- Mark Watson - Unfriendly Man
- Zooey Deschanel - Elena
- Todd Kimsey - Steve
- Cynthia Mann - Virginia
- Ingo Rademacher - Reg
- Anya Longwell - Tree
- Jennifer Milmore - Waitress
- Jay Leno - Jay Leno
- Christopher McDonald - Bryce Anderson
- Tamala Jones - Tina
- Chuck Scarborough - Chuck Scarborough
- Leeza Gibbons - Leeza Gibbons
- Bob Goen - Bob Goen
- Jennifer Campbell - Tiffany
- Lisa Canning - Lisa Canning
- Richie Keen - Office Worker Guy
- Richard Zavaglia - Workman
- Dan Finnerty - Pizza Guy
- Richard McGonagle - Ronnie's Lawyer
- Allan Wasserman - Bryce's Lawyer
- Cynthena Sanders - Secretary
- Cynthena Sanders - Female Office Worker #2
- Paul Hayes - Janitor
- Darlene Kardon - Older Female Office Worker
- NiCole Robinson - Female Office Worker
- Matthew Sullivan - David
- Jeffrey Nordling - Tom
- Portia de Rossi - Carolyn
- Lupe Ontiveros - Louisa
- Ever Carradine - Pepper
- Richard Fancy - Judge
- Vanessa Angel - Suzanne
- Don Bovingloh - Veterinarian
- Nancye Ferguson - Deborah
- William Mesnik - Ronnie's Lawyer
- Mo Gaffney - Karen
- Eileen Brennan - Grammy Anderson
- Lainie Kazan - Dottie
- Eric McCormack - Griffin
- Paul Satterfield - Dan
- Patrick Kerr - Todd
- Denice Kumagai - Woman with Clipboard
- Billy Connolly - Campbell
- Markus Flanagan - Alex
- Karen Maruyama - Event Official
- Conan O'Brien - Conan O'Brien
- Greg Wrangler - Man in Self-Exploration Group
- Ted Danson - Nick Vanover
- Brigid Brannagh - Nancy
- Yasmine Bleeth - Katrina
- Karen Dior - Moronica Chaste / Dennis
- Eleanor Mondale - Eleanor Mondale
- Brian Posehn - Maintenance Guy
- Michael Jeter - Edwin
- Harry Van Gorkum - Alan
- Maxwell Caulfield - Brian
- Julia Pennington - Kelly
- Michael Welch - Aaron
- Michele Kelly - Woman
- Mark Derwin - David
- Symba - Model
- Joanna Bacalso - Kari
- Marci Brickhouse - Tammy
- Nestor Carbonell - Tony Tony
- Pilar Sanders - Laurel
- Renee Tenison - Dakota
- David Gaines - Mark
- James Wilder - Hunter
- Jim Bentley - Waiter
- Jim Bentley - Jay
- Phil Leeds - Vince
- Paul Cassell - Toby
- Holland Taylor - Millicent
- John C. Moskoff - Elderly Man #1
- Ed Cambridge - Elderly Man #3
- Connie Sawyer - Margaret
- Christopher Carroll - Lawyer
- Dona Hardy - Gram
- Maria Canals-Barrera - Dani
- JoNell Kennedy - Tanya
- Scott Thompson - Scotty
- Carole Goldman - Saleswoman
- Deirdre O'Neil - Girl
- Jon Polito - Mr. Lehman
- Amy Van Horne - Michelle
- Keith MacKechnie - Photographer
- Tia Carrere - Kim
- Mark Harelik - Paul
- David Lascher - Jeremy
- Kari Coleman - Ms. Jenkins
- Mary Manofsky - Lab Technician
- Jolene Blalock - Woman #3
- Sandy Brown - Peri
- Michael McKean - Dave Whitby
- Lindsay Taylor - Little Girl
- Tyne Daly - Emily Blair
- John Bennett Perry - Byron Blair
- Patrick Cranshaw - Mr. Leeds
- Cynthia Frost - Mrs. Gordon
- Sandra Gould - Mrs. Riley
- John Timothy Botka - Todd
- Marc Grapey - Phil
- John Doe - Jimmy Walsh
- Eric Fleeks - Police Officer
- Joanne Baron - Waitress
- Anna Nicole Smith - Donna
- Scott Mosenson - Larry
- Andrea Doven - Madeline
- Helen Greenberg - Rebeca
- Susan Mosher - Woman with Clipboard
- Jonathan Osser - Noah
- RuPaul - Brett
- Mary Lynn Rajskub - Chloe
- John Ritter - Tim Margolin
- Luigi Amodeo - Santo
- Marguerite MacIntyre - Lily
- Hamilton Mitchell - Man
- Trie Donovan - Young Woman
- David Starzyk - Pete
- John Mariano - Chris
- Cindy Lu - Waitress
- Wendy Worthington - Nurse #1
- Jill Matson - Nurse #2
- Connie Ray - Jan Schaefer
- E.J. Callahan - John Mulligan
- Tom Whiteknight - Boyfriend
- Van Epperson - Man #2
- Pauley Perrette - Nicole
- Greg Evigan - Justin
- Alfred Dennis - Doorman
- Brian Palermo - Usher
- Paul Gleason - Hank
- Bob Stephenson - Fred
- John Schneider - Tom
- Jennifer Lyons - Female Co-Worker
- Michael Halpin - Male Employee
- Kenneth Alan Williams - Dave
- Kevin Farrell - Clerk
- Brad Koepenick - Fireman
- Tara Lipinski - Tara Lipinski
- Tom Arnold - Chris
- Jim Wise - Man #1
- Jim Wise - Dale
- Marsha Warfield - Shirley
- Pete Rose - Pete Rose
- Fred Stoller - Fred
- Brad Johnson - Jeff
- Isaac Hayes - Isaac Hayes
- Alexia Robinson - Lana
- Danny Woodburn - Eddie
- Jim Pirri - Enrico
- Angelle Brooks - Journalist
- Lise Simms - Yoga Instructor
- Al Ruscio - Phil
- Tom La Grua - Official
- Alan F. Smith - Brian
- Richard Burgi - Mark
- Greg Proops - Richard
- Scott Baio - Kevin
- Tait Ruppert - Lester
- Donald Gibb - Spaz
- Marc Goldsmith - Roger
- Ernie Grunwald - Pizza Guy
- Jeff Blumenkrantz - Terrance
- Matt Kaminsky - Mark
- Tanya Garrett - Stacy
- Joe Ochman - Minister
- Robert Gant - Bernie
- Ken Marino - Wayne
- Bodhi Elfman - Neil
- Lisa K. Wyatt - Olivia
- Russ Fega - Mike
- Darcas Macopson - Alan
- Matt Reid - Michael
- Stuart Pankin - Phil
- Clifton Davis - Brian's Father
- Mariann Aalda - Brian's Mother
- Troy Evans - Waiter
- Marta Kauffman
- David Crane
- Kevin S. Bright
Kirstie Alley interpreta a Veronica "Ronnie" Chase en la serie.
Dan Cortese interpreta a Laird "Perry" Rollins en la serie.
Wallace Langham interpreta a Josh Nicolé Blair en la serie.
Daryl Mitchell interpreta a Leo Michaels en la serie.
Kathy Najimy interpreta a Olive Massery en la serie.
Capítulo disponible en las siguientes plataformas:
