- Dick Martin - Grandpa Charlie
- Michael Welch - Michael Rush
- Nancy Lenehan - Dr. Peel
- Fred Willard - Frank Farber
- Kathy Kinney - Mimi Bobeck
- Bill Macy - Mr. Harrison
- Joel Higgins - Sharon's Father
- Sean O'Bryan - Ted
- Michael Ensign - Chairman at Presentation
- Jason Clarke - Hank
- Julene Renee - Molly
- Carmen Electra - Isabella
- Bill Burr - Fitzey
- Michelle Stafford - April
- Jean Speegle Howard - Mrs. Wexler
- Howard Hesseman - Mr. Bergen
- Harve Presnell - Edgar J. Hagerty
- Suzanne Krull - Bates Balou
- Robert Joy - Ed
- Elisabeth Harnois - Translator
- Stephen Tobolowsky - Father Viteri
- Amy Hill - Pete's boss
- Steve Landesberg - Berg's Dad
- Kenneth Kimmins - Mr. Walker
- Cheryl Ladd - Berg's Mom
- Bette Ford - Marge Ryecart
- Pat Crawford Brown - Librarian
- Anthony Stewart Head - Dr. Staretski
- Maury Ginsberg - Kamen
- Brian Dunkleman - Pizza delivery guy
- Brian Dunkleman - Customer
- Brian Dunkleman - Pizza Place Chess Fan
- James Patrick Stuart - Priest
- Beverly Leech - Claudia
- Lyle Kanouse - Tessio
- Bobbie Phillips - Shawn
- Constance Marie - Venita
- Brigitta Dau - Britney Walker
- Jon Cryer - Justin
- Adam Carolla - Self
- Marguerite MacIntyre - Kaitlin Rush
- Beth Grant - Tufts College Employee
- Sam Lloyd - Career Counsellor
- Conchata Ferrell - Shawn's Mother
- Giuseppe Andrews - Germ
- Rena Sofer - Lauren
- Mark Hoppus - Self
- Tom DeLonge - Self
- Travis Barker - Self
- Danny Jacobson
- Pat Bullard
Stephen Tobolowsky hace el papel de Father Viteri.
Harve Presnell interpreta a Edgar J. Hagerty en la serie.
Conchata Ferrell interpreta a Shawn's Mother en la serie.
Traylor Howard interpreta a Sharon Carter en la serie.
Ryan Reynolds hace el papel de Michael 'Berg' Bergen.
Richard Ruccolo hace el papel de Peter Dunville.
Suzanne Cryer hace el papel de Ashley Walker.
Nathan Fillion interpreta a Johnny Donnelly en la serie.
Jillian Bach hace el papel de Irene.
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