- Olivia d'Abo - Marie Blake
- Olivia d'Abo - Delilah
- John F. O'Donohue - Fireman
- Julia Louis-Dreyfus - Tina, Danger Girl
- Suzanne Pleshette - Sarah Eliot
- Arye Gross - Tony
- Lydie Denier - Monique
- Sandra Taylor - Belinda
- Mitchell Ryan - Mr. Bremley
- Mark Harelik - Jeff
- Cassidy Rae - Nikki Gordon
- Ellen Travolta - Mrs. Cordova
- Alan Blumenfeld - Vince
- Conan O'Brien - Cameron Duncan
- Ron Fassler - Paul
- Patrick Cranshaw - Old Man
- Peter Boyle - Walter Eliot
- Joe Liss - Joe
- Michael Spound - Andy Felner
- Paula Abdul - Paula Abdul
- Dana Ashbrook - Keith
- Jeffrey Combs - Klein
- Jenna Elfman - Jordan
- Kevin Weisman - Lyle
- John Michael Higgins - Reverend Fuller
- John Kassir - Maitre 'D
- Al Roker - Dr. Benjamin
- Tatjana Patitz - Cinderella
- Maureen McCormick - Valerie
- Jonathan Lipnicki - Rudy
- Paula Marshall - Isabella
- Davy Jones - Davy Jones
- Tom Gallop - New Yorker Interviewer
- Dana Wheeler-Nicholson - Erika
- Larry Miller - The Cable Guy
- Bruce Kirby - Uncle Mike
- Marshall Bell - Mr. Gottlieb
- Steve Hytner - Jamie Barron
- Catherine Lloyd Burns - April
- Audie England - Melissa
- Kevin Tighe - Jack Blake
- Donal Logue - Billy
- Mary Pat Gleason - Patton
- Mariska Hargitay - Kate Conklin
- Keene Curtis - Mr. Klug
- Al Ruscio - Bob
- Brian Doyle-Murray - Captain Conklin
- Cara Buono - Christie
- Leah Lail - Renee
- Illeana Douglas - Martha
- Wendie Malick - Dr. Cornick
- Marie Osmond - Marie Osmond
- Robert Mailhouse - Ricky
- Brad Grunberg - Strip Club Guy
- Julie Benz - Cranberries Girl
- Ken Marino - Big Tipper
- Chao Li Chi - Mr. Pao
- Don Rickles - Dr. Dick Sloan
- Patricia Belcher - Newsweek Interviewer
- Michael Winters - Mike
- Lynn Clark - Sara
- Nicole Forester - Emma
- David Schwimmer - Ross Geller
- Marianne Muellerleile - Mrs. Fingerman
- Megan Ward - Monica
- Rick Overton - Carl Gannon
- Brooke Langton - Amanda
- Arthur Roberts - Ambassador Grady
- George Plimpton - George Plimpton
- Amanda Peet - Kathy
- Jean Speegle Howard - Old Woman
- Juanita Jennings - Liz
- Kristin Davis - Leslie
- Richard Riehle - Mr. Van Wagner
- Willie Garson - Ted
- Irene Tsu - Mrs. Pao
- Andy Buckley - Mike Conklin
- Andrea C. Robinson - Bernie
- Saul Stein - Back Specialist
- Diane Delano - Pit Boss
- Silas Weir Mitchell - Floyd
- Albie Selznick - Director
- Rodney Dangerfield - Rodney Dangerfield
- Don Murray - Chip Bremley
- Carlos Lacámara - Esteban
- Robin Pearson Rose - News Reporter
- Wendy Gazelle - Ginger
- Jay Kogen - Pretzel Vendor
- Pat Kilbane - Leo
- Jim Metzler - Mr. Gordon
- David Wohl - Bobby Driscoll
- David Valcin - Antonio the Waiter
- Peggy Rea - Aunt Heidi
- Jimmy Breslin - Jimmy Breslin
- Cristi Conaway - Kari
- Jack Shearer - Repairman
- Dion Anderson - Harry
- Nancy Fish - Betty
- David DeLuise - Booth Guy
- Winifred Freedman - Soap Opera Digest Interviewer
- David Doty - Conductor
- Joe Sabatino - Buff Guy
- Tim Haldeman - Waiter
- Paul Bates - Fish
- Kevin Contreras - Jeans Guy
- Lauren Bowles - Paula
- Louis Guss - Rosie Flowers
- John Vickery - Seth
- Amy Yasbeck - Amy Yasbeck (uncredited)
- Colton James - Kid
- Brian Klugman - Teenager
- Gerry Bamman - Dr. Bradford
- Emilio Estevez - Emilio Estevez
- Antwon Tanner - Teenager
- Maury Sterling - Mordecai
- Eric Saiet - Ted
- Robert Arevalo - Juan Uno
- Molly Shannon - Melody Pugh
- Jenna Mattison - Superwoman
- Jack Black - Randy
- Walker Brandt - Bambi
- O'Neal Compton - TY
- Viveka Davis - Bonnie
- Caitlin Keats - Dana
- David Pressman - Engineer
- Zaid Farid - Ticket Man
- Jim Lampley - Self
- Charles Rahi Chun - Cop
- Charles Rahi Chun - Policeman
- Bob Miller - Self
- Christopher Reed - Derek
- Alecia Guzman - Pretty Woman
- Sarah Ann Morris - Pretty Woman
- W. Earl Brown - Cabbie
- Suzanne Lanza - Gorgeous Woman
- Peter Spellos - Customs Official
- Morgan Hunter - Customs Official
- Jensen Daggett - Charlie McCarthy
- Andrew Bilgore - Gene
- Tony V. - Freaky Lou
- Jeff Bornstein - 3-Card Monte Man
- Tom Williams - Baby V.O.
- Eric Sharp - The Mugger
- Steve Paymer - Dr. Mesner
- Eric Poppick - Mr. Bringle
- Renée Taylor - Zelda
- André Nemec - Eric
- James Arone - Jury Foreman
- Cazimir Milostan - Neighbor
- Michele Farr - Mrs. Glance
- Daniel Passer - Sam Wolf
- Paul Cassell - Edgar Conklin
- Eric Payne - Goodwill Man
- Julia Montgomery Brown - Sarah Fuller
- Brant Cotton - Shirtless Guy
- Spencer Beglarian - Ivan
- Tracy Douglas - Tina
- Tony Boldi - Doug
- Antony Ponzini - Alfredo
- Eric Michael Zee - Eric Chow
- Dan Cortese - Dan Montgomery
- Frank Pesce - Cabbie
- Robert Aguilar Jr. - The Man
- Michael Leydon Campbell - Father
- Cris Borgnine - Waiter
- Anthony Diaz-Perez - Juan Uno
- Eric Matheny - Gary Shapiro
- Nikki Tyler-Flynn - Paula
- Tushka Bergen - Ilsa
- Evan Arnold - Gomer Pyle
- Carlos Oscar - Cuban Guy
- Stan Cahill - Terry Conklin
- Mark Sivertsen - Instructor
- Fred Sanders - Stock Broker
- Bari K. Willerford - Take-Out Customer
- John Mendoza - Nurse
- Linda Hawkins - Sandy
- Mara Holguin - Mother
- Shirley Prestia - Saleslady
- Michael P. Byrne - Judge
- Michael Leopard - Bailiff
- Karen Bankhead - Annulment Clerk
- Irwin Keyes - Heckler
- Frank Kopyc - Roulette Guy
- David Trainer
- Gail Mancuso
- Max Tash
- Kim Friedman
- Andrew Tsao
- Alan Myerson
- John Masius
- Rachel Sweet
- Brad Hall
- Jay Kogen
- Andrew Gottlieb
- Gayle Abrams
Jonathan Silverman interpreta a Jonathan Eliot en la serie.
Joey Slotnick interpreta a Sam Sloan en la serie.
Ming-Na Wen interpreta a Trudy Sloan en la serie.
Ernest Borgnine interpreta a Manny Cordoba en la serie.
Shawn Michael Howard hace el papel de Russell.
Olivia d'Abo interpreta a Marie Blake en la serie.
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