- Eric Scott - Ben Walton
- Kami Cotler - Elizabeth Walton
- Joe Conley - Ike Godsey
- Judy Norton - Mary Ellen Walton
- Stacey Nelkin - Mary Frances Conover
- Michael O'Keefe - Chad Marshall
- Helen Page Camp - Allie
- Richard Gilliland - Arlington Wescott 'Jonesy' Jones
- Jonathan Frakes - Ashley Longworth Jr.
- Brion James - Henry Ferris Jr.
- Richard X. Slattery - Clyde "Preacher" Harroway
- Dean Jagger - Professor Bowen
- Ed Lauter - Hyder Rudge
- Ned Beatty - Curtis Norton
- Jack Ging - Stuart Henry
- Wilford Brimley - Horace Brimley
- Lloyd Nolan - Cyrus Guthrie
- Lynn Hamilton - Verdie Grant Foster
- Moosie Drier - Georgie
- Barbara Tarbuck - Saleslady
- Walter Brooke - Mr. Clarence Johnson
- Billie Bird - Mrs. Cox
- Sheila Allen - Fanny Tatum
- Dorothy Shay - Thelma
- Britt Leach - Easy Jackson
- Robert Donner - Yancy Tucker
- James Gammon - Zack Rosswell
- Bruce Davison - Bob Hill
- Robert Sorrells - Older Son
- John Ritter - Rev. Matthew Fordwick
- John Ritter - Rev. Ezekiel L. Henshaw
- Mary Jackson - Emily Baldwin
- Beulah Bondi - Martha Corinne
- Lucille Benson - Tilly Shanks
- Deirdre Lenihan - Daisy Garner
- Diana Douglas - Mrs. Denman
- Rance Howard - Dr. McIvers
- Don 'Red' Barry - Deputy Sheriff
- Jennifer Jason Leigh - Kathy Seals
- Art Gilmore - Newscast Announcer (voice)
- Art Gilmore - Radio Announcer (voice)
- Art Gilmore - The Radio Announcer (voice)
- Art Gilmore - Radio Host (voice)
- Cindy Eilbacher - Martha Rose Coverdale
- John Crawford - Sheriff Ep Bridges
- Victor Izay - Dr. Matthew Vance
- Doreen Lang - Mrs. Baker
- Sandy Kenyon - Willis
- Helen Kleeb - Mamie Baldwin
- Bettye Ackerman - Belle Becker
- Lynn Carlin - Sara Griffith Bridges
- Paul Fix - Senator Lucas Avery
- George DiCenzo - Calvin Satterfield
- Michael McGreevey - Hobart 'Hobie' Shank
- Arthur Franz - Police Chief Moresdale
- Hal Williams - Harley Foster
- Garry Walberg - Mr. Will Guffy
- Shawn Shea - Norma Lee
- Scott McCartor - Beaumont
- Hank Stohl - Radio Announcer / The Lieutenant
- Jonathan B. Woodward - Young Boy (as Jonathan Woodward)
- Jack O'Leary - Mac
- Bill Erwin - Senator Rogers
- Greg Mabrey - Bellhop
- Bob Stephens - Robber #1
- Richard Kelton - Anson Collier
- Virginia Gregg - Mrs. Butterworth
- Lew Palter - Personnell Director
- Kip Niven - Rev. Tom Marshall
- Neva Patterson - Aunt Kate Grover Daly
- Dan Frazer - Col. Henry Brunson
- Len Wayland - Mr. Gentry
- Macon McCalman - Deputy Abe
- Macon McCalman - Deputy Sheriff
- Dorothy Neumann - Fanny Tatum
- Pippa Scott - Alvira Drummond
- Jean Allison - Louise Haines
- Ted Jordan - Carpenter
- Ted Jordan - Man at Bar
- David Doremus - George William 'G.W.' Haines
- Herbert Anderson - Mr. Bennett
- M. Emmet Walsh - David Fletcher
- Ed Call - Electric Company Man
- Audrey Christie - Zelda Maynard
- Ethelreda Leopold - Party Guest (uncredited)
- Ethelreda Leopold - Townswoman (uncredited)
- F. William Parker - Man #2
- Bill Quinn - Senator Burgess
- Mills Watson - Mr. Blake
- Pamela McMyler - Betty Howell
- Tom Bower - Dr. Curtis Willard
- Bob Harks - Church Member (uncredited)
- Warren Vanders - Ham Denby
- Bob Bralver - Robber #2
- Mike Lally - Counterman (uncredited)
- Noah Beery Jr. - Charlie Harmon
- Mariclare Costello - Mrs. Rosemary Fordwick
- John Karlen - Rev. Ezekiel L. Henshaw
- Jean Howell - Mrs. Lillian Spencer
- David Frankham - Neville Chamberlain (voice)
- Lee Rich
- Earl Hamner, Jr.
- Robert L. Jacks
- Jerry Goldsmith
George DiCenzo hace el papel de Calvin Satterfield.
M. Emmet Walsh interpreta a David Fletcher en la serie.
Brion James interpreta a Henry Ferris Jr. en la serie.
Jonathan Frakes hace el papel de Ashley Longworth Jr..
Doreen Lang interpreta a Mrs. Baker en la serie.
Ralph Waite hace el papel de John Walton Sr..
Jon Walmsley interpreta a Jason Walton en la serie.
Mary Beth McDonough hace el papel de Erin Walton.
David W. Harper hace el papel de Jim-Bob Walton.
Eric Scott hace el papel de Ben Walton.
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