- Tim Heidecker - Tim
- Eric Wareheim - Eric
- Dan McBride - Frank
- Zach Galifianakis - Zach
- Clara York - Dan's Wife
- Michael Bower - Barry
- Shant Nareg Roohinian - Brian
- Katie Silverman - Katie
- Angela Tom - Barb
- Rey Borge - Couch Potato
- Bob Odenkirk - Dr. Stork
- Gillian Jacobs - Young Patient
- M. Emmet Walsh - Detective
- Alexandra Kenworthy - Old Woman
- Diane Sellers - Receptionist
- Jake Shelton - Ben
- Matthew Cardarople - Teenager
- Lauren Cohan - Stephanie
- David L. King - Businessman
- Jack Knight - Super
- Julie Rei Goldstein - Marcie
- Ilka Urbach - Dana
- Dwain S. Tucker - J. P. Pourke
- Doug Long - Patrick
- Lana Kinnear - Girl #1
- William Miller - Hernando
- Sharon Noble - Judith
- Alan O'Neill - Bartender
- Jason Schwartzman - Self
- Jimmy Kimmel - Self
- Julia Barna - Sasha
- Shira Lazar - Host
- Dawnn Lewis - Agent
- Amy Lyndon - Wardrobe Person
- David Mattey - Man-Monster
- Andrew Rush - Brian
- Brent Weinbach - Brett the Young Intern
- Guy Perry - Damien
- Ian Watson - Crew Member
- John C. Reilly - Jordan
- Laurie Metcalf - Gabrielle
- Percy A. Smith - Man #1
- Steve Kaufmann - Man #2
- Jon Morgan Woodward - Felix Hernandez
- Tim Harris - Driver
- Steven Lamprinos - Man / Baby
- James Madio - Tommy
- Johnny Williams - Sam
- Mark Berry - Group Leader
- Susan James Berger - Mama Pantone
- Wayne Alon Scott - Speaker
- Adam Cagley - Patrick's Friend
- Michael Bova - Wise Guy at Bar
- Pamela Wistrom - Buxom Patron
- Michael Leland Burton - Group Member (uncredited)
- Zach Gilford - Matt Peters
- Rosa Salazar - Lucy
- Lance Reddick - Joseph Zagan
- Jamey Sheridan - Matt's Dad
- Cynthia Stevenson - Matt's Mom
- Kurtwood Smith - Father Krang
- Eileen Barnett - Aunt Joan
- Clint Culp - Carl
- Jacob Timothy Manown - Teenage Matt
- Tuc Watkins - Boss
- Gary Kraus - City Worker Rich
- Eric Zuckerman - Doctor
- Boni B. Alvarez - Manny
- Myles Cranford - Warren
- Joyce Greenleaf - Customer #2
- Ron Michaelson - Customer #1
- Frank Gerrish - Mr. Ortiz
- Tennessee Luke - Narrator (voice; uncredited)
- Summera Howell - Janie
- Rhea Perlman - Maureen
- Jorge Garcia - Bryan
- Ray Wise - The Duke
- Isaac Cheung - Stevie
- Howard Chan - Dealer #2
- Phil Lodwick - Dealer #1
- Lynne Oropeza - Casino Cocktail Waitress
- Andre Royo - Isaiah
- Keith Blaney - Audience Member
- Davison Locksley - Audience Member
- Joe Sachem - Mr. Jack
- Clyde Yasuhara - Doctor
- Chelsea Kulback - Passed Out Teen
- Michael A. MacRae - Passed Out Teen
- Emmet Flores - Mental Patient
- Will Forte - Will
- Fred Willard - Dan
- Sarah Sutherland - Dayna
- Christopher Gehrman - Bloody Passenger
- Emily Rowan - Jogger
- Emily Berry - Woman on Bench
- Robert Lewis Stephenson - Jackson Garrison
- Paul Rae - Buck
- Jace Berina - Juan Carlos
- Dylan Henry Lau - Mongo
- Iaroslac Riabinin - Dimitri
- Malea Emma Tjandrawidjaja - Maylene
- Bruce Van Norman - Butter-Churning Boy
- Barbara J. McCarthy
- Clark Reinking
- Dave Kneebone
- Mark Costa
- Tim Heidecker
- Eric Wareheim
- Alex Altman
- William Levins
- Chase Sampson
- Brooke Blair
- Will Blair
Tim Heidecker interpreta a Tim en la serie.
Eric Wareheim interpreta a Eric en la serie.
Dan McBride hace el papel de Frank.
Zach Galifianakis interpreta a Zach en la serie.
Clara York hace el papel de Dan's Wife.
Michael Bower interpreta a Barry en la serie.
Shant Nareg Roohinian hace el papel de Brian.
Katie Silverman hace el papel de Katie.
Angela Tom hace el papel de Barb.
Rey Borge interpreta a Couch Potato en la serie.
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