- David Selby - Abraham Lincoln
- Sean Murray - Will Heller
- Lee Horsley - Guy Garfield
- Tracy Nelson - Lisa Magdaleno
- Jeannetta Arnette - Dr. Gus Jacobs
- John Beck - Capt. Meyers
- Vanessa Bell Calloway - Debra Willis
- James Marsden - Jake
- Maya Angelou - Clarice Mitchell
- Tone Loc - Albert Turner
- Jack Scalia - Max Chamberlain
- Brian Bloom - Clay Martin
- Rosalind Allen - Evie Mateos
- Bradley Whitford - Steve Bell
- Bill Nunn - Frank Champness
- Harley Cross - Marshall Redding
- Sally Jessy Raphael - Mrs. Angeli
- Kim Murphy - Teen Morgan
- Talia Balsam - Dr. Joanne Glassberg
- Michael Cudlitz - Pvt. 'Chug' Landau
- Chris Burke - Taylor
- Alexis Cruz - Rafael
- Robert Guillaume - Judge Dawes
- Ashleigh Aston Moore - Abby Fontaine
- Jack Riley - Leo
- Jordan Charney - Official
- Polly Bergen - Stella Applegate
- Chris Mulkey - Erskine Hughes
- Haley Joel Osment - John Henry
- Tom Poston - Ed Yablonsky
- Jeannie Elias - Lisa Weiss
- Mercedes McNab - Jill Everett
- Olympia Dukakis - Clara
- Channon Roe - Lucas Tremaine
- Carl Lumbly - Willis Thompson
- Corey Parker - Henry Moskowitz
- Robert Hays - Scott Walden
- Estelle Getty - Dottie
- James Karen - Mark Abernathy
- Kay Lenz - Rocky McCann
- Lawrence Monoson - Tony Du Bois
- Clyde Kusatsu - Dr. Robertson
- Holly Robinson Peete - Vanessa Hamilton
- Loretta Devine - Tonya Hawkins
- Ben Masters - Prof. Brian Salter
- Sean O'Bryan - Jake Monroe
- Darren McGavin - George Zarko
- Charlie Schlatter - Kevin Greeley
- Anndi McAfee - Rebecca Browner
- Linda Hart - Christine Morrow
- Kevin Dobson - Coach Earl Rowley
- Phylicia Rashād - Elizabeth Jessup
- Nia Peeples - Angela Evans
- Alyson Hannigan - Cassie Peters
- Montrose Hagins - Sister Mary Francis
- Nancy Allen - Megan
- Stefan Gierasch - Gus
- Bryan Cranston - Dr. Tom Bryant
- Céline Dion - Self
- Richard Burgi - Frank
- Carrie Snodgress - Judy Bowers
- Sheila Kelley - Carrie Carver
- Rondell Sheridan - Harvey
- Nathan Lawrence - Jeremy Gray
- Conchata Ferrell - Irene
- Tara Lipinski - Alex Thorpe
- Arabella Field - Natalie Billings
- Montel Williams - Brother David
- Josh Keaton - Young Nick
- Justin Cooper - Dylan Mackenzie
- Fred Applegate - Ed
- Hayden Panettiere - Diana
- Saundra Quarterman - Kerry
- Andrew Kavovit - Eddie Rourke
- Nancy McKeon - Rachel Waters
- Charlotte Church - Alice Childers
- Ann Jillian - Liz Bradley
- James Read - Nick
- Emily Osment - Alyssa Sullivan
- Stephen Caffrey - Phil Grabowski
- Kenny Rogers - Denny Blye
- Jon Huertas - Warren
- Ed Asner - Bud
- Melanie Chartoff - Connie Berger
- Doug E. Doug - Ronnie Billings
- Jeremy James Kissner - Davey Tucker
- Jean Stapleton - Emma
- Evan Rachel Wood - Sarah Radcliff
- Julianna McCarthy - Catherine Knight
- Lee Weaver - Candy McCloud
- Benito Martinez - Officer Dave
- John Savage - Simon Miller
- Gregory Smith - Patrick Lewis
- Lee Garlington - Dr. Josephs
- Mare Winningham - Dr. Maggie de Santo
- Lee Chamberlin - Charlotte Hunter
- Bill Cobbs - Henry Baldwin
- Jacob Tierney - Max Rigney
- Marla Gibbs - Millie
- Glynn Turman - Sheriff Ernie Guthrie
- Mary Alice - Georgia Bishop
- Martin Spanjers - Brian Harrigan
- Isaiah Washington - Rev. Austin Davis
- Agnes Bruckner - Lisa
- Michael Stephenson - Jordan (uncredited)
- Richard Lawson - Nicholas Freeman
- James Eckhouse - Dr. Brad Renslow
- Mandy Patinkin - The Driver / Satan
- Robert Pastorelli - Joe Collette
- Grant Shaud - Ed Gold
- Christine Lakin - Ashlee
- Nicholas Turturro - Rolando Wells
- Stacy Edwards - Lorena Watkins
- Dan Byrd - Scott Hardwick
- Jodi Thelen - Agnes
- Charles Durning - Father Thomas Madden
- Timothy Carhart - Rob Kellerman
- Louis Mandylor - Marty
- Geoff Pierson - Richard Dardenne
- Jessica Walter - Naomi
- Gregory Jbara - Scott Morgan
- Scott Baio - Det. Frank McCovey
- Tony Denman - Ryan Dempsey
- Jeff Yagher - Mike Rice
- Grant Heslov - Gale Harper
- Dinah Manoff - Callie Martin
- Paul Rodríguez - Ben Rivera
- John Spencer - Leo
- Jack Black - Monte
- Natalie Cole - Megan Brooks
- Terumi Matthews - Ginger
- Alicia Coppola - Ava
- Wanda De Jesus - Sue Cheney
- Clark Gregg - Don Dudley
- Stephanie Faracy - Sally Redding
- Anthony Michael Hall - Thomas Prescott
- David Naughton - Michael Russell
- Paul Walker - Jonathan
- Craig Wasson - Tim Porter
- Betsy Brantley - Joanne McNabb
- Cloris Leachman - Ruth
- Larry Gelman - Larry
- Doris Belack - Elaine Weiss
- Senta Moses - Katy
- Ashley Crow - Jocelyn
- Ray Buktenica - Allan Pound
- Janet Carroll - Diana Abernathy
- Peter Michael Goetz - Jordan Du Bois
- Isabella Hofmann - Sara Perkins
- Esther Rolle - Mary Harding
- Priscilla Presley - Dr. Meg Salter
- Christina Pickles - Stephanie Hancock
- Mary Elizabeth Winstead - Kristy Cordis (uncredited)
- Mark Metcalf - Nick Morrow
- Jarrad Paul - Dink Whitten
- Erica Gimpel - Sydney Jessup
- Rick Rossovich - Marshall
- Kent Williams - Oliver MacGregor
- Brooke Adams - Susana
- Malcolm-Jamal Warner - Zack
- John Amos - Sheriff James Mackey
- Reg Rogers - John Wilkes Booth
- Joseph Cross - Petey Carmichael
- Margot Kidder - Rita Lasky
- Wren T. Brown - Tom Larson
- Sondra Currie - Anne
- Maury Sterling - Eddie Williams
- Brie Larson - Rachel / Samantha
- Eric Roberts - Nick Stratton
- Davenia McFadden - Lavonda
- William R. Moses - Charlie
- William R. Moses - Pepper Kellerman
- Gabrielle Carteris - April Campbell
- Gabrielle Carteris - Linda Craig
- Joe Morton - Jake Stone
- Joe Morton - Martin Hunter
- Lindsay Crouse - Sen. Kate Cooper
- Kimberly J. Brown - Amy Lumpkin (uncredited)
- Marcia Cross - Lauren Bradley
- Kirk Douglas - Ross Berger
- William Daniels - Whit Russell
- William Daniels - George
- Phil Fondacaro - Leroy Tucker
- William Russ - Prof. Thomas North
- Gloria Stuart - Grams
- Daveigh Chase - Heather Albright
- Zachary Quinto - Mike Dorin
- Geoffrey Blake - Jimmy Rendon
- Neil Patrick Harris - Jonas
- Rue McClanahan - Lila Winslow
- Rue McClanahan - Amelia Bowthorpe Archibald
- Tom Verica - Dr. Brian Winslow
- Richard Biggs - George
- Angela Lansbury - Lady Penelope Berrington
- Joel Grey - Ronald
- Lois Smith - Mildred Mancini
- Rachel Luttrell - Marla Falstaff
- Ryan Hurst - Doug Jackson
- America Ferrera - Charlee Wells
- Bob Gunton - Sidney Alcott
- Holmes Osborne - Sgt. Richardson
- Billy Aaron Brown - Ben Everett
- Sal Lopez - Alex
- Jenica Bergere - Hannah
- Jim Calvert - Carl Britton
- Jim Calvert - Chris
- Eddie Mills - Joshua Wren
- Matt Ross - Pete Rowley
- Ann Dowd - Paula Dardenne
- Stuart Fratkin - Chris
- Patty Duke - Jean
- Patty Duke - Nancy Williams
- Suzzanne Douglas - Brianna Springbelt
- Suzzanne Douglas - Dr. Rebecca Dixon
- John Hawkes - Mason Cook
- Miko Hughes - Daniel Duncan
- James Pickens Jr. - George
- Melissa Joan Hart - Claire Latham
- Joel Polis - Garland Ketter
- Brandon Douglas - Alex Jackson
- Randy Oglesby - Pastor Mike
- Marsha Warfield - Bebe Manero
- Denise Dowse - Judge Caldwell
- Brian Howe - Jerry Fleming
- Brian Howe - Sherriff Charlie
- Shanna Reed - Morgan Bell
- Bill Smitrovich - Bill McNabb
- Russell Wong - George
- Dwight Schultz - Dr. Adam Litowski
- Aimee Graham - Danielle Dawson
- Brian Keith - Leonard Pound
- Mark Derwin - Jeff
- George Newbern - Michael Burns
- Alice Ghostley - Mrs. DeWinter
- Ian Abercrombie - George Taylor
- Ivan Sergei - Peter Enloe
- Rodney Eastman - Craig
- M.C. Gainey - Smoky
- Ed Marinaro - Jack
- Michael Sutton - Man in Box
- Delta Burke - Diana Winslow
- Delta Burke - Julia Fitzgerald
- Chad Lowe - Arthur Bowers
- Joe Regalbuto - Donnie Mancuso
- Melissa Gilbert - Michelle Tanner
- Spencer Garrett - Brother Jacob / William Kitchell
- Stacy Keach - Ty Duncan
- Stacy Keach - Maury Hoover
- Ruben Santiago-Hudson - Dr. Joe Acot
- Kathy Ireland - Karla
- Howard Hesseman - Flynn Hodge
- Roy Dotrice - Micah
- Skye McCole Bartusiak - Sarah McGregor
- Molly Hagan - Karen Schultz
- Penny Johnson Jerald - Eleanor Hunter
- Madison McReynolds - Madeline
- Taylor Handley - Ricky Collette
- Sam McMurray - Carl Norris
- Sarah Thompson - Kristie Jackson
- Dempsey Pappion - Kobe
- Sarah Hyland - Grace Watkins
- Daniel Baldwin - Buzz Wescott
- Ashley Johnson - Natalie Tate
- Charles Shaughnessy - David Satterfield
- Christopher Marquette - Tim
- Christopher Marquette - Cody Benson
- Austin Pendleton - Mr. Piltdown
- Deirdre Lovejoy - Courtney Kellerman
- Wendie Jo Sperber - Tricia
- David Ogden Stiers - Jones / Satan
- Bruce Altman - Henry
- Barbara Stock - Jill Bennett
- Robert Kelker-Kelly - Matt Duncan
- Jeffrey Nordling - Jackson Spears
- Ted Shackelford - Joel Redding
- Debra Mooney - Mrs. Shaw
- Barbara Alyn Woods - Penny Russell
- Jane Sibbett - Emily Houghton
- Allyce Beasley - Kate Pound
- Bill Cosby - Phil
- Bumper Robinson - Matthew Mackey
- Fredric Lehne - Eric Casey
- Samaria Graham - Candy
- Marian Mercer - Flo
- Dick Van Patten - Eb
- Dick Van Patten - Jerry
- Cynthia Ettinger - Rebecca / Carolyn
- Joe Spano - James Cooper
- John Ratzenberger - Merl
- Kirk Cameron - Chuck Parker
- Wendy Phillips - Claire Greene
- Wendy Phillips - Ruth Ann Russell
- Mary-Margaret Humes - Sandy Collette
- Nancy Linehan Charles - Sally
- Reno Wilson - Tony
- Brian Patrick Clarke - Coach Mike Johansen
- Brian Patrick Clarke - Bud Clarke
- Nancy Everhard - Rebecca
- Kenneth Tigar - Dr. Coburn
- Steven Culp - Dr. Rence Patterson
- Kathie Lee Gifford - Wendy
- Kathie Lee Gifford - Jolene
- Earl Billings - Henry W. 'Cueball' Seek
- Mika Boorem - Cornelia 'Celine' Casey
- Mika Boorem - Melissa Houghton
- Diahann Carroll - Grace Willis
- Jack Coleman - Jeff Ritchy (uncredited)
- Melora Hardin - Elizabeth Chamberlain
- Valerie Harper - Kate Prescott
- Ross Malinger - Nick Albright
- Ross Malinger - Jesse Bell
- Dante Basco - Robbie Hawkins
- Scarlett Pomers - Penny
- Wendy Makkena - Robin Dunwoody
- Lee Tergesen - Blake Chapman
- Jake Thomas - Thomas Cooper
- Michael Welch - Robby McGregor
- Marcia Strassman - Lisa Patcherik
- Joe Penny - Zack Bennett
- Terri Hoyos - Mary Garcia
- Elizabeth Ashley - Sandy Latham
- Allison Smith - Jennifer
- Peter Scolari - Tim Albright
- Peter Scolari - Charles Hibbard
- Gary Hudson - Tom Pound
- Ossie Davis - Erasmus Jones
- Ossie Davis - Gabriel
- Ken Page - Ox
- Dwier Brown - Sheriff Kyle
- Chris Potter - Michael Reilly
- William Mapother - Eddie
- John Putch - Todd Barber
- Sam Gifaldi - Young Leonard
- Jack McGee - Bubba Mitchell
- Ivar Brogger - Peter
- Leila Kenzle - Leigh Alcott-Rendon
- Patrick Duffy - Mike
- Scott Bairstow - Zack / Jesus Christ
- Scott Bairstow - Zack
- Bruce Boxleitner - Scott Tanner
- Nell Carter - Cynthia Winslow
- Randy Travis - Wayne
- Randy Travis - Jed Winslow
- John Ritter - Sheriff Tom McKinsley
- John Ritter - Mike O'Conner
- Sierra Pecheur - Professor (uncredited)
- Nate Richert - Matt Fleming
- Faith Hill - Karen Lamar
- Courtland Mead - Matthew Mills
- Sarah Schaub - Dinah Greene
- Richard Thomas - Joe Greene
- Gerald McRaney - Russell Greene
- Gerald McRaney - Dr. Joe Patcherik
- Eddie Karr - Nathaniel Greene
- Celeste Holm - Hattie Greene
- Connie Ray - Sandra Mills
- Ben James-Ellis - Ryan Mills (uncredited)
- John James - Sam Carver
- Mimi Paley - Kiki
- Eli Marienthal - John Ashburn
- Judith Hoag - Janet Grabowski
- Johnny Green - John Manori
- Olesya Rulin - Student (uncredited)
- John Schneider - Joshua Winslow
- John Schneider - Frank Littleton
- Kim Rhodes - Liz Williams
- T.J. Lowther - David Morrow
- Darlene Cates - Claudia Bell
- Maureen McCormick - Jodi
- Abe Vigoda - Receptionist Angel
- Jasmine Guy - Kathleen
- Austin O'Brien - Josh Greene
- Jennifer Morrison - Melissa Dunnigan
- Katherine LaNasa - Fran
- Kyle Gallner - Josh Walker
- Angela Bettis - Laura Keane
- Jena Malone - Casey Peña
- Christina Vidal - Ilena
- María Conchita Alonso - Dr. Sandra Peña
- Alan Oppenheimer - Gary Stein
- Alan Oppenheimer - Judge
- Travis Tritt - Dan McConnell
- Soon-Tek Oh - Kim Chyung Kyung
- Soon-Tek Oh - Mr. Aramaki
- Muhammad Ali - Self
- Richard Roundtree - Murray
- Robert Ri'chard - Alex Wilson
- Robert Ri'chard - Samuel Dixon
- Rosa Parks - Self
- Charles Rocket - Adam
- Harold Gould - Albert Einstein
- Harold Gould - Sam Moskowitz
- Jayne Luke - Waitress
- Karl Simmons - Boy
- Hal Linden - Sam Brown
- Hal Linden - Dave Price
- Linda Gehringer - Laura Enloe
- Marjorie Hilton - Dr. Cronin
- Hayward Buchanan - Will
- Michael Ruud - Lundy
- Michael Ruud - Mac
- Joyce Cohen - Doctor
- Obba Babatundé - Carter Evans
- Rick Bugg - Joe 'Sully' Sullivan
- Tony J. Rivas - Gregory
- Alexis Fernández - T.V. Reporter
- Kelsey Mulrooney - Joni Albright
- Kelsey Mulrooney - Tanya Brenner
- Murphy Cross - Lydia Feldman
- María Celedonio - Shannon
- Dennis Saylor - Manny
- Pierrino Mascarino - Mikal
- Nancy Borgenicht - Robin Dunwoody
- Tom Markus - Mr. Trent
- Robin Thomas - Dr. Harrison Trowbridge Archibald IV
- Gail Edwards - Barbara Archibald
- Cameron Sawyer - Howie
- Amanda Bruce - Matron
- Joan Fisher - Woman
- John McMartin - Ed Greeley
- John McMartin - Earl Gray
- Rae'Ven Larrymore Kelly - Serena
- Paul Wittenburg - Joey
- Toni Lynn Byrd - Serena's Mother
- Johnny Biscuit - Harry
- Monique Ridge-Williams - Edna
- Charles Metten - Deacon Jamison
- Kareem Ferguson - Josh
- Kareem Ferguson - Delivery Man
- Kathryn Rossetter - Julie Taylor
- Bus Riley - Policeman
- Carolyn Hurlburt - Female Guard
- Oscar Rowland - Man
- Richard Jewkes - Man
- Stephanie Zimbalist - Jessica Albright
- Stephanie Zimbalist - Dr. Kate Caulder
- John Cothran - Keegan
- John Cothran - Jackson
- Karl Wilson - Guard
- Maria Carr - Female Guard
- Matt Kaminsky - Luke Stevens
- Liliana Cabal - Vicki
- Marion Ross - Sophie
- Marion Ross - Emma
- Kristi Hendrickson - Nurse
- Andy Gill - Bank Robber
- Kathryn Little - Miss Randall
- Donré Sampson - Parishioner
- Donré Sampson - Wiseman
- Jim Platt - Customer
- Jim Platt - Shepherd
- Douglas Roberts - Ethan Parker
- La Sondra Zarif - Amy
- Josh James - Eric
- Barbara Jane Reams - Krystal
- Jason Binn - Male Employee
- Scottie Haskell - Female Music Vocal
- Sherwood Ball - Male Music Vocal
- Paul Winfield - Sam
- Tom Proctor - Tim's Father
- Bob Evans - News Anchor
- Shelley Young - Andrea Gallagher
- Chris Hansen - Speaker
- Seth Adkins - Nick Beringer
- Seth Adkins - Sam Kellerman
- Michael Beach - Sam Mitchell
- Miles Feulner - Jeremy Barlow
- Brian McNamara - Capt. Greg Saunders
- Brian McNamara - James Berrington
- Alanna Ubach - Cookie
- Alanna Ubach - Lydia Evans
- Susan Diol - Susan Duplain
- David Newsom - Mark Monfort
- Concetta Tomei - Kate Carpenter
- Harvey Vernon - Joe Carpenter
- Priscilla Pointer - Elizabeth Carpenter
- Hansford Rowe - Dr. Donald Chappell
- Ed Begley Jr. - Chris Carpenter
- Joan Van Ark - Kim Carpenter
- Ivey Lloyd - Samantha Mateos
- Spencer Klein - Dylan Mateos
- A Martinez - Jon Mateos
- Kathleen Sullivan - Kathleen Sullivan
- Geoffrey Nauffts - Isaac 'Zach' Brown
- B.B. King - B.B. King
- Dr. John - Dr. John
- Al Hirt - Al Hirt
- Cindy Williams - Claire
- Jane Kaczmarek - Bonnie Bell
- D. David Morin - Matt Tracy
- Tyler Cole Malinger - Young Jesse Bell
- Brenda Vaccaro - Al
- Mel Winkler - Pete
- Willie Garson - Eddie Brenner
- Elliott Gould - Max
- Patricia Belcher - Ms. Raphael
- Vince Grant - Lt. Cmdr. Neil Campbell
- Linda Gray - Marian Campbell
- Norman Parker - Leonard Page
- Royana Black - Teen Claudia
- Jonathan Slavin - Michael
- Richard Gant - Johnson
- De'Aundre Bonds - Luther Dixon
- Norris Young - Dre
- Christopher Darden - Pastor George
- Debbie Allen - Valerie Hill
- Russell Means - Edison
- Adam Beach - Dillon New Eagle
- Holly Fulger - Rosanne Fitzgerald-Moskowitz
- Heidi Swedberg - Marty Dillard
- Roy Thinnes - Senator Guy Hammond
- Jack Conley - Mr. Phelps
- Ben Vereen - Ulysses Dodd
- Yul Vazquez - Tony Portino
- Justin Garms - Jeremy
- Al Jarreau - Rev. Gentry Hall
- Al Jarreau - Al Jarreau
- Richard Gilliland - Stan Miller
- Linda Kelsey - Harriet Miller
- Brigid Brannagh - Alison Miller
- Edward Kerr - Kevin Abernathy
- Holly Fields - Peggy Abernathy
- Sally Kellerman - Augusta Abernathy
- Monica Mikala - Young Alison
- David Marciano - James Block
- Lori Alan - Rachel Carson
- Kirsten Dunst - Amy Ann McCoy
- Taylor Negron - Chuck
- Roy Fegan - Jimmy
- John Randolph - Horace Widdenberg
- Joey Miyashima - Ted Vender
- Joey Miyashima - Eddie
- Peg Phillips - Zelda Widdenberg
- Erik King - Peter Lakes
- Erik King - Kevin Carter
- Robert Gossett - Paul Stettling
- Jeff Olson - Sheriff
- Jeff Olson - Jerry
- Jeff Olson - Agent Bradford
- Harley Venton - Bill McCann
- Kyla Pratt - Annie
- Michael Flynn - Ben Feldman
- Michael Flynn - Howard
- Michael Flynn - Lyle
- Millie Perkins - Willa Du Bois
- Romy Rosemont - Gwen Gold
- Romy Rosemont - Diane 'Dee Dee' Mangione
- Lisa Waltz - Nora
- Cameron Finley - Matt
- Carol Lawrence - Charlotte Perkins
- Ja'net DuBois - Esther Hamilton
- Tim DeKay - J.D. Sinclair
- Kadeem Hardison - Marc Hamilton
- Ilene Graff - Gloria Brewer
- Kimberlee Peterson - Karen Gregg
- Christopher Pettiet - Luke Brewer
- Martha Hackett - Kelly Monroe
- Susan Ruttan - Joanne Peters
- Susan Ruttan - Mrs. Donovan
- Chad Everett - Pastor Daniel Brewer
- Hudson Leick - Celeste
- Jeanne Cooper - Estelle
- Heather McAdam - Young Estelle
- David Leisure - Councilman Hinkley
- Corbin Bernsen - Eric Weiss
- James Earl Jones - The Angel of Angels
- Keb' Mo' - The Angel of Music
- Keb' Mo' - J.D. Winslow
- Keb' Mo' - Isaac
- Jenifer Lewis - Queenie
- Sean Nelson - Calvin Cantrell
- Charmaine Neville - Charmaine
- John Ortiz - Nicky Pacheco
- Lynn Whitfield - Dr. Serena Hall
- Louis Gossett Jr. - Anderson Walker
- A.J. Langer - Olivia Marland
- Paul McCrane - Grant Abbott
- Michelle Joyner - Amy Monroe
- Bradley Pierce - Hank Monroe
- Clifton Powell - Mr. Burns
- Clive Revill - Claude Bell
- Tracy Middendorf - Amethyst
- Edie McClurg - Loafer
- Eddie Jones - Noah
- Gwen Verdon - Lorraine McCully
- Fred Sanders - Ernie Wachinski
- Terri Hanauer - Marie Wachinski
- Greg Evigan - Bill Salisbury
- Greg Evigan - Bo Beaumont
- Jonathan Hernandez - Manny Galinga / Luís Perron
- Jonathan Hernandez - Alex Cassada
- Tim Reid - Buddy Baker
- Vicellous Shannon - Jason DeLee
- Camryn Manheim - Anita
- Rhonda Stubbins White - Lena DeLee
- Michael Peña - Ray Estes
- Barbara Mandrell - Ada Dobbin
- Barbara Mandrell - Terri Hayman
- J.A. Preston - Waters
- Alex McArthur - Ed Bingham
- Jessica Steen - Sarah Bingham
- Kim Gillingham - Emily
- Chris Noth - Carl Atwater
- Kathleen Garrett - Laura Sanders
- Andrea F. Friedman - Jeannie
- Trevor Morgan - Stevie Sanders
- Diane Ladd - Carolyn Sellers
- Travis McKenna - Tiny
- Vincent Berry - T.J. Browner
- Bart Conner - Bart Conner
- Nadia Comăneci - Nadia Comaneci
- Reggie White - Coach Pruitt
- Dee Wallace - Sandra Browner
- Tom Whyte - Peter Browner
- Casey Biggs - Dr. Duncan Danzig
- Steve Vinovich - Roger
- Steve Vinovich - Ron Walker
- Scott Terra - Young Lonnie
- Chad Doreck - Teen Lonnie
- Tara Strong - Emily
- Titus Welliver - Lonnie / Gregory
- Donnie Biggs - Teen Duncan
- Shia LaBeouf - Johnny
- Reiley McClendon - Young Duncan
- Charles Malik Whitfield - Eric Zachariah 'E.Z.' Mony
- Jamil Walker Smith - Darnell Thomas
- Marquise Wilson - Marlon
- Craig Bolerjack - Ryan Eckles
- Bill Spooner - Referee
- Jimmy Hodson - Sportscaster
- Christopher Masterson - Doc
- Madeline Zima - Ally
- Azura Skye - China
- Rashaan Nall - Lightning
- Debra Jo Rupp - Mayor Risa Hoigard
- J. Kenneth Campbell - Cotton
- Donnie Jeffcoat - Gordon
- Jennifer Lambert - Leela Jones
- Ray Xifo - Stretch
- John de Lancie - Justinian Jones
- Thora Birch - Erin
- Olivia Hack - Kim
- Meagan Good - Nikki
- Pamala Tyson - Teresa
- Shashawnee Hall - Lee Fisher
- Sal Viscuso - Dennis
- Scott Wilkinson - Principal Artmeir
- Scott Wilkinson - Coach Hall
- Scott Wilkinson - Businessman
- Estelle Parsons - Jennette Fisher
- William Devane - Benjamin Parker
- Keene Curtis - Norman Delmonico
- Lisa Eichhorn - Dr. Beth Hoppit
- Morgan Fairchild - Jackie Sykes
- James Gleason - Leo
- James Gleason - Phil Palmer
- Paul Keith - Waiter
- Elayn J. Taylor - Doctor
- Joseph Campanella - Clive Hathaway
- Kimberly Oja - Young Vera
- Janet Leigh - Vera King
- Michael A. Goorjian - Budd Glaser
- Swoosie Kurtz - Libby Glaser
- Carrie Hamilton - Allison Bennett
- Jim Metzler - Charlie
- Jim Metzler - Dr. H.C. Arnovitz
- Michele Maika - Young Amanda
- Tim Conway - Freddy
- Al Hirschfeld - Al Hirschfeld
- Carol Channing - Carol Channing
- Lisa Jane Persky - Stasi Reynolds
- Lisa Jane Persky - Alison Spears
- Rita Moreno - Amanda Revere
- Matt Clark - Markus Cavanaugh
- Sterling Brimley - Russell Brewster
- Suzanne Ventulett - Young Annie
- Michael Trucco - Tommy Doyle
- Piper Laurie - Annie Doyle
- Helena Carroll - Kate Leary
- John Cullum - Mark Twain
- Victoria Jackson - Lydia
- Don Cosney - Joseph
- Elizabeth Berridge - Holly
- J.C. MacKenzie - Dr. Ray Craig
- Joe Pichler - Alex Craig
- Alexandra Artrip - Michelle Craig
- Tina Lifford - Sis
- K. Todd Freeman - Vinegar
- Adam Wylie - Andy Hughes
- Morgan Rusler - Pearhead
- Renee Olstead - Bits
- Mary-Joan Negro - Margaret Evans
- Susan Traylor - Karla
- Kiều Chinh - Lang
- Kiều Chinh - Mrs. Kim
- Dan Lauria - Bill Evans
- Romany Malco - Bulldog
- Linda Purl - Sally
- Ian Meltzer - George
- Cyril O'Reilly - Dutch Wilson
- Todd Rulapaugh - Derek
- Mary Donnelly-Haskell - Kerri Colletti
- Jeff Cahill - Carl
- William Hubbard Knight - Stan
- Steve Monroe - Denny
- Michael Chiklis - Matt Colletti
- Vincent Laresca - Pvt. Tomás Parades
- Rose Portillo - María Parades
- Edward James Olmos - Col. Victor Walls
- Noah Fleiss - Aaron Gibson
- Gregg Daniel - Coach Higby
- Bess Armstrong - Mary Gibson
- Dakin Matthews - The Colonel
- Devon Odessa - Sue Ellen
- Gary Grubbs - Brother Jim
- Gregory Harrison - Richard
- Gregory Harrison - Don Costello
- Gregory Harrison - Pete Taylor
- Connor Trinneer - Paul Ratcliff
- Irma P. Hall - Effie Taylor
- Michael Moriarty - Dr. Chester Crayton
- Tom Dreesen - Tom Dreesen
- Johnny Brown - Johnny Brown
- Jack Carter - Jack Carter
- Johnny Dark - Johnny Dark
- Howard Storm - Fred Fontaine
- Lisa Pescia - Donna
- Jerry Stiller - Maury Salt
- Ele Keats - Tracy Beringer
- George O. Gore II - Tyler
- Melody Garrett - Bonita
- Jeremy Foley - Michael Weiss
- Nealla Gordon - Young Elaine
- Jack Laufer - Sol Weiss
- Stuart Margolin - Stuart Deane
- Stuart Margolin - Ray Bishop
- Bruce Davison - Jake Weiss
- Justin Jon Ross - Young Jake
- Alley Mills - Liz Banks
- Karen Austin - Candace Everett
- Corbin Allred - Greg Banks
- Bai Ling - Jean Chang
- Ben Bode - Alex Stella
- Ping Wu - Zhang Xiao 'Gus' Gang
- Jack Ong - Hotel Clerk
- Adrian Pasdar - Edward Tanner
- Christina Ma - Prisoner
- Ming Lo - George's Associate
- Daxing Zhang - Police
- Larry Zeng - Soldier
- Debbie Fan - Tour Guide
- Elaine Kagan - Jo
- Logan Robbins - Young Arthur
- Tracey Gold - Darlene Jones
- Jennifer Echols - Valerie
- Karen Sillas - Sandra Mills
- Nick Whitaker - Boy in Classroom
- Erich Anderson - Billy Hamstead
- Brandon Karrer - Young Billy
- Paul Taylor - Young Tom
- Donna Bullock - Stacey Costello
- Donna Bullock - Anita
- Brendon Ryan Barrett - Cameron Mancuso
- Tait Smith - Ferdie
- Marsha Kramer - Gloria
- Kathy Buckley - Laurel Gray
- Richard Penn - Dr. Evans
- Mark Kiely - Michael Williams
- Veronica Hamel - Judge Dory Chaphin
- Wynonna Judd - Audrey Carmichael
- Paul Robert Langdon - Cory Taylor
- Paul Robert Langdon - Tyler
- Greg Serano - Jorge
- Justina Machado - Marisol
- Michael Harney - Carl
- Adrian Sparks - Mel
- Jerome Butler - Bart
- Tom Hodges - Jasper
- George Grizzard - Charley Nott
- Paige Moss - Sarah Parker
- Sharon Madden - Joan Parker
- Robert David Hall - Harry
- Joey Lawrence - Jesse Archer
- Alan Rosenberg - T.K. McKenna
- Del Hunter-White - Writer
- Jack Blessing - Howard Heller
- David Lascher - Jett Rudin
- Jim Lampley - TV Announcer
- Anastasia Emmons - Haley Ewing
- Ron Orbach - Carl Thorpe
- Jack Wagner - Bart Ewing
- Michael Jeter - Gus Zimmerman
- Frank Ashmore - Mac
- Michael Rispoli - Frankie
- Scotty Cox - Rupert
- Scotty Cox - Toby Bowers (photo only)
- Sydney Walsh - Ellen
- Stacey Travis - Sharon Mangione
- Joshua Carmichael - Buddy Mangione
- Joyce Van Patten - Sylvia Mangione
- Pat Hingle - Ben Mangione
- David Graf - Dewey Burton
- Mariangela Pino - Faye Burton
- Elyssa Davalos - Penny Woodhouse
- Kaleigh Krish - Jamie Wooodhouse
- Dan Butler - Dr. Ivar Kroneberger
- Drew Snyder - Doug Randolph
- Linda Lavin - Amanda Randolph
- Cynthia Nixon - Melina Richardson / Sarah
- Jennifer Paz - Am-Nhac Nguyen
- Toshi Toda - Cadao Nguyen
- Montae Russell - Lester
- Gwen McGee - Charlotte
- Brooke Marie Bridges - Molly
- Rick Worthy - James
- Paul Francis - Carson
- Shelley Robertson - Loretta
- Charles Robinson - Cyrus
- J. Evan Bonifant - Steven
- Vince Melocchi - Workman
- Vince Melocchi - Neil
- Vince Melocchi - J.J.
- Sonya Eddy - Mrs. Taggert
- Chachi Pittman - Kenny
- Sam Saletta - Jimmy
- Ned Vaughn - Charles Lindbergh
- Kamar de los Reyes - Eddie Testaverde
- Scotch Ellis Loring - Matt Demille
- Tim Lounibos - Brad Wong
- Sherry Stringfield - Major Josie Saunders
- Christian Mills - Dr. Timothy Cantor
- Sally Ride - Self
- Michael Tomlinson - Sumner
- JJ Neward - Irene
- Christian Leffler - Pvt. Joe Faraday
- Steven Martini - Nick
- Esteban Powell - Homer
- Amy Locane - Stella
- Jack Sydow - Pet Shop Owner
- David Kaufman - Corey Leonard
- Lenny Clarke - Larry Lumpkin
- Mark Moses - Seth Waters
- Eileen Brennan - Dolores Freeman
- Julie Carmen - Elisa Morante
- Efrain Figueroa - Roberto Morante
- Carlo Alban - Tino Morante
- Romeo Rene Fabian - Miguel
- Julie White - Molly Avery
- Chris L. McKenna - David Herold
- Chris L. McKenna - Greg
- Jordan Baker - Donna
- Bobby Edner - Jimmy Avery
- Kevin Kilner - Jordan Avery
- Jill Gascoine - Ms. Piper
- Wade Williams - Bum
- John Patrick White - Ray Ripken
- Ernie Hudson Jr. - Det. Joe Hicks
- Jennifer Holliday - Norma
- Tom Sullivan - Clarence
- Louie Anderson - Uncle Dudley
- Cleavant Derricks - Robert Springbelt
- Ruby Dee - LaBelle Springbelt
- Madison Eginton - Young Angela
- Ann-Margret - Angela Britton
- Rayford Barnes - Older Carl
- Kim Greist - Shawn Sullivan
- Julio Oscar Mechoso - Marco
- Marnette Patterson - Katie Sullivan
- David Andrews - Jim Sullivan
- Jason Ross-Azikiwe - Marshal Scott Willey
- William Ostrander - Carl
- Peter Onorati - Martin Ashburn
- Brad Hawkins - Young Denny
- Judy Geeson - Pookie Longfellow-Smith
- Kathy Baker - Ellen Sawyer
- Keith McErlean - Tommy Doyle
- Elaine Symons - Maggie
- Brian Glanney - Angus O'Neill
- Lainie Kazan - Doris Bernstein
- Lainie Kazan - Aunt Meg
- Christopher Babers - Dion
- Ryan Goldstein - Ian Wesley
- Christine Healy - Renee Harris
- Christine Healy - Mary Todd Lincoln
- Careena Melia - Fiona
- Eugene Lee - Charley
- Gerard McCabe - Kieran
- Denis Arndt - Darrell
- Samantha Esteban - Renee
- John Caponera - R.C.
- Mark Christopher Lawrence - Hank
- Arnetia Walker - Sweeney
- Sharon Gless - Ziggy
- Giancarlo Esposito - Antonio Gaudi
- April Grace - Constance
- Robert Bailey Jr. - Morgan
- Dennis Boutsikaris - Prof. Alan Berger
- Kate Fuglei - Charlotte
- Kate Fuglei - Jean Clemens
- Shawn Pyfrom - Aaron Berger
- Viveka Davis - Carla Robinson
- Castulo Guerra - Santos Gonzalez
- Juanita Jennings - Warden Davis
- Kimberly Scott - Enshake
- Devyn LaBella - Meredith
- Ray Abruzzo - Paul
- Amanda Barfield - Amy
- Sean Marquette - Angelo
- Robert Cicchini - Coach Duncan
- Robin Bartlett - Toni
- Carol Burnett - Self - Host
- Carol Burnett - Lillian Bennett
- Cicely Tyson - Abigail Peabody-Jackson
- Sherman Augustus - Phillip Jackson
- Tonea Stewart - Lois
- JoNell Kennedy - Judith Jackson
- Rick Gonzalez - Ramone
- Donald McKayle - Wilbur
- Nick LaTour - Pepper
- Pedro Pascal - Ricky Hauk
- Deborah Strang - Ellen Hauk
- Nathan Anderson - Marshall Fuller
- Taylor Stanley - Shelley
- Alex D. Linz - Joey Hauk
- Bonnie Bartlett - Loretta
- Bonnie Bartlett - Dr. Lucy Scribner
- Bonnie Bartlett - Emily Vincent
- Jay Patterson - Russell Tate
- Mimi Lieber - Greta
- Raye Birk - Mr. McFarlane
- Steven Gilborn - Simon Tate
- John Mahon - Wally
- Rachel Snow - Mary Jane
- Naomi Judd - Liz
- Abigail Mavity - Millie Radcliff
- Christine Estabrook - Kate Radcliff
- Gary Cole - Charlie Radcliff
- Bill Mondy - Bernie
- Anthony DeFilippo - Eddie
- Keith Szarabajka - Barkley Stubbs
- Ray Walston - Benjamin Clay
- Richard Chamberlain - Jack Clay / Everett Clay
- Jere Burns - Sam Rigney
- Eric Jungmann - Jamie Larson
- Joel Berti - Zach
- Karina Arroyave - Annie Higuerra
- Guillermo Díaz - Rick Higuerra
- Jeremy Roberts - Cal
- Thomas Dekker - Dennis
- Alix Elias - Clara
- Noelle Parker - Stevie Noonan
- Steven Petrarca - Young Chandler
- Ken Lerner - Sid Lumsky
- Adria Tennor - Ruby Rice
- Gregory Scott Cummins - Barney
- Robert Loggia - Chandler Crowne
- Joe Chrest - Joe
- William Marquez - Willard
- Troy Winbush - Langford T.
- Randall Batinkoff - Calvin Chilcutt
- Kathy Mattea - JJ
- Tess Harper - Betsy Baxter
- George Dzundza - Bud Baxter
- Paula Jai Parker - Billie Holiday
- Antwon Tanner - Lamont
- Tina Alexis Allen - Laura
- Matthew Glave - Sgt. Walker
- Matthew Glave - Young Max
- David Jean Thomas - Security Guard
- Porscha Coleman - Renee
- Kenya Williams - Charnelle Bishop
- John Billingsley - Peter Garfield
- Enrique Castillo - Carlos Jimenez
- Elizabeth Sung - Yung Shim Noh
- Cathy Lee Crosby - Samantha Munson
- Bill Macy - Walter Titlebaum
- Bonnie Franklin - Carol Anne Larkin
- Robert Prosky - Dr. Robert Harrigan
- Lindsay Pulsipher - Teenage Lucy
- Taran Killam - Teenage Robert
- Richard Lineback - Joe Benson
- Kathleen Wilhoite - Kathy Benson
- Jonathan Osser - Travis Benson
- Jessica Sara - Cassie Benson
- Jesse Borrego - Tommy Hernandez
- Laura Cerón - Lorena Acosta
- Crystle Lightning - Ana Hernandez
- Abel Soto - Steve 'Gonzo' Gonzalez
- Leah Lail - Candy Koppelman
- Leah Lail - Kim Jackson
- Renoly Santiago - Miguel Acosta
- Robert E. Hartenberger - Father O'Grady
- Mel Harris - Kelly Rockhill
- Ben Siegler - Brandon White
- Larry Joshua - Det. Paul Daniels
- Cynthia Martells - Madeline Griffin
- Mary B. Ward - Jan McCovey
- Jeffrey Schoeny - Brian McCovey
- Arye Gross - John Baker
- Eve Gordon - Erica Baker
- Amanda Fuller - Lucy Baker
- Patti LuPone - Alice Dupree
- Joshua Bryant - Harry
- Juliana Donald - Jamie Cadegan
- Jon Pennell - Josh Whitman
- J. Grant Albrecht - Walter Harlow
- Harry Hamlin - Liam Cadegan
- Robert Jackson - Matt Cadegan
- Shannon Cochran - Val Osgood
- Matt Weinberg - Mickey Dempsey
- David Nathan Schwartz - Fan
- Michael Nouri - Greg Sawyer
- Michael Nouri - Carl Northum
- Ryan Merriman - Jason Harris
- Tom Irwin - Dr. Will Harris
- Kim Abunuwara - Joanie
- Zachery Ty Bryan - Jeff McHenry
- Eric Pierpoint - Jack McHenry
- Brian Gross - Chase Jennings
- Adam Hendershott - Randy Templeton
- Eddie Frierson - Announcer (voice)
- Star LaPoint - Stephanie
- James A. Watson, Jr - Carl
- Larry Brandenburg - Slave Catcher
- Scott Lawrence - Toby / Mason Freeman
- Thomas Calabro - Ben Mason
- Annabella Sciorra - Dr. Sarah Conover
- Carolyn Mignini - Penny Gatewood
- Jake Dinwiddie - Joey De Falco
- Hugh Holub - The Doctor
- Alfred Dennis - Saul
- Cameron Bowen - Danny Winslow
- David Canary - Carter Winslow
- Faye Dunaway - Dr. Rebecca Markham
- Bill Gaither - Vaughn Winslow
- Mark Lowry - Tyler Winslow
- Guy Penrod - Kevin Winslow
- David Phelps - Kyle Winslow
- Gloria Gaither - June Winslow
- Sheri Easter - Kay Winslow
- Charlotte Ritchie - Tyler's Wife
- Eva Mae LeFevre - Maisy Winslow
- R.D. Robb - Paul Slocum
- Omar Gooding - Ben McCloud
- Bradford English - Felix
- Hinton Battle - Candy 'the Clown' McCloud
- Chaz Lamar Shepherd - Young Candy McCloud
- Andre Jamal Kinney - Young Norm
- Hank Aaron - Hank Aaron
- Ernie Hudson - Norm McCloud
- Michael Patrick McGill - Babe Ruth
- Jeremy Hoop - Rosenthal
- Tarance Edwards - Bo-Bo
- Christian Stevens - Brzsciewski
- James MacDonald - Gary McGregor
- Sarah Paulson - Zoe
- Jennifer Leigh Warren - Maggie
- Chris Jacobs - Jeff
- Scott Reeves - Peter
- Christopher Wiehl - Billy
- Debbie Reynolds - Betty Poplovich
- Meredith Scott Lynn - Rachel Silverstein
- Carol Locatell - Eva Silverstein
- David Margulies - Sam Silverstein
- Richard Gross - Jack
- Ashlynn Rose - Young Rachel
- Mark Rolston - Delroy Gibbons
- John Prosky - Greg Hatcher
- Eve Brenner - Florence Gibbons
- Lucas Elliot Eberl - Young Daniel
- Sean Patrick Flanery - Daniel Lee Corbitt
- Veronica Cartwright - Shirlee Gibbons
- Christopher Daniel Barnes - Dennis Loggins
- Dylan Bruno - Ricky Jessup
- Toby Keith - Toby Keith
- Ange Billman - Celestine
- Annie Corley - Allison Dorin
- A.J. Johnson - Yvette Lakes
- Blair Brown - Mayor Victoria Lewis
- Lauren Robinson - Beth
- Arreale Davis - Ashley Lockwood
- Mykelti Williamson - Tevis Lockwood
- Rene L. Moreno - Joaquin
- Lance E. Nichols - Minister Russell
- Tom Bosley - Elmer
- Ernest Borgnine - Max Blandish
- Sherry Hursey - Debbi Stonelake
- Jeanette Brox - Erica Lowry
- Trever O'Brien - Robbie Stonelake
- Bernard White - Dr. Nathans
- Patricia Kalember - Janice Lowry
- John Heard - Allen Lowry
- J.W. Smith - Stuart
- Jennifer Crystal Foley - Gail Blake
- David Barry Gray - Dan Jackson
- Laurel Holloman - Nicole Blake
- David Kriegel - Walter Jackson
- Kieran Mulroney - Sherriff J.T.
- Holliston Coleman - Danni Blake
- Lukas Behnken - Cory
- Dwight Armstrong - Bobby
- Mary McDonnell - Sister Theodore Claire
- Doris Roberts - Rose de Santo
- Andrea Sevilla - Annie
- Deborah Lee Douglas - Sue
- Thom Gossom Jr. - Dr. Winston
- Luther Vandross - Reggie Hunter
- Kate McNeil - Sarah Berrington
- Bethany Richards - Kimmie Costello
- Myles Jeffrey - Justin Costello
- Mike Erwin - Blake
- Dayton Callie - Rocco
- Angela Oh - Su Kim
- Tom Schanley - Howard
- Sam Vlahos - Carlos
- Matt Malloy - Christopher Murphy
- Christie Lynn Smith - Joy Wren
- José Zúñiga - Oscar
- Amanda MacDonald - Delphina
- Kelly Connell - Jim Grant
- William Stanford Davis - Doug
- Scott G. Anderson - Lennie Blackwood
- Kirk Baltz - Mike Rowley
- Cress Williams - Riley
- Tembi Locke - Amanda
- Lennie Loftin - Ben
- Edwin Hodge - Jesse Cartwright
- Robert LaSardo - Lionel Florés
- Gilbert Leal - Guillermo Florés
- Lesley Ann Warren - Kelly Cartwright
- Tyler Francavilla - Ty
- Jonathan Lipnicki - Stan Lewis
- Dennis Weaver - Emmett Rivers
- Eric Jacobs - Zach
- Joel Bishop - Bill
- Cliff DeYoung - Charles Jackson
- Billy Kay - Victor Jackson
- Marita Geraghty - Deborah Jackson
- Alex Rocco - Ben Horner
- Ethan Phillips - Wally Kniver
- Scott Thompson - Herbert
- Elisa Bocanegra - Latrina
- Jake Richardson - J.Z.
- Gavin MacLeod - Calvin
- Michael Milhoan - Alex Waters
- Bob Bancroft - Mr. Carver
- Karina Logue - Rindy
- Reese Phillip Purser - Head Juror
- Tony Crane - Young Clive
- Jack North - Joe
- Gabrielle Beaumont
- Noel Nosseck
- Gene Reynolds
- John Behring
- Jeff Kanew
- Joel J. Feigenbaum
- Marilyn Osborn
- Rob Loos
- Steven Phillip Smith
- Arnold Margolin
- Bob Colleary
- Glenn Berenbeim
María Conchita Alonso hace el papel de Dr. Sandra Peña.
Abe Vigoda interpreta a Receptionist Angel en la serie.
Jeannetta Arnette interpreta a Dr. Gus Jacobs en la serie.
Holmes Osborne hace el papel de Sgt. Richardson.
Kirk Douglas interpreta a Ross Berger en la serie.
Wendie Jo Sperber interpreta a Tricia en la serie.
Stacy Keach hace el papel de Maury Hoover.
William Russ hace el papel de Prof. Thomas North.
Tony Denman interpreta a Ryan Dempsey en la serie.
Benito Martinez interpreta a Officer Dave en la serie.
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