- Rob Benedict - Walt King
- Ayelet Zurer - Rosemary Mathis
- Amy Sloan - Becca Klepper
- Greg Ellis - Trevor Wilcox
- Bodhi Elfman - Avram Hadar
- Roxana Brusso - Sheri Strepling
- Karen David - Kayla Graham
- Samantha Whittaker - Nell Plimpton
- Slade Pearce - Quest Boy
- Aidan Andrews - Boy
- Anna Diop - Lila James
- Isabella Acres - Soleil Friedman
- Dileep Rao - Vikash Nayar
- Amelia Rose Blaire - Natalie
- Katherine McNamara - Evie Woods
- Titus Welliver - Randall Meade
- Simon Delaney - Niles Borne
- David de Lautour - Simon Plimpton
- Rana Alamuddin - Mrs. Kozari
- Shak Ghacha - Abdul Kozari
- Wesam Keesh - Tarik
- Joey Naber - Abdul's Father
- Philip Shahbaz - Abdul's Uncle
- Nick Hodaly - Abdul's Uncle
- Eijiro Ozaki - Japanese Businessman
- Franco Vega - State Trooper
- Ray Ford - Cell Company Workman
- Javier Calderon - Lost and Found Guy
- Mike Madrigal - MTA Cop
- Judy Echavez - News Reporter
- Bill Seward - Morning News Anchor
- Maria Quiban - Morning Weather Girl
- Stevens Gaston - Security Guard
- Jude Ciccolella - Arnie Klepper
- Karan Soni - Ravi
- Blake Shields - Peanut Vendor
- Mike Batayeh - Arnie's Friend
- Mark Ivanir - Yuri Andreev
- Randall Batinkoff - Patrick McGrath
- Daniel Polo - Pavel Andreev
- Tatiana Chekhova - Pavel's Mom
- Melvin Abston - Detective
- Alexandra Peters - Russian Girl
- Shane Blades - Security Guard
- Tony Pasqualini - Boss
- Tom Riordan - Taxi Driver
- Eugene Alper - Magic Shop Owner
- Olga Cramer - School Principal
- Tony Brubaker - Bus Driver
- Deidrie Henry - Maggie Miller
- Vince Grant - Charlie King
- Graham Hamilton - Rush Middleton
- Yetide Badaki - Grace
- Olesya Rulin - Red Dress
- Stephen 'tWitch' Boss - The Beastmaster
- Kwesi Boakye - Farai
- Dante Brown - Thabo
- Kida Burns - Ade
- Khanya Mkhize - Sauda
- Darrell Lake - Baruti
- Elijah Nelson - Matt King
- Kate Fuglei - Middle-Aged Woman
- Janeline Hayes - Young Waitress
- Karen Strassman - Receptionist
- Craig Stepp - Anchorman
- Brett Wagner - Security Guy
- Sprague Grayden - First Lieutenant Laura Davis
- Kiko Ellsworth - Bobby Aresa
- Monique Gabriela Curnen - Lisette
- Joshua Leonard - King Roadie
- Jamie Martz - Sullivan
- Dahlia Salem - Jeweler
- Johnny Kostrey - Corporal Magnus Shea
- Mari Morrow - Ann-Marie
- T.W. Leshner - Man with Phone
- Amir Talai - Sami
- Ron Yuan - Wember Hsu
- Zuleyka Silver - Marisol Flores
- Rolando Molina - Hector
- Iyad Hajjaj - Norah's Father
- Richardson Chery - Alexandre
- Jay Harik - Rich Father
- Noa Dori - Woman
- Ben Wise - Aakif
- Christopher Murray - Montreal Doctor
- Melissa Carnell - Metro Girl
- Charlet Chung - Mandy Hsu
- Blair Hickey - Step-Dad
- Alexander von Roon - German Tourist
- David Julian Hirsh - Will Davies
- Carlease Burke - Clea's Mother
- Matt McCoy - Lamont
- Michelle Krusiec - Lanny Cheong
- Camille Chen - Serena
- Diego Serrano - Mr. McNichols
- Boyuen - George
- Kelly Keaton - Nurse
