- Don Diamont - Brad Carlton
- Kristoff St. John - Neil Winters
- Darcy Rose Byrnes - Abby Newman (young)
- Kimberlin Brown - Sheila Carter
- Kate Linder - Esther Valentine
- Christian LeBlanc - Michael Baldwin
- Jess Walton - Jill Abbott
- Cait Fairbanks - Tessa Porter
- Tracey E. Bregman - Lauren Fenmore Baldwin
- Eric Braeden - Victor Newman
- Bronson Pinchot - Patrick Dalton
- Matthew Atkinson - Austin Travers
- Amy O'Neill - Molly Stark
- Annalisa Cochrane - Zoey
- Janzy Paraiso - Leah
- Jason Canela - Arturo Rosales
- Sasha Calle - Lola Rosales
- Jerry Douglas - John Abbott
- Brenda Epperson - Ashley Abbott Newman
- Veronica Redd - Mamie Johnson
- Quinn K. Redeker - Rex Sterling
- Camryn Grimes - Cassie Newman
- Peter Barton - Dr. Scott Grainger
- John Castellanos - John Silva
- Jeanne Cooper - Katherine Chancellor
- Michael Corbett - David Kimble
- Beau Kayser - Brock Reynolds
- Nathan Purdee - Nathan Hastings
- Victoria Rowell - Drucilla Barber
- Tonya Williams - Dr. Olivia Barber Hastings
- Brenda Dickson - Jill Foster
- Kenley Smyth - Little Ashley
- Melody Thomas Scott - Nikki Newman
- Amelia Heinle - Victoria Newman
- Peter Bergman - Jack Abbott
- Tricia Cast - Nina Webster
- Lauralee Bell - Christine Blair Williams
- Beth Maitland - Tracy Abbott
- Adrienne Frantz - Ambre Moore
- Davenia McFadden - Lorena Davis
- Nick Meaney - Laird Worthington
- Mary Wickliffe - Valerie Greer
- Catherine Carlen - Agnes
- Carlease Burke - Prison Official
- Sheryl Underwood - Claire Collins
- Jeanette O'Connor - Miranda
- Millena Gay - Maid
- J.R. Cacia - Detective Harvey
- Jhoanna Flores - Adriana Stone / Adriana
- Lisa Costanza - Army Colonel
- Lachlan Buchanan - Kyle Abbott
- Arena Marissa - Marissa Barton
- Tristan Lake Leabu - Reed Hellstrom
- Cathy Marks - Young Dina
- Raven Wynn - Teen Girl
- J. Anthony Pena - Technician
- Ana Dela Cruz - Meredith
- Margarita Franco - Mrs Martinez
- Hartley Sawyer - Kyle Abbott
- Marvin Jordan - Cop
- Jack Briggs - Alan
- Hayes Mercure - Firefighter
- Alice Greczyn - Emma Randall
- Jason Heymann - Minister
- Michael Masini - Tony Kingsman
- Susan Angelo - Clare Sumner
- James Michael Gregary - Clint Radison
- Brad Slaight - Izzy Adams
- Patty Weaver - Gina Roma
- Nina Arvesen - Cassandra Rawlins
- Michael Bofshever - Dr. Hedges
- Sienna Mercuri - Katherine Abbott Newman
- Kendra Slaubaugh - Self
- Marla Adams - Dina Abbott Mergeron (voice)
- Krista Slaubaugh - Self
- Holden Hare - Johnny Abbott
- Ryan Hare - Johnny Abbott
- Cristina Serafini - Angelina Marchetti
- John McCook - Eric Forrester
- Elizabeth Leiner - Tara Locke
- Sean Carrigan - Ben Rayburn
- Telma Hopkins - Denise Tolliver
- Kellen Enriquez - Harrison Locke
- Janice Lynde - Leslie Brooks
- Hunter King - Summer Newman
- Jack Landron - Sutton Ames
- Ptosha Storey - Naya Benedict
- Tessa Bartholomew - Marty
- Jamison Jones - Jesse Gaines
- Roxanne Hart - Kim Dunaway
- Jacob Aaron Gaines - Moses Winters
- Eileen Davidson Van Patten - Ashley Abbott
- Diane Behrens - Louise
- Judah Mackey - Connor Newman
- Michael Mealor - Kyle Abbott
- Judith Chapman - Gloria Abbott Bardwell
- Micah Tayloe Owens - Trick or treater (uncredited)
- Richard Burgi - Ashland Locke
- River Ware - Dominic Chancellor
- Rainn Ware - Dominic Chancellor
- Leigh-Ann Rose - Imani Benedict
- Tish Daniels - Dr. Alston
- Elizabeth Sung - Luan Volien Abbott
- Mishael Morgan - Amanda Sinclair
- Melissa Ordway - Abby Newman Chancellor
- Joshua Morrow - Nicholas Newman
- Reylynn Caster - Faith Newman
- Sharon Case - Sharon Rosales
- Rory Gibson - Noah Newman
- Gabriella Hart - Cindy
- Bryton James - Devon Hamilton
- Jason Thompson - Billy Abbott
- Melissa Claire Egan - Chelsea Lawson
- Christel Khalil - Lily Winters
- Elizabeth Hendrickson - Chloe Mitchell
- Sean Dominic - Nathan Hastings
- Brytni Sarpy - Elena Dawson
- Greg Rikaart - Kevin Fisher
- Jordi Vilasuso - Rey Rosales
- Conner Floyd - Chance Chancellor
- Jeremiah Jahi - Dr. Huffman
- Courtney Hope - Sally Spectra
- Mark Grossman - Adam Newman
- Michelle Stafford - Phyllis Summers Newman
- Robert Newman - Ashland Locke
- Kelsey Wang - Allie Nguyen
- Susan Walters - Diane Jenkins
- Morgan Obenreder - Crystal Porter
- Allison Lanier - Summer Newman Abbott
- Sam McMurray - Dwight
- Sharon Case - Sharon Rosales
- Antione Grant - Shawn Giancarlo
- Natalie Morales - Talia Morgan
- Denise Boutte - Imani Benedict
- Sean Kanan - Deacon Sharpe
- Zuleyka Silver - Audra Charles
- Trevor St. John - Tucker McCall
- Paxton Mishkind - Johnny Newman
- Robby Descant - Patron
- Tom Virtue - Henry Aldridge
- James Hyde - Jeremy Stark
- Paul Walker - Brandon Colins
- Anna Khaja - Dr. Malone
- Michael Graziadei - Daniel Romalotti
- Marilyn Bass - Glam Club Hostess
- Mo Rocca - Milton
- Edd Hall - TV News Reporter (voice)
- Ryan Mitchell - Patron
- Jonas Fisch - Kent Grazier
- Bayley Corman - Summer Newman
- Matthew Stephen Smith - Bartender
- Keith Carlos - Danny
- Judy Kain - Judge McGarrett
- Noel Gugliemi - Drug Dealer
- Nayo Wallace - FBI Agent Ryerson
- Burt Bulos - Manny
- Corbett Tuck - Kelly
- Michael Nouri - Elliot Hampton
- Randy Robbins
- Heather Hill
- Mike Denney
- Owen Renfroe
- Michael Eilbaum
- Steven Williford
- Kay Alden
- John F. Smith
- Jerry Birn
- Linda Schreiber
- Sara A. Bibel
- Natalie Minardi Slater
- Nancy Nayor
- Edward Scott
- Nancy Wiard
- Matthew J. Olsen
- Jonathan FIshman
- Vivian Gundaker
- Smokey Westerfield
- Mark Mooney
- Joe Lawrence
- Mike Dobson
- RC Cates
Doug Davidson interpreta a Paul Williams en la serie.
Tammin Sursok interpreta a Colleen Carlton en la serie.
Sean Young hace el papel de Meggie McClaine.
Linden Ashby interpreta a Cameron Kirsten en la serie.
Laura Bryan Birn hace el papel de Lynne Bassett.
Jason Olive hace el papel de Dr. Isaiah Jones.
Anne Betancourt interpreta a Estella Munoz en la serie.
Don Diamont hace el papel de Brad Carlton.
Kristoff St. John interpreta a Neil Winters en la serie.
Darcy Rose Byrnes interpreta a Abby Newman (young) en la serie.
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