- Monica Horan - Amy MacDougall-Barone
- Monica Horan - Amy MacDougall
- Tommy Lasorda - Tommy Lasorda
- Steffani Brass - Friend at Bus Stop
- Julie Hagerty - Charlotte
- Jennifer Sciole - Swing Dancer (uncredited)
- Bob Joles - Guy
- Brian Posehn - Warren
- Renee Faia - Colleen
- Susan Yeagley - Mariann
- Cheryl Hines - Lauren Williamson
- Michael Papajohn - Waiter
- Jeff Garlin - Jimmy
- Emy Coligado - Claudia
- Sherri Shepherd - Sergeant Judy
- Mitch Holleman - Ian
- David Proval - Marco Fogagnolo
- Lauri Johnson - Sister Ann
- Dan Castellaneta - Bryan
- Ana Ortiz - Natasha
- Boris Cabrera - Ron Fernandez
- Stephanie Courtney - Woman
- Sam Anderson - Special Agent Thomas Garfield
- Debra Mooney - Lee
- Katherine Helmond - Lois Whelan
- David Garrison - William Dennison
- Jason Kravits - Sam
- Holmes Osborne - Scott
- Robert Joy - Mr. Putnam
- Magda Harout - Cousin Bella
- Fred Willard - Hank MacDougall
- Skyler Gisondo - Chris
- Henriette Mantel - Nurse
- Victor Raider-Wexler - Stan
- Stephen Lee - Leo
- Terry Bradshaw - Terry Bradshaw
- Kareem Abdul-Jabbar - Kareem Abdul-Jabbar
- Jerry Lambert - Guy
- Ashley Crow - Jennifer Whelan
- Meeghan Holaway - Cheryl
- Kristin Bauer - Lisa
- Barry Bonds - Barry Bonds
- Patience Cleveland - Phyllis
- Mary Kay Adams - Dr. Nora Sarrazin
- Roy Firestone - Roy Firestone
- Linda Kash - Celia
- Pat O'Brien - Pat O'Brien
- John Lee - Wo-Hop
- John F. O'Donohue - Harry
- Christine Cavanaugh - Erin
- Argentina Brunetti - Zia Sarina
- Paul Reubens - Russell
- Dom Irrera - Seth Stipe
- Senta Moses - Lisa
- Jack Betts - Walter
- Chip Heller - Officer
- Maggie Wheeler - Linda Gruenfelder
- Geoff Stults - Mailman
- Scotty Leavenworth - Tyler
- Patricia Belcher - Ruth
- Suzie Plakson - Joanne Glotz
- Diana Maria Riva - Sarah
- Matt Romano - Lion Kid
- Bob Odenkirk - Scott Preman
- J.G. Hertzler - Everett Munce
- Aaron D. Spears - Rick
- Tara Karsian - Jean
- Rhyon Nicole Brown - Grace
- Julie Claire - Alexis
- Arnetia Walker - Friendly Mom
- Tom McGowan - Bernie Gruenfelder
- Shailene Woodley - Snotty Girl
- Hira Ambrosino - Receptionist
- Alex Meneses - Stefánia Fogagnolo
- Chris Elliott - Peter MacDougall
- Len Lesser - Garvin
- Jean Stapleton - Aunt Alda
- Jerry Hauck - Parent
- Jack Blessing - Dr. Hammond
- Katarina Witt - Katarina Witt
- Desmond Howard - Desmond Howard
- Iqbal Theba - Dr. Sundram
- Phil Leeds - Uncle Mel
- Andre Jamal Kinney - Kid
- Robert Culp - Warren Whelan
- Dave Attell - Dave
- Phil Abrams - Sales Clerk
- Ancel Cook - Lodge Member
- Nancy Lenehan - Pamela
- Elizabeth Bogush - Angela
- Betty Murphy - Margaret
- Elsa Raven - Mrs. Lopman
- Jon Manfrellotti - Gianni
- Jon Manfrellotti - Cable Guy
- Daniel Hansen - Young Ray
- Gary Grossman - David Atkins
- Alexandra Romano - Molly
- Alexandra Romano - Flower Girl
- Christopher Michael Moore - Guy
- Marv Albert - Marv Albert
- Nora Dunn - Helen
- Mark Dobies - Nick
- Allan Lurie - Lodge Member
- Charles Durning - Father Hubley
- Joseph V. Perry - Nemo
- Joseph V. Perry - Stan
- Georgia Engel - Pat MacDougall
- Fred Ornstein - Lodge Member
- Tina Arning - Angelina
- Carrie "CeCe" Cline - Mary Ellen
- Hugh Holub - Funeral Director
- Susan Varon - Suzy
- Carmen Filpi - Ancient Guy
- Wayne C. Dvorak - Maitre'd
- Peggy Doyle - Elderly Woman
- Rosario Coppolino - Pizza Guy
- Vincenzo Vitagliano - Bocce Player
- Silvana De Santis - Aunt Colletta
- Pierrino Mascarino - Giorgio
- Sergio Sivori - Italian Man #1
- Vanni Bramati - Italian Man #2
- Joey Dente - Audience Member
- Kotoko Kawamura - Japanese Woman
- Murray Rubin - Eddie
- Pearl Shear - Emma
- Andy Kindler - Andy
- Cynthena Sanders - Parent #1
- Jonathan Chapin - Parent #2
- Hannah Swanson - Little Kid
- Curtis Blanck - Staring Kid
- Lance E. Nichols - Mack
- Cathy Ladman - Lilly
- Steven Hack - Arthur
- Don Perry - Priest
- Eugene Greytak - The Pope
- Ethan Glazer - Young Robert
- Jason Weiss - John
- Pamela Bowen - Jessica Bell
- Marty Rackham - Pete
- Stella Farentino - Anna Barone
- Mike Batayeh - Cab Driver
- Jenny Buchanan - Lisa
- Yolanda Snowball - Teacher
- Susan Segal - Pregnant Woman
- Richard Marion - Don
- Sarah Rush - Sarah
- Fred Stoller - Gerard
- Philip Benichou - TV Announcer
- David Hunt - Bill Parker
- Tess Oakland - Sally Parker
- Vinnie Buffolino - Dracula
- Zach Robinson - Trick-Or-Treater
- Nick Rossitto - Trick-Or-Treater
- Anna Berger - Rita Stipe
- David Byrd - Harry Stipe
- Janelle Paradee - Sandy
- Kelly Rebecca Walsh - Jessica
- Betsy Monroe - Michelle
- Patricia Bethune - Exchange Lady
- Drenda Spohnholtz - Leann
- Natalia Reagan - Drunk Girl
- Elizabeth Herring - Carrie Parker
- Elizabeth Herring - Mary Parker
- Elizabeth Herring - Party Guest
- Shelley Robertson - Sareesa
- Kivi Rogers - Man #1
- Charles C. Stevenson Jr. - Milt
- John David Conti - Abe
- T.R. Richards - Guy
- Jack Axelrod - Lodge Member
- Lou Charloff - Lodge Member
- Al Eben - Lodge Member
- Greg Lewis - Lodge Member
- Tom Paris - Tom
- Tom Paris - Announcer
- Hiram Kasten - Ted
- Sharon Houston - Mary Beth
- Beecey Carlson - Merry Widow #1
- Leigh Rose - Merry Widow #2
- Jean Sincere - Merry Widow #3
- Edrie Warner - Merry Widow #4
- John Fairlie - Man #3
- Harry Freedman - Man #2
- Bud Harrelson - Bud Harrelson
- Cleon Jones - Cleon Jones
- Ed Kranepool - Ed Kranepool
- Dave Mallow - Event Announcer
- Tug McGraw - Tug McGraw
- Ron Swoboda - Ron Swoboda
- Kristi Yamaguchi - Kristi Yamaguchi
- Amy Aquino - Peggy
- Ping Wu - Customer
- Richard A. Romano - Richard
- Richard A. Romano - Course Official
- Richard A. Romano - Security
- Richard A. Romano - Policeman
- Kimberly Scott - Miss Purcell
- Lynn Tufeld - Mother
- Julie Dretzin - Mother
- Diana Tanaka - Teacher
- Henry LeBlanc - Board Member
- Craig Anton - Neil Williamson
- Chelcie Ross - Reverend Stevens
- Kevin James - Kevin
- Kevin James - Doug Heffernan
- John C. McDonnell - D.J.
- Dan Kinsella - Bartender
- Dan Martin - Policeman
- Christopher T. Wood - Waiter
- Max Rosenthal - Max
- Ja'net DuBois - Dottie
- Ruben Pla - Wendi's Father
- Adrian Ricard - Lesley Gorman
- Joe Durrenberger - Funeral Director
- Joe Durrenberger - Delivery Person
- Donna Cooper - Nurse
- Elizabeth Anne Smith - Eileen
- Richard Israel - Adam
- Mary Gillis - Sister Beth
- Rocky McMurray - Janitor
- Mark Edward Smith - Contractor
- Timmy Deters - Child
- Brooks Almy - Katie
- Joel McKinnon Miller - George
- Charles Rahi Chun - Doctor
- John Del Regno - Sal
- Luck Hari - Clerk
- Bunny Levine - Hilda
- Norma Michaels - Mrs. Pechi
- Lynn Milgrim - Cecily
- Rick Hall - Bill
- Beth Skipp - Pam
- Mary Jo Keenen - Lori
- Stephanie Erb - Elise
- Lawrence LeJohn - Man
- Rich Grosso - Man
- John Harnagel - Man
- Lew Schneider - Steven Golden
- Christy L. Medrano - Nurse
- Dana Tyler - Newscaster
- Richard Assad - Owner
- Alex Solowitz - Teenager
- Tinsley Grimes - Erica
- Bob Ruth - Nemo
- Marla Frees - Mary Jo
- Edward James Gage - Doug
- J.J. Boone - Lori
- Amy Janon - Hotel Clerk
- Tricia O'Kelley - Carol Marshall
- Michelle Beauchamp - Lisa
- Monique Edwards - Doctor
- Darlene Kardon - Aunt Gina
- Richard Penn - Doctor
- Heather McPhaul - Parent
- Raymond Patterson - Parent
- Todd Sandler - Referee
- Patricia Place - Emma
- Kevin Brief - Principal
- Philip Hyland - Guy
- Anne Gee Byrd - Hilda
- Steve Vinovich - Jerry Musso
- Renata Scott - Harriet Lichmann
- Ralph Monaco - George Caputo
- Joel Brooks - Mr. Rodell
- Billy Mayo - Police Officer
- Emiliano Díez - Hector
- Darcas Macopson - Donald
- April Ortiz - Liz
- Melanee Murray - Ruth
- Daniele O'Loughlin - Carol
- Ellen Ratner - Sara
- Jeremy Stevens
- Leslie Caveny
- Rory Rosegarten
- David Letterman
- Steve Skrovan
- Kathy Ann Stumpe
Phil Leeds interpreta a Uncle Mel en la serie.
Katherine Helmond hace el papel de Lois Whelan.
Ray Romano hace el papel de Ray Barone.
Nora Dunn hace el papel de Helen.
Charles Durning interpreta a Father Hubley en la serie.
Kimberly Scott interpreta a Miss Purcell en la serie.
Dan Castellaneta interpreta a Bryan en la serie.
David Proval interpreta a Marco Fogagnolo en la serie.
Patricia Heaton interpreta a Debra Barone en la serie.
Doris Roberts interpreta a Marie Barone en la serie.
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