- Tracy Vilar - Sophia Ortiz
- Joe Colligan - Police Officer
- Rick Scarry - Melvin
- Shar Jackson - Angel
- Charlotte Ayanna - Jody
- Dawnn Lewis - Alise Peyton
- Bumper Robinson - Lawrence
- Sab Shimono - Bobby Wong
- T.K. Carter - T-Bone
- Alaina Reed Hall - Corinthia Grier
- Phil Morris - Trent Underwood
- Kel Mitchell - Vincent
- Claudette Wells - Rochelle
- Steve Monroe - DeAndre
- Judyann Elder - Ms. Crabtree
- Esther Scott - Auntie Pearl
- Brook Kerr - Holly
- Gabrielle Union - Naomi Parson
- Veronica Redd - Gladys Steele
- Marjean Holden - Max Sundance
- Bianca Lawson - Rosalind
- Vernee Watson-Johnson - Dr. Glenda Burke
- Vanessa Williams - Nina
- Rick Fitts - Dr. Leland Powell
- Megalyn Echikunwoke - Allison Hightower
- Chrystee Pharris - Angel
- Marissa Jaret Winokur - Kimmie
- Tasha Smith - Kimberly Davis
- Nikki Cox - Herself
- Persia White - Monique
- Kent King - Tessa
- Kellita Smith - Ava Whitley
- Meagan Good - Alicia
- Mel Jackson - Julian
- Elise Neal - Juanita Du'Shea
- Dorian Gregory - Derek
- Clinton Derricks-Carroll - Doc
- Kenan Thompson - Junior
- Bari K. Willerford - Scar
- Dartanyan Edmonds - Bill
- Jesse D. Goins - Bill
- Adrian Zmed - Derrick Love
- Craig Kirkwood - Sylvester
- Earl Billings - Reginald Steele
- Boris Kodjoe - Dexter
- Busta Rhymes - Zack
- Arnetia Walker - Judge Maxine Sharp
- Antonio Fargas - Smitty Rollins
- Aloma Wright - Tulabett
- Wayne Wilderson - Byron Clark
- Rosie Tenison - Candy
- Ronald Isley - Pretty Tony
- Renee Tenison - Cherry
- Bebe Drake - Betty
- Daphnée Duplaix Samuel - Sheila
- Furley Lumpkin - School Play Viewer
- Monica Allison - Candy
- Dori Brenner - Dr. Langer
- Jamal Hamilton - Student
- Lydell M. Cheshier - Student
- Bert Rosario - Ned
- Susan Isaacs - Myrna
- Ivelka Reyes - Imani
- John Eric Bentley - Kenneth
- Chaz Lamar Shepherd - Dexter
- Danny Rimmer - Kid
- Monique Ridge-Williams - Cheryl
- Tom Williams - Baby
- Dawn McMillan - Nicole
- Isabel Sanford - Mother Hightower
- Christine Wilson - Bullethead's Girlfriend
- Brian McKnight - Himself
- Brad Blaisdell - Joey
- James Boyce - Inmate
- Lamont Johnson - Flea
- Raymond O'Connor - Officer Kelly
- Charles Emmett - Prison Guard
- John H. Freeland Jr. - Police Officer
- Saadia Persad - Ashley Hawkins
- Snoop Dogg - Himself
- Sean Combs - Himself
- Ellis E. Williams - Lynwood Grier
- Tyrees Allen - Sterling
- Brien Perry - Paramedic
- Jerry Springer - Himself
- Jackie Roberts - Tiffany Toussaint-Cartier
- Paul Eckstein - Roscoe
- Kimberly Bailey - Rolanda Winfrey
- Ernest Harden Jr. - Marcus
- Fred Pinkard - Pastor Farrell
- The Lady of Rage - Coretta Cox
- Cory King - Norman
- Joe Costanza - Mark
- Suzanne Mari - Precious
- Jennifer Lyons - Kim
- Adele Givens - Odetta
- Lance E. Nichols - Man in Chicken Suit
- Charles Rahi Chun - Karate Instructor
- Aaron Brumfield - Bouncer
- Dorien Wilson - Warrington Steele
- Rainbow Borden - Tim
- Damon Standifer - Club patron
- Lisa Arrindell - Rachel
- Víctor Contreras - Announcer
- Lauren Robinson - Amy
- Anil Raman - Delivery Man
- Richard Gant - Clarence Hightower
- Jaqueline Fleming - Jasmine
- Lakeesha Williams - School Play Actress 1
- Tom'ya Bowden - School Play Actress 2
- Natasha Pearce - Mindy Plum
- Tori Reid - Nikki
- Lalanya Masters - Ameetha
- Bill Sehres - Croupier
- Aaron Seville - Randolph
- Jordan Wood - Veronica
- Darrow Igus - Butler
- Nick LaTour - Mr. Austin
- Starletta DuPois - Ms. Pittman
- Mark Chaet - Doctor
- Daniel Escobar - Joaquin
- Tom Bailey - Handyman Dan
- Kenya Moore - Miss Gerard
- Ludo Vika - Suzy
- Gina St. John - Leah Love
- Chip Heller - Prison Guard Bob
- Wendy Worthington - DMV Tester
- Robin Michele Stewart - Officer Hodges
- Corey Joshua Taylor - Ray
- Edith Grant - Moan Ranger
- Michelle Silveira - Geroniho
- De'Aundre Bonds - Mo-Mo
- John Knight - Marty
- Leslie Danon - Amber
- Thomas Anthony Jones - Male Exotic Dancer
- Thomas Anthony Jones - Male Stripper
- Ishtar Uhvana - Lauren Holmes
- Billy 'Sly' Williams - Bartender
- Kimberly Russell - Naomi
- Patience Cleveland - Mrs. Becker
- Kathrin Middleton - Dr. Dorothy Maybanks
- David Alan Graf - Mr. Sullivan
- Karan Ashley - Carrie McKnight
- Larry Gelman - Elderly Man
- Roxanne Beckford - Simone Dupri
- Alex Datcher - Donna
- Courtney Peldon - Cindy
- Kiami Davael - Christina
- James Ingersoll - Jack
- Sarah Lilly - June
- Enya Flack - Raina Storm
- Shuko Akune - Principal Sito
- Brooks Almy - Mrs. Sims
- Ja'net DuBois - Delores
- Damon Chandler - Joe
- Paulette Braxton - Niki
- Barry Shabaka Henley - Tom Cunningham
- Dante Basco - Lee
- Rolonda Watts - Janet
- Donald Gibb - Tiny
- Larry O. Williams Jr. - Male Police Officer
- Diana Theodore - Kelly
- Johari Johnson - Woman Police Officer
- Michele Morgan - Laverne
- Toby Smith - Lashonda
- Bobby McGee - Anthony
- Chuti Tiu - Masseuse
- Ernest Lee Thomas - Reverend Franklin
- Tim Powell - Park Security
- David Moreland - Edmundo
- Charlene Bloom - Mystery Girl
- Cullen Douglas - Arthur
- Walter Franks - Roger
- Leon Morenzie - Joseph
- Vivian Smallwood - Mrs. Hill
- Sonia Jackson - Selma
- Randy J. Goodwin - Reggie Carmichael
- Charity Hill - Jessie
- Ted Davis - Bill
- Mayah McCoy - Rosie
- Dawn Stern - Margo Spencer
- Michael Flowers Jr. - Waiter
- Edward Moss - Michael Jackson Impersonator
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