- Ritu Arya - Lila Pitts
- Cameron Britton - Hazel
- Colm Feore - Sir Reginald Hargreeves
- Sheila McCarthy - Agnes
- Genesis Rodriguez - Sloane Hargreeves
- Adam Godley - Pogo (voice)
- Jordan Claire Robbins - Grace
- Marin Ireland - Sissy Cooper
- Yusuf Gatewood - Raymond Chestnut
- John Magaro - Leonard Peabody
- Kate Walsh - The Handler
- Paskal Vaklev - Teenage Boy
- Janet Monid - Instructor
- Lee Rumohr - Ringleader
- Phil Borg - Paparazzi #2
- Cherie D'Elia - Paparazzi #3
- George Wyner - Dan Frankel
- Mindy Sterling - Edna Frankel
- Colleen Reynolds - Landlord
- Kjartan Hewitt - Hal
- William Poulin - Norm
- Jesse Noah Gruman - Young Harold
- Peter Outerbridge - The Conductor
- Cody Ray Thompson - Dave
- Laura Cilevitz - Carla
- Soo Garay - Gloria
- Cameron Brodeur - Young Luther
- Dante Albidone - Young Klaus
- Ethan Hwang - Young Ben
- Rainbow Sun Francks - Detective Chuck Beaman
- Alyssa Gervasi - Young Vanya (Age 4)
- Lise Cormier - Madame Bellview
- Tanu Ravi - Gimble Brothers Clerk
- Matt Biedel - Sgt. Dale Chedder
- Heather Sanderson - Lady on Bus
- Heather Sanderson - Kenny's Mom
- Heather Sanderson - Lady Who Takes Bus to Rave
- John Gleeson Connolly - Manager
- Patrick Garrow - Buck
- Thomas Mitchell - Mr. Jenkins
- Eli Ham - Drug Dealer
- Karl Campbell - Goon Leader
- Moni Ogunsuyi - Secretary
- Murray Furrow - Syd
- Eric Peterson - AI
- Zachary Bennett - Lance Biggs
- Celest Chong - Mandarin Woman
- Timm Zemanek - Older Man
- Melody O'Brian - Teenage Girl
- Jeremy Legat - Young Man
- Aliska Malish - Ghoulish Face #3
- Jim Watson - 35 Year Old Man
- Alison Smiley - Claudia (Housekeeper)
- Dan Willmott - Mel
- Emily Piggford - Helen
- Darrin Maharaj - TV Anchor
- Thomas Craig - Gene
- Patrick Stevenson - Larry
- Jordana Blake - Young Allison (Age 4)
- Ashley Madekwe - Detective Eudora Patch
- Ray Kahnert - Immigration Clerk
- Christian Lloyd - Kyle (Orderly)
- Steve Coombes - Guard
- Richard Waugh - Mason Dumont
- Bo Martynowska - Autumn
- Dominic Cuzzocrea - Homeless Man
- Jesse Buck - Bartender
- Matthew Edison - Doctor Moncton
- David Feehan - Milkman
- Sean Sullivan - Super Old Five
- Sean Sullivan - Older Five
- Sean Sullivan - Middle Aged 5
- Sean Sullivan - Old Man Five
- Jason Blicker - Desk Cop
- Janet Land - Kitty
- Connor Laidman - Cherubic Boy
- Katherine Trowell - Waitress
- Robert Maillet - Lights Out Lubbock
- Rod Wilson - Brian
- Jameson Kraemer - Phil the Landlord
- Tom Sinclair - Oscar
- Carson Durven - Greyhound Driver
- Raven Dauda - Odessa
- Dewshane Williams - Miles
- Massey Ahmar - Follower #1
- Marium Carvell - Vernetta
- Herschel Andoh - Deano
- Cliff Saunders - Hammond
- Alexander Nunez - Follower #3
- Mouna Traoré - Jill
- Jonathan Malen - Ned
- Birva Pandya - Young Woman on Bike
- Birva Pandya - Young Person on Bike
- Robin Atkin Downes - Carmichael
- Morgan Kelly - William Gates
- Jason Bryden - Otto
- Julia Chantrey - FBI Nurse
- Eden Cupid - Young Allison
- T.J. McGibbon - Young Vanya
- Robert Verlaque - Hoyt Hillenkoetter
- Durward Allen - Ghoulish Face #1
- Durward Allen - Specter #4
- Stephen R. Hart - Ghoulish Face #2
- Stephen R. Hart - Specter #3
- Peter Schoelier - Mr. Edelman / Pale Man
- Kevin B Hartley - Member of MJ 12 #1
- David Boyce - Member of MJ 12 #2
- William Ng - Dressmaker
- Violeta Ortega - Lady in Red
- Kristen Holden-Ried - Axel
- John Kapelos - Jack Ruby
- Dov Tiefenbach - Keechie
- Calem MacDonald - Young Dave
- Seunghwan Min - Teenage Boy
- Augustus Oicle - College Kid
- Graham Parkhurst - College Kid #2
- Chai Valladares - Employee
- Indy Saluja - Manager
- Rachel Delduca - Delores
- Krista Bridges - Sarah-Beth
- Noah Lamanna - Friendly Waitress
- Mark Cowling - Homeless Guy
- Basel Daoud - Taxi Driver
- Douglas E. Hughes - Sid
- Marnie Delwo - Fanny
- Clare Butler - Fanny 20's
- Kenny Robinson - Earl
- James Hicks - Fanny Husband
- Gordon Harper - Young Sid
- Dorly Jean-Louis - Newscaster
- Corey Bright - Paula
- Chantal Cabrera - Elena (Diego's Mom)
- Kayla jo Farris - Efa (Five's Mom)
- Gracie Callahan - Monica (Luther's Mom)
- Laura Hopper - Rachel Herschberger
- Edward A. Queffelec - Reporter #2
- Patrice Goodman - Dot
- Kevin Rankin - Elliot
- Britne Oldford - Fei Hargreeves
- Justin Cornwell - Marcus Hargreeves
- Jake Epstein - Alphonso Hargreeves
- Cazzie David - Jayme Hargreeves
- Javon Walton - Stan
- Shiva Safari - Wife
- Shiva Safari - Lila's Mom
- Callum Keith Rennie - Lester Pocket
- Meryn Jackson - Tammy
- Stephen Bogaert - Carl Cooper
- Adam Tomlinson - Moabiker #1
- Tracy Rowland - Bus Driver
- Michael Antwi - Specter #2
- Shawn Devlin - Rex McDonnell
- Walter Rinaldi - Contractor
- Julian Richings - Chet Rodo
- Liisa Repo-Martell - Abigail Hargreeves
- John Beale - Neville Cowles
- Andre Tricoteux - Boss Guardian
- Warren Scherer - Guardian #2
- Matthew G. Taylor - Guardian #2
- Coco Assad - Claire
- David Cross - Sy Grossman
- Nick Offerman - Dr. Gene Thibedeau
- Megan Mullally - Dr. Jean Thibedeau
- Millie Davis - Claire Hargreeves
- Martin Roach - Lance Ribbons
- Marqus Bobesich - Eddy
- Michael Dyson - Jerry
- Katharine King So - Amy
- James Wallis - Gus
- Gurbir Bal Gogo - Lila's Aunty Banu
- José Arias - Director
- Izaak Smith - Larry
- Ciara Rose Feeney - Grace Stanley Hargreeves
- Uppekha Jain - Lila's Aunty #2
- Rachel MacMillan - Karen
- Kip Brown - Bouncer
- Carolyn Bridget Kennedy - Waitress
- Victoria Sawal - Jennifer
- Aidan Devine - Gary
- Lynne Griffin - Dottie
- Elise Bauman - Fake Jennifer
- Sharon Canovas - Strip Club Patron Lifted #1
- Jeanette Roxborough - Strip Club Patron Lifted #2
- Liise Keeling - Caroller #1
- C.J. Lusby - Caroller #3
- James Binkley - Caroller #4
- George Tchortov - Quinn
- Dan Duran - Dan Tannenbaum
- Allison Brennan - Jessica Holmes
- Steffi DiDomenicantonio - Fatima Ali
- Chris Locke - Rolfe
- Derek Johns - Hank
- Troy Blundell - Hargreeves Guard
- Brian Quintero - Keeper Guard
- Vinessa Antoine - Loretta
- Al Sapienza - Dick
- Eamon Stocks - Teen Alphonso
- Jessica Greco - Bea
- Nick Biskupek - Underpass Inn Clerk
- Sam Al Esai - Friendly Man
- Matt Baram - Frank 'Bud' Parnell
- Richard Tse - Glue Sniffing Agent
- Meher Pavri - Reporter
- Kevan Kase - Big Ass Keeper
- Dianne Aguilar - Trudy
- Jonnie Katz
- Gerard Way
Julian Richings interpreta a Chet Rodo en la serie.
Callum Keith Rennie interpreta a Lester Pocket en la serie.
Sean Sullivan hace el papel de Super Old Five.
Yusuf Gatewood hace el papel de Raymond Chestnut.
Aidan Gallagher interpreta a Number Five en la serie.
Elliot Page hace el papel de Viktor Hargreeves / Number Seven.
Tom Hopper interpreta a Luther Hargreeves / Number One en la serie.
Emmy Raver-Lampman interpreta a Allison Hargreeves / Number Three en la serie.
Robert Sheehan hace el papel de Klaus Hargreeves / Number Four.
David Castañeda hace el papel de Diego Hargreeves / Number Two.
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