- Anna Maria Everett - Mother Superior
- Shaquille Ali-Yebuah - Gavin
- Sylvie Bolioli - Sister Francoise
- Claire Brown - Prison Guard
- Sarah de Freitas - Rosita
- Sophie Fletcher - UK Newsreader
- Natasha Gordon - Higgs
- Wendy Kweh - Nurse
- Divian Ladwa - Jamie's Solicitor
- Nigel Lindsay - Adren
- Philip Mizzi - Priest
- Nigel Barber - General
- Ray Callaghan - Elderly Man
- Charlie Condou - Father Alphonse
- Laurel Lefkow - Politician
- Piotr Baumann - Mortician
- Fiona Button - Skye
- Nick Offerman - Buddy
- Nicholas Pauling - Tim
- Ian Porter - Homeland Spokesman
- Janusz Sheagall - Polish Hospital Official
- William Meredith - Newsreader
- Phelim Kelly - Warsaw Protester
- Will Attenborough - Bobby Jr.
- Sanjeev Kohli - Doctor
- Antonio Magro - Giovanni
- Louis Mahoney - Cardinal Anderson
- Adam McNamara - Security Guard
- Brendan Murray - Neil Duncan
- André Agius - Waiter
- Tom Clarke Hill - Todd Sr.
- Holli Dempsey - Jolene
- Simon Gregor - Tramp
- Branka Katić - Atonia
- Erica Muscat - Homeless Woman
- Adam Nagaitis - Todd Jr.
- Paul Portelli - Homeless Man
- Ann Akinjirin - Bank Customer
- Anastasia Hille - Mary
- James McNeill - Eddie
- Naoko Mori - Nocturnapram Professor
- Elizabeth Moynihan - Carrie
- Geoffrey Burton - Arless
- Debbie Chazen - Myrta
- Denis Khoroshko - Mirinov
- Tommy Knight - Dealer Dan
- Suzann McLean - Ruth
- Lloyd McGuire - Magistrate
- Kevin Shen - Johansson
- Steve Barnett - Court Juror
- Jane Bertish - Mother Benedicta
- Jeff Mash - Jacob Gardner
- Eben Young - US Newsreader
- Andrew Byron - Prosecutor
- Oliver Ford Davies - Cardinal Crawshaw
- Christopher Goh - UK Newsreader
- Diana Rigg - Sutton
- Diana Rigg - Sutton (voice)
- Alana Hood - Genesis Survivor
- Bruce Mackinnon - Molby
- Anthony Howell - Father Christophe
- Sara Powell - Naomi
- Robert G. Slade - Judge
- Ronan Summers - Guard Chardwick
- Lloyd Owen - US President
- Pauline Quirke - Paula
- Megan Mullally - Leanne
- Prasanna Puwanarajah - Rajesh
- Karla Crome - Layla
- Bronagh Gallagher - Larsson
- Max Brown - Dr. Samuel
- Tim Wallers - Vicar
- Nina Sosanya - US Marshall Tess Carter
- Jean-Philippe Boriau - Rambo Gang
- Steve Jablonsky
Mathew Baynton interpreta a Jamie / Ariel en la serie.
Jenna Fischer hace el papel de Rhonda.
Joel Fry interpreta a Dave en la serie.
Gaia Scodellaro interpreta a Sister Celine en la serie.
Paterson Joseph hace el papel de General Arnold Gaines.
Anna Jones interpreta a News Anchor en la serie.
Kyle Soller interpreta a Scotty McNeil en la serie.
Rob Lowe interpreta a Father Jude en la serie.
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