- Ruta Gedmintas - Dutch Velders
- Sean Astin - Jim Kent
- Rupert Penry-Jones - Mr. Quinlan
- Natalie Brown - Kelly Goodweather
- Jack Kesy - Gabriel Bolivar
- Jack Kesy - The Master
- Andrew Kraulis - Ryan
- Inga Cadranel - Diane
- Benjamin Beauchemin - David
- Tom Ellis - Rob Bradley
- Jacqueline Byers - Cleo
- Jocelyn Hudon - Abby
- Manuel Rodriguez-Saenz - Jorge
- David Knoll - Teenage Boy
- Lance Henriksen - Narrator (voice)
- Andrew Divoff - Peter Bishop
- Rachael Crawford - Therapist
- Dov Tiefenbach - Air Traffic Controller
- Karen Glave - Rose - Flight Attendant
- Adriano Sobretodo Jr. - Peter - Flight Attendant
- Joe Pingue - Caldwell
- Lindsay Owen Pierre - Det. Marc Weber
- Jean Pearson - Germaine
- Peter Spence - Richard
- Egidio Tari - NYPD Cop
- Jonathan Potts - Captain Doyle Redfern
- Barry Flatman - Flaxton
- Genevieve Kang - Jax
- Ali Momen - Dr. William Lester
- Scott Yaphe - Sledge
- Matthew Bennett - Foster
- Sofia Wells - Barclay
- Neil Crone - Dr. Box
- Craig Gardner - Misdemeanor Judge
- Deborah Grover - Family Court Judge
- Joanna Swan - Surgical Nurse
- Isabelle Nélisse - Emma Arnot
- Steven McCarthy - Gary Arnot
- Kingsley Ngadi - Nigerian
- Kathleen Chalfant - Abraham's Grandmother
- Larry Fessenden - Jack Noon
- Regina King - Ruby Wain
- Alex Paxton-Beesley - Ann-Marie Barbour
- Rhys Ward - Jacob Setrakian
- Joan Massiah - Doris
- Shawn Lawrence - Dr. Morse
- Darrin Baker - Trip Taylor
- Tara Spencer-Nairn - Dr. Evanston
- Carolyn Scott - Ms. Byrne
- Dan Lett - Special Agent Monroe
- Jeffrey R. Smith - Dr. Bennett
- Conrad Coates - Mike Rivers
- Katy Breier - Lauretta
- Cody Ray Thompson - Brian
- Yasin Sheikh - Farouk
- Joshua Peace - Special Agent Woodbridge
- Thomas Mitchell - Beau
- Dimitri Vantis - Horace
- Andrew Hinkson - Chauffeur
- Alex Mallari Jr. - Carlo
- John Kalbhenn - Biggs
- Aaron Douglas - Roger Luss
- Leslie Hope - Joan Luss
- Melanie Merkosky - Sylvia Kent
- Kim Roberts - Neeva
- Jayden Greig - Keene Luss
- Shailene Garnett - Sebastiane
- Vas Saranga - Hassan
- George Buza - Buck Norris
- Pedro Miguel Arce - Felix
- Matthew D. Matteo - Julius Styles
- Michel Issa Rubio - Ronnie
- Drew Nelson - Matt Sayles
- Rothaford Gray - Corrections Officer Hernandez
- Quincy Tyler Bernstine - Brea
- Theresa Tova - Beverly
- Michelle Mylett - Receptionist
- Francis Capra - Crispin Elizalde
- Donald Burda - Kevin Farrell
- Tiffany Martin - Syndie
- James Cade - Roman
- Camille Stopps - Val
- Anne Betancourt - Mariela Martinez
- Dwight Ireland - Gregg Nelson
- Maria Ricossa - Margaret Pierson
- Tanya Allen - Sarah
- Josh Horvath - Ancient's Victim
- Adina Verson - Miriam Setrakian
- Lucy Hill - Risa Crouse
- Christopher Kelk - Bewildered Man
- Brenda Bazinet - Pauline McGeever
- Stephen McHattie - Vaun
- Catherine Burdon - Robin Fitzwilliam
- Dax Ravina - Officer Nick Edmondson
- Romaine Waite - Tom Perry
- Ron Lea - Harrison McGeever
- Kevin Hanchard - Curtis Fitzwilliam
- Glen Grant - Arthur Fitzwilliam
- Warren Chow - Stoneheart Security / Driver
- Daniel Kash - Dr. Everett Barnes
- Bruce Hunter - Neil Archer
- Ricky Tollman - Michael 'Mikey' Williams
- Samantha Michelle - Brooke
- Bruce Dow - Dale
- J.D. Nicholsen - Ron
- Andrew Fleming - Antonio
- Michael A. Miranda - Gianni
- Jason Martorino - Dempsey
- Wayne Ward - Officer Wilson
- Mio Adilman - Janitor
- Paloma Nuñez - Janitor's Wife
- Chris Owens - Medical Officer
- Junior Williams - Homeland Security Officer
- Danny Waugh - Transportation Officer
- Tara Koehler - Sick Wife
- Mila Kanev - Old Russian Lady
- Nadia Bowers - Leigh Thomas
- Roger Cross - Reggie Fitzwilliam
- Mimi Kuzyk - Nikki's Mother / Mrs. Taylor
- Mimi Kuzyk - Nikki's Mother
- Asim Wali - Bennett
- Miranda Edwards - Eve
- Chris Locke - Louis
- Brian Paul - General Dean Rushing
- Rhea Akler - Deedee
- Mark Irvingsen - Homeless Man
- Tadhg McMahon - Senator Sertorius
- Tim O'Halloran - Patrick
- Omar Alex Khan - Romani Father
- Charlie Ebbs - Worker
- Matthew G. Taylor - Opponent
- James Binkley - Stoneheart Security Agent
- Alex Cruz - Stoneheart Security Agent
- Tom Kemp - Cardinal McNamara
- Grace Lynn Kung - Grace Wu
- Ho Chow - Jimmy Wu
- Neil Girvan - Officer Green
- Pat Kiernan - Newscaster
- Adam Langton - Carl
- Austin Strugnell - Glenn
- Philip Williams - Captain Messina
- Mark Eric Charbonneau - Bob
- Morgan Kelly - Stevens
- Brett Ryan - Joshua
- Kaleb Alexander - Reynolds
- Michael McMurtry - Surgeon
- Adrian Griffin - Lawyer
- Emilie Paquet - Staten Island Resident
- Anthony Furey - Reporter
- Ron Canada - Mayor George Lyle
- Nicola Correia Damude - Nikki
- Craig Eldridge - Councilman Chuck Cohen
- Alex Karzis - Detective Paul Sampson
- Nigel Bennett - Dr. Draverhaven
- Nigel Bennett - Shop Owner / Dr. Draverhaven
- Ian Paola - Hector Perez
- Alan Rosenthal - Councilman Andrew Bernstein
- Michael Gordin Shore - Dr. Arley
- Bruno Verdoni - Correction Officer Harris
- Lizzie Brocheré - Coco Marchand
- Blake Mawson - Cole
- Daniel Morrison - James
- Jason Oliveira - Paco
- Dan Warry-Smith - Dylan
- William-Christopher Stephens - Jordan
- Juan Carlos Velis - Mr. Ortega
- Sonya Anand - Vhini Gupta
- David Schaal - Rudyard Fonescu
- Julie Engelbrecht - Helga Richtler
- Parveen Kaur - Aanya Gupta
- M. John Kennedy - Karl Spurzem
- John Nelles - Oscar Brandt
- Stephen Park - Klaus Schnurrbart
- Sugith Varughese - Naren Gupta
- Miguel Anthony - Big Man
- Natasha Bromfield - Nurse
- Ted Charette - Night Patrol Officer #2
- Cam Fergus - Holmes (Navy Seal)
- David Patrick Flemming - Night Patrol Officer #1
- Carlos Gonzalez-Vio - Nick Coley (Navy Seal)
- Bobby Manning - Raul
- Ronnie Rowe - Kenny Ford (Navy Seal)
- Al Vrkljan - Vannelli (Navy Seal)
- Ben Carlson - Dr. Wilson Kerry
