- Grey DeLisle - Lola Loud / Lana Loud / Lily Loud (voice)
- Grey DeLisle - Lola Loud / Lana Loud / Lily Loud / Mrs. Jelinski (voice)
- Lara Jill Miller - Lisa Loud (voice)
- Lara Jill Miller - Lisa Loud / Nun (voice)
- Jack Griffo - Blke Bradley
- Mariel Sheets - Darcy (voice)
- Marc Summers - Himself (voice)
- Kirk Fogg - Himself (voice)
- Jace Norman - Steak (voice)
- Cooper Barnes - Stan (voice)
- Maureen McCormick - Jancey (voice)
- Barry Williams - Bumper Yates Sr. (voice)
- Brec Bassinger - Margo Roberts (voice)
- Blair Dinucci - Bernice (voice)
- Blair Dinucci - Bertha (voice)
- Lily Mae Silverstein - Renee
- Kapil Talwalkar - Raj (voice)
- Jill Talley - Rita Loud (voice)
- Catherine Taber - Lori Loud (voice)
- Catherine Taber - Lori Loud / Terrifying Zombie (voice)
- Catherine Taber - Lori Loud / Female Voice (voice)
- Catherine Taber - Lori Loud / Computer Voice (voice)
- Daran Norris - Announcer / Bachelor (voice)
- Brian Stepanek - Lynn Loud Sr. / Game Voice (voice)
- Brian Stepanek - Lynn Loud Sr. / Police Officer (voice)
- Brian Stepanek - Lynn Loud Sr. / Hunter Spector / TV Announcer (voice)
- Brian Stepanek - Lynn Loud Sr. (voice)
- Zoe Pessin - Classmate #1 (voice)
- Jay Gragnani - Classmate #2
- Daniel DiMaggio - Artie (voice)
- Alexandra Ryan - Fiona (voice)
- Tucker Chandler - Little Boy (voice)
- Bill Mumy - Timothy Mccole
- Tom Kenny - Announcer/Ice Cream Man
Cristina Pucelli interpreta a Luan Loud (voice) en la serie.
Grey DeLisle interpreta a Lola Loud / Lana Loud / Lily Loud (voice) en la serie.
Liliana Mumy interpreta a Leni Loud (voice) en la serie.
Nika Futterman interpreta a Luna Loud (voice) en la serie.
Jessica DiCicco interpreta a Lynn Loud Jr. / Lucy Loud (voice) en la serie.
Lara Jill Miller interpreta a Lisa Loud (voice) en la serie.
Grant Palmer interpreta a Lincoln Loud (voice) en la serie.
Caleel Harris interpreta a Clyde McBride (voice) en la serie.
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