- Esther Dale - Ellen the Maid
- Yuki Shimoda - Koto
- Kenneth Haigh - Detective Insp. Harry Roberts
- Jester Hairston - Papa Benjamin
- Marlo Thomas - Susan Baker
- Dianne Foster - Judy Patterson
- Dan Tobin - Ray
- Sam Edwards - Charles Larrimore
- Frank Overton - Bart Hattering
- Adele Mara - Lydia Adler
- Luciana Paluzzi - Madalena
- Richard Chamberlain - Larry Carter
- Mort Sahl - Sam Lynch
- Clancy Cooper - Chief Constable
- Macdonald Carey - Hector Vane
- Rip Torn - Duncan Corey
- Jay C. Flippen - Harry Gans
- Judson Pratt - Lt. Bill Gordon
- Hardie Albright - Willet Goodfield
- Richard Kiel - Master Styx
- Susan Oliver - Edith Landers
- John Craven - Dr. Hilton
- Alan Carney - Burgin
- Herbert Rudley - Max Quinke
- Philip Carey - Darryl Hudson
- Donald Woods - Dr. John Carmody
- Brandon De Wilde - Timothy Branner
- Henry Silva - Toby Wolfe
- Doro Merande - Melba Pennaroyd
- Jo Van Fleet - Mrs. Cissy Hawk
- Oskar Homolka - Pierre Jacquelin
- Tom Poston - Charlie Denham
- Natalie Schafer - Beatrice Graves
- Ursula Andress - Luana
- Alberta Nelson - Marie Browning
- Martita Hunt - Celia Sommerville
- Norma Crane - Nell Le Jean ('Welcome Home')
- Gina Gillespie - Priscilla
- Ann Todd - Sylvia Lawrence
- Leo G. Carroll - Major Downey
- Dick York - Fred Bancroft
- Jackie Joseph - Miss Martin ('Goodbye, Dr. Bliss')
- Robert Douglas - Antony Hugh Swinburne
- Edward Platt - James Weeks
- Patricia Breslin - Dinah Duffay
- Pippa Scott - Marcia Elizabeth Hunter
- Nancy Kelly - Janet Willsom
- Reta Shaw - Celia Hooper Somers
- Jack Carson - Burt Lewis
- Jeanne Bal - Judy Wilson
- Ray Teal - Sheriff Wiley
- Boris Karloff - Self - Host
- Boris Karloff - Dr. Albert Farnham
- Boris Karloff - Clayton Mace
- Boris Karloff - Dr. Thorne
- Boris Karloff - Pop Jenkins / Col. Jackson Beauregard Finchess
- Boris Karloff - Doktor Konrad Markesan
- Torin Thatcher - Jeremy Teal
- Guy Rolfe - Vladimir Vicek
- George Macready - Mr. Smith
- Bert Remsen - First Detective
- Beverly Garland - Ruth Kenton
- Larry Blyden - Ralphie Teal
- Sue Ane Langdon - Queenie de Lyte
- Russ Conway - Lt. Boutaric
- Al Ruscio - Allah El Kazim
- Roberto Contreras - 2nd Guerrilla
- Natalie Trundy - Lily Hanson
- Rhodes Reason - Anthony Page
- John Marley - Dr. Tony Romano
- Jessie Royce Landis - Mrs. Kilburn
- Whitney Blake - Jane Kimball
- Seymour Green - Sir John Herbert
- Stuart Erwin - Uncle Florian
- Jack Mullaney - Fred Forrest
- Judith Evelyn - Mildred Adler Beaumont
- Martin Kosleck - Col. Andre Bertroux
- Bruce Dern - Johnny Norton
- David McLean - Ben T. Willsom
- Adam Williams - Hymie Kralik
- John Qualen - Streetcar Conductor
- Fifi D'Orsay - Toinette
- Rosemary Murphy - Lavinia Sills / Alice Quimby
- Ned Glass - Vince Fennaday
- Beverly Washburn - Lollie Harrod
- Estelle Winwood - Aunt Emily Finchess ('Welcome Home')
- Elizabeth Montgomery - Rosamond Denham
- Carl Benton Reid - Dr. Marcus Graham
- Robin Hughes - Collins ('A Terribly Strange Bed')
- Crahan Denton - Sheriff Buckner
- Vito Scotti - Buddy Welsh
- Otto Kruger - Bert Farrington
- Phil Arnold - Curly
- Berry Kroeger - Paul Mowry
- John Banner - Prof. Martin Vander Hoven
- Gary Clarke - Arthur Smith
- Angela Greene - Mrs. Carlisle
- Argentina Brunetti - Anna Romano
- Larry Pennell - Larry Weeks
- Sue Randall - Kay Salisbury
- Ross Elliott - Charles Merriweather
- Charles McGraw - Sheriff Cliff Wrights
- Barry Gordon - 'Slip-Slip'
- Ramon Novarro - Maestro Giuliano
- John Emery - The Pawnbroker
- Cloris Leachman - Beatrice Stafford
- John Mitchum - Policeman
- Cynthia Pepper - Receptionist
- Richard Carlson - Guy Guthrie
- Russell Johnson - Adam Talmadge
- Henry Corden - Detective Sid Benajain
- John Ireland - Eddie Wilson
- Virginia Christine - Marge
- Joe Maross - Ray Kenton
- Sidney Blackmer - Edward Stapleton
- James Westerfield - Al Matthews
- Gregory Gaye - The President
- Robert Ellenstein - Dr. Brauner
- Gale Robbins - Mary Jerold
- Jim Bannon - The Police Lieutenant
- Frieda Inescort - De Chantenay's Mother
- William Schallert - Prof. John MacFarland ('Friend of the Dead')
- Edgar Buchanan - Doc O'Connor
- Phyllis Thaxter - Ursula Sommerville
- John Fiedler - Herbert Bleake
- Richard Long - Dick Farrington
- Edmon Ryan - Capt. Pete Jago
- Mary Grace Canfield - Ally Rose
- Mary Grace Canfield - Celia Perry
- Reginald Owen - The Hussar ('A Terribly Strange Bed')
- Charles Aidman - George Mikos
- Charles Aidman - Jerry Welch
- Ron Ely - Lt. Mike Hudson
- Virginia Gregg - Edna Leggett
- Howard Morris - Myron Sills / Dr. Wilfred Bliss
- Robert Middleton - Monsieur de Paris
- Robert Middleton - Ohrback
- Abraham Sofaer - Gus Kostopulos
- Abraham Sofaer - Nicolai
- Robert Lansing - Lieutenant Brian Rome
- Scott Marlowe - Julian Boucher
- Richard Anderson - Oliver Judson
- George Mitchell - Doc Mulloy
- George Mitchell - Sheriff Pete Browning
- Donna Douglas - Laura Bellman
- Burt Mustin - The Redcap
- Robert Vaughn - Dr. Frank Cordell
- Hayden Rorke - Dr. Frank
- Paddi Edwards - The Nurse
- Robert Colbert - Capt. Bartolomeo Antonio Fernandez
- Constance Ford - Louise Jenkins
- Constance Ford - Connie Walworth
- Billy Barty - Sam
- Jon Lormer - Undetermined Role (credit only)
- Stanley Adams - Mr. Schwenk
- Frank Silvera - Cesare Romano aka Charlie Roman
- Parley Baer - Fisherman on Mountain
- James Gregory - Howard Yates
- K.T. Stevens - Virginia Grant
- K.T. Stevens - Olive Guthrie
- Robert H. Harris - Jerry Roberts
- Tom Nolan - Hank Hattering
- Tom Nolan - Rennie Harrod
- Glenn Strange - Indian (scenes deleted)
- Victor Sen Yung - Bartender
- Paul Hartman - Uncle Gregory Stafford
- Elizabeth Allen - Liz Talmadge
- Elizabeth Allen - Dorothy Lyndon
- Willis Bouchey - Lt. Farnham
- Werner Klemperer - Mr. Clark
- Hal Baylor - Pete Gogan
- Robert Webber - Arthur Henshaw
- Lloyd Bochner - Prof. Harry Langham
- Patricia Medina - Nadja
- Patricia Medina - Victorine Lafourcade
- Lillian Bronson - Adelaide Leggett
- George Kennedy - John Paterson
- Jack Lambert - Lem Carta
- Philip Ober - Elmer Hooper
- Philip Bourneuf - Dr. Weatherbee
- Ruth Warren - Mrs. Rooney
- John Williams - Sir Guy
- Antoinette Bower - Annette Jacquelin
- Antoinette Bower - Sheila Corbett
- Danielle De Metz - Babette Lamont
- Kasey Rogers - Anthea Jason
- Jack Weston - Edward Dean
- Jack Weston - Maurice Reynard
- Elisha Cook Jr. - Harry Elser
- Bethel Leslie - Gale Hattering
- Bethel Leslie - Ann Merriweather
- Kathleen Crowley - Dr. Lois Walker
- Kevin Hagen - Sgt. Spivak
- Kevin Hagen - Arno Lunt
- Milton Parsons - Butler
- Denver Pyle - Ortho Wheeler
- William Windom - Lou Walters
- Diana Millay - Ellen McKinstry
- Mary Astor - Rose French
- James Seay - Herb Innes
- Peter Leeds - Larry (uncredited)
- Sean McClory - Patrick Galt
- Sean McClory - Sean O'Danagh
- Shepperd Strudwick - Douglas Kilburn
- Jeanne Cooper - Ethel Bankstrom
- Irene Hervey - Mrs. Edith Pettit
- William Allyn - Randy Hagen
- Guy Mitchell - Detective Hazlett
- Anthony Caruso - Johnny Longo
- John Carradine - Jed Carta
- John Carradine - Jason Longfellow
- Joe De Santis - Col. Sangriento
- John Newland - Robertson Moffat (uncredited)
- John Newland - Ellis Corbett
- Frank De Kova - Lieutenant Vincoli
- Warren Oates - Benny
- Warren Oates - Hugo Wheeler
- Oscar Beregi Jr. - Rev. Burkhardt
- Alejandro Rey - Robert Lamont
- Alejandro Rey - Tonio Bellini
- Jody Fair - Helen Weeks
- Howard Freeman - Jared Leggett
- Maurice Dallimore - George Griffith
- Maurice Dallimore - Bokor
- Michael Pate - Shanner ('The Mask of Medusa')
- Clegg Hoyt - Kyle
- Gil Perkins - Eddie
- Gil Perkins - Mechanic
- Vladimir Sokoloff - Papa Glockstein
- Vladimir Sokoloff - The Janitor
- Marion Ross - Kay Forrest
- Will Wright - Constable Tom Walker
- Jocelyn Brando - Myrtle Hooper
- Jocelyn Brando - Emma Snyder
- James Griffith - Ed Brandies
- James Griffith - Victor Harrod
- Tommy Farrell - The Messenger
- Jane Greer - Ann Moffat
- Jack Livesey - Haley Dalloway
- Chubby Johnson - Charlie Pringle
- Frank Albertson - Charles Salisbury
- George Grizzard - Merle Jenkins
- Audrey Dalton - Meg O'Danagh Wheeler
- Audrey Dalton - Norine Burton
- Audrey Dalton - Nesta Roberts
- Anne Seymour - Aunt Hortense Stafford
- Alan Napier - Attorney Pinchot
- Alan Napier - Lawyer Ridgewater
- Alan Napier - Constable Evans
- Hazel Court - Leonie Vicek
- Grandon Rhodes - Judge Pfluger
- Edgar Dearing - The Police Sergeant
- Alan Caillou - Roscoe Burton
- Alan Caillou - Sir Wilfred
- Alan Caillou - Police Superintendent
- Everett Sloane - Lou Adams
- Rachel Ames - Betty Follett
- Booth Colman - Lieutenant Bailey
- Steve Brodie - Sgt. George Dumont
- Terence de Marney - Uncle Julian ('The Extra Passenger')
- Terence de Marney - Amos Wilder
- Alan Baxter - Sergeant Dane
- Alan Baxter - Sheriff Phil Archer
- John Anderson - Jacob Grant
- John Abbott - Kriss Milo ('The Mask of Medusa')
- Iphigenie Castiglioni - Madame Roberti
- Walter Reed - Police Sgt. Burke
- John van Dreelen - Joel Stone
- Mala Powers - Consuelo De La Varra
- Dayton Lummis - Clarence Kramer
- Dayton Lummis - Millard Braystone
- Robert Osterloh - Capt. Greer
- William Shatner - Paul Graves
- William Shatner - Gil Thrasher
- Peter Brocco - Prof. Thibault
- Peter Brocco - Major Domo ('A Terribly Strange Bed')
- Peter Brocco - Padre Herrera
- Peter Brocco - The Assistant Director
- Mildred Dunnock - Miriam Olcott
- Harry Bartell - Mr. Dalquiss
- Eduardo Ciannelli - Gen. De La Varra
- Eduardo Ciannelli - Inspector Le Boude
- Edward Binns - Lt. Giddeon
- Mona Freeman - Sylvia Walsh
- Nan Leslie - Midge Lewis
- Delores Wells - Flo
- Pepe Hern - Lt. Contreras
- William Phipps - Harry Laxer
- Richard Lupino - Simon ('The Extra Passenger')
- Ellen Corby - Mrs. Peele
- Jeanette Nolan - Granny Harrod
- Jeanette Nolan - La Strega
- Edward Andrews - Maynard Thispin
- Edward Andrews - Frank Logan
- Edward Andrews - Miles Tundifer
- Howard McNear - Jack Passasstroy
- Noel Drayton - Superintendent ('The Mask of Medusa')
