- Melissa Villaseñor - Sister Mary Margaret (voice)
- Kurtwood Smith - Carpenter K. Smith (voice)
- Tim Heidecker - Mayor Kevin De Maximum (voice)
- Chris Conrad - Detective Nico Onasis (voice)
- Julian Barratt - The Most Dangerous Man in the World (voice)
- Kristen Bell - Donella Pecker (voice)
- Luis Guzmán - Rodrigo Smalls (voice)
- Sunita Mani - Detective Jaya Mukherjee (voice)
- Caleb McLaughlin - Trevor Johnson (voice)
- Tim Meadows - Jeff Thumb (voice)
- Terry O'Quinn - Captain Krieger (voice)
- Dax Shepard - Chris Pecker (voice)
- Debra Winger - Trish McSapphire (voice)
- Jason Mantzoukas - Tim Snodgrass (voice)
- Jason Mantzoukas - Second Flophouse Resident (voice)
- Hana Mae Lee - Christina Smalls (voice)
- Hana Mae Lee - Passerby 1 (voice)
- Alia Shawkat - Little Grace (voice)
- Alia Shawkat - Woman's Voice (voice)
- Damon Herriman - Street Hustler Boy (voice)
- Damon Herriman - First Motherless Three (voice)
- Damon Herriman - First Flophouse Resident (voice)
- Tony Fitzpatrick - Promoter Tip Snarski / Policeman Driver (voice)
- Jermaine Fowler - TMZ Operator / Second Young Hustler (voice)
- Antoine McKay - Chinatown Devin / Passerby 2 / Pedestrian (voice)
- Antoine McKay - Chinatown Devin / 254 Bouncer (voice)
- Dana DeLorenzo - Sissy Smith / Voice on Earpiece (voice)
- Mike O'Connell - Anchor Man (voice)
- Mike O'Connell - Anchor Man / Arena Announcer / Man's Voice on Phone (voice)
- Valerie Azlynn - Space Bitch (voice)
- Chris Waters
- Matthew Senreich
- Seth Green
- Eric Towner
- John Harvatine IV
- Jeff Dieter
Giancarlo Esposito interpreta a Pruit Normings en la serie.
Tom Waits interpreta a The Narrator (voice) en la serie.
Jimmi Simpson interpreta a Detective David Mills (voice) en la serie.
Da'Vine Joy Randolph interpreta a Detective Gail Johnson (voice) en la serie.
John C. Reilly interpreta a Donovan Smith (voice) en la serie.
Bebe Neuwirth interpreta a Lady Andrea The Giant (voice) en la serie.
Jason Mantzoukas interpreta a Tim Snodgrass (voice) en la serie.
Damon Herriman interpreta a Street Hustler Boy (voice) en la serie.
Melissa Villaseñor interpreta a Sister Mary Margaret (voice) en la serie.
Kurtwood Smith hace el papel de Carpenter K. Smith (voice).
Capítulo disponible en las siguientes plataformas: