- Jayne Eastwood - Emma Price
- Gwynyth Walsh - Madeline Strong
- Carolyn Scott - Business Woman
- Jonelle Allen - Dr. Grace Grant-Geistings / Nurse Daisy Bradford
- David Sparrow - Vendor
- Susan Blakely - Tory Van Dyke / Markie James
- Patrick Duffy - Peter Hogan / Father Daniel Morrissey
- Bree Williamson - Carol Anne
- Jack Duffy - Samuel Gold
- Michael Cera - Skateboarder #2
- Andrew Airlie - Detective David Hayes
- Brenda Bazinet - Pauline Parnell
- Alycia Purrott - Callie
- Donna Mills - Linda MacCullen / Lana Kasalas
- David Julian Hirsh - Zeke
- Brooke Nevin - Young Katie
- Emily Hampshire - Young Blair Wilson
- Karl Pruner - Barry Lewis
- Brent Carver - Harry
- William Hutt - Lionel
- Stephanie Mills - Lisa
- Lindy Booth - 17 Year Old Caitlin Taylor
- Steve Landesberg - Barry Kirkbride / George Doorwood
- Rachel Skarsten - Young Julie Adams
- Alex House - Billy - Age 12
- Ralph Macchio - Officer Dan Payello / Phillip Barbosa
- Laura Vandervoort - Misty Reynolds
- Diahann Carroll - Jael
- Polly Shannon - Vicki Sue
- Trevor Blumas - Young Ben Bogart
- Brenda Devine - Mary Flynn
- Michael Seater - 12 Year Old Steven Stovall
- Maurice Dean Wint - Dr. Sam Heistings
- Dean Armstrong - Bruce Bennett
- Jeff Roop - Young Randy Jackness
- Michelle Nolden - Melanie
- Cedric Smith - Dr. Eldridge Hawke
- Liam Titcomb - Teenager
- Michele Greene - Jenny Parnell / Dr. Karen Lantz
- Rufus Crawford - Officer Perez
- Joe Penny - Flash Jericho / David Lazarus
- Tracey Gold - Blair Wilson / Polly Murtaugh
- Michelle Phillips - Edwina Lewis
- Jere Burns - Thomas 'Tom' Lasky / Tom the Homeless Man
- Gema Zamprogna - Young Sarah Carlyle
- Peter Cox - Dealer #1
- Torri Higginson - Rebecca Curtis
- Roger Dunn - Mr. Kingsley
- Anthony Christian Potenza - Young Barry Kirkbride
- Markie Post - Nancy Waldron / Peggy McIntyre
- Peter Keleghan - Ira Finkelstein
- Natalie Radford - Young Eloise Hawke
- Fiona Reid - Head Nurse Fike
- Amos Crawley - Josh Strong
- Diana Reis - Elaine Stovall
- David Ferry - Jerry
- Mariette Hartley - Brooke Canby / Janet Bryant
- Merwin Mondesir - Young Charlie Winters
- Kate Jackson - Julie Smith / Mildred
- Cameron Graham - Stage Manager '99
- Jake Goldsbie - Mickey
- Joanna Cassidy - Meg McCleary / Christine Esposito
- Maria Ricossa - Olympia
- Daniel Hugh Kelly - Rex Stanford / Charles
- Julia Duffy - Sophie Price / Barbara Nash
- Asia Vieira - 14 Year Old Angel Ryder
- Reagan Pasternak - Ramona
- Miko Hughes - Max Bogart
- Lesley Ann Warren - Rhonda Finkelstein / Sadie Arnstein
- Dean McDermott - Albert Weaver
- Janaya Stephens - Mrs. John Paul O'Brien
- Stephanie Zimbalist - Dana Hancock / Ann Rutherford
- Tim Progosh - Gary Ray
- David Hewlett - Mr. Green
- Ron Glass - Charlie Winters / Charlie Summers
- Anne Openshaw - Aliandra Dunne
- Joshua Peace - Young Rex Stanford
- David Nerman - Sgt. Selden Nichols
- Thomas Ian Nicholas - Sam Ryder / Jordan Curtis / Kirk Ivers
- Tamara Gorski - Young Louise
- Johnie Chase - Jack
- Hayley Lochner - TV Daughter
- Noam Jenkins - Hector Soto
- Noam Jenkins - Tony Rosett
- Polly Bergen - Judge Deborah
- Kathryn Zenna - Annie
- Jesse Nilsson - Young Eric Lee
- Lauren Lipson - Victoria
- Philip Akin - Todd
- Roberta Maxwell - Eloise Hawke / Eileen Kotter
- Ari Cohen - Adult Axel
- Bruce Boxleitner - Ray Patterson / Dr. Goode
- Jennifer Pisana - Lucy Rosetti
- Kelly King - Grace Kincaid
- Jennifer Hill - Amy
- Patrick Garrow - Jimmy
- Linda Griffiths - Margie
- Martin Roach - Dwight White
- Aaron Ashmore - Paul Harper
- Christopher Jacot - Julio
- Christopher Jacot - Young Ray Jericho
- Anthony Lemke - Young Dr. Hugh Janyk
- Patrice Goodman - Lauren
- Matthew Lemche - Paul Wheeler
- Matthew Lemche - Teenaged Sean Price
- Elisabeth Rosen - Young Madeline Flynn
- Austin Strugnell - Ryan
- Peter Snider - Doctor
- Lili Francks - OB Nurse
- Vickie Papavs - Mrs. O'Brien
- Kerry Dorey - Mr. O'Brien
- Rob Tinkler - Young Man
- Alexa Gilmour - Young Woman
- Corbin Bernsen - Roger Stovall / Bill Water
- Hardee T. Lineham - Robby Turner
- Patrick Galligan - Agent Citrano
- Russell Yuen - Agent Hoye
- Bill Lake - Sheriff
- Todd Schroeder - Traffic Cop
- Evan Caravela - 4 Year Old Steven Stovall
- Nancy McAlear - Forest Ranger
- Lisa Hynes - IRS Secretary
- Emmanuel Mark - George Di Pietro
- Janet Bailey - Young Dr. Grace Grant
- David Eisner - Dr. Dan Brickner
- Jennifer Gould - Lisa Rudinsky
- Janet van de Graaf - Nurse Louise
- Christina Collins - Nurse Thelma
- Andrew Meikle - Tommy Heistings
- Melody Johnson - Young Dana Hancock
- Mark Wilson - Steve
- David Frisch - Ben
- Balázs Koós - Adam
- Ardon Bess - Dr. Harold Roth
- Rob McClure - Jon
- Christiane MacKenzie - Carly
- Graham Losee - David
- Erica Fairfield - Suzy
- Serena Lee - Tracy
- Jim Codrington - Coach Cronin
- Timm Zemanek - Defendant (uncredited)
- Richard Eden - Mark Smith
- Kelly Ivey - Young Julie
- Jordy Benattar - Little Kimberly Smith
- Lori Hallier - Julie's Mother
- Linlyn Lue - Young Police Woman
- Sam Malkin - Cook / Owner
- Ben Mayer-Goodman - Young Axel
- Brad Austin - Brad
- Brad Austin - John Paul O'Brien
- Ralph Small - Police Officer
- Amy Stewart - Kimberly Smith
- Max Morrow - Young Sean Price
- Max Morrow - Gabe
- Lynn Vogt - Jan Meshkoff
- Heidi von Palleske - Sonja
- Mandy Lee Jones - Diner Patron (uncredited)
- Clé Bennett - Charlie Winters Jr.
- Scott Henderson - Skateboarder #1
- Jack Mather - Sammy
- L.J. Vasilantonakis - Biker
- Kevin Zegers - Young Flash Jericho
- Boyd Banks - Murphy
- Robert Clark - Kyle
- Ian Downie - Clarence
- Kenneth McGregor - Adult Ray Jericho
- Jonathan Potts - Peter
- Kim Roberts - Brenda
- Chuck Shamata - Coach Rybeck
- Catherine Swing - Katie
- Egidio Tari - Officer Moline
- K. Trevor Wilson - Young Coach Duane
- Mary-Lu Zahalan - Louise
- Tony Curtis Blondell - Clerk
- Marion Day - Ms. Lane
- James Downing - Adult Eric Lee
- Nicholas Kilbertus - Mr. Powell
- Megan Fahlenbock - Young Brooke Canby
- Timothy Burd - Robber
- David Crean - Flynn
- Tracy Dawson - Pauline Kraft
- Scot Denton - Governor Stanton
- Barry Flatman - Nathaniel Canby
- David Fraser - City Attorney
- Joyce Gordon - Edith Gold
- Kristen Holden-Ried - Young Ken Stryker
- Jack Jessop - Judge Carl Horner
- Dave Nichols - Older Ken Strykler
- Billy Otis - Cabbie
- David Rosser - Court Bailiff
- Grant Nickalls - Young Peter Hogan
- Leila Johnson - Young Susan Hewitt
- Anais Granofsky - Isabel Sanchez
- Ross Petty - Jim Hewitt
- Nancy Cser - Adult Susan
- Steve Cumyn - Duncan Price
- Kevin Frank - MC
- Glen Gaston - Wayne
- Paulino Nunes - Agent Metcalfe
- Tara Samuel - Young Mother
- Thick Wilson - Judge Samuel Mooney
- Carly Street - Young Meg McCleary
- Henry Alessandroni - Martinez
- Heather Brown - Heather McCleary
- Rogue Johnston - Michael Johnson
- Giulio Kukurugya - Judge
- David MacKay - Assistant D.A. Knelman
- Duane Murray - Mantee
- Nicholas Pasco - Lt. Waxman
- Beatriz Pizano - Graciela
- Patrick Stevenson - Graphia
- Kim Schraner - Young Linda MacCullen
- Thomas Mitchell - Tom Miller
- Larry Day - Director
- Andrew Dinner - Kenny
- Debbie Fleming - Singing Louise
- Eddie Glenn - Window Washer
- Lee MacDougall - Stage Manager '79
- R.D. Reid - Ernie Slate
- Nicole Crozier - Young Tory Van Dyke
- Alexandra Amini - Emily
- Marty Moreau - Paramedic
- Marty Moreau - Detective Gephart
- Jesse Farb - Peter at 14
- Larissa Gomes - Young Nurse
- Tanya Henley - Adult Tina
- Sandi Ross - Kate Winters
- Sandi Ross - Hannah Steele
- Paul Miller - Adult Randy Jackness
- Sunday Muse - June
- Steve Ferguson - Bartender
- Steve Ferguson - Young Mark Smith
- Jonathan Whittaker - Nicholas Parnell
- Adrian Hough - Dan Russell
- Erin McMurtry - Older Wendy Parnell
- Kevin Hare - Mike Soroko
- James Loxley - Dr. Levine
- Lee Taylor-Allan - Florence Russell
- Ron Payne - Minister
- Tamara Levitt - Charlotte McKnight
- Trent McMullen - Young / Old Stan
- Howard Jerome - Nate
- Gareth Bennett - Mark
- Brad Hopkins - Carlton
- Lynda Mason Green - Older Louise
- Phillip Jarrett - Gas Station Owner
- Phillip Jarrett - Tommy
- Shelley Peterson - Sarah Carlyle
- Frank Zotter - Mikey
- James Thomas - Rex's Son
- Darren Hynes - Joe
- Ned Vukovic - Mr. Ladenheim
- Alexandra Stapley - Young Jenny Parnell
