- Amy Hill - Judge Gu
- Lucy Punch - Sally
- Tom Virtue - Mayor Wittels
- Kristen Stewart - Announcer (uncredited)
- Susan Yeagley - Denise
- Tig Notaro - Tig
- Marin Hinkle - Rose Silverman
- Ken Marino - Patient
- Bob Odenkirk - Mister Wadsworth
- Victor Yerrid - Ookie
- Paul F. Tompkins - Paul
- Jeff Ross - Jeff
- Tucker Smallwood - God
- Lindsey Stoddart - Peggy
- Larry Hankin - Mister Johnson
- Adair Tishler - Young Laura
- Masi Oka - Clerk
- Matt Berry - Sir Corin Ashley
- Matt Berry - Owl
- Ava Acres - Little Laura
- Tim Heidecker - Frances
- Justin Roiland - Blonde Craig
- Justin Roiland - Chant Leader
- Karri Turner - Young Woman
- Laura Marano - Young Sarah Silverman
- Laura Marano - Heather Silverman / Young Sarah Silverman
- BJ Porter - Arthur
- Chris Tallman - Officer Thwidge
- Chris Tallman - Weatherman
- Laura Hayes - Old Woman
- Kelli Dawn Hancock - Crack Whore
- Rachel Germaine - Crack Whore
- Tanjareen Martin - Crack Whore
- Zach Galifianakis - Fred Blorth
- Jeff Bryan Davis - D.A.
- Jeff Bryan Davis - Crying Boyfriend
- Jeff Bryan Davis - Waiter
- Sal Iacono - Neighbor
- Missi Pyle - Scarlett Lacey
- Joanna Sanchez - Nurse
- Rachael Harris - School Teacher
- Mike Ivy - Homeless Mike
- Jill Talley - Patty Jenkins
- Jill Talley - The Ghost
- Jimmy Kimmel - Joan the Dispatcher
- Fred Stoller - Taser Cop
- Stanley Ullman - Officer
- Todd Bishop - NSA Agent
- Brian Carpenter - Judge
- Justine Dorsey - Amber
- Abed Gheith - Terrorist
- Kate Freund - Margaret
- Kate Freund - Whitney
- Jon Schroeder - Jim Jenkins
- Melinda Hill - Joyce
- Jonathan Kimmel - Pageant Host
- Jonathan Kimmel - Homeless Blind Willy Joe
- Jonathan Kimmel - Bob
- Ron Lynch - Dr. Lynch
- Ron Lynch - Doctor
- Brad Grunberg - Fat Boyfriend
- Jon Hamm - Cable Guy
- Eddie Pepitone - Eddie Pepitone
- Candace Brown - Natalie
- Eve Brenner - Mrs. Ramstack
- David Earl Waterman - Bomb Squad Leader
- David Earl Waterman - VVAP Officer
- Carrie Aizley - Carol
- Eric Marseglia - Eric
- Chris Romano - Stencil
- Chris Romano - Male Cheerleader
- Steve O'Donnell - Pastor
- Kurt Scholler - Jo-Jo
- Kurt Scholler - Male Cheerleader
- Ellerine Harding - Mailwoman
- Alex Désert - Eugene
- Beth Tapper - Grace Bradley
- Henriette Mantel - Middle-Aged Woman
- G. Ja Nee' Davis - Church Choir
- Tony Wilkins - Church Choir
- Karen Y. McClain - Large Woman
- Karen Y. McClain - Karen McClain
- Norma Jean - Black-Faced Sarah Supporter
- Paul Raff - Morgan Freeman Type
- Ngaio Bealum - Onlooker
- Ngaio Bealum - Poet
- Don Barris - Warm-Up Guy
- Armen Weitzman - Armen
- Armen Weitzman - Store Clerk
- Meredith Roberts Quill - Tabitha
- Dan Sterling - Producer
- Greg Pitts - Oh Face Guy
- Mark Cohen - Max Silverman
- Mark Cohen - Dad
- Eric Schaar - Check in Guy
- Blake Bertrand - Kid
- Joe Wagner - Ethan
- Jane Yamamoto - Jane Yamamoto
- Jane Yamamoto - Reporter
- Tonita Castro - Dora
- Christopher DerGregorian - Well-dressed Mexican Man
- Patricia Place - Francine
- Garry Marshall - Sharkcorp President
- Dawn Cody - Secretary
- Eric Falconer - Man
- Cleto Escobedo Jr. - Mayoral Aide
- Harris Wittels - Patient
- Harris Wittels - Random Guy
- Harris Wittels - Sebastian
- Todd Glass - Man
- Todd Glass - Robert Woodliff
- Jason Clay - Onlooker
- Murray Gershenz - Murray
- Murray Gershenz - Old Man
- Becky Thyre - Pageant Mom
- Becky Thyre - Suzette Williams
- Ping Wu - Borjijin
- Allan Havey - Judge
- Lucille Soong - Mrs. Xiongnu
- Raymond Ma - Mr. Xiongnu
- Jason Sarayba - Mongolian Party-Goer
- Lidet Viravong - Tiny Mongolian
- Peter Chen - Chinese Man
- Americus Abesamis - Mongolian Gay Guy
- Jason Rogel - Mongolian Gay Guy
- Randall Park - Mongolian Aide
- Eric Acosta - Ouncy Bouncy Member
- Rob Schrab - Off-Screen Guy
- Rob Schrab - Driver
- Rob Schrab - Mini Coffee
- Rob Schrab - Background Guy
- Rob Schrab - Patient
- Rob Schrab - Gene
- Rob Schrab - Nessy
- Rob Schrab - Fuzzy Pants
- Rob Schrab - Weird Hostage
- Rob Schrab - Saveco Larry
- Rob Schrab - Maintenance Guy / Voice of Toot
- Rob Schrab - Baby-Man Sr.
- Myke Chilian - Ouncy Bouncy Member
- Christian Le Guilloux - Ouncy Bouncy Member
- Ingrid Coree - Reporter
- Chester Tam - Chester
- Chester Tam - Maurice
- Todd Barry - Nathan
- Aedin Mincks - Balloon Holding Kid
- Ryan Ridley - Delivery Man
- Ryan Ridley - Ouncy Bouncy Member
- Ryan Ridley - Onlooker
- Erick Avari - Alex Gilbert
- Fred Armisen - Taylor Magenheim
- Joe Lo Truglio - Kenneth
- Matt Walsh - Tennis Player
- Hong Chau - Asian Masseuse
- Craig Anton - Reporter
- Adam Carolla - Carl
- Sydney Park - Stella
- Sevan Najarian - Paramedic
- Sevan Najarian - Ouncy Bouncy Member
- Sevan Najarian - Onlooker
- Sevan Najarian - Officer
- Phyllis Applegate - Mrs. Ivy
- Nick LaTour - Mr. Ivy
- Keedar Whittle - Basketball Guy
- Scott Aukerman - Officer Leach
- Scott Aukerman - Agent Falconer
- Dick Van Patten - Dr. Eddie Hackmeyer
- Patty Jenkins - Jill Talley
- Matt Besser - Jim
- Erin O'Malley - Business Woman
- Wade Randolph - Cabbie
- Wade Randolph - Bob
- Wade Randolph - Follower
- Kent Shocknek - TV Reporter
- Kent Shocknek - Anchor
- Bud Mathis - Homeless Bert
- Kathleen Hartman - Screaming Nurse
- Michael Blaiklock - Trevor Kaufman
- Tom Ohmer - Security Agent
- Christopher Eccleston - Dr. Lazer Rage
- Lisa Loeb - Lisa Loeb
- Fabienne Maurer - Violinist (Globetrotters)
- Stephen Root - Johnny Forrealz
- Amad Jackson - Tokie
- Jonathan Halyalkar - Hipster
- Isaac C. Singleton Jr. - Tricky-D
- Natasha Leggero - Dr. Leggero
- Rich Fulcher - Reverend Fulcher
- Barbara Ann Duffy - Jay's Party Guest
- Graham Elwood - Paramedic
- Graham Elwood - Officer
- Gary S. Mann - Outrageously Good Looking Guy
- Gary S. Mann - Cult Member with Well Proportioned Nose
- Scott Chernoff - Chernoff
- Bill Maher - Bill Maher
- Mia Barron - Lauren Corrao
- Bill Wiley - Patrick Pillows
- Michael McCafferty - Xavier Peretti
- Derek Waters - Production Assistant
- Joshua Salvati - Small Boy
- Robert Gossett - Judge Willie Joe Blackwell
- David Juskow - Slip Yeagley
- Paul Scheer - Producer
- Jonathan Mangum - Matt Markus
- Ben Schwartz - Writer
- Gene LeBell - Carl
- Phil Culotta - Fireman
- Scott Leva - Fireman
- John Ennis - Stranger at Fan-Tasti-Mart!
- John Ennis - Free Hug Guy
- Maria Bamford - May Kadoody
- Bradley Whitford - Toby Grossnickel
- Vatche Panos - Clerk
- Vatche Panos - Ouncy Bouncy Member
- Vatche Panos - Vendor
- Joshua Malina - Supervisor Bill Wilson
- Matthew Patrick Davis - Ace Ventura
- Art Evans - Commander
- Tara Sands - Campaign Manager
- Les Mahoney - City Election Official
- Andