- Charles Mesure - Kyle Hobbes
- Mark Hildreth - Joshua
- Jane Badler - Diana
- Alan Tudyk - Dale Maddox
- Michael Filipowich - Cyrus
- Michelle Harrison - Mary Faulkner
- Fred Keating - Cardinal Janusz Wolichek
- Nicholas Carella - Alex Caruso
- Stacy Fair - Evelyn
- Stefan Arngrim - Roy
- Alex Kliner - Jeweler
- Hrothgar Mathews - Doomed Man
- Jan Bos - Station Manager
- Brett Le Bourveau - Visitor Technician
- Omari Newton - Soldier
- Nimet Kanji - Doctor
- Jeremy Jones - National Guard Officer
- Crystal Balint - Floor Manager
- Dejan Loyola - College Kid
- Tyler Johnston - College Kid
- Lossen Chambers - Reporter
- Benjamin Wilkinson - Reporter
- Clay St. Thomas - Reporter
- Ingrid Kavelaars - Jocelyn Maddox
- Darcy Laurie - Angelo Russo
- Stephen Park - Emergency Operator
- Josh Blacker - Interrogator
- Derek Hamilton - Nathan
- Kyle Labine - College Kid
- Billy Mitchell - Harold Stern
- Jacqueline Ann Steuart - Marion Geiger
- Marci T. House - Agent
- Craig March - Agent
- Ryan Kennedy - David
- Craig Fraser - Peter Combs
- Veena Sood - V Physician
- Colin Foo - Monk
- Quelemia Sparrow - Mother
- Benita Ha - Reporter
- Benita Ha - News Anchor
- Benita Ha - News Reporter
- Chris Shields - Dr. Martin
- Marie West - V Technician
- Kis Yurij - V Security Guard
- Revard Dufresne - V Mate
- Dalias Blake - Swat Commander
- Ian Butcher - Greg
- Brandi Alexander - Mia
- Jesse Hutch - Trevor
- Michael Trucco - John May
- Jessica Parker Kennedy - Grace
- Terry Chen - Dr. Maeta
- Brett Dier - James May
- Erica Carroll - Lillie
- Beverley Elliott - Elizabeth Parker
- Jim Byrnes - Matthew
- Gary Peterman - Locksmith
- Sean Michael Kyer - Brian
- Radek Hewson - Evan
- Ernesto Griffith - Pributi Chima
- Ken Camroux-Taylor - Victor Caruso
- Dawn Chubai - Reporter
- John Samaha - Guest
- Gilles Tanguay - V Doctor
- Giles Panton - V Med Tech
- Ty Olsson - Jeffrey
- Philip Granger - Henry Thompson
- Sarah-Jane Redmond - Susan Thompson
- Sonya Salomaa - Mary
- Havana Guppy - Summer
- Kacey Rohl - Woman
- Brad Turner - V Solider
- Makena Joy - Teenage Girl
- Laura Wilson - Young Mother
- Tara Wilson - Young Woman Friend
- Paul Lazenby - Burly Agent
- Darren Bennett - Husband
- Samantha Ferris - Private Investigator
- Paul McGillion - Dr. Lawrence Parker
- Sophie Lui - News Reporter
- Rob Carpenter - Running Man
- Michael Warren Choi - Little Boy
- Chad Riley - Ed Carr
- Lexa Doig - Dr. Leah Pearlman
- Lucas Wolf - Samuel
- Chris Burns - V Soldier
- D. Harlan Cutshall - Head V Guard
- Frank Topol - V Doctor
- Silver Kim - V Med Tech
- Sean Carey - V Body Guard
- Peter Ciuffa - Angry Parishioner
- Kevin Kazakoff - French Pilot
- Jackie Blackmore - Homeless Woman
- Brent McLaren - V Guard
- Aleks Holtz - V Guard
- Devielle Johnson - V Surveillance Tech
- Carmen Aguirre - Woman
- Alison Araya - Mother W / Child
- Nelson Wong - Cameraman
- Keegan Connor Tracy - Eileen Rounick
- John Shaw - Will Mabyee
- Françoise Robertson - Melanie Singer
- Tom Pickett - Preacher
- Jacob Blair - V Lab Tech
- Chenier Hundal - V Med Tech
- Lesley Ewen - Val's Mother
- William S. Taylor - Val's Father
- Jason Beaudoin - Man
- Rekha Sharma - Sarita Malik
- Chilton Crane - Betty Allen
- Michael Patric - Angry Man
- Sean Tyson - Parishioner
- Christopher Rosamond - Ed
- John Paul McGlynn - Terrified Man
- Jonathan Walker - Father Piers Moreau
- Teach Grant - Steve Gunn
- Peter Bryant - Neil Stern
- Nicholas Lea - Joe Evans
- Scott Hylands - Father Travis
- Oded Fehr - Eli Cohn
- Garnet Harding - Suicide Bomber
- Adrian Holmes - Agent Caldwell
- Ash Lee - Wen Chiang
- Marny Eng - Dr. Veena Rai
- Jarod Joseph - V Med Tech
- Doug Chapman - V Guard
- Miranda Frigon - Melissa Hartswell
- Kennedi Clements - Jennifer Hartswell
- Jodi Balfour - V Greeter
- Kal Weber - Pryce
- Linda Kee - Screaming Chinese Woman
- Charlie Carrick - Rafael Mendoza
- Michael Karl Richards - Will Lerner
- Bethany Brown - Barista
- Harrison Xu - Chinese Boy
- Bret Harrison - Dr. Sidney Miller
- Ona Grauer - Kerry Eltoff
- Zak Santiago - John Fierro
- Elfina Luk - Floor Director
- Rene Wang - Terrified Woman
- Darcy Hinds - Contact
- Roark Critchlow - A.D. Paul Kendrick
- Martin Cummins - Thomas
- Marc Singer - Lars Tremont
- David Richmond-Peck - Georgie Sutton
- Jesse Wheeler - Brandon
- Britt Irvin - Haley Stark
- Jay Karnes - Chris Bolling
- Dean Redman - V Guard
- Ross Tweedale - Processing Agent
- Tyler McClendon - Steven
- Jenn Griffin - Woman
- Patrick Keating - Parishoner
- Ann Warn Pegg - Parishoner
- Dru Williams - Parishoner
- Patricia Mayen-Salazar - Parishoner
- Scott Peters
- Yves Simoneau
- Jace Hall
- Scott Rosenbaum
Elizabeth Mitchell interpreta a Erica Evans en la serie.
Morena Baccarin hace el papel de Anna.
Morris Chestnut interpreta a Ryan Nichols en la serie.
Joel Gretsch interpreta a Father Jack Landry en la serie.
Laura Vandervoort hace el papel de Lisa.
Logan Huffman interpreta a Tyler Evans en la serie.
Scott Wolf interpreta a Chad Decker en la serie.
Christopher Shyer interpreta a Marcus en la serie.
Charles Mesure interpreta a Kyle Hobbes en la serie.
Mark Hildreth interpreta a Joshua en la serie.
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