- Jessica Camacho - Santana
- Simu Liu - Faaron
- Jennifer Marsala - Riley
- Tonjha Richardson - Esme Flynn
- Romano Orzari - Carlos Mejia
- Aaron Roman Weiner - Mark James
- Gary Hudson - General Reed
- Brian J. White - Julius Vox
- Tara Nicodemo - Allie Graham
- Albert Lapi - Train Security Guard
- Isaac Kragten - Young Bryan Mills
- Vladimir Raiman - Boris
- Darryl Flatman - Officer Drabek
- Nick E. Tarabay - Boone
- Rachel Nichols - Eve
- Sabryn Rock - Cereus
- Sasha Roiz - Maximillion
- Zoie Palmer - Meg
- Miguel Anthony - Drunk Guard
- Arlen Aguayo-Stewart - Lucia
- Matthew Bennett - Gary Martello
- David Julian Hirsh - Clayton Bass
- Romaine Waite - Langston
- Reese Alexander - Zaid
- Pedro Miguel Arce - Bookie
- Michael Ayres - Parks
- Marcello Bezina - Coyote
- Ted Charette - Calvin
- Gavin Fox - Payne
- Rico Garcia - Trafficker
- Jose Joaquin Perez - Jose
- Conrad Pla - El Major
- Adriana Santos - Amelia
- Nancy Ticotin - Salome
- Alex Draper - Paul Graham
- Colin Lawrence - Terry Hicks
- Troy Blundell - Young Gabe Mills
- Sean Patrick Dolan - Jimmy
- Anthony Gerbrandt - Dell
- Gabriel Varga-Watt - Jamie Graham
- Sean Baek - Shinigami
- John Bolger - Lester Benedict
- Peter Bryant - Norman
- Chantele Francis - Kate
- Melissa Hood - Regina
- Paul Kingston - Aaaron
- Maria Syrgiannis - Gwen
- Sonia Dhillon Tully - Valerie Banner
- Richard Young - Samuel Patel
- Luke Humphrey - Neal
- Sarah Lind - Nancy Clarke
- Carl Bauer - Prison Guard
- James Binkley - S.S. Cat Agent
- Devan Cohen - Evan (10 Yrs)
- Navi Dhanoa - Reception Guard
- Nneka Elliott - News Correspondent
- Mark Ingram - POTUS
- Kevan Kase - Merc
- Michael Gordin Shore - Plant Manager
- Edie Inksetter - Diane
- Briar May - Ava
- Jeremy Ratchford - Detective Lyons
- Eyas Younis - Beren Hasan
- Dalton Derek - Molina
- Shaun Bishop - Cop
- Billy Otis - Landlord
- Jeni Ross - Strung Out Girl
- Asante Tracey - Cesar
- Sam Kalilieh - Michael Fortman
- Amanda Lisman - Beth Childers
- Amy Rutberg - Anna Warren
- Sebastian Spence - Senator Warren
- Jerald Bezener - Ukrainian Thug
- Mathieu Bourassa - Reporter
- Mikhail Bronnikov - Andriy
- Karl Campbell - Theo
- Colton Gobbo - Bret
- Ayesha Mansur Gonsalves - Brie Collins
- Neven Pajkic - Ivan
- Violetta Pioro - Ella
- Roman Roytberg - Vlad Korchenko
- Mitchell Verigin - Ukrainian Thug
- Bruce Baek - North Korean Guard Kim
- Michael Benyaer - Liad Meidar
- Daniel Yang - Joon
- Cyrus Aazam - Liad Meidar
- Roger Doche - Mike Keech
- Jung-Yul Kim - North Korean Guard Lee
- Jennifer Krukowski - Rachel Meidar
- Yasmin Lau - Ji-Su
- Christine Mao - Older Japanese Woman
- Frank Nakashima - Old Japanese Man
- Uni Park - Kai Mok
- Gabriella Sundar Singh - ND Backpacker
- Parmida Vand - Hostess
- Denis Akiyama - Sensei
- Scott Cohen - Kasparov
- Rafael Petardi - Viktor
- Albert Chung - Chinese Business Man
- Alexander Krstich - Russian Business Man in Hat
- Daniel Matmor - Conductor
- Jennifer Vallance - Redhead in Mink
- Jeremy Crittenden - Russian Merchant Sailor
- Slavic Rogozine - Russian Merchant Sailor
- Rachael Ancheril - Tatiana Moore
- Alexei Bondar - Ruslan Varayev
- David Haydn-Jones - Peter Darien
- Mark Antony Krupa - Ruslan's Lieutenant
- Sean Connolly Affleck - Embassy Security Guard
- Massey Ahmar - Malik
- Lara Arabian - Amira
- Natasha Krishnan - Marika
- Peter Bou-Ghannam - Sahib
