- Drew Roy - Joel
- Pete Ploszek - Airline Passenger
- Amanda Brooks - Claire Gillman
- Colman Domingo - Bass Reeves
- Daniel Lissing - Jesse James
- Zahn McClarnon - Grant Johnson
- Jesse Luken - Charles Lindbergh
- Tiffany Daniels - Josephine Baker
- Brandon Barash - Ernest Hemingway
- Chris Mulkey - Frank Hamer
- Jacqueline Byers - Bonnie Parker
- Shantel VanSanten - Kate Drummond
- Donal Thoms-Cappello - Herb Morrison
- Jara Zeimer - Irene Doehner
- Aiden Longworth - Werner Doehner
- Joel Cottingham - Charlie Nehlson
- Hiro Kanagawa - Agent Kondo
- Kurt Max Runte - Commander Rosendahl
- Noel Johansen - Captain Max Pruss
- Primo Allon - Deputy
- Fulvio Cecere - Sheriff
- Matthew Mandzij - Cop
- Chad Riley - Derek
- Sandy Robson - Grounds Crewman
- Bracken Hanke - Crying Girl / Kid Singer
- Neal Bledsoe - Robert Todd Lincoln
- Kelly Blatz - John Wilkes Booth
- Mike Wade - Nicholas Biddle
- Michele de Broel - Clara Harris
- Terry Lewis - Gen. Ulysses Grant
- Sam Spear - Fanny Seward
- Travis MacDonald - George Atzerodt
- Jason Stevens - Harry Hawk
- Kurt Ostlund - Lewis Powell
- Ryan Hesp - John Parker
- Lucia Frangione - Mary Lincoln
- Peter Hall - William Seward
- Ken McNicol - VP Andrew Johnson
- Trevor Lerner - Bartender
- Curtis Tweedie - Bellhop
- Donna Soares - Military Doctor
- Maria Marlow - Actress on Stage
- Balázs Koós - Policeman
- Erica Carroll - Lorena
- Elena Satine - Judith Campbell
- Scott Bailey - John F. Kennedy
- Marc Senior - Sammy Davis Jr.
- Ronnie Scott - Dean Martin
- Peter Grasso - Sam Giancana
- Lindsay Maxwell - Miss Atomic
- Matthew Smalley - Paul the Guard
- Colm Hill - Western Union Clerk
- Barclay Hope - General
- Jesse Reid - Bellman
- Nathan Cann - Bartender Casino Bar
- Sean Maguire - Ian Fleming
- Christian Oliver - Wernher von Braun
- Art Kitching - Albert Speer
- Greg Delmage - German Soldier
- Gavin Langelo - SS Guard
- Manfred Maretzki - Bartender
- Artur Stofel - Launchpad Guard #1
- Joshua Murdoch - Launchpad Guard #2
- David Chisum - Col. William Barret Travis
- Alex Fernandez - General Santa Anna
- Chris Browning - James 'Jim' Bowie
- Jeff Kober - Davy Crockett
- Sean Michael Kyer - John Smith
- Victor Zinck Jr. - MSG Dave Baumgardner
- Sari Mercer - Susanna
- Hyuma Frankowski - Zach
- Mitch Ainley - Sentry
- Mustafa Shakir - Gregory Hayes
- Tom Amandes - Mark Felt ("Deep Throat")
- Shelley Robertson - Mrs. Carlin
- Tiffany Mack - Doc
- Nathan Mitchell - Jay
- Romuald Hivert - Black Panther
- Gareth Rees - Peacenik
- Sean Kuling - Soldier
- Grayson Maxwell Gurnsey - Teenager
- Hector Hugo - Patrick Ramsey
- Salvator Xuereb - Lt. Louis Coulon de Villiers
- Karina Lombard - Chief Nonhelema
- Philip Prajoux - Jacques
- Paul Rogan - French Camp Surgeon
- Lauren K. Robek - Archaeologist
- Edwin Perez - Lead Tech
- Albert Nicholas - Fort Duquesne Officer
- Jason Beaudoin - Stocky Soldier
- Caitlin Carver - Maria Tompkins
- Nadine Ellis - Katherine Johnson
- Matt Frewer - Anthony Bruhl
- Robert Pine - Old Wayne Ellis
- John Brotherton - Gene Kranz
- Joel Berg - Wayne Ellis
- Jason William Lee - Charles Duke
- Gary Jones - Vincent Sullivan
- Brenden Sunderland - Gabriel
- Andrew Moxham - Flight Controller
- Shaine Jones - Computer Engineer
- Bruce Blain - Plumber
- Wolsey Brooks - Police Officer
- Sam Strike - Clyde Barrow
- Billy Wickman - Henry Methvin
- Brendan Riggs - Bank Manager
- Curtis Caravaggio - Gen. Benedict Arnold
- Damian O'Hare - Gen. George Washington
- Armin Shimerman - David Rittenhouse
- Jake Brennan - John Rittenhouse
- Annie Young - Peggy Arnold
- Brad Dryborough - Earl Cornwallis
- Marci T. House - Michelle
- Conor Gomez - British Officer
- Nathan Dashwood - Continental Soldier
- Joshua Harding - Continental Soldier #2
- Michael Drayer - Harry Houdini
- Katherine Cunningham - Sophia Hayden
- Link Baker - Thomas Edison
- Lyova Beckwitt - Dash Houdini
- John Hensley - Pat Quinlan
- Joel Johnstone - George / H.H. Holmes
- Marcus Hondro - J.P. Morgan
- Chad Rook - Karl
- James Clayton - Teddy Roosevelt
- Jason William Day - Pinkerton
- Laura K. MacDonald - Waitress
- Alex Rose - Charles Ford
- Michael Adamthwaite - Wes Gillman
- Daryl Shuttleworth - Marshal Hoffman
- Sean Campbell - Marshal Greer
- Natalie Trent - Saloon Waitress
- Lucie Guest - Becky
- Leanne Lapp - Alison
- Colin Lawrence - State Trooper
- Clay St. Thomas - Weatherman
- Timothy Daniel Selby - Technician
- Ian Farthing - Businessman
- Anita Brown - Businesswoman
- Mathew Yanagiya - Guard #1
- Cameron Gharaee - Al Capone
- Mather Zickel - Richard Hart / Jimmy Capone
- Richard Portnow - Mayor William Hale Thompson
- Misha Collins - Eliot Ness
- Paul Moniz de Sa - Frank Galluccio
- Liviu Rain - Sgt. Maj. Caleb Sullivan
- Jagua Arneja - Agent Singer
- Charles Rahi Chun - Priest
- Brandyn Eddy - Reporter
- Allison Riley - Hart's Wife
- Jim Beaver - NSA Agent Jake Neville
- Spencer Garrett - Senator Joseph McCarthy
- Johnathan Tchaikovsky - Young Ethan Cahill
- Bruce Gray - Old Ethan Cahill
- Daniel Di Tomasso - Noah
- Vincent Dangerfield - FBI Agent #1
- Gwenda Lorenzetti - Nurse #1
- Thomas Elms - Man at Bar
- Teddy Sears - Lucas Calhoun
- Susanna Thompson - Carol Preston
- Annie Wersching - Emma Whitmore
- John Getz - Benjamin Cahill
- Michael Rady - Nicholas Keynes
- Randy Lee - Goon #1
- Ed Anders - Goon #2
- Chris Ippolito - Slave Master
- Naika Toussaint - Slave Woman
- Bailey Noble - Amy Preston
- Hélène Cardona - French Voices (voice) (uncredited)
- David Sutcliffe - Lucy's Boss
- Matthias Brunert - Piano Player
- Cameron Forbes - Blue Collar Local
- Melissa Farman - Irene Curie
- Kim Bubbs - Marie Curie
- Jonathan Stanley - Mac
- Matthew Atherton - Captain Albright
- Alexander Neher - Doughboy
- Tino Struckmann - Corporal Lewis (uncredited)
- Matt Long - Ryan Millerson
- Joseph Lee Anderson - Wendell Scott
- Annie Tedesco - Mrs. Millerson
- Jack Armstrong - Vincent
- Jim Hanna - Inspector Carl
- Scott Broderick - Roy
- Doug Hurley - Reporter
- Stewart Skelton - Sponsor
- James Huang - Homeland Security Agent
- Torrey Drake - Goon Mark
- Brett Gipson - Guard
- Bianca Lopez - Aide
- Josh Randall - Lucas' Father
- Alyssa Sutherland - Hedy Lamarr
- James DuMont - Barney Balaban
- John Colton - William Randolph Hearst
- Beau Brians - George Antheil
- Matthew Downs - Officer Hank Wilson
- Ryan Cargill - Young Lucas
- Mari Weiss - Secretary
- Chet Grissom - Director
- Jordan Farris - Roman Chariot Driver
- Tim Trobec - Hearst Goon
- Chris Gann - Security Guard #2
- Ravi Naidu - Doctor
- Tonya Glanz - Jessica Logan
- Henri Lubatti - Judge John Hathorne
- Sofia Vassilieva - Abiah 'Abby' Folger Franklin
- Emily Swallow - Bathsheba Pope
- Patrick Fischler - Joseph Pope
- Todd Weeks - Judge Samuel Sewall
- Shiloh Nelson - Elizabeth 'Betty' Paris Sewall
- Jennifer Christopher - Alice Parker
- Sally Berman - Martha Cory
- Jennifer L. Marshall - Mary Estey
- David Wells - Samuel Wardwell
- Preston Acuff - Jailer
- Dylan Rourke - Barkeep
- Grant Jordan - Young John F. Kennedy
- Adam Cropper - Lem Billings
- Adam Pilver - Mr. Greer
- Jared Wernick - Gas Station Clerk
- Reina Hardesty - Kayla
- Tyler Clark - Sara
- McKenna Roberts - Olivia
- Matthew Avery - Smart-Ass Kid
- Carin Chea - Receptionist
- Freedom Bridgewater - Security Guard #1
- Gavin Stenhouse - Donald 'Don' Law
- Radha Blank - Bessie Smith
- Wiley B. Oscar - Muddy Waters
- Keith Machekanyanga - Son House
- Theodus Crane - Johnny Sharecropper
- Natasha Marc - Betty
- Erica Dasher - Alice Stokes Paul
- Sarah Sokolovic - Mary Grace Humiston
- Bryan Scott Johnson - President Woodrow Wilson
- Tom Virtue - Senator James Walcott Wadsworth Jr.
