- Paula Jai Parker - Mia
- Eric Saiet - Matty
- Shari Headley - Dawn
- V.P. Oliver - Timmy
- Thea Vidale - Big Mama
- Beverly Johnson - Miss Kika
- Kim Wayans - Sheila
- Jaime Cardriche - Huge
- Esther Scott - The ER Nurse
- Clyde Kusatsu - Mr. Mitsumoto
- Stack Pierce - Captain Strawn
- Antonio Fargas - Uncle Nate
- Meta Golding - Gina
- Erik Estrada - Erik Estrada
- Iona Morris - Carmella
- Kene Holliday - Harold
- Amy Hunter - Tracy
- Sandra Ellis Lafferty - Mrs. Gibbs
- Fred Willard - Dick Ferndale
- Reynaldo Rey - Preacher
- Ajai Sanders - Amber
- Nika Futterman - Assistant
- Brook Kerr - Hostess
- Monica Calhoun - Vanessa
- James A. Watson, Jr - Greg
- Orlando Brown - Charlie
- Dionne Warwick - Mrs. Jackson
- Bill Cobbs - Fred Watson
- Tammy Townsend - Amy
- Tamala Jones - Wanda
- Ron O'Neal - Sergeant Scully
- Carmen Filpi - Officer Young
- Pat Harrington, Jr. - Mr. Neidermeyer
- T.J. Thyne - Steve
- Crystal Scales - Woman
- David Leisure - Bud Masada
- Todd Susman - Mr. Ennis
- Nelson Mashita - Japanese Buyer
- Michael Winters - Mr. Crump
- Roy Jones Jr. - Roy Jones Jr.
- Frank Novak - Contractor
- Ronnie Schell - Councilman Ted McKay
- Missy Elliott - Missy Elliott
- Phill Lewis - T.C.
- Gary Coleman - Gary Coleman
- Bern Nadette Stanis - Thelma Evans
- Nick Spano - Rico Davinci
- Paula Abdul - Sasha
- Lawrence Hilton-Jacobs - Richie
- Dee Jay Daniels - Young Marlon
- Richard Whiten - Kenny
- Garcelle Beauvais - Rachel
- Tracey Cherelle Jones - J'Leeta
- Elise Neal - Tanya Cooper
- Joel Brooks - Archibald
- Gretchen Palmer - Sylvia
- Shirley Hemphill - Coco
- Gloria Gaynor - Gloria Gaynor
- Kym Whitley - Phyllis
- Idalis DeLeon - Sandra
- Beau Billingslea - Mr. Kellog
- Samaria Graham - Dion
- Helen Martin - Mother Evans
- Tim Choate - Patient
- Mike Hagerty - Stage Manager
- Mike Hagerty - Brazilla
- Paul Bates - The Customer
- Paul Bates - Burl
- Rolando Molina - Orson
- Ivelka Reyes - Jane
- Constance Zimmer - Vanessa
- John Capodice - The Detective
- Jazzmun - Albert / Alberta
- Rick Ducommun - Bernie
- Bibi Osterwald - Saleslady
- Jessica Hecht - Agent Johnson
- Jazsmin Lewis - Lena
- Jesse Burch - Bearded Man
- Roxanne Beckford - Stacey
- Roxanne Beckford - Charlene
- Dominique Jennings - Ina
- Kenny Lofton - Kenny Lofton
- Joe Lisi - Officer
- Michael Clarke Duncan - Big Mike
- Essence Atkins - Nina
- Paul Willson - Councilman Peters
- Bruce French - Mr. Peterman
- Radmar Agana Jao - Waiter
- Rif Hutton - Agent Doug Steckler
- Dona Hardy - Letitia Benton
- Clayton Prince - Otis Campbell
- Adam West - TV Host
- Phil Morris - Parker
- Michael Ensign - Lloyd
- Heidi Lucas - Toni Jackson
- Cleo King - Ethel
- Cal Gibson - Man
- Kent King - Chrissy
- Busta Rhymes - Busta Rhymes
- Ken Weiler - Customer
- Earl Billings - Rick
- Adrienne Barbeau - Trish Neidermeyer
- Keith Sweat - Keith Sweat
- Keith Sweat - Travis / Self
- Gary Beach - Ken
- Barney Martin - Santa
- Tucker Smallwood - Lionel Cooper
- Andre Jamal Kinney - Walter
- Johnny Brown - Bookman
- Johnny Brown - Maurice
- Jim Fyfe - Monty
- Dorian Gregory - Dr. Peters
- Jack Plotnick - Ted
- Jennifer Leigh Warren - Jennifer
- Mitch Mullany - White Mike
- Dan Martin - Cop
- Andre Rosey Brown - Black Caesar
- Alan Young - Reverend Benton
- Pam Grier - Erica
- Andrew Hill Newman - Jason
- Marianne Muellerleile - Nurse Benson
- Melissa De Sousa - Charmaine
- Bebe Drake - Ms. James
- LaRita Shelby - Customer
- Kellita Smith - Claire
- Cheryl Hines - Helen
- Candace Kita - April
- Jeremy Suarez - Dexter
- Lillian Lehman - Judge Marshall
- Sherman Hemsley - Mr. Stone
- Marc Gomes - Roland Grant
- Donna Pieroni - Madge
- Faizon Love - Nigel Lovejoy
- Brent Barry - Brent Barry
- Mary-Pat Green - Mildred
- Richard Roundtree - Dr. Saunders
- Nicholas Kadi - Rasaan
- Angela Nicholas - Dr. Leveau
- Gregory White - Mr. Morton
- Kimberly Brooks - Simone
- Billy Van Zandt
- Jane Milmore
Rick Ducommun hace el papel de Bernie.
Marianne Muellerleile hace el papel de Nurse Benson.
Paul Bates interpreta a Burl en la serie.
Sandra Ellis Lafferty interpreta a Mrs. Gibbs en la serie.
Pam Grier interpreta a Erica en la serie.
Clyde Kusatsu interpreta a Mr. Mitsumoto en la serie.
Shawn Wayans hace el papel de Shawn Williams.
Marlon Wayans hace el papel de Marlon Williams.
Anna Maria Horsford interpreta a Deirdre 'Dee' Baxter en la serie.
John Witherspoon interpreta a John 'Pops' Williams en la serie.
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