- Kai Owen - Rhys Williams
- Katy Wix - Rhiannon Davies
- Madeleine Rakic-Platt - Lilly Frobisher
- Hilary Maclean - Anna Frobisher
- Nicholas Farrell - Brian Green
- Cush Jumbo - Lois Habiba
- Susan Brown - Bridget Spears
- Julia Joyce - Holly Frobisher
- Peter Capaldi - John Frobisher
- Lucy Cohu - Alice Carter
- Ian Gelder - Mr Dekker
- Liz May Brice - Johnson
- John Normington - Tom Flanagan
- Alan Dale - Copley
- Richard Briers - Parker
- Julian Bleach - Ghostmaker
- James Marsters - Captain John Hart
- Murray Melvin - Bilis
- Paul Copley - Clement McDonald
- Matt Rippy - The Captain
- Patti Clare - Ruth
- Colette Brown - Carrie
- Robert Barton - Martin
- Nicola Duffett - Bronwen Jones
- Anthony Lewis - Tommy
- Caroline Chikezie - Lisa
- Owen Teale - Ewan Sherman
- Daniela Denby-Ashe - Mary
- Jan Anderson - Marie
- Bryan Dick - Adam
- Siobhan Hewlett - Harriet
- Steven Meo - Josh
- Mark Lewis Jones - John Ellis
- Eileen Essell - Christina
- Camilla Power - Pearl
- Badi Uzzaman - Suzie's Father
- Nikki Amuka-Bird - Beth
- Togo Igawa - Dr Tanizaki
- Lauren Phillips - Hen Night Girl
- Sara Gregory - Carys
- Melissa Moore - Singer
- Freema Agyeman - Martha Jones
- Nerys Hughes - Brenda
- Shaheen Jafargholi - Danny
- Andrea Lowe - Katie
- Gareth Thomas - Ed Morgan
- Rhea Bailey - Jade
- Robert Pugh - Jonah
- Paul Chequer - Eugene Jones
- Louise Delamere - Diane
- Clare Clifford - Milton
- Roger Ashton-Griffiths - Mr Garrett
- Ruth Jones - Nikki
- Eve Pearce - Estelle
- Jack Montgomery - Young Jack
- Christine Bottomley - Maggie
- Skye Bennett - Little Girl
- Amy Manson - Alice Guppy
- Olivia Hallinan - Emma
- Jacqueline Boatswain - Plummer
- Demetri Goritsas - Jack's Father
- Julian Lewis Jones - Alex
- Finn Wittrock - Danny
- Brian Guest - Alexander Peterssen
- Penny Bunton - Female Hiker
- Ron Butler - Senior Professor
- Rick Chambers - Senior Male Anchor
- Hymnson Chan - Male Nurse
- Van Epperson - Archivist
- Laura Gardner - Female Expert
- Lauri Hendler - Angry Nurse
- Carla Jeffery - Teenage Girl
- Clint Jung - Male Professor
- Jessica Mathews - Female Anchor #3
- Rocky McMurray - Senior Guard
- Phil Nice - Male Hiker
- Bunnie Rivera - Rosita
- Robin Sachs - British Professor
- Jackie Torres - Female Anchor #2
- Nischelle Turner - Female Anchor
- David Grant Wright - Male Anchor
- Nila Aalia - Flying Instructor
- Shenell Edmonds - WRZ Interviewee
- Graham Paige - Patient
- Indira Varma - Suzie Costello
- Lauren Ward - Jack's Mother
- Dillon Casey - Brad
- Alen Toric - Prison Guard
- Tre Williamson - Hero Orderly
- Dichen Lachman - Agent Lyn Peterfield
- Megan Duffy - Claire
- Constance Wu - Shawnie Yamaguchi
- Tug Coker - Geoff Reed
- Halley Feiffer - Lianna
- Amy Benedict - Bridget Howe
- Ewan Chung - Yu-King So
- Rachel Leah Cohen - Laurie
- Scott Hoxby - Paul Goldstein
- David O'Donnell - Dr. Mandell
- Jeffery Self - James Percey
- Richard Wharton - Dr. Paul Bell
- Glenn Taranto - Security Chief
- A.J. Tannen - Government Clerk
- Bari Hochwald - ER Nurse
- Chrissie Fit - Assistant
- Antonio D. Charity - Airport Security Cop
- Don Luce - Gate Guard
- Richard Gilliland - Congressman Morganthall
- Tasha Ames - Carla
- Richard Augustine - George Sayer
- David Youse - Dr. Rosenbloom
- Ronobir Lahiri - Simran Baidwan
- Ronobir Lahiri - Simran
- Michelle Wong - Nurse
- Maurice Webster - Cop
- George Murdock - Preacher
- Jason Medwin - Sunroof Screamer
- Mary Garripoli - Woman Tourist
- Matt Eyde - Atlanta Cop
- Mitchell Edmonds - Senior TV Anchor
- Thea Andrews - Local Reporter
- C. Thomas Howell - The Gentleman
- Mare Winningham - Ellis Hartley Monroe
- Paul James - Agent Noah Vickers
- Paul James - Noah Vickers
- Juanita Jennings - Bisme Katusi
- Kelvin Yu - Nicolas Frumkin
- Roy Lee Jones - Maurice
- JoNell Kennedy - Veronica
- Christian Svensson - Chauffeur
- Barbara Mallory - Scared Old Woman
- Michael D. Nye - Sick Man
- Anthony Dilio - Lobby Guard
- April Clark - Young Mother
- Katsy Chappell - Woman
- Roger V. Burton - Thin Old Man
- Desean Terry - Male Nurse
- Eve Mauro - Maria Candido
- Vito Viscuso - Angry Man
- Caroline Whitney Smith - Paramedic
- Tracy Pfau - Pale Woman
- Francine Morgan - Stressed Woman
- Ria Jones - Pushy Woman
- Masami Kosaka - Japanese Newscaster
- Jonathan Dane - Handsome Man
- Jim Conway - Man
- Charles Carpenter - News Reporter
- Daniel Adegboyega - Guard
- Arlene Tur - Dr. Vera Juarez
- Teddy Sears - Blue Eyed Man
- Tom Price - PC Andy Davidson
- Marc Vann - Colin Maloney
- Ernie Hudson - Stuart Owens
- Brendan Hughes - Pidgeon
- Jason Brooks - Press Secretary
- Frederick Koehler - Ralph
- Ciera Payton - Janet
- Jonathan Spencer - Tony
- Eric Steinberg - Zheng Yibao
- Lena Kaur - Dr. Patel
- Liz Jenkins - Rachel
- Inger Tudor - Mrs. Owens
- Marty Ryan - Older Guard
- William Patrick Riley - Hat Check Boy
- Isaac Stephen Montgomery - Stern Soldier
- Janice Kent - Psychiatrist
- Alexis DeLaRosa - Guard
- Daniele Favilli - Angelo Colasanto
- Cris D'Annunzio - Salvatore Maranzano
- Paul Hayes - Costerdane
- Everton Lawrence - Ablemarch
- Shawn Parsons - Frines
- Jayne Taini - Mrs. Giardano
- Darren Dupree Washington - SWAT Leader
- Vanna Salviati - Elderly Woman
- Gioia Blu - Girl in Crowd
- Griffin Matthews - Young Man
- Will Green - Priest
- Michael Chomiak - SWAT Member
- Pat Asanti - Inspector
- Wayne Knight - Brian Friedkin
- Nana Visitor - Olivia Colasanto
- David DeSantos - Agent Baylor
- Nayo Wallace - Wilson
- Adam Silver - The Young Man
- Willis Chung - Chinese Man
- Danny Szam - Surveillance Guy
- Jesse Wang - Chinese Worker
- Gilbert Wynne - Old Man
- Marina Benedict - Charlotte Wills
- Candace Brown - Sarah Drummond
- John de Lancie - Allen Shapiro
- Benito Martinez - Captain Santos
- Chris Butler - The Cousin
- Laura Waddell - Cat One Nurse
- Cici Lau - Chinese Woman
- Veronica Milagros - Soldier
- McKenzie Applegate - Girl
- Jason May - Soco
- Olwen Medi - Yvonne
- Gwyn Vaughan Jones - D.I. Jacobs
- Jâms Thomas - Hospital Porter
- Adrian Christopher - Private Moriarty
- Ross O'Hennessy - Sgt. Johnson
- Ceri Mears - Banksy
- Justin McDonald - Matt
- Brendan Charleson - Ivan Fletcher
- Robert Störr - Gavin
- Lloyd Everitt - Mikey
- Ben McKay - Bernie
- Llinos Daniel - Eleri
- Christopher Elson - Young Ed Morgan
- Ryan Conway - Kid In Arcade
- Bethan Walker - Annie
- Adrienne O'Sullivan - Lynn
- William Travis - Roy
- Roger Barclay - Goodson
- Ffion Wilkins - WPC
- Nathan Sussex - Custody Sergeant
- Paul Kasey - Weevil
- Paul Kasey - Blowfish
- Maxine Evans - Helen Sherman
- Rhys ap Trefor - Huw
- Ravin J. Ganatra - Neil
- Eiry Thomas - Carol
- Daniel Llewelyn-Williams - Alex Arwyn
- Gary Pillai - Mark Brisco
- Shend - Max
- Luke Bromley - Young Eugene
- Celyn Jones - Gary
- Robyn Isaac - Linda
- Gareth Potter - Shaun Jones
- Amy Starling - Waitress
- Janine Carrington - Alesha
- Alex Hassell - Mark Lynch
- David Gyasi - Hospital Patient
- Ciaran Dowd - Barman
- Alexandra Dunn - Barmaid
- Sharon Morgan - Mary Cooper
- Sharon Morgan - Mary
- Matthew Raymond - Boyfriend
- Andrew MacBean - Flying Instructor
- Elen Rhys - Nancy
- Gavin Brocker - George
- Peter Sandys-Clarke - Tim
- Ciaran Joyce - Smiler
- Matthew Gravelle - Doctor
- Jamie Belton - Roman Soldier
- Menna Trussler - Old Woman
- Crispin Layfield - Mugger
- Claire Cage - David's Wife
- Seán Carlsen - Mr Grainger
- Victoria Pugh - Mrs Grainger
- Dominic Coleman - Policeman
- Derek Lea - Paramedic
- Roderic Culver - Gerald
- Lizzie Rogan - Nurse
- Ricky Fearon - Foreman
- Garry Lake - Vic
- Matt Ryan - Dale
- Ger Carey - Greg
- Rhodri Miles - Billy
- John Samuel Worsey - Policeman
- Natalie Danks-Smith - Elin Morgan
- Joanna Griffiths - Nurse
- Ben Walker - Jamie Burton
- Janie Booth - Hospital Patient
- Rhys ap William - Police Officer
- Rik Makarem - Dr. Rupesh Patanjali
- Phylip Harries - Water Taxi Man
- Crisian Emanuel - Mother
- Osi Okerafor - Kodak
- Emmanuel Ighodaro - Paramedic
- Quill Roberts - Guard
- Rachel Ferjani - Parliamentary Secretary
- Charles Abomeli - Colonel Oduya
- Patrice Ettienne - Sandwich Shop Man
- Lorna Bennett - Teacher
- Colin McFarlane - General Pierce
- Deborah Findlay - Denise Riley
- Nicholas Briggs - Rick Yates
- Louis Decosta Johnson - Farrington
- Patrice Naiambana - Defence Secretary
- Brett Allen - Taylor
- Sophie Hunter - Vanessa
- Gil Kolirin - Webb
- Louise Minchin - Newsreader
- Ben Loyd-Holmes - Operative
- Anthony Debaeck - French Newsreader
- Lachele Carl - Trinity Wells
- Simon Poland - 456 Voice (voice)
- Robin Griffith - Barry
- William Thomas - Geraint Cooper
- Danielle Henry - Megan
- Morgan Hopkins - Mervyn
- Jonny Owen - Banana Boat
- Craig Gallivan - Jonathan
- Caroline Sheen - Nurse
- Tom Langford - Young Boy
- Lorna Gayle - Helen
- Oliver Ferriman - Young Jonah
- Heather Craney - Emily Holroyd
- Simon Shackleton - Bob
- Noriko Aida - Toshiko's Mother
- Selva Rasalingam - Psychiatrist
- Lachlan Nieboer - Gray
- Golda Rosheuvel - Dr Angela Connolly
- Syreeta Kumar - Nira Docherty
- Cornelius Macarthy - Charles Gaskell
- Calum Callaghan - Kieran
- Paul Jones - Man In Street
- Guy Lewis - Young Cop
- Julie Gardner
- Jane Tranter
- Russell T Davies
George Murdock hace el papel de Preacher.
C. Thomas Howell interpreta a The Gentleman en la serie.
Benito Martinez interpreta a Captain Santos en la serie.
Wayne Knight interpreta a Brian Friedkin en la serie.
Frances Fisher interpreta a The Mother en la serie.
John Barrowman hace el papel de Jack Harkness.
Eve Myles interpreta a Gwen Cooper en la serie.
Alexa Havins hace el papel de Esther Drummond.
Mekhi Phifer interpreta a Rex Matheson en la serie.
Bill Pullman interpreta a Oswald Danes en la serie.
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