg Harper - News Anchor
- Jannen Karr - Receptionist
- Elle McKinnon - Anna Hamilton
- Omari Newton - Orderly
- Yobdee - Bree
- Benjamin Rogers - Drake
- Karly Warkentin - Anna's Mom
- David Quinlan - Anna's Dad
- Penelope Good - Girl 1
- Parveen Dosanjh - Crystal
- Ian Tracey - Ray Green
- Stephen Lobo - Wakefield
- Chad Krowchuk - Simon
- Jason McKinnon - Officer
- Jason McKinnon - Police Officer
- Donna Yamamoto - Deputy Oslin
- Josh Blacker - Agent Callahan
- David Attar - Agent Tanner
- Laura Drummond - Agent Quinn
- Don McLeod - FBI SWAT Leader
- Barbara Wallace - Laverna
- Timothy Paul Coderre - Traveler 2383
- Callum Seagram Airlie - Taylor
- Callum Seagram Airlie - Taylor Age 12
- Nicole Anthony - Dr. Sheppard
- Henry Mah - Doctor
- Gracyn Shinyei - Naomi Davies
- Amanda Tapping - Dr. Perrow
- Fanta Sesay - Michelle
- Haig Sutherland - Doctor Mori
- Lyle Reginald - Jordan
- Sean Depner - Mikey
- Christine Lee - Nurse
- Marilyn Norry - Linda MacVicar
- Steve Makaj - Sergeant
- Steve Makaj - Sarge
- Steve Makaj - Police Sergeant
- Forbes Angus - Mr. MacVicar
- David Allan Pearson - Ned
- Genevieve Fleming - Ms. Bayle
- Malcolm Craig - Ronnie
- David Raynolds - Aleksander
- David Raynolds - Aleksander / Patrick
- Nevin Burkholder - Bartender
- Devon Alexander - Jimmi
- Bronwen Smith - Marion
- Gaalen Engen - Greg
- Beatrice Kitsos - 11 Year Old Girl
- Cody Davis - 10 Year Old Boy
- Shanel Pratap - News Anchor #2
- Garfield Wilson - Carter
- Kis Yurij - Russian #1
- Jason William Day - Russian #2
- Angela Moore - Carol
- Jesse Reid - Military Scientist
- Chris Webb - Businessman
- Karen Khunkhun - Reporter
- Audrey Smallman - 10 Year Old Girl
- Michael Meneer - News Anchor #1
- Garry Chalk - Detective Gower
- Teryl Rothery - Patricia Holden
- Angela Palmer - Tory
- Andre Tricoteux - Captor
- Mike Li - Faction Member
- Mike Li - Second Guardsman / Traveler 5402
- Lyova Beckwitt - Jackson
- Adrien Dorval - Yard Worker
- Aaron Hutchinson - Security Guard
- Milo Shandel - Pastor
- Emy Aneke - Sergeant
- Brenda Matthews - Becky
- Curtis Lum - Morrison
- Nathan Witte - Traveler Security Guard
- Sian Sladen - Nurse
- Alyssa Lynch - Rene Bellamy
- Simon Longmore - Agent Riley
- Ken Dresen - Colin
- Alex Barima - Nick
- Erika Walter - MacLaren's Future Wife
- Darren E. Scott - Masked Guy #1
- Kirk Caouette - Masked Guy #2
- Leif Havdale - Masked Guy #3
- Kirby Morrow - Hickman
- Howard Siegel - Bookie
- Michael Denis - Jeff's Lawyer
- Françoise Yip - Judge
- Magda Apanowicz - Dawn
- Magda Apanowicz - Kimberley Sustad
- Cindy Piper - Store Owner
- Lanie McAuley - Candy
- Keisha Haines - Web Cam Girl #2
- Jennifer Cheon - Web Cam Girl #3
- Lisa Marie DiGiacinto - Flight Attendant #1
- David Cubitt - Stevenson
- David Cubitt - FBI Director
- Carmel Amit - Flight Attendant #2
- Darcy Laurie - Hank
- Kathleen Duborg - Mrs. Hayes
- Mark Brandon - Hayes
- Carter Evancic - 9 Year Old Boy
- Jenny Mitchell - Stacey Nichols
- Paul Lazenby - Big Guard
- Melanie Papalia - Beth
- Kwesi Ameyaw - Doctor
- Georgia Hacche - Nurse
- Liam Hughes - Sickly Child
- Preston Vanderslice - Man Texting
- Ben Immanuel - Dr. Teslia
- Ben Immanuel - Ivon Teslia
- Lee Shan Gibson - Construction Worker
- Kylee Dawson - Shy Girl
- Balinder Johal - Indian Woman
- Paul Chih-Ping Cheng - Tall Man
- Grace Chin - News Anchor
- Glenn Ennis - Tall Man #3
- Mathew Yanagiya - EMT Traveler
- Mathew Yanagiya - Tristen
- Dan Payne - Tall Man #4
- Norm Sherry - Tall Man #6
- Enrico Colantoni - Vincent Ingram
- Ben Cotton - Christopher Rockwell
- Zak Santiago - Daniel Sosa
- William MacDonald - Gary Holden
- Aaron Craven - Ken
- Christopher Ang - SWAT Leader
- Nicole Hombrebueno - Katie Sosa
- Adam Lolacher - Officer Ross
- Naiah Cummins - 3rd AD
- Sarah Johns - Miss Davies
- Seth Whittaker - Team Leader
- Esabella Anna Karena Strickland - Maria
- Louis Ferreira - Rick Hall
- Dylan Playfair - Kyle
- Kerry Sandomirsky - Therapist
- Veenu Sandhu - Singh
- Jeb Beach - Mitch
- Eric Pollins - Priest
- Doug Chapman - Luca
- Tasya Teles - Traveler 009
- Lauren K. Robek - Mrs. Gillen
- Giles Panton - Dan Gillen
- Dan Quinn - Johnson
- Tim Carlson - Masked Figure
- Tim Carlson - Ben
- Joshua Pak - Historian
- Nevis Unipan - Child Messenger
- Jim Byrnes - James Edward Bailey
- Gary Jones - Landlord
- Linda Pollard - Sandra Wilson
- Robert Corness - Old Man
- Christopher Heyerdahl - Andrew Graham
- Veronika Hadravá - Katrina
- Veronika Hadravá - Karina
- Lisa Chandler - Emily
- Enid-Raye Adams - Amanda Myers
- Brad Mann - Tall Man #1
- Todd Mann - Tall Man #2
- Dion Riley - Reporter #1
- Jilena Cori - Reporter #2
- Leo Chiang - Swat Leader
- Fraser Corbett - Faction Member
- Natalie Moon - News Anchor 1
- Karen Holness - Samantha Burns
- Karen Holness - Samantha
- Zain Meghji - News Anchor 2
- Tarun Keram - Traveler Guard
- Mike Carpenter - Tall man
- Paul Wu - Traveler 1
- Brian Ho - Traveler 2
- Steve Ellis - Uber Driver (uncredited)
- J. Alex Brinson - Jeff Conniker
- Kimberley Sustad - Joanne Yates
- Kristine Cofsky - Officer Boyd
- Giacomo Baessato - Private Wilson
- Latonya Williams - Jessica Moore
- Hugo Raymundo - Brant Moore
- Warren Abbott - Traveler 5226
- Rebecca Shoichet - Ilsa (voice)
- Hannah Drew - Traveler 6359
- David Bloom - Priest
- Valencia Budijanto - Young Girl
- Michael Antonakos - Director (voice)
- J. Douglas Stewart - Man
- Kenneth Liu - General Chin
- Leah Cairns - Kathryn MacLaren
- Larry Hoe - FBI Agent
- Glynis Davies - Jacqueline Peele
- Benjamin Wilkinson - Corrigan
- John G. Lenic
- Eric McCormack
- Jim O'Grady
- Sally Dixon
- Brad Wright
- Carrie Hall-Mudd
- Adam Lastiwka
Eric McCormack interpreta a Grant MacLaren en la serie.
David James Lewis hace el papel de Major Gleason.
MacKenzie Porter hace el papel de Marcy Warton.
Nesta Cooper hace el papel de Carly Shannon.
Jared Abrahamson interpreta a Trevor Holden en la serie.
Reilly Dolman hace el papel de Philip Pearson.
Patrick Gilmore hace el papel de David Mailer.
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