- Jordan Masterson - Ryan Vogelson
- Jonathan Adams - Chuck Larabee
- Molly McCook - Mandy Baxter
- Jet Jurgensmeyer - Boyd Baxter
- Molly Ephraim - Mandy Baxter
- Kaitlyn Dever - Eve Baxter
- Krista Marie Yu - Jen
- Danielle Bisutti - Michelle
- Paul F. Tompkins - Chester McAllister
- Art Evans - Mort
- Cassandra Peterson - Elvira
- Audrey Wasilewski - Kim
- Phil Abrams - Male Executive
- Andrea Bendewald - Charlie
- Nick Jonas - Ryan
- Steve Talley - Chad Bickle
- Jerry Minor - Mel
- Mike Rowe - Jim
- Kim Kardashian - Self
- Uriah Shelton - Ben Milbauer
- Rick Overton - Ted Dryer
- Christina Moore - April
- Kenton Duty - Victor Blake
- John Marshall Jones - Frank Lippy
- Emily Rutherfurd - Rebecca
- Natalie Distler - Debbie
- Michael Weaver - Tom
- Frankie Muniz - Richard
- Melanie Paxson - Liz
- Shaun Robinson - Self
- Don Lake - Professor
- Kenneth Choi - Dr. Wong
- Bob Stephenson - Marvin Slater (Security Officer)
- Andy Daly - Mr. Peckem
- David Anthony Higgins - Bill Calhoun
- Joel David Moore - Care Center Employee
- Shira Scott Astrof - Summer
- Mary-Margaret Lewis - Paula
- Elaine Ann Hu - Mrs. Wong
- Greg Pitts - Pete
- Audra Griffis - April
- Daphnée Duplaix Samuel - Misty Cavanaugh
- Marmee Regine Cosico - Audience Member
- Paris Dylan - Church Flirt (uncredited)
- Tim Lacatena - Hipster
- Alison Lani - Hipster
- Alison Lani - Female Assistant
- Tony Hawk - Himself
- Jamie-Lynn Sigler - Gabriella
- Matt Shively - Elliot
- Laura Silverman - Brenda
- James Logan - Bank Robber #1
- Alex Skuby - Frank Milbauer
- Shane Coffey - Terrence
- Deborah May - Stella
- Erika Alexander - Carol
- Amy Tolsky - Mrs. Flagg
- Robin Riker - Wanda
- Bo Barrett - Young Guy
- Joseph Whipp - Ron
- Brandon Killham - Dylan
- Evie Thompson - Marjorie
- Kurt Scholler - Large Man
- Hope Lauren - Chloe
- Richard Karn - Bill McKendree
- Maile Flanagan - Dr. Kathy Pullman
- Kevin Kirkpatrick - Calvin Lentz
- Jackie Seiden - Alyssa Warren
- Shaun Rylee - Mourning Coworker
- Carla Jimenez - Blanca
- Sal Lopez - J.J.
- Mcabe Gregg - Airdog
- Sarah Gilman - Cammy
- Sarah Gilman - Cammy Harris
- Bryce Durfee - Greg Archer
- Cody Jones - Thunderheart
- Ezequiel Stremiz - Octavio
- Crista Flanagan - Miss Clevenger
- Beck Bennett - Police Sergeant
- Beau Billingslea - Walter
- Melendy Britt - Dolores
- Gladys Holland - Maureen
- Jonathan Taylor Thomas - John Baker
- Willie Robertson - Brody
- Si Robertson - Uncle Ray
- Larry Joe Campbell - Phil Munroe
- Dale Dickey - Dorris
- Clint Culp - Customer
- Mackenzie Mason - Susan
- David Figlioli - Officer
- Zachary Gordon - Andrew
- Tye Sheridan - Justin
- Ryan McCartan - Matt
- Taryn Southern - Rachel
- Maz Jobrani - Jerry
- Joely Fisher - Wendi
- Michael Gross - Mr. Hardin
- Matthew Boehm - Jason
- Chris Dougherty - Security Patrolman
- Will Roberts - Rodeo Cowboy
- Philip Maurice Hayes - Voice on PA
- Mel Fair - Announcer
- Sam Lant - Greg
- Roy Jenkins - Customer #2
- Jason Sims-Prewitt - Customer
- Elaine Loh - Receptionist
- Allan Murray - Prospector Pete
- Tyler Poelle - Employee
- Patricia Richardson - Helen Potts
- Patrick Bristow - Salesman
- Daniel Montgomery - Mandy's Date
- Mike Cochrane - Dave
- Lee Doud - Waiter
- Nadji Jeter - Brandon
- Jere Burns - Victor Vogelson
- Yvette Nicole Brown - Movie-Goer
- Matthew Downs - Officer Schlumbrecht
- Adolfo Álvarez - Little Boy
- Ava Davila - Little Girl
- Jon Curry - TV Actor
- Calvin Jung - Outdoor Man Employee
- Blake Clark - Clark
- Joey Luthman - Nigel
- Tim Acres - The Ugly Mutts
- Robin Roberts - Teresa
- Reba McEntire - Billie
- Kelly Walker - Jenna
- Quynh Thi Le - Lindsey
- Scott Parkin - Reporter
- Rochelle Robinson - Female Customer
- Robert Forster - Bud Baxter
- Jay Leno - Joe
- Stacie Greenwell - Officer Devore
- Dion LaMarr - Worker
- Melissa Peterman - Celia "CeCe" Powers
- Melissa Peterman - Celia "CeCe"Powers
- Tisha Campbell - Carol Larabee
- Alex Solowitz - Lonny
- Susan Sullivan - Bonnie
- Bill Engvall - Reverend Paul
- Bill Engvall - Rev. Paul
- Tony Stewart - Self
- Travis Tope - Rob
- Logan Kishi - Jack
- Tim Allen
- Shawn Levy
Rick Overton hace el papel de Ted Dryer.
Tim Allen interpreta a Mike Baxter en la serie.
Joely Fisher interpreta a Wendi en la serie.
Maz Jobrani hace el papel de Jerry.
Nancy Travis interpreta a Vanessa Baxter en la serie.
Hector Elizondo interpreta a Ed Alzate en la serie.
Christoph Sanders hace el papel de Kyle Anderson.
Amanda Fuller interpreta a Kristin Baxter en la serie.
Jordan Masterson hace el papel de Ryan Vogelson.
Molly McCook hace el papel de Mandy Baxter.
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