- Don Harvey - Mr. Warshaw
- Angela Paton - Mrs. Ransom
- Bibi Besch - Ethel Garvey
- Rick Overton - Mr. McNamara
- Adriana Barraza - Dolores Salazar
- Jonathan Banks - Robert Truman
- Joe Grifasi - Tom Williams
- Jorja Fox - Maggie Doyle
- Jeannetta Arnette - Mrs. Hawkes
- Brian Tarantina - Joe Barkley
- Patrick Collins - Dr. Netzley
- Marianne Muellerleile - Mrs. Jarnowski
- Larry Holden - Chris Pendry
- George Murdock - Mr. Sidowski
- Sally Field - Maggie Wyczenski
- Keram Malicki-Sánchez - Rick
- Holmes Osborne - Dr. Sayers
- Marc McClure - Paul Huffner
- Mary McDonnell - Eleanor Carter
- Maria Bello - Anna Del Amico
- Stacy Keach - Mike Gates
- Josh Cruze - Boss
- David St. James - Kaplan
- C. Thomas Howell - Vincent Jansen
- Susan Traylor - Mrs. Schudy
- William H. Macy - David Morgenstern
- Kathy Griffin - Dolores Minky
- Harve Presnell - Mr. Venema
- Marc Lawrence - Mr. Newton
- Mekhi Phifer - Greg Pratt
- Sean Young - Anna Hayes
- Trevor Morgan - Scott Anspaugh
- Evan Jones - Todd
- Carl Weathers - Louie Taylor
- William Sanderson - Mr. Percy
- Elpidia Carrillo - Pilar
- John Diehl - Johnson's Son
- Frances Conroy - Becky Riley
- Michael Rapaport - Paul Canterna
- Taylor Nichols - Mr. Adams
- Eugene Byrd - James Connor
- Robert Ellenstein - Dr. Swanson
- Ned Bellamy - Detective
- Tobin Bell - Hospital Administrator
- Don Cheadle - Paul Nathan
- Phil Leeds - Husband
- Eddie Jemison - Lysander Martin
- Steve Buscemi - Art Masterson
- Conchata Ferrell - Mrs. Jenkins
- Susan Blommaert - Sarah McKenzie
- Julie Delpy - Nicole
- Glenn Plummer - Timmy Rawlins
- Jenny O'Hara - Rhonda Sterling
- John Doman - Carl Deraad
- Cameron Bowen - Marten
- Frances Fisher - Helen Kingsley
- Forest Whitaker - Curtis Ames
- Wentworth Miller - Mike Palmieri
- James Waterston - Mr. Barney
- Castulo Guerra - Judge Alter
- Lucy Liu - Mei-Sun Leow
- Paul Freeman - Charles Corday
- Jenette Goldstein - Judy Stiles
- Xander Berkeley - Detective Wilson
- Mickey Rooney - George Bikel
- Christopher Wynne - Resident
- John Mahoney - Bennett Cray
- Jessica Capshaw - Sally McKenna
- Rick Rossovich - John Taglieri
- Lois Smith - Gracie
- James Woods - Dr. Nate Lennox
- Larry Bagby - Second Reporter
- Djimon Hounsou - Mobalage Ikabo
- Tomas Arana - State's Attorney Rifkin
- Leland Orser - Lucien Dubenko
- Lee Arenberg - Juke
- Garry Marshall - Harry Feingold
- George Clooney - Dr. Doug Ross
- Michael Bowen - Boy's Father
- Mary McCormack - Debbie
- Wayne Duvall - Umpire
- Kimberly Scott - Sandy's Mother
- Alan Rosenberg - Samuel Gasner
- Eli Wallach - Mr. Langston
- Mike Colter - Watts
- Celia Weston - Maureen Chapman
- Michael Peña - Police Officer
- Natasha Gregson Wagner - Mary Warner
- Frank McRae - Freddie
- Clyde Kusatsu - Review Board Doctor #1
- James Cromwell - Bishop Stewart
- James Keane - Workman
- Maz Jobrani - Henry Aquino
- Kirsten Dunst - Charlie Chiemingo
- Rick Marzan - Camacho
- Sara Gilbert - Jane Figler
- Mark Pellegrino - Nathan Conley
- Gregg Henry - Officer Mark Downey
- Jack Kehler - Jail Officer
- Stephi Lineburg - Ellie Reiser
- Shannon Cochran - Mrs. Klingman
- Bradley Gregg - Ken Parker
- Stanley Tucci - Kevin Moretti
- Dakota Fanning - Delia Chadsey
- Ewan McGregor - Duncan Stewart
- Vito D'Ambrosio - Forchet
- Danny Glover - Charlie Pratt Sr.
- Scott Grimes - Archie Morris
- David Lyons - Simon Brenner
- Angela Bassett - Catherine Banfield
- John Stamos - Tony Gates
- Samantha Corbin-Miller
- Lance Gentile
- Janine Sherman Barrois
- Lisa Zwerling
- Christopher Chulack
- Joe Sachs
Don Harvey interpreta a Mr. Warshaw en la serie.
Angela Paton interpreta a Mrs. Ransom en la serie.
Bibi Besch hace el papel de Ethel Garvey.
Rick Overton hace el papel de Mr. McNamara.
Adriana Barraza hace el papel de Dolores Salazar.
Jonathan Banks interpreta a Robert Truman en la serie.
Joe Grifasi hace el papel de Tom Williams.
Jorja Fox hace el papel de Maggie Doyle.
Jeannetta Arnette interpreta a Mrs. Hawkes en la serie.
Brian Tarantina hace el papel de Joe Barkley.
Capítulo disponible en las siguientes plataformas:
