- Adam Donshik - Fayez Ahmed / Tommy Smith
- Kelly Hu - Agent Mia Chen
- Marshall Allman - Teen Boy
- Derek Webster - Capt. Hanson
- Hira Ambrosino - Reporter
- Treva Etienne - Mr. Kumala - Airport Manager
- Megan Follows - Denise
- Jack Guzman - TAC Unit Member
- Sung Kang - Ray Lee
- Lombardo Boyar - Victor Benitez
- Leyna Nguyen - Reporter
- Courtney Ford - Staci
- Scott Paulin - Tom Shelby
- Griff Furst - Security Guard
- Kim Myers - Karen
- Steve Tom - News Anchorman
- Marina Sirtis - Dr. Nabila Hassan
- Sandra Hess - Simone Benoit
- Timothy Carhart - CSAF Scott
- Ian Paul Cassidy - Captain Barkley
- Edoardo Ballerini - Bobby DaCosta
- James Shigeta - Kang Sok-Joo
- Wayne Wilderson - Ellis
- Pasha D. Lychnikoff - Konstantin Noskeno
- Tamlyn Tomita - Special Agent Nicole Hill
- Aaron Paul - Shane
- Raja Fenske - Young Boy
- Julie Warner - Carrie Richmond
- Sherman Augustus - Sal Miller
- Karly Rothenberg - Mom in Van Explosion (uncredited)
- Paul Ganus - FBI Agent
- Patrick Bauchau - Frederick Vorn
- Will Yun Lee - Danny Roh
- Geoffrey Rivas - Juan Alcadar
- Denise Crosby - Gillian Sadler
- Andrew Hoeft - Young Heath Shelby
- Gary Weeks - State Policeman
- Jim Fitzpatrick - Camp Pendleton Security Chief Robert Burkehart
- Bobby Hosea - Kenneth Holmes
- Bennet Guillory - Army Surgeon
- Wade Williams - Teddy
- Alice Krige - Senator Lily Randolph
- Michael Dempsey - Coach Sadler
- Corbin Allred - Pvt. Perry
- Marc Casabani - Ham Bali
- John Bennett Perry - Senator Otto
- James Kyson - Vargas Killer
- Colby French - Journalist
- George Perez - Perro
- Terry Maratos - Sheriff
- Joan McMurtrey - Laura Shelby
- David Vincent - Clerk
- Sean Hannity - Self
- Dendrie Taylor - Waitress
- Andre Ware - Vorn's Bodyguard
- Kathleen Luong - Min-Young
- Rodney Eastman - Billy
- Brandon Barash - Marine#1
- Brian Evers - Senator Casper
- Maz Jobrani - Yousef
- Liane Curtis - Counter Waitress
- Dar Dixon - Detective Fawk
- Tiiu Leek - Newscaster
- Kortney Manns - Terrorist #1
- Dahlia Salem - DEA Agent Maria Cruz
- Mary Strong - Reporter #2
- Matthew Sullivan - Reporter #1
- Paul Webster - Detective Joe Miller
- Marcus Coloma - Checkout Clerk
- Shoshannah Stern - Holly Brodeen
- Larry Bagby - Silo Tech
- Darion Basco - Teen Terrorist
- Danny Chambers - Highway Patrolman
- Nathan Chew - Security Guard
- Gregg Daniel - General Tucker
- Brad Greenquist - Radenmacher
- Brittany Haid - Police Officer
- Teddy Lane Jr. - Secret Service
- Fred Maske - Security Guard
- Christopher Michael - Exchange Guard
- E. Roger Mitchell - Silo Tech
- Clifford A. Pellow - Gas Station Owner
- David Rountree - Broker
- Kristen Shaw - Journalist
- Janet Song - Journalist
- Matthew Yang King - Broker
- Kurt Caceres - Tim Vargas
- Matthew Jones - Border Guard
- Eloy Méndez - Field Worker
- Wells Rosales - Field Worker
- Brooks Almy - Hannah's Mother
- Nancy Anderson - Old Lady
- Loanne Bishop - Doctor
- Henry Brown - Baggage Handler
- Juan Carlos Cantu - Baggage Supervisor
- Kyle Davis - Joe
- Donna M. Duffy - Nurse
- Brent Hinkley - Bartender
- Jamie Anne Allman - Hannah McLoughlin
- Charles Howerton - Sheriff
- Marina Palmier - Mayor
- Ray Proscia - Man in Black
- Jared Farid Ward - Paramedic
- Michael Aronov - Amir Abadiyah
- Andrew Cappelletti - Andrew Jefferson Prokop
- Veralyn Jones - Nardino
- Jimmy Marriot - Arab Teen
- Michael Massee - Campbell Prokop
- Albert Owens - Skouras
- Russell Sams - Trevor
- Mark Arnold - Reporter
- Wanda-Lee Evans - Hotel Manager
- Bashir Salahuddin - Tower Supervisor
- Joseph Stephens Jr. - Airport security guard
- Diana Burbano - Customs Officer
- Neil Colin - Dark-haired Man
- Jean-Christophe Febbrari - The Assassin
- Mark Ivanir - Alpha-126
- Roman Mitichyan - Drug dealer
- Gregory Silva - Bellman
- Lorraine Toussaint - Carina Wright
- Lorraine Toussaint - NSA Agent Hodges
- Edward Edwards - Major
- Ron Morehouse - Heath Shelby
- Michael Rothhaar - Ben Tupper
- Phil Valentine - Talk Show Host (voice)
- Raff Anoushian - Garbis
- Frank Crim - Armed Courier
- Christopher Goodman - Ralph
- Gunther Jenson - Melvin Pomeroy
- Peter J. Lucas - Oleg Kretzin
- Patrick O'Connor - Coroner
- Steven Petrarca - Agent Adam Anders
- Damara Reilly - Gail Hopper
- Dean Shelton - Austin
- James Castle Stevens - FBI Agent Crawford
- Joe Wandell - TAC Unit Leader
- Aldo Ceceña - Teenage Hostage
- Al Coronel - Manuel Gonzales
- Cristián de la Fuente - Special Agent Wilmar Sanchez
- Efrain Figueroa - Ambassador Guzman
- Mike Moroff - General Mendoza
- Diego Serrano - Martin Quintero
- Armando Valdes-Kennedy - Vega
- Yun Choi - Bartender
- Brian Imada - Asian Kidnapper
- Steve Kim - Asian Kidnapper
- James Sang Lee - The Man
- Tina Lifford - The female pathologist
- Tom Yi - Korean Aide
- Jerry T. Adams - Courtroom Bailiff
- Nicholas Guilak - Sam Bari
- Cazimir Milostan - Military Police
- Navid Negahban - Fred
- Kevin Sizemore - Coast Guard Lieutenant James
- Scott Vance - Daniel Hemming
- Tessa Vonn - Laila
- Mark Adair-Rios - Ahmed Ali Al Muhairi / Domingo Vara
- Yareli Arizmendi - Ephia Rasekh
- Melody Butiu - Raza's Wife
- Michael Emanuel - White Al Qaeda / Holst
- Currie Graham - Agent Daley
- Robert Hallak - Suryan Reza
- Henry Maguire - Ned Whitte
- Steve Monroe - Billy
- Leonard Roberts - Tom Purdy / Ibrahim Kureshi
- William-Christopher Stephens - Guard
- Sam Vance - Tech
- John Bishop - Man
- Jerry Brennan - Security Guard
- Joe Bucaro III - Bob Colt
- Eugene A. Clark - Honorable Justice Lamb
- Michele Greene - Anne Colt
- Chris Hendrie - Mr. Packer
- Buddy Joe Hooker - Andy Wader
- Wayne Mitchell - DC Police
- John Rixey Moore - Senator Penzler
- Saul Rubinek - Peter Tomashevski
- Nestor Serrano - Senator Martin Cabrera
- Yaniv Sharon - German Phone Caller
- Heidi Sulzman - Judy Correy
- Yoni Tabac - Paul West
- Edward C. Gillow - CIA Agent
- Jim Lau - Pilot
- Eddie Mui - Khmer Tep
- Leon Russom - Ray Miller
- Jeanne Sakata - Dara Tep
- Dollar Tan - (voice)
- Emile B. Levisetti
- Michael Edelstein
- Daniel Voll
- James D. Parriott
- Keith Addis
James Denton interpreta a John Kilmer en la serie.
Kelly Rutherford interpreta a Frankie Ellroy-Kilmer en la serie.
Will Lyman interpreta a Roger Atkins en la serie.
Kurt Caceres interpreta a Tim Serrano en la serie.
Mahershala Ali hace el papel de Jelani Harper.
Melora Walters interpreta a Anne 'Lark' Larkin en la serie.
Anthony Azizi hace el papel de Mohammad 'Mo' Hassain.
Shoshannah Stern interpreta a Holly Brodeen en la serie.
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