- Alexandra Stapley - Young Nancy Waldron
- Alexandra Stapley - Young Tina
- Blair Johannes - Sam Logan
- Edward A. Queffelec - Dealer #2
- Joanna Bennett - Make-up Woman
- Amy Price-Francis - Young Edwina Lewis
- Jason Knight - Young Barry Lewis
- Andrew Gillies - Dr. Hugh Janyk
- Wendy Coles - Nan Millerd-Gatwick
- Neil Foster - Brad Millerd
- Janet Amos - M.C. Chandler
- Bruce Deller - Clerk
- Jack Manchester - Walker Lewis
- Lance Kinsey - Ron Taylor / Handy Randy
- Liz Gordon - Mrs. Kingsley
- Jack Newman - Mr. Doorson
- Judy Marshak - Iris
- Donald Carrier - Roger
- Noah Klar - Speed / Meat
- Maxine Guess - Ellen
- Karen Glave - Senior Nurse
- Karen Glave - Emergency Nurse
- Brooke Johnson - Maureen Wilson
- Stacy Grant - Veronica Rydell
- Heather Bertram - Justine
- Craig Eldridge - Don
- Drew Roby - Ray
- Nick Baillie - Adult Kevin Pappas
- Jennifer Phipps - Bess Lasky
- Holly Dennison - Younger Bess Lasky
- Ed Fielding - Mr. Hunt
- Rose Graham - Asylum Nurse
- Kathryn Kirkpatrick - Bingo
- Claudio Masciulli - Popsy
- Tony Meyler - Paramedic
- Robert A. Silverman - Homeless Man
- Aidan Devine - Mr. Ryder
- Patricia Gage - Mrs. Gerson
- Mung-Ling Tsui - Mrs. Brady
- Danielle Bouffard - 5 Year Old Angel Ryder
- Tracey Cook - Julie Bogart
- Tracey Cook - Tammy Taylor
- Robbie Bugbee - Baby Sam
- Nancy Harewood - Lindsay Patterson
- Aaron Poole - Ritchie Patterson
- Brandon Carrera - Jason Driver
- Cindy Cook - Mrs. Driver
- Nicole Hardy - Girl
- Mark Melymick - Fire Chief
- Marni Thompson - Vickie Myers
- Christopher Bondy - Older Billy
- Hamille Rustia - Hayley
- Steve Morel - New Harold
- Danielle Brett - Molly Finkelstein
- Jeff Topping - Allan Hollander
- Sandie Berenger - 45 Year Old Molly
- Rebecca Brenner - 11 Year Old Molly
- Leigh Lewis - Mrs. Chaser
- Robert McCarrol - Beer-belly Construction Worker
- Michael Spencer-Davis - Eddie
- Ed Marinaro - Mr. Bogart
- Stewart Bick - Ben Bogart
- Lori Nancy Kalamanski - Jenny Payello
- Ian D. Clark - Monsignor
- Andreas Apergis - Officer Raymond Santiago
- Richard Comar - Officer Russ Payello
- Joe Pingue - Frank
- Angelo Tucci - Marco
- Sean Campbell - Welsh
- Jared Wall - Andy Payello
- Sarah Stevens - Godmother
- Domenic Cina - Nicky
- Eleanor Yeoman - Older Woman
- Lisa Yamanaka - Georgia
- Pamela K. Long
Ralph Macchio interpreta a Officer Dan Payello / Phillip Barbosa en la serie.
Joanna Cassidy interpreta a Meg McCleary / Christine Esposito en la serie.
Kim Roberts hace el papel de Brenda.
Timothy Burd hace el papel de Robber.
Jayne Eastwood interpreta a Emma Price en la serie.
Emily Hampshire interpreta a Young Blair Wilson en la serie.
Aidan Devine hace el papel de Mr. Ryder.
Bruce Boxleitner interpreta a Ray Patterson / Dr. Goode en la serie.
Al Waxman interpreta a Judge Othniel en la serie.
Paul Popowich interpreta a Mr. Smith en la serie.
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