- Brendan Fletcher - Derek De Luca
- Maggie Lawson - Megan Roberts
- Adrian Holmes - Victor
- William Sadler - Travis
- Lizzy Caplan - Avery Bishop
- Rachael Bella - Jen De Luca
- Georgia Craig - Vivian
- Steve Braun - Billy
- Parry Shen - Tyler Li
- Carly Pope - Kate Wilson
- Kaj-Erik Eriksen - Cole
- Erick Avari - Dr Thomas Burell
- Johnny Pacar - Adam Whitman
- Michael Reilly Burke - Russell Marks
- Liz Vassey - Carrie Allen
- Dominic Zamprogna - Donald Stuart Mitchell III
- Greg Anderson - Professor Seidel
- Eric Christian Olsen - Jensen Ritchie
- Nicole Muñoz - Little girl waiting for Santa
- Alaina Huffman - Paige Sanders
- Nick Wechsler - Marc Colvin
- Eddie Matos - Charlie
- Jeremy Guilbaut - Hank
- Joe Flanigan - Andrew Webb
- Matthew Harrison - Gregory
- Shane Meier - Sam
- Ryan Kwanten - Jake Voight
- Mary Elizabeth Winstead - Bridget Elkins
- Garwin Sanford - Bridget's father
- Michael Adamthwaite - Military police #1
- Christina Hendricks - Alyssa
- Chris William Martin - Justin Burke
- Emily Holmes - Nicole Simms
- Michael Teigen - Alex the groom
- Lisa Marie Caruk - Waitress
- Louise Grant - Elderly woman who refuse help
- BJ Harrison - Tackled woman
- Travis MacDonald - Meredith's drug dealer
- Samuel Patrick Chu - Kid losing his ball
- Tinsel Korey - Jen the bridesmaid
- Jodi Lyn O'Keefe - Candace Aimes
- David James Lewis - Curtis Connor
- Chad Krowchuk - Billy Lambert
- Jesse Hutch - Ronny Clifton
- Kyle Cassie - Craig Burke
- Sean Carey - Glenn Carpenter
- Alec Newman - Michael Mancuso
- Jaren Brandt Bartlett - Boy in corner shop
- Paulo Ribeiro - Corner shop clerk
- Lorena Gale - Receptionist
- Eileen Pedde - Patricia Norris, social worker
- Jennifer Spence - Stephanie Brandis
- Dena Ashbaugh - Linda Mancuso
- Michael Rogers - Robber dressed in blue
- Layla Alizada - Woman who gets a parking ticket
- Andrew Moxham - Police writing parking ticket
- Craig Veroni - ER doctor
- Sean Rogerson - Harrison's friend
- Devon Gummersall - Kevin Rafferty
- Sarah Deakins - Eileen Rafferty
- Noah Beggs - Highway patrolman
- Marc Baur - Sheriff
- Rondel Reynoldson - Woman with red wallet
- John Mann - Hank Timmons
- Jim Shepard - Carl
- Michelle Harrison - Michelle Carey, reporter
- Alexandra Holden - Jackie Connors
- Clare Kramer - Alex Reynolds
- Ted Friend - MC
- William R. Moses - Julian Barnes
- Rachel Hayward - Adrian Barnes
- Stephen Spender - Tyler
- Leah Graham - Tabitha, Luc's date
- Kerri Smith - Stage manager
- Jerry Wasserman - Marlon Todd
- Erica Durance - Angela Todd
- Benjamin Easterday - Frank, security guard
- Laura Leighton - Jordan Davies
- Emily Anne Graham - Claire Davies
- Wade Williams - Carl Neesan
- Sonja Bennett - Beth
- Julia Arkos - Diner cashier
- David MacKay - Waiter
- Eric Breker - Desk Sergeant
- Courtnee Draper - Melissa Summer
- Agam Darshi - Dawn Pullman
- Jessica Schreier - Helene Clarke
- Alf Humphreys - Mr Sumner
- Gwenda Lorenzetti - Mrs Sumner
- Jodie Graham - Bartender
- Craig March - Man in paisley tie
- Mercedes de la Zerda - Anna
- Tony Alcantar - Monty the used car salesman
- Ivan Cermak - Actor
- Alex Zahara - Peter
- Alexis Llewellyn - Isabelle Anders
- Ben Cotton - Carjacker
- Andrea Anders - Chris Barronson
- Derek Hamilton - Chris Barronson
- Jesse Moss - Matt Baxter
- John Reardon - Randall Thompson
- Louis Chirillo - Pawnbroker (scene deleted)
- Suzanne Bastien - Clerk at the car rental
- Andrew Airlie - Dr Frank Colvin
- Lisa Waltz - Grace
- Natasha Wilson - Lily
- Jason McKinnon - Busboy
- Scott Nicholson - Bus driver
- Mark Pawson - Ambulance driver
- Lauren Stamile - Emma
- David Lipper - Donnie McCrane
- Brent Sheppard - Minister # 1
- Pamela Hart - OR nurse
- Bonnie Smart - Desk nurse
- Ron Chartier - Store owner
- John Treleaven - Mnister # 2
- Jana Mitsoula - Detective Gomez
- Christopher Attadia - Teen # 2
- Eileen Barrett - Bystander
- Nickol Tschenscher - Screaming girl
- Artine Brown - Officer Murray
- Leanne Adachi - Richard's receptionist
- Marnie Alton - Lexi
- Bro Gilbert - Maintenance guy
- Michael Roberds - Cab driver
- Mylène Dinh-Robic - Roommate
- Janet Pinnick - Mom asking for a form
- Miranda Frigon - Wendy Roberts
- Alistair Abell - OTB Guy
- Nancy Sorel - Barbara
- Wayne Charles Baker - Guard
- Sean Campbell - Stan Kirby
- Sue Cremin - Vanessa Marks
- Maria Marlow - Anne Moore
- Chantal Conlin - Cambria Moore
- Beverley Elliott - Soloist at church
- Stacy Fair - Maid of Honor / Andrea
- Ty Olsson - Matt
- Jeffrey Dean Morgan - Geoffrey Pine
- Evangeline Lilly - Party Guest
- Nate Dushku - Marty
- Hudson Leick - Rebecca Morgan
- Heath Freeman - Cameron
- John Newton - Aaron McCann
- Callum Keith Rennie - Elliot Winters
- Brenda Campbell - Allison Evans
- Ingrid Tesch - Carol Winters
- Tori Anderson - Meredith Davies (Age 15)
- Victoria Tennant - Tru Davies (Age 12)
- Rick Tae - Card Player #1
- Phoenix Ly - Mr. Chang
- Jacqueline Ann Steuart - Nurse
- Kurt Evans - Priest
- Woody Jeffreys - Gary
- Johnson Phan - Tough Guy One
- Robert Wilson - Dr. Green
- Michael Trucco - Nick Kelly
- Jillian Fargey - Diane
- Reece Thompson - Kevin
- Reg Tupper - Neil Ford
- Karin Konoval - Head Nurse
- Karin Konoval - Detective
- Missy Peregrym - Gina
- Dee Jay Jackson - Fire Captain
- Vincent Laresca - Marco
- Ron Selmour - Jerry
- Brendan Bailey - Waiter
- G. Michael Gray - Serge
- Leonard Roberts - Blake
- Gabriel Olds - John
- John Sloan - Ethan
- Julia Benson - Tara
- Aaron Craven - Hat
- Kwesi Ameyaw - Tall Guy
- Patrick Gilmore - Blonde
- David Neale - Clayton
- Dana Pemberton - Bartender
- Andrew Campbell - Concierge
- Mark Matkevich - Dan Taggart
- Kal Penn - Steven
- Jim Francis - Mr. Sanders
- William MacDonald - Neighbour
- Andrew McIlroy - Professor Coleman
- Rhonda Dent - Jessica Hanson
- Bruce James - Jeremy
- Chris Shields - Proctor
- Chelah Horsdal - Admissions Officer
- Kristoffer Polaha - Mark Evans
- Fred Ewanuick - Brian
- Leah Cairns - Julie Spence
- Courtney Kramer - Nurse #1
- Simon Hayama - Military Police #2
- Alison Matthews - Marjorie
- Kirsten Alter - Nurse #2
- Mike Power - Patient
- John Shaw - Doctor
- Daniel Bacon - Professor
- Benjamín Benítez - Gardez
- Jen Halley - Elise Davies (Tru's Mother)
- Sage Testini - Ethan
- Cotter Smith - Richard Davies
- Tamyra Gray - Carly Anders
- Paul David Stewart - Aaron
- Jennifer Marie Chung - Shopper
- John MacCarthy
- Marty Adelstein
- Dawn Olmstead
- R. W. Goodwin
- Neal H. Moritz
Callum Keith Rennie interpreta a Elliot Winters en la serie.
Vincent Laresca interpreta a Marco en la serie.
David James Lewis hace el papel de Curtis Connor.
Eliza Dushku interpreta a Tru Davies en la serie.
Zach Galifianakis interpreta a Davis en la serie.
Shawn Reaves interpreta a Harrison Davies en la serie.
Jason Priestley hace el papel de Jack Harper.
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