- Bruce Weitz - Art Blankey
- Nancy O'Dell - Nurse Lisa
- Paul Gleason - Principal Squires
- Lisa Darr - Angela Nichalos
- Marcy Goldman - Maitre d'
- Bradley James - Mark
- Michael Monks - Clown
- John O'Hurley - Mr. Bill Erlicht
- Shirley Prestia - Secretary
- David Reivers - Bystander
- Samantha Smith - Hannah
- Travis Wester - Wayne
- Brian McLaughlin - Young Jack
- Emmett Shoemaker - Young Larry
- Matt Battaglia - Dan
- Kate Walsh - Stace
- Elaine Hendrix - Jamie
- Charlton Heston - Charlton Heston
- Paula Marshall - Katie
- Heidi Klum - Annika
- Deena Dill - The Blonde
- Kathleen Marie Archer - Barb
- Amber Collins - Sandy
- Lisa Dinkins - Nurse
- Melissa Paull - Candy Striper
- Jackie Debatin - Stephanie
- Ian Meltzer - Kid
- Jack Salvatore, Jr. - Kid in Wheelchair
- Steve Keyes - Volunteer
- Anthony Edwards - Ricky
- Andrea Bendewald - Lucy Keith
- Lori Loughlin - Natalie Keith
- Whoopi Goldberg - Whoopi Goldberg
- Kevin Ruf - Waiter
- Eben Ham - Businessman
- Simon Helberg - Andy Tinker
- Spencer Garrett - Jim
- Jane Lynch - Carla
- Kali Rocha - Sophie
- Wendy Davis - Alice Fullmer
- Adam Gregor - Vladimir Gogol
- Richard Libertini - Dr. Saul Weitzman
- Alex Veadov - Sergei
- Max Baker - Simon
- Meeghan Holaway - Woman
- Jim Jenkins - Gentleman
- Rena Sofer - Dawn Cheswick
Jane Lynch interpreta a Carla en la serie.
Kate Walsh interpreta a Stace en la serie.
Capítulo disponible en las siguientes plataformas:
