- John Carroll Lynch - Joe York
- Richard Hamilton - Captain
- Robert Knepper - Alex Burton
- Lori Heuring - Laura Scott
- Jessica Tuck - Lawson
- Matt Clark - Monroe
- Turhan Bey - Rusha
- Charles Hallahan - Sheriff
- Walter Olkewicz - Ozzie Faulkner
- Richard Riehle - Principal Shinagel
- Steve Monroe - Steven
- Lucinda Jenney - Nadine Walden
- Tammy Lauren - Charlotte MacArthur
- Mary Mara - Magnolia Vale
- Harry Shearer - Louis Faraday
- Vanessa Zima - Melissa
- Rosemary Murphy - Tour Guide
- Sam Gifaldi - Stephen Burton
- Dennis Burkley - Louie
- Rosie Malek-Yonan - Maria
- Efrem Zimbalist Jr. - Wayland Scott
- Alonzo Bodden - Lt. Warren Reed
- Jill Remez - Dr. Patricia Ryan
- Dianne Turley Travis - Dr. Pauline Greenfield
- Adam Baldwin - Michael O'Ryan
- Adam Baldwin - Michael O'Ryan / Joe York
- Diana Bellamy - Mother
- Barbara Bain - Constance MacArthur
- Travis Wester - Young Vise
- Courtney Peldon - Donna
- Rachel Winfree - Nurse
- Ellen Bry - ER Doctor
- Jan Hoag - Nurse
- Chad Cox - Clerk
- Bruce French - Father Traylor
- Paul Raci - Dark Grey Suit
- Richard Cox - Asst. Director Grushaw
- Lola Glaudini - Constance MacArthur
- Amy Parrish - Betty York
- Michael Harney - Warden Burke
- Mary Carver - Winifred Quick
- Fred Pinkard - Beauregard Wilde
- Michael Haywood Norris - Sheriff Lonnie Parks
- Jack Rader - Randall Craig
- Eve Brenner - Hospital Administrator
- Sue Goodman - Neighbor
- Dominic Oliver - Benny
- Fred Saldone - Cop
- Don Brunner - Security Guard
- Scott L. Treger - Hazmat Man #2 (uncredited)
- Brooks Almy - Sheila Logan
- Darwyn Carson - ER Nurse
- Andre M. Johnson - Lt. Wayne (uncredited)
- Laurie Lathem - Sally Wickan
- Conrad Bachmann - Male Shadow
- Wendy Worthington - Female Shadow
- Glenn Taranto - FBI Agent
- Adam Biesk - David
- Burke Roberts - Tony
- David Sawyer - Guard
- Mark Newsom - Federal Prison Guard #2 (uncredited)
- Bill Morey - Henry Milton
- Jackie Debatin - Louise
- Paul Terrell Clayton - Military Policeman
- Michael Bacall - Carlo
- Marte Boyle Slout - Mother
- Scott Shaw - James (uncredited)
- Nicolas Surovy - Ben Proctor
- Christine Healy - Elaine Barker
- David Drew Gallagher - McNally
- Teddy Lane Jr. - Cop
- Thomas Newton - Young Ben Jordan
- Angela Miller - Young Elaine Barker
- Stephen Berra - Danny
- Tony Amendola - Thomas
- Larissa Laskin - Katherine
- Granville Ames - Sgt. Roberts
- Kenneth Ryan - Senator
- Chuck Sloan - Danny's Father
- Richard Lyons - NSA Lieutenant
- Judy Jean Berns - Member
- Wendy Gazelle - Ruth Burton
- Cynthia Mace - Congresswoman Wagstaff
- Gregg Almquist - Congressman Hamilton
- Eric Don - Young Jason
- Eric Don - Jason
- Michael O'Hagan - Dr. Howard Stein
- Judy Kain - Nurse
- Jon Cowart - Kid at birthday party (uncredited)
- Sam Anderson - Army General
- Charles Rahi Chun - Satcom Officer
- Greg Callahan - NSA General
- Sandra Thigpen - Security Guard
- Rob Elk - Father
- Matthew Bartilson - Glenn
- Nichole Pelerine - Sarah
- Chris Ufland - Soldier
- Ryan Christopher Keys - Agent Ricks
- Miguel Angel Caballero - Michael (uncredited)
- Jason Sutliff - Computer Police (uncredited)
- Brian Vaughan - Tyler
- Frank Gerrish - Sheriff Newsom
- J. Scott Bronson - Captain Marshall
- Mowava Pryor - NSA Agent
- George Sullivan - NSA Superior
- Steven Anderson - Doctor
- Jack Moore - Soldier #1
- Ben Hopkin - Soldier (uncredited)
- Dan Rudert - Helicopter Pilot (uncredited)
- John Masius
Adam Baldwin hace el papel de Michael O'Ryan / Joe York.
John Carroll Lynch interpreta a Joe York en la serie.
Matt Clark hace el papel de Monroe.
John Corbett interpreta a Adam MacArthur en la serie.
Grand L. Bush hace el papel de Agent Douglas Wilcox.
Leon Rippy hace el papel de Agent Nicholas LaRu.
John Storey interpreta a Agent Craig Van Patten en la serie.
Steve Railsback interpreta a Colonel James Vise en la serie.
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