- Matt Dawson - Policeman
- Emily Dickinson - Penny
- Brennan Martin - Adlan
- Daniel Kelly - Raphael Fratelli
- Al McFoster - Green House Security Guard
- Kelly Penner - Tieri Fratelli
- Gianpaolo Venuta - Jean-Paul
- Sugith Varughese - Edwin Brown
- Lovina Yavari - Cancer Charity Photographer
- Brittany Allen - Ella Riordan
- Vinny Chhibber - Vikram Desai
- James Colby - Agent John McCarron
- Philip Craig - Bob
- Diane Johnstone - Mayor
- Jonathan Koensgen - PMC Kane
- Ian Matthews - Morse
- Michael Potts - Hanson
- Michael Xavier - Ramsey's Assassin
- Jamaal Grant - Councilman Torres
- Vijay Mehta - Dilip Desai
- Aliyah O'Brien - Dr. Bleier
- Nykeem Provo - PMC Allen
- Lara Binamé - Young Woman
- Kathryn Davis - Young Mom
- Jean Paul Najm - Dogan
- Jean Paul Najm - Mature Student Agent #1
- Rakhee Morzaria - News Reporter
- Rose Napoli - EMT
- Dennis Nimoh Jr. - Plaza - Admin
- Emy Aneke - Special Agent Johnson
- Ryan Blaney - Special Agent Wood
- Joris Jarsky - Niko's #2
- Emmanuel Kabongo - Domingo
- Adoni Maropis - Niko Xanatos
- Murry Peeters - Isabel Edu
- Bruce Beaton - Captain of Feeder Ship
- Garrett Jamieson - Shipmate
- Drew Moss - Merc
- Dana Drori - Elizabeth Warner
- Poorna Jagannathan - Judith Chapman
- Jonathan Watton - Colin Grant
- Sana Asad - Young Woman
- Byron Abalos - Orderly
- Danielle Chambers - Child
- René Escobar Jr. - Officer
- Caroline Gillis - Maria Verdin
- Ache Hernandez - Jaime
- Paul Johnston - Helicopter Pilot
- Jordan Kronis - Oliver (15 Yrs)
- Cheryl MacInnis - Woman
- Maddy Martin - Taken Person
- Ish Morris - Marco
- Bryce Arden Poe - Taken Person
- Carlos Gonzalez-Vio - Dr. Anton Ruiz
- Barry Flatman - Bryan's Dad
- Kevin McGarry - Officer Shine
- Timothy V. Murphy - Lynch
- Al Sapienza - Deputy Director Davis
- Victoria Snow - Sarah Mills
- Robbie Sublett - Mitchell Mills
- Milton Barnes - Federal Agent
- Aldrin Bundoc - Border Patrol Agent
- Howard Jerome - Owner
- John Blackwood - Farmer
- Roger Dunn - Walter
- Jai Jai Jones - Crowe
- Michael Rhoades - Officer Cloak
- Christopher Tai - Fisherman
- Rishma Malik Scott - Lawyer
- Steve Bacic - Augustin Vikhrov
- Christian Bako - Krystiyan
- Matt Cooke - John Ogilvie
- Kiana Madeira - Amy
- Grisha Pasternak - Renko
- Rebecca Kwan - Jean
- Danijel Mandic - Jan / Bouncer
- Catherine McGregor - Rita Collins
- Jeff Miller - Daniel Collins
- Andrew Musselman - Detective Ganz
- Benz Antoine - Senator McDermott
- Jeremy Crutchley - Senator Buchanan
- Nabeel El Khafif - Kamara
- Brian Paul - Director Owens
- Tahmoh Penikett - David Ramsey
- Wass Stevens - Sykes
- Joanna Areti - Amina
- Peter Outerbridge - James Casey
- Peter Outerbridge - James Casey (uncredited)
- Val Cole - Newscaster
- Basel Daoud - Eland
- Craig Henry - PMC Banks
- Dani Jazzar - Grieving Father
- Jacob Soley - Boy
- Daniel Kash - Byron Kaine
- Sharron Matthews - Marcy
- George Masswohl - Farmer
- Ayelet Zurer - Leah
- Dominic Fumusa - Harry Ward
- Ramsey Faragallah - Zev
- Billy Parrott - U.S. Customs & Patrol Officer
- Shant Srabian - Professor Saadon
- Ola Sturik - Action 7 Reporter
- Kane Mahon - Mossad Tourist #1
Clive Standen interpreta a Bryan Mills en la serie.
Jennifer Beals hace el papel de Christina Hart.
Adam Goldberg interpreta a Kilroy en la serie.
Jessica Camacho interpreta a Santana en la serie.
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