- James Babson - Officer Halpern (Front Desk)
- Brendan Bradley - Officer Daly
- Maxwell Glick - Journalist
- Daniel Robbins - Andrews
- Glennellen Anderson - Jane
- Lauren Baldwin - Mary
- Riley Rose Critchlow - Charlotte
- Dustin Lewis - Officer #1
- Max Bird-Ridnell - Man
- Daniel Holm - Journalist (uncredited)
- Karen David - Young Officer Denise Christopher (Dhriti Sirivastava)
- Pooja Batra - Ananya Sirivastava
- Matthew Alan - Owen (Sleeper Agent)
- Erik Stocklin - John Hinckley Jr.
- Clint Culp - Officer Thomas Delahanty
- Jefferson Black - President Ronald Reagan
- Michael Garza - Mark
- Vishal Patel - Sunil Devati
- Sathya Jesudasson - Puja Devati
- Andrew Pifko - Young Rudy Giuliani
- Chuck McCollum - Lieutenant Green
- Edith Fields - Elderly Woman
- Christine Horn - Harriet Tubman
- Terry Maratos - Stanley Fisher
- Megan Liu - Fei Yunshan
- Evan Lai - Feng Yushan
- Kevin Sizemore - Colonel Ryerson
- Ben Bowen - Colonel Montgomery
- Brad Gage - Captain Nevins
- John Deignan - Plantation Owner
- Ethan Drake Davis - Samuel
- Kristen Marie Kelly - Nancy
- Tarnue Massaquoi - Isaiah
- Scott Vance - Slave Catcher
- Conphidance - Dying Union Soldier
- Adam Weber - Young Confederate Soldier
- Bryan Dodds - Zac (uncredited)
- Bryan Friday - Secret Service Agent Jerry Parr (uncredited)
- Lauren Greer - Rollergirl (uncredited)
- JF Davis - White Man
- Darren Darnborough - Waylon FKA Angry Gambler
- Erik Audé - Jimmy the Goon
- Kahyun Kim - Young-Hee
- Paul Alayo - Joaquín Murrieta Carrillo
- Zachary Bostrom - Dennis Langford
- Becka Adams - Lorena Flynn
- Alan Pietruszewski - Colonel Edward Hanna Forney
- Albert Kong - Dr. Hyun Bong-Hak
- Caleb Jeon - Tae Woo
- Andrew Boyle - Mike
- Andrew Bridges - Brock
- Jesse Bush - Rittenhouse Agent
- Crystal Coney - Teacher
- Dillan Ostrom - Stevens
- Anthony Traina - Clifford
- Arabella Grant - Girl 1 (Amy)
- Anslem Richardson
- Arika Lisanne Mittman
- Marney Hochman
- John Fox
- Michaela Starr
- Nick Bradley
- Rebecca Mangieri
- Evyen Klean
- Eduardo Ponsdomenech
- Jennifer Reeve
- Wade Barnett
- Robert Duncan
Richard Portnow interpreta a Mayor William Hale Thompson en la serie.
Damian O'Hare hace el papel de Gen. George Washington.
Abigail Spencer interpreta a Lucy Preston en la serie.
Matt Lanter interpreta a MSG Wyatt Logan en la serie.
Malcolm Barrett hace el papel de Rufus Carlin.
Goran Visnjic interpreta a Garcia Flynn en la serie.
Paterson Joseph hace el papel de Connor Mason.
Sakina Jaffrey interpreta a Agent Denise Christopher en la serie.
Claudia Doumit interpreta a Jiya en la serie.
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