- Jim Titus - Reggie Blaylock
- J. Anthony Pena - Gary Lopez
- Sola Bamis - Afeni Shakur
- Amirah Vann - Justine Simon
- Jamie Hector - Duane Keith David's Lawyer
- Luke James - Sean "Puff Daddy" Combs
- LeToya Luckett - Sharitha Golden
- P.J. Marshall - Frank Lyga
- Lahmard J. Tate - Duane Keith David
- Maestro Harrell - James "Lil' Cease" Lloyd
- Dondraico Johnson - Paul Offord
- Rick Otto - Sergeant Dorsey
- Kevin Phillips - Damion "D-Roc" Butler
- Six Reasons - Eugene Deal
- Mustafa Speaks - Kevin Gaines
- Yolanda Whitaker - Pretty Woman
- Terrence Terrell - Neck Bone
- Pooch Hall - Frank Alexander
- Dorian Missick - Scott Shepard
- Avery Kidd Waddell - Ernest Anderson
- Wendell Pierce - Detective Lee Tucker
- Mychal Thompson - Orlando Anderson
- James Bland - Easy Mo Bee
- Rhys Coiro - Jim Black
- Omar Gooding - David Mack
- Donald Faison - Jacques "Haitiani Jack" Agnant
- Laurie Fortier - Donna Kading
- Malik Barnhardt - Baggy Polo
- Michelle Hayden - Errolyn Romero
- Malieek Straughter - Michael "Psycho Mike" Robinson
- Woody McClain - Jimmy "Henchman" Rosemund
- Scott Michael Campbell - Officer Tim "Blondie" Brennan
- Antwon Tanner - Jo Jo Miller
- Erica A. Watson
- Darren Grant
- Samir Mehta
- Greg Kading
Josh Duhamel hace el papel de Detective Greg Kading.
Jimmi Simpson interpreta a Detective Russell Poole en la serie.
Bokeem Woodbine interpreta a Officer Daryn Dupree en la serie.
Marcc Rose interpreta a Tupac Shakur en la serie.
Wavyy Jonez interpreta a Christopher Wallace en la serie.
Dominic L. Santana interpreta a Suge Knight en la serie.
Sarkis Ninos hace el papel de Detective.
Michael Harney hace el papel de Lieutenant Paul Larson.
Aisha Hinds hace el papel de Voletta Wallace.
Capítulo disponible en las siguientes plataformas:
