- Jane Lynch - Donna (voice)
- Sarayu Blue - Diya (voice)
- Karl-Anthony Towns - Handsome Jock (voice)
- 'Weird Al' Yankovic - Dandruff Tuba (voice)
- Natalia del Riego - Becca (voice)
- Nicole Byer - Blythe (voice)
- Cherry Jones - Victoria (voice)
- Ken Leung - Darren (voice)
- Frank Welker - William (voice)
- James Adomian - Thespian (voice)
- Gary Cole - Lamont (voice)
- Gary Cole - Lamont / General Meeting (voice)
- Roger Craig Smith - Stoner (voice)
- Themo Melikidze - Skinhead (voice)
- Dimitry Rozental - Russian Soldier (voice)
- Jim Rash - Mayor Dave (voice)
- Melissa Fumero - Sophie (voice)
- Melissa Fumero - Sophie / Uncle Scoobi (voice)
- Russell Peters - Aman (voice)
- Russell Peters - Aman (voice
- Wanda Sykes - Linda (voice)
- Wanda Sykes - Krista (voice)
- Debby Ryan - Krista (voice)
- Debby Ryan - Donna (voice)
- Tiana Camacho - Kimmy (voice)
- Ming-Na Wen - Carroll (voice)
- Fortune Feimster - Olive (voice)
- Fortune Feimster - Olive / Pim (voice)
- Yvonne Orji - Gigi (voice)
- Yvonne Orji - Sammy (voice)
- Shay Mitchell - Brenda (voice)
- Kulap Vilaysack - Lola (voice)
- Kimberly Brooks - Susan (voice)
- Kimberly Brooks - Cool Edy Girl (voice)
- Stephen Root - Chief Cogburn (voice)
- Stephen Root - Chief Cogburn / Merie Cogburn (voice)
- Stephen Root - Merie Cogburn (voice)
- Chris Schleicher - Male Nurse (voice)
- Gary Anthony Williams - Don (voice)
- Gary Anthony Williams - Sgt. Gigisfather / Private Eye (voice)
- Jennifer Hale - Thorn (voice)
- Kari Wahlgren - Evelyn (voice)
- Kari Wahlgren - Chestiny (voice)
- Kari Wahlgren - Amanda (voice)
- Kari Wahlgren - Amanda / Maxine / Moira (voice)
- Kari Wahlgren - Evelyn / Paramedic (voice)
- Kari Wahlgren - Moira (voice)
- Kari Wahlgren - Evelyn / Female News Anchor (voice)
- Kari Wahlgren - Mary Louis (voice)
- Kari Wahlgren - Anchor Woman (voice)
- Kari Wahlgren - Acne Saxophone (voice)
- Kari Wahlgren - Female News Anchor (voice)
- Kari Wahlgren - Seductive Woman (voice)
- Ed Weeks - Mr. S (voice)
- Andia Winslow - Gigi (voice)
- Andrew Morgado - Fro Yo (voice)
- Andrew Morgado - Commanding Officer (voice)
- Andrew Morgado - Froyo (voice)
- Andrew Morgado - Normal Coroner (voice)
- Andrew Morgado - Fro Yo / Jerry Brown (voice)
- Neil deGrasse Tyson - Neil deGrasse Tyson (voice)
- Yoshi Amao - Japanese Dad (voice)
- Alpha Takahashi - Japanese Mom (voice)
- Vanessa Williams - Dr. Perdue (voice)
- Piotr Michael - Father O'Rourke (voice)
- Piotr Michael - Board Member / Lion Tamer (voice)
- Piotr Michael - Creepy Coroner (voice)
- Piotr Michael - Casey Kasem (voice)
- Piotr Michael - Deputy Greg / Pencil (voice)
- Piotr Michael - Whisper / Voice (voice)
- June Squibb - Older Woman (voice)
- Carolyn Hennesy - Elizabeth (voice)
- Jason Mantzoukas - Scrappy (voice)
- Winsome Brown - Female Librarian (voice)
- Sara Ramirez - Amber (voice)
- Nicholas Braun - Black Knight / Geoff (voice)
- Richard Kind - Richard Kind (voice)
- Saweetie - Saweetie (voice)
- Stephanie M. Johnson
- Jen Chuck
- Liz Carroll
- Agnes Kim
- Charlie Grandy
- Karina Benesh
- Vishnu Athreya
- Charlie Carpenter
- Kelly Ann Foley
- David M. Cowan
- Craig Deleon
- Mark A. Keatts
- Michael Garcia
- Jeff O. Collins
Ken Leung hace el papel de Darren (voice).
Cherry Jones hace el papel de Victoria (voice).
Constance Wu interpreta a Daphne Blake (voice) en la serie.
Sam Richardson hace el papel de Norville Rogers (voice).
Glenn Howerton interpreta a Fred Jones (voice) en la serie.
Jane Lynch interpreta a Donna (voice) en la serie.
Melissa Fumero interpreta a Sophie (voice) en la serie.
Russell Peters interpreta a Aman (voice) en la serie.
Sara Ramirez interpreta a Amber (voice) en la serie.
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