- Kofi Natei - Foreman
- Kevin Rock - Lead Guy
- Natalia Castellanos - Mrs. McNichols
- JJ Snyder - News Anchorwoman
- Roy Werner - News Anchorman
- Caroline Whitney Smith - TSA Agent
- Allegra Carpenter - Celeste
- London Vale - Amelia
- Catherine Dent - Abigail Kelsey
- Eyal Podell - Professor Logan Coteweiler
- Alan Blumenfeld - Poker Player
- Sean McGowan - Devon Michael Jones
- Alberto Frezza - Paolo
- Angela Gots - Stacey
- Robert Pike Daniel - Zeke
- Bart McCarthy - Constable
- Christopher May - Unfriendly Man
- Brian Groh - Player
- Jeremy Luke - Dealer
- Arturo del Puerto - Jorge
- Natalie Lander - College Girl
- Phil Hellmuth - Black Cap
- Ravi Kapoor - Cabbie
- Meera Simhan - Simrin
- Vincent Guastaferro - Sal
- Jim Piddock - Dr. Knox
- Anne Dudek - Allegra
- Tiya Sircar - Veronique / Nandu
- Marisa Petroro - Ipolita
- Pasquale Cassalia - Gio
- Ian Alda - Nervous Young Man
- Sherri Parker Lee - Jackie
- Tomas Pais - Alexis
- Emma Pasarow - Tween Girl
- Louis Ferreira - Felipe
- Linara Washington - Yarah
- Scott Michael Campbell - John Tenney
- Deborah Van Valkenburgh - Dee Dee
- Francis Capra - Biker Guy
- Phil Miler - Alfredo
- Don Harvey - Joey Deluca
- Sean Peavy - Tomer
- Mark Rolston - Ed
- Robert Romanus - Nelson
- Jeremiah Birkett - Larry
- Katherine Kamhi - Sharon Deluca
- Marwan Naji - Fadi
- Aline Elasmar - Arab Woman
- Ian Gomez - Wade
- Matthew Glave - Frank Robbins
- Brent Jennings - Medical Examiner
- Tamlyn Tomita - Kazuko Osugi
- Junichi Yanagita - Tatsoro Osugi
- Peter Murnik - Officer McKinney
- Jacqueline Scislowski - Amelia Robbins
- Alan Gray - Hasidic Jew
- Jackson Davis - Zack
- Sundra Oakley - Thomas Becko
- Melissa Ponzio - Gwen Davis
- Charles Henry Wyson - Colin Davis
- Jernard Burks - Jimar Becko
- Kai Braden - Skater Kid
- Manny Perry - Bus Driver
- Sean Carrigan - Security Guard
- Mary Stuart Masterson - Beth Cooper
- William Ragsdale - Travis Cooper
- Skyler Stone - DJ Oliver
- John Getz - Henry Williams
- James Handy - Lanford Biddle
- Wade Williams - Braeden
- Mark Kelly - Nick Fowler
- Kat Purgal - Colleen
- Julian Barnes - Doctor
- Pippa Hinchley - Therapist
- Adam Campbell - Tony Rigby
- Kirk B.R. Woller - Private Detective
- John Prosky - Lawrence Pearl
- Ray Santiago - Reuben Santiago
- Anthony Debaeck - Waiter
- Ray Proscia - Frederick LeMay
- Aileen Burdock - Receptionist
- Madison Leisle - Nicole
- Susan Angelo - Jeanne Black
- Harvey J. Alperin - Old Hasidic Jew
- Ursula Burton - PR Person
- Chad Guerrero - Security Guard
- Brian Brummitt - Security Guard
- Linda Gehringer - Frances
- Randy Oglesby - Carl Hirsch
- John Boyd - Kase
- Wendy Benson-Landes - Beth Friedman
- Kavi Raz - Sanjay Nayar
- Dimiter D. Marinov - Taxi Driver
- Ricky Russert - Burly Man
- Carlos Ragas - Thug
- Emrhys Cooper - Publicist
- Preston James Hillier - Bodyguard
- Audrey Marie Anderson - Mallory Kane
- Mackenzie Astin - Mr. Kane
- Patricia Bethune - Miss Herrera
- Patricia Rae - Sophia Corliss
- Alex Ruiz - Vicente Corliss
- Rizwan Manji - Pakistani Interrogator
- Amol Shah - Pakistani Officer
- Sanjay Chandani - Nazim Farzat
- Rajni Kareer - Abida Farzat
- Salman Bokhari - Pakistani Officer
- Jack Guzman - Big Man
- Rob Nagle - Detective Latham
- Candice Coke - Patricia Grimes
- John Barbolla - Doorman
- Toshi Toda - Hiroshi
- Shawn Huang - Japanese Kid
- Joe Abraham - Man in Laundry Service Uniform
- Jonny Lee - Texting Man
- Manuel Garcia-Rulfo - Father Esteban
- Castulo Guerra - Father San Felipo
- David Hoflin - William Norburg
- Maria Russell - Security Guard
- Elena Evangelo - ER Doctor
- Armazd Stepanian - Friend of Avram
- Eric Lange - Dr. Stanley
- Ransford Doherty - Park Ranger
- Leslie Stevens - Katie
- Brian Elerding - IT Guy
- Keith David - Dutch
- Krys Marshall - Claire
- Gabriel Luna - Ted
- Christina Scherer - Julie
- Bill Parks - Philip
- John Lacy - Jerry Woods
- Gonzalo Menendez - Cooper
- D.B. Sweeney - Joseph Tanner
- Frances Fisher - Nicole Farington
- Anthony Molinari - Guard
- Michael Broderick - Guard
- Annie Wersching - Dr. Kate Gordon
- Scott Klace - Ben Miller
- Jamie McShane - Mike O'Brien
- Paul Vincent O'Connor - Phillip Green
- Karis Campbell - Jenny O'Brien
- George Wyner - Lee Zedner
- Kevin E. West - Dixon
- Blake Bertrand - Max O'Brien
- Anthony Alabi - Gate Guard
- Daniel Steven Gonzalez - Prison Guard
- Patrick Brown - Prison Guard
- Damian Cecere - Man at Bus Station
- Ravil Isyanov - Landlord
- David H. Lawrence XVII - Morgue Worker
- Mykelti Williamson - Detective Lang
- David Ury - Rizzi
- Corey Michael Eubanks - Businessman
- Leland Orser - Dr. Linus
- Bernard White - Dr. Robert McCormick
- Jennifer Riker - Det. Rose Tyler
- Travis Aaron Wade - Shane Stevens
- Brian Maillard - Randy Kitson
- Marcus Choi - Security Guard
- Rafael J. Noble - Bus Station Clerk
- Alec Medlock - Nicole's Assistant
- Sumalee Montano - Nurse Liz
- Hiram A. Murray - LAPD Cop
- Craig Baxley Jr - Burke
- David Robert Lewis - Detective Joe
- Nadine Ellis - Coroner
- Tacey Adams - Receptionist
- Maggie Egan - Shop Owner
- James J. Collins - Anton Kusmi
- Elijah Alexander - Yosef
- David Lengel - Lab Tech
- Ron Rifkin - Isaac
- Margaret Easley - Nurse Judy
- Tracey Costello - Greyber Nurse
- Nick Jaine - Lab Tech
- Kiefer Sutherland
- Carol Barbee
- Tim Kring
- Peter Chernin
- Francis Lawrence
- Katherine Pope
Kiefer Sutherland interpreta a Martin Bohm en la serie.
Greg Ellis hace el papel de Trevor Wilcox.
Danny Glover interpreta a Professor Arthur Teller en la serie.
David Mazouz interpreta a Jacob Bohm en la serie.
Maria Bello interpreta a Lucy Robbins en la serie.
Saxon Sharbino interpreta a Amelia Robbins en la serie.
Lukas Haas interpreta a Calvin Norburg en la serie.
Saïd Taghmaoui interpreta a Guillermo Ortiz en la serie.
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