- Uma Thurman - Anouk
- Maria Tucci - Koula
- Dylan Schombing - Hugo
- Victor Garber - Narrator (voice)
- Sophie Okonedo - Aisha
- Khalid Alzouma - Adam
- Derek Michalak - Detective Mulrooney
- Cliff Moylan - Detective Forester
- Owen Tanzer - Rocco
- Michael Nouri - Thanassis
- Penn Badgley - Jamie
- Noah Robbins - Lee
- Ashley Aufderheide - Melissa
- Waltrudis Buck - Patient Lady
- Brandon S. Martinez - Benny
- Nancy Sun - June
- Otoja Abit - Coach
- John Dreher - Mehmet
- Tess Frazer - Pretty Girl
- Bobby Kruger - Prosecutor
- Julian Leong - Linus
- Chris Meyer - Jay
- Curtis Shumaker - Court Officer
- Blythe Danner - Virginia
- Freya Adams - Dania
- Catherine A. Callahan - Avy
- Cedric Cannon - Tommy the Doorman
- Jon Goracy - Ben Michaels
- Kenneth Maharaj - Dr. Patel
- Chivonne Michelle - Sarah
- Michael Angeloe - Self
- Blanca Camacho - (voice)
- Ellen Adair - Bridget Saltire
- Roya Shanks - Runya Stamos
- Rebecca Schull - Georgia
- David Pendleton - Homeless Man
- Dillon Mathews - Parent
- Dillon Mathews - Art Gallery Attendee
- Patrick Breen - Malcolm
- Kelly AuCoin - Tony
- Alma Cuervo - Judge Leguillou
- Lorraine Farris - Vivian
- Odiseas Georgiadis - Xander
- Rachel Hilson - Liz
- Jen Ponton - Janice
- Daniel Velasco - Sean
- Bubba Weiler - Leon
- Kathleen Wilce - Administrator
- Kevin Yamada - Teacher
- Omar Metwally - Ajay
- Johnathan Tchaikovsky - Britton
- Tommy Bayiokos - Yianni
- Catherine Cain - Kid at Playground
- Charles Cain - Kid at Playground
- Brooke Capuano - Kid at Playground
- Siraj Huda - Cab Driver
- Adam Wade McLaughlin - Mr. Grenier
- Dante Pereira-Olson - Hero Kid
- Austin Purnell - Bookstore Patron
- Haley Rawson - Kiki Bleifer
- Ian Volandt - Preschooler
- Allison Jean White - Kid's Mom
- Allison Mullaney - Kid at Playground (uncredited)
- Nancy Ellen Shore - Clinic Patient (uncredited)
- Molly Price - Fiona
- Amelia Campbell - Mrs. Bajaria
- Jack Davidson - Developer Sam
- Annabelle Attanasio - Young Woman
- Jabari Gray - Writer Guy
- Gil Deeble - Bailiff
- Roger Brenner - Courtroom Gallery Attendee (uncredited)
- Brenda Kuciemba - Pedestrian
- Harrison Nesbit - Teacher
- Geoffrey Owens - Dr. Fletcher
- Jyoti Singh - Pharmacist
- Jon Goracy
- Chris Oliver-Taylor
- Helen Bowden
- Michael McMahon
- Dann Fink
- Jon Robin Baitz
- Jason Derlatka
- Jon Ehrlich
Brian Cox hace el papel de Manolis.
Melissa George interpreta a Rosie en la serie.
Lucas Hedges interpreta a Ritchie en la serie.
Marin Ireland interpreta a Sandi en la serie.
Makenzie Leigh interpreta a Connie en la serie.
Thandiwe Newton hace el papel de Aisha.
Zachary Quinto hace el papel de Harry.
Thomas Sadoski interpreta a Gary en la serie.
Peter Sarsgaard interpreta a Hector en la serie.
Uma Thurman interpreta a Anouk en la serie.
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