- Alexa PenaVega - Hilary Cole
- Ingrid Torrance - Mrs. Rundle
- Ryan Beil - Avery
- Dylan Kingwell - Young Stephen
- Andrew Stewart-Jones - Damian
- Nnamdi Nwosa - Lead Agent
- Mark Tallman - Burly Guy
- Derek Klena - Dylan
- Roberto Lopez - Guard #1
- Corey Pierno - Guard #2
- Derrick Simmons - Guard #3
- Roy Jackson - Security Guard
- Clyde Baldo - Teacher
- Allison Thomas Lee - Mrs. D'Amico
- Victor Pagan - Homeless Man
- Carter MacIntyre - Vaughn
- Bernadette Beck - Teller
- Nicholas Carella - Harold
- Burkely Duffield - Tyler Miller
- Cali Fredrichs - Emily Hightower
- Al Sapienza - Dennis Coburn
- Doug Abrahams - Sheriff
- Víctor Ayala - Nice Hipster
- Dalila Bela - Cara's Sister
- Adam Boys - Deputy
- Deni DeLory - Margaret Hightower
- Ryleigh Gillespie - Cheerleader
- Levi Hildebrand - 1st Time Drunk Boy
- Bryce Hodgson - Simon
- Tim Zhang - Geeky Boy
- Jason Dohring - Killian McCrane
- Connor Dunn - Young Killian
- Shaine Jones - Highway Patrolman #1
- Sophie Lui - Newscaster #1
- Michael Meneer - Newscaster #2
- Jaden Rain - Foster Child
- Chris Shields - Ultra Doctor
- Howard Siegel - Man
- Alison Wandzura - Ultra Agent #2
- Nick Eversman - Kurt Rundle
- Hiro Kanagawa - Corbin
- Dagan Nish - Bryce
- Christopher Pearce - Bouncer
- Meta Golding - Darcy Nichols
- Mathias Retamal - Mark Menendez
- Aeriél Miranda - Piper Nichols
- Artine Brown - Bouncer
- Emily Fonda - Trixie
- Michael Jonsson - Kyle
- Nik Markovina - Bartender
- Derek Morrison - Scary Boss
- James Yi - Russell's Father
- Ben Cotton - Rapist
- Jarod Joseph - Juergens
- Chloe Babcook - Jenny
- Max Chadburn - Pauline
- Vaughn Clements - Security Guard
- Jordan Connor - David
- Anthony Konechny - Agent Perkins
- Sean Mahaffey - Rory
- Darren Mann - Stoner
- Yuki Morita - Eliza
- Chelsey Reist - Krysten
- Sean Baden - Security Guard
- Reilly Dolman - Man under Mask
- Don McLeod - MTA Worker
- Nicholas Young - Dr. Aldus Crick
- Nicholas Young - Professor Aldus Crick
- Terry Mullett - Telepath #2
- Byron Lawson - Ultra Agent
- Byron Lawson - Ultra Captain
- Byron Lawson - Kill Squad Leader
- Byron Lawson - Senior Agent
- Christian Sloan - Telepath
- Sylvesta Stuart - Kill Squad #2
- Thomas Cadrot - Agent
- Thomas Cadrot - Ultra Agent #1
- Thomas Cadrot - Ultra Medic
- Shamier Anderson - Mike
- Benjamin Hollingsworth - Agent Troy
- Leah Cairns - Lucy
- Travis MacDonald - Miggs
- Eva Day - Mandy
- William 'Big Sleeps' Stewart - Clint
- Monique Ganderton - Nelly
- Doug Chapman - Man
- Nathan Mitchell - Scary Ultra Agent
- Nathan Mitchell - Ultra Agent #1
- Vicky Huang - Ultra Trainee
- Rebecca James - Homeless Girl
- Luvia Petersen - Ursa
- Patrick Sabongui - Andrew
- Fulvio Cecere - Tony
- Robert Gant - Peter MacKenzie
- Michasha Armstrong - Ultra Instructor
- Jeffrey Pierce - Jack Jameson / Roger Price
- Jeffrey Pierce - Jack Jameson
- Paul Lazenby - Ultra Guard
- Jaeson Lee - Kill Squader
- Jaeson Lee - Kill Squad #1
- Synthia Yusuf - Assistant
- Synthia Yusuf - Ultra Techie
- Dejan Loyola - Ray
- Samuel Smith - Robber
- Reese Alexander - Henry Finch
- Lee Tichon - Police Officer
- William Vaughan - Ultra Agent
- James Landry Hébert - Nathan / Cyrus
- Raresh DiMofte - Sasha
- Raphael Kepinski - Alexei
- Nels Lennarson - Federal Marshall
- Giles Panton - Ultra Agent #2
- Giles Panton - Ultra Agent #3
- Mathew Yanagiya - Young Agent #1
- James Mackay - Julian Masters
- Heidi Ford - Female Ultra Analyst
- Dalias Blake - Ultra Agent
- Dalias Blake - Agent Peterson
- Dalias Blake - Ultra Agent #2
- Elisabeth Rosen - Agent Mills
- Elisabeth Rosen - Ultra Agent
- Carly Pope - Morgan Burke
- Melissa Roxburgh - Talia
- Lyndon Smith - Mallory
- Jenna Burgess - Judge's Daughter
- Don Lew - Ling
- Darryl Quon - Thug
- Darren E. Scott - Businessman
- Andrew Wheeler - Judge Fairbanks
- Elise Gatien - Sophie Coburn
- Serinda Swan - Cassandra Smythe
- Jared Ager-Foster - Young Jedikiah
- Trish Allen - Nurse
- Kwesi Ameyaw - Head of Security
- Radek Hewson - Young Roger
- Wesley Taylor - Monty the Magnificent
- Toby Levins - Commander
- Aiden Longworth - Subway Kid
- Chad Bellamy - Kill Squad Leader
- Kurt Evans - Agent Veras
- Cindy Busby - Med Tech
- Cindy Busby - Sexy Med Tech
- Jason Griffith - Security Guard
- Madeleine Arthur - Charlotte Taylor
- Riun Garner - Test Subject
- Adrian Hein - Ultra Guard #5
- Artin John - Control Subject
- Jacob Kogan - Luca Jameson
- Laura Slade Wiggins - Irene Quinn
- Sarah Clarke - Marla Jameson
- Doron Bell - Security Guard #1
- Daniel Boileau - Barry
- Rob Compton - Soldier
- Simon Merrells - Hugh Bathory / The Founder
- Shawn Roberts - Ultra Agent
- Leven Rambin - Natalie
- Michael Hogan - Senator Kelsey
- Russell Porter - Coach Tanner
- Mitchell Kummen - Young John
- Haig Sutherland - Jonah
- David Bloom - Dr. Lehrman
- Elizabeth Hurley - A.L.I.C.E. (voice)
- Darla Taylor - Hottie
- Susan Hanson - Russell's Mother
- Shaker Paleja - Head Tech
- Ty Olsson - Errol
- Joe Costa - Dealer
- Roger Damon Price
- Jeff Rake
- Greg Berlanti
- Phil Klemmer
Robbie Amell interpreta a Stephen Jameson en la serie.
Peyton List interpreta a Cara Coburn en la serie.
Luke Mitchell hace el papel de John Young.
Aaron Yoo interpreta a Russell Kwon en la serie.
Madeleine Mantock interpreta a Astrid en la serie.
Mark Pellegrino interpreta a Dr. Jedikiah Price en la serie.
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