- Shanice Wilson - Self
- Meat Loaf - Self
- Kim Delaney - Self
- Amanda Bynes - Herself
- Guy Pearce - Self
- Ricky Martin - Self
- Fiona Apple - Self
- John Fogerty - Self
- Angie Stone - Self
- Patricia Arquette - Self
- Neil Diamond - Self
- Wentworth Miller - Himself
- Sienna Miller - Herself
- Steve Irwin - Self
- David Gilmour - Self - Musical Guest
- Jennifer Love Hewitt - Self
- Bruce Springsteen - Self - Musical Guest
- Rihanna - Self - Musical Guest
- George Carlin - Self
- Cat Deeley - Herself
- José González - Self
- Brooke Shields - Self - Guest
- Jennifer Connelly - Self
- Joan Jett - Self - Musical Guest
- Hilary Swank - Self
- Tom Vilsack - Self
- Peter O'Toole - Self
- Katt Williams - Self
- Dan Rather - Self
- Mika - Self
- Amy Poehler - Self
- Craig T. Nelson - Self
- Rose McGowan - Self
- Hayden Panettiere - Herself
- Leslie Feist - Self
- Fred Thompson - Himself
- Robin Williams - Himself
- John Legend - Self
- Lucinda Williams - Self - Musical Guest
- Vanessa Carlton - Self
- Jim Lauderdale - Self
- Leslie Mann - Self
- Joe Torre - Self
- Duffy - Self
- Phil McGraw - Self
- Terrence Howard - Self
- Carlos Mencia - Self
- Allison Moorer - Self
- Spencer Pratt - Self
- David Hyde Pierce - Self
- Martin Scorsese - Self - Guest
- Tina Majorino - Herself
- Brie Larson - Self
- Richard Marx - Self
- Steven Seagal - Self
- Pierce Brosnan - Self
- Robbie Williams - Self - Musical Guest
- Martin Short - Self
- Diana Krall - Self
- Mary Lynn Rajskub - Self
- Kristen Bell - Herself
- Emilio Estevez - Self - Guest
- Kylie Minogue - Self
- Sandra Bullock - Self
- Lindsay Lohan - Herself
- Kelly Rowland - Self
- Farrah Fawcett - Self - Guest
- Christina Aguilera - Self
- Nicollette Sheridan - Self
- Martha Stewart - Self
- Nicole Richie - Self
- Garth Brooks - Self
- Anthony Hopkins - Self
- Paul Newman - Self - Guest
- Mariah Carey - Self - Guest
- Jeremy Piven - Self
- Matthew Perry - Self
- Tony Bennett - Self - Guest
- Demi Moore - Herself
- Mel Gibson - Self
- John Edwards - Self
- Meredith Vieira - Self
- Phyllis Diller - Herself
- Beyoncé - Self - Guest
- Dustin Kensrue - Self
- Gerard Butler - Self
- Pete Rose - Self
- Angélique Kidjo - Self
- Gloria Estefan - Self - Guest
- James Blunt - Self - Musical Guest
- Andrea Bocelli - Self - Musical Guest
- Ryan Phillippe - Self
- Lisa Lampanelli - Self
- Helen Hunt - Self
- KT Tunstall - Self
- Anderson Cooper - Self
- John Krasinski - Self
- Harry Connick Jr. - Self
- Elvis Costello - Self - Musical Guest
- Colin Hanks - Self
- Nigel Marven - Self
- Melanie Chisholm - Self
- Troy Aikman - Self
- Ralph Stanley - Self - Musical Guest
- Bryan Ferry - Self
- Dolly Parton - Self - Guest
- Shaggy - Self
- Nick Carter - Self
- Tony Siragusa - Self
- John Mayer - Self
- Chris Isaak - Self
- Chris Isaak - Self - Musical Guest
- Tim McGraw - Self
- Carrie Underwood - Self
- Kurt Russell - Self
- Ludacris - Self
- Kirk Franklin - Self
- Brian Setzer - Self
- Jerry Seinfeld - Self
- Geraldo Rivera - Self
- Alison Krauss - Self
- Al Franken - Self
- Jon Favreau - Self
- Brian Wilson - Self
- Shelley Berman - Self
- Bryce Dallas Howard - Herself
- John Leguizamo - Self
- Avril Lavigne - Self
- Ron Livingston - Himself
- Ryan Reynolds - Self
- Branford Marsalis - Self - Musical Director
- Andrew Zimmern - Self
- Lauren Graham - Herself
- Alicia Keys - Self
- Mickey Rourke - Self
- Jennifer Aniston - Self
- Shia LaBeouf - Self
- Elton John - Self - Guest
- Elton John - Self - Musical Guest
- Conan O'Brien - Self
- Jessica Alba - Self
- Barry Humphries - Dame Edna Everage
- Sigourney Weaver - Self - Guest
- Jason Lee - Self
- Emily Blunt - Herself
- Chelsea Handler - Herself
- Beck - Self - Guest
- Scarlett Johansson - Self
- Michael Ormsby - Boy at White House Egg Throw (uncredited)
- Billy Crystal - Self - Guest
- Tim McGrath - The P.A. 'Alex'
- Joe Pesci - Self - Guest
- Curtis Stigers - Self
- Kenny Wayne Shepherd - Himself
- Johnny Mathis - Self
- Jim Carrey - Self
- Chris Cornell - Himself
- Cate Blanchett - Self
- Tim Reid - Self
- Taylor Swift - Self
- Heidi Klum - Self
- Lady Gaga - Self
- Molly Shannon - Self
- Rosie Perez - Herself
- Robin Thicke - Self
- Seth Rogen - Self
- D.L. Hughley - Self
- Gillian Anderson - Self - Guest
- Will Ferrell - Self
- Adam Carolla - Self
- Michael Caine - Self
- Solomon Burke - Himself
- Bette Midler - Self - Guest
- Kenny Smith - Himself
- Justin Timberlake - Self
- Usher - Self
- Jeff Foxworthy - Self
- Arianna Huffington - Self
- Rob Schneider - Self
- Josh Groban - Self
- Simon Cowell - Self
- Terry Bradshaw - Self
- Matthew McConaughey - Himself
- Hilary Duff - Self
- Annette Bening - Self - Guest
- Jenna Fischer - Self
- Harrison Ford - Self - Guest
- Harrison Ford - Self
- Nick Nolte - Self
- Jesse Malin - Himself
- Jesse Malin - Himself - Musical Guest
- Toby Keith - Himself
- Quentin Tarantino - Self
- Bil Dwyer - Himself
- Ruben Studdard - Himself
- Ben Curtis - Himself
- Miranda Lambert - Herself
- Jimmy Carter - Self
- Ann Coulter - Self
- Dave Koz - Self
- Dennis Kucinich - Himself
- Tyler Champagne - Darth Vader
- Tyler Champagne - Sweat Shop Kid
- Don Francisco - Self - Guest
- Mollie King - Herself
- Frankie Bridge - Herself
- Rochelle Humes - Herself
- Una Healy - Herself
- Vanessa White - Herself
- Billy Connolly - Himself
- Nicki Minaj - Herself
- Sananda Maitreya - Self
- Bob Nelson - Self
- Susan Collins - Self (archive footage)
- Edd Hall - Announcer
- Angelea Preston - Self - Celebrity All-Star
- William Moseley - Self
- Gwyneth Paltrow - Self
- David Lynch - Self
- Aaliyah - Self
- Michael Patrick Jann
- Larry Jacobson
- Jon Macks
- Steve Ridgeway
- Michael Riedel
- Suli McCullough
- Jay Leno
Harrison Ford hace el papel de Self.
Pierce Brosnan hace el papel de Self.
Martin Short interpreta a Self en la serie.
Guy Pearce interpreta a Self en la serie.
Barry Humphries hace el papel de Dame Edna Everage.
Emilio Estevez hace el papel de Self - Guest.
Anthony Hopkins hace el papel de Self.
Patricia Arquette hace el papel de Self.
Demi Moore hace el papel de Herself.
Robin Williams interpreta a Himself en la serie.
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