- Daveed Diggs - Marshall Zucker
- Sienna Miller - Becca Shearer
- Kit Harington - Nicholas Bilton
- Matthew Rhys - Junior
- Meryl Streep - Eve
- David Schwimmer - Harris Goldblatt
- Edward Norton - Jonathan Chopin
- Indira Varma - Gita Mishra
- Heather Graham - Hannah
- Peter Riegert - Ben Zucker
- Leslie Uggams - Isabel Zucker
- Yara Shahidi - Carmen Jalili
- Lemon Andersen - Holographic Speaker
- Noel Arthur - Jordan
- Cherien Dabis - Lina
- Cara Gee - Becca's Colleague
- Alexander Sokovikov - Vadim
- Kate Beahan - Reporter #3
- Zuhdi Boueri - Imam Aslan
- Mark James Fernandes - Airport Ezra's Father
- Manny Galan - Paramedic
- Malerie Grady - Stripper
- Jabari Gray - Reporter #1
- Megumi Haggerty - Director
- Minda Larsen - Concerned Woman
- Elizabeth Maille - Martine Gilbert
- Rebecka Ray - Brain Surgeon
- James Roberts IV - Yoga Instructor
- Maya Rosewood - Mikey Hampton
- James Levine Scherr - Airport Ezra
- Samir Zaim-Sassi - Samir
- Joaopaulo Malheiro - Young Ezra
- Bella Patel Sauer - Young Lola
- Eisa Davis - Christina
- Ato Essandoh - Marco J.
- Douglas Hodge - Hendricks
- Louis Arcella - Jorge
- Glenys Javier - Co-Worker
- Ana Maria Jomolca - Ophelia
- Emily Nash - Referee
- Aldan Liam Philipson - Cesar
- Antonio Watson - Alfonso
- Judd Hirsch - David Goldblatt
- Nick Kroll - Alpha (voice)
- Kapil Bawa - Dr. Shah
- Fredi Bernstein - Devoted Congregant
- Quinn Jackson - Myra (FBI)
- Shirleyann Kaladjian - Dahlia Klubeck
- David Kramer - Lawrence Zabler
- Lynn Kim Do - Nurse
- Rosanna Magarelli - Sharon
- Allen McCullough - Reverend McGhee
- Zell Steele Morrow - Max Borenstein
- Laura Patinkin - Sarah Stillman
- Sean Shannon - Homeless Elijah
- Adam B. Shapiro - Richard Klubeck
- Neska Rose - Alana Goldblatt
- Annelise Cepero - Julia
- Judy Gold - Sophie
- Kathryn Kates - Mrs. Goldblatt
- Marianne Rendón - Gabriela
- Tahar Rahim - Omar Haddad
- Tahar Rahim - Ezra Haddad
- Michael Gandolfini - Rowan Chopin
- Cherry Jones - President Elizabeth Burdick
- Deidre Goodwin - Special Agent Sanchez
- Mía Maestro - Mariama Cruz
- Aimee Mullins - Secretary of State Garrett
- Ajay Naidu - Hiram
- Roslyn Ruff - White House Official
- Cathy Salvodon - President's Aide
- Jean Goto - NSI Tech
- Jay Horton - SEAL Commander
- Dante Jeanfelix - NSI Tech
- Mohit Prajapati - Young Boy
- Devendra Patel - Scooter Guy
- Kevin Craig West - DNI Ratcliffe
- Diane Lane - Martha Russell
- Adarsh Gourav - Gaurav
- Gaz Choudhry - Neel
- Keri Russell - Olivia Drew
- Waris Ahluwalia - Harbaksh
- Zuleikha Robinson - Madam
- Karan Choudhary - Cop
- Siraj Huda - Village Doctor
- Parinaz Jal - Bossy Lady
- Deepti Menon - Desk Clerk
- Keshav Moodliar - Sunil
- Rishi Mukherjee - Bellhop
- Sheikh Niloy - Armed Guard
- Sasha Sen - Mother
- Linden Tailor - Nepalese Mechanic
- Martin Fisher - Jeremy (FBI)
- Gemma Chan - Natasha Alper
- Devika Bhise - Lola
- Isabelle McCalla - Stand-in
- Andrew Richardson - David Alper
- Scarlett Sher - Harlyn
- Tara Summers - Isabel Wick
- Marilee Talkington - Janice
- Shirine Babb - Teacher
- Manuel Cabrero - Elderly Man
- Feiga Martinez - Elderly Woman
- Victoria Ric - Employee
- Faron Salisbury - Rager Husband
- Mitchell Sink - Mopey Teenager
- Marion Cotillard - Sylvie Bolo
- Forest Whitaker - Auggie Bolo
- Eiza González - Elodie
- Tobey Maguire - Nic
- Hari Nef - Anna
- Lee Avant - Environmental Scientist
- Amy Gordon - Talking Head Scientist
- Gabriel Gutierrez - Technician
- Murray Bartlett - Mr. Turner
- Maameyaa Boafo - Lucy Adobo
- Ben Harper - Tyrone Downs
- Anna Deavere Smith - Arden Miller
- Lily Buchanan - Decima
- Kirin Kim - Dr. Russell Burner Avatar
- Rami Margron - Bailiff
- Waverly Corinne Meier - Young Decima
- Robert Newman - Carpenter
- Calidore Robinson - Friend
- Sprague Theobald - Mr. Palmer
- Daniel Radcliffe - Alpha (voice) (uncredited)
- Yan Xi - USAF Fighter Jet Pilot
- Kelly McCready - Assistant
- Valéry Lessard - AI Servant
- Kimberlee Monroe - Dr. Russell Burner Avatar
- Sanjay Gupta - Sanjay Gupta
- Sagar Sharma - Secret Service Agent
- Michael Ellenberg
- Scott Z. Burns
- Salvatore Schiavone
- Gregory Jacobs
- Coco Kleppinger
- Lindsey Springer
- Season Kent
Forest Whitaker hace el papel de Auggie Bolo.
Cherry Jones hace el papel de President Elizabeth Burdick.
Tobey Maguire interpreta a Nic en la serie.
Ajay Naidu interpreta a Hiram en la serie.
Daveed Diggs hace el papel de Marshall Zucker.
Sienna Miller interpreta a Becca Shearer en la serie.
Kit Harington hace el papel de Nicholas Bilton.
Matthew Rhys interpreta a Junior en la serie.
Meryl Streep hace el papel de Eve.
David Schwimmer hace el papel de Harris Goldblatt.
Capítulo disponible en las siguientes plataformas:
