- Natasia Demetriou - Carmen
- Greg Canestrari - Will Willis
- Flaminia Cinque - Phyliss Willis
- Matthew Holness - Richard Chickentoss
- Joseph May - Hoop Kaaak
- Belinda Stewart-Wilson - Bellender Bojangles
- Nigel Betts - Dr. Harold Shitman
- Larry David - Sola Mirronek
- Caroline Harker - Sue Pipkins
- Sarah Mayhew - Nancy
- Kayvan Novak - Des Wigwam
- Tracy-Ann Oberman - Mrs. Purchase
- Guy Combes - Daniel Day-Lewis
- Freddie Fox - Edward Fox
- Bill Hader - Dwight Difference
- Susan Wokoma - Nina Armenian
- Gina Bellman - Shepherd Jerbil
- Colin McFarlane - Weech Beacon
- Isaura Barbé-Brown - Snorky
- Nell Hudson - Gypsy
- Stuart Milligan - Old Timer Bill
- Charlie Parker-Swift - Desert Cop
- Doon Mackichan - Brooke Hooberman
- Doon Mackichan - Jane Plough
- Doon Mackichan - Jane Plough / Brooke Hooberman
- Morgana Robinson - Wildcat Lil
- Robert G. Slade - Doc Brown
- Aidan Turner - Barney
- Benedict Wong - Rusty Halloween
- Freddie Annobil-Dodoo - Agent Saucepan
- Fred Armisen - Russ Nightlife
- Jennifer Armour - Woman In Coffee Queue
- Tim Downie - Danny Bear
- Robert Bathurst - Ed Howzer-Black
- Hanako Footman - Sorry Johnson
- Joe Gallina - Wallace
- Rashida Jones - Billy Tarzana
- Shazad Latif - Clem Fandango
- Adrian Lukis - Blair Toast
- Lewis Macleod - Orson Welles
- John Owen-Jones - Neil Doobla-Decca
- Harry Peacock - Ray Purchase
- Paul Rudd - Paul Rudd
- Jaimi Barbakoff - Jennifyer Madraass
Kayvan Novak interpreta a Des Wigwam en la serie.
Matt Berry hace el papel de Steven Toast.
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