- Zarrin Darnell-Martin - Fay
- Kaniehtiio Horn - Kimberly (as Tiio Horn)
- Christopher Jacot - Braden
- George Nickolas K. - George
- Tre Smith - Captain John Cushnell
- Janaya Stephens - Dr. Amanda Edmondson
- Deanna Dunagan - Ancharia
- America Olivo - Kate Rogers
- America Olivo - Captain Kate Rogers
- Matthew Binkley - Night Patrol 1
- Charlie Gallant - Young Palmer
- Charlie Gallant - Young Eldritch Palmer
- Michael Chwastiak - Vex
- Eric Hicks - Night Patrol 2
- Daniel Junghuan Park - Grocer Strigoi
- Tim Cody - Scaggs (Navy Seal)
- Tim Cody - Marauder #1
- Laara Sadiq - Dr. Arva Somani
- Dustin Faith - Marauder #2
- Dustin Faith - McDonald (Navy Seal)
- Jeananne Goossen - Bella
- Jarrett Downey-Shaw - Guard
- Jessica Embro - Yoga Mom Strigoi
- Phillip Jarrett - Ray
- Charles-Henry Joseph - Fulton
- Jeffrey Knight - Carl
- Tim MacLean - Billy
- Martin Roach - James
- Premika Leo - Staffer #1 (uncredited)
- Leslie Takeda - Strigoi Detective (uncredited)
- Daniel Matmor - Boat Captain
- Erin Noble - Saskia van Orden
- Allison Wilson-Forbes - Female Cop
- Dalton Derek - Charles Lee
- Paul Ebejer - Prisoner #1
- Tracy Perez - Maria
- Jsin Sasha - Prisoner #2
- Ryan Hollyman - Lar (Sun-Hunter)
- Ryan Hollyman - Lar
- Lee Tergesen - Tardi
- Mike Dopud - Sergei Fetrovski
- Costa Ronin - Alexei Boiko
- Aaron Lazar - Kroft
- Aaron Lazar - Kroft (uncredited)
- Damir Andrei - Alexei Fet
- Makenna Lyn Beatty - Little Girl
- Lukas Penar - German Wehrmacht Soldier
- Elizabeth Saunders - Nurse Carla Davis
- Nick Stojanovic - Safe Streets Guard #2
- David D'Lancy Wilson - Safe Streets Guard #1
- Joanna Haughton - Mother (uncredited)
- John Jacob - Wounded Soldier (uncredited)
- Michelle Arvizu - Young Guadalupe
- Adriana Barraza - Guadalupe Elizalde
- Thomas L. Colford - The Ancients
- Elias Edraki - Cheevo
- Jonathan Higgins - Cyrus Minow
- Doug Jones - The Ancient
- Clayton Scott - Ancient #2
- Chris Young - Nando
- Samantha Mathis - Justine Feraldo
- Paulino Nunes - Frank Kowalski
- Joaquín Cosío - Angel Guzman Hurtado
- Don Stark - James O'Neill
- David Huband - Bob Borgen
- Tim Post - Captain James Bonner
- Michelle Alexander - Gay Hayden (uncredited)
- Ryan Turner - Sgt. Crouse (uncredited)
- Joe Delfin - Randy
- Jeff Kassel - Xun
- Dwain Murphy - Sean Duncan
- Jason Gosbee - Hank
- Jason Gosbee - Oates (Navy Seal)
- Hannan Younis - Lindsay
- Elena Khan - Survivor (uncredited)
- Robert Maillet - The Master
- Robert Maillet - The Master / Jusef Sardu
- Lindsey Connell - Karen
- Adrian G. Griffiths - Neil
- David Ingram - Ross
- Marvin Kaye - Harvey
- Jessica Reynolds - Frontier Woman Raider
- Sabryn Rock - Alannah
- Darryl Scheelar - Prepper
- Jason Boyd - Frightened Passerby
- Taylor David - Karl
- Cyndy Day - Mourner #2 (uncredited)
- Kylee Evans - Megyn Jones
- Dave Barclay - Hollow-Eyed Woman's Husband
- Jonathan Malen - Jeremy
- Michael Rhoades - Eddie
- Boomer Phillips - Human Guard
- Thomas Darya - Sway
- Thomas Darya - Sway (uncredited)
- Ehren Kassam - Dukali
- Dani Jazzar - Strigoi
- Matthew Willson - Tanker Driver
- Helen Taylor - Dr. Weiss
- Helen Taylor - Doctor Weiss
- Lisa Ryder - Nurse Greenwood
- Supinder Wraich - Selah
- Rainbow Sun Francks - Jason Green
- Chandler Loryn - Nadia
- Evan Stern - Roach
- Shamus Fynes - Faran
- Brian J. Graham - Ricci
- Aidan Moreno - Shifty Guy
- Hubert Tran - Waiter
- Indy Saluja - Anaesthesiologist
- Jhonattan Ardila - Resistance Fighter (uncredited)
- Tonya Pinkins - Francis
- Jess Salgueiro - Sherry
- Katie Messina - Flores
- Katie Messina - Flores (uncredited)
- Brian Hamman - Coffer
- Kathleen Pollard - Hollow-Eyed Woman
- Kathleen Pollard - Sam
- Gavin Williams - Anglican Priest
- Ava Preston - Emily
- Troy James - Street Mongrel Philly (uncredited)
- Troy James - Castle Mongrel (uncredited)
- Troy James - Street Mongrel (uncredited)
- Troy James - Mongrel (uncredited)
- Troy James - Airport Mongrel (uncredited)
- Troy James - Street Mongrel
- Jordan Pettle - Doctor Himoff
- Mike 'Nug' Nahrgang - Convoy SUV Driver
- Regan Moore - Convoy Semi Truck Driver
- Matt Birman - Prep Room Guard
- Katherine Cullen - Nurse Cohen
- Rhona Mitra - Charlotte
- Glen Gould - Ben
- Lauren Collins - Sophie
- Lauren Collins - Sophie (uncredited)
- Kjartan Hewitt - Jeremiah
- Gugun Deep Singh - Pinsky
- Hannah New - Louisa
- Mung-Ling Tsui - Hu Die
- Jack Newman - Milos
- K.C. Collins - Roman
- K.C. Collins - Roman (uncredited)
- Jamie Hector - Alonso Creem
- Jamie Hector - Alonso Creem (uncredited)
- Patrick Stevenson - Dooley
- Angel Parker - Alex Green
- Michael Reventar - Raul
- Katherine Gauthier - Jenn
- Martin Samuel - Strigoi
- Dorren Lee - Lucy
- Nicki Whitely - Marta
- David Bronfman - Jack Murphy
- Jarrod MacLean - Cather
- Cas Anvar - Sanjay Desai
- Richard Young - Stanley
- Robin Atkin Downes - The Master (voice)
- Dewshane Williams - Marcus
- Dayton Sinkia - Oscar
- Derek Barnes - 2nd Officer
- Jim Watson - Abraham (Young Setrakian)
- Ken Linton - Strigoi (uncredited)
- Molly Kidder - Stephanie
- Amanda Smith - Grandmother
- Matthew Lemche - Hazmat Worker (as Matt Lemche)
- Adam Butcher - Terkel
- Jonnie Katz
- Ramin Djawadi
Adriana Barraza interpreta a Guadalupe Elizalde en la serie.
Sean Astin interpreta a Jim Kent en la serie.
Kim Roberts hace el papel de Neeva.
Lance Henriksen hace el papel de Narrator (voice).
Stephen McHattie interpreta a Vaun en la serie.
Corey Stoll interpreta a Dr. Ephraim Goodweather en la serie.
Kevin Durand interpreta a Vasiliy Fet en la serie.
Miguel Gómez interpreta a Augustin 'Gus' Elizalde en la serie.
David Bradley interpreta a Professor Abraham Setrakian en la serie.
Jonathan Hyde interpreta a Eldritch Palmer en la serie.
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