- Lane Bradford - Boles
- Ronald Howard - Dr. Edward Stone
- Ronald Howard - Martin Gresham
- Ronald Howard - Robert Penrose
- June Kenney - The Girl
- Myrna Fahey - Alice Page
- Henry Jones - Erik Borg
- Henry Jones - Carl Somers
- Bart Patton - Joe
- Harry Ellerbe - Walter Devon
- Fay Bainter - Geraldine Redfern
- Conrad Nagel - Mayor Walker Wylie
- Ken Renard - Jacob Blunt
- David Whorf - Johnny Banner
- Guy Wilkerson - Howard
- Ottola Nesmith - The Zuvembie, Eula Lee Blassenville
- Bernard Fein - I.L. Gluckman
- Bernard Fein - Lester Clyne
- Bernard Fein - Stage Manager
- Sandy Kenyon - Mason
- Victor Buono - Carolik
- Victor Buono - Dr. Van de Velde
- Vaughn Taylor - Uncle Philip Landers
- Vaughn Taylor - Pontifex Tundifer
- Louis Mercier - Monsieur Armand
- Louis Mercier - The Wall Guard
- Henry Daniell - Count Alexander Cagliostro
- Henry Daniell - Pierre Radin
- Henry Daniell - Vicar John Weatherford
- Henry Daniell - Squire Moloch
- Henry Daniell - Dirk Van Prinn
- Reggie Nalder - Gafke
- Reggie Nalder - Andrew Bentley
- Ed Nelson - Brundage
- Ed Nelson - Charlie
- Ed Nelson - Tom Ellison / Daniel Le Jean
- Richard Reeves - Truck Driver (uncredited)
- Richard Reeves - Patrolman
- Richard Reeves - Truck Driver
- Paul Newlan - Sgt. Bernstein
- Paul Newlan - Paul Hawkins
- Paul Newlan - Sheriff Tom Ulysses Willetts
- Paul Newlan - Joe Henshaw
- Walter Burke - Croxton
- Walter Burke - Lucas
- Doris Lloyd - Dame Alice
- Doris Lloyd - Landlady
- Doris Lloyd - Mother Evans
- Doris Lloyd - Mrs. Edith Pringle
- Linda Watkins - Sylvia Slattery
- Linda Watkins - Arabella Foote
- Linda Watkins - Maggie Henshaw
- Mary Tyler Moore - Sherry Smith
- Mary Tyler Moore - Mary Snyder
- Clem Bevans - Obed
- Clem Bevans - The Old Gaffer
- Lin McCarthy - Frank Clyde
- Lin McCarthy - Peter Duncan
- Joyce Bulifant - Jinny Wells
- Jack Gordon - Arab (uncredited)
- Fred Graham - Sgt. Hannigan
- Fred Sherman - Doctor
- J. Pat O'Malley - The Morgue Attendant
- J. Pat O'Malley - Street Singer
- J. Pat O'Malley - First Pub Patron
- Hal Taggart - Spectator at Inquest (uncredited)
- Cyril Delevanti - The Old Man
- Ron Harper - Younger Thug
- Sol Gorss - George Adams
- Eddie Hice - Barfly (uncredited)
- Stuart Randall - Sgt. Crowell
- Stuffy Singer - Art Brinkerhoff
- Olive Sturgess - Evie Bishop
- Isobel Elsom - Mrs. Purdy (uncredited)
- Michael St. Clair - Road Workman
- Dorothy Neumann - Ruthie Carta
- Andrew Prine - Young Lou (uncredited)
- Pat O'Malley - The Butler
- Sam Gilman - Police Lieutenant
- Gloria Blondell - Maggie Radevik
- Pamela Curran - Second Victim
- Pamela Curran - Gloria
- George Ford - Club Patron (uncredited)
- Marjorie Bennett - Mercedes
- Fletcher Markle
- Maxwell Shane
Jay C. Flippen hace el papel de Harry Gans.
Elisha Cook Jr. interpreta a Harry Elser en la serie.
James Griffith hace el papel de Victor Harrod.
John Qualen interpreta a Streetcar Conductor en la serie.
Percy Helton interpreta a Replaced (credit only) en la serie.
Vaughn Taylor interpreta a Pontifex Tundifer en la serie.
John Marley interpreta a Dr. Tony Romano en la serie.
Jessie Royce Landis hace el papel de Mrs. Kilburn.
Leo G. Carroll interpreta a Major Downey en la serie.
Philip Ober interpreta a Elmer Hooper en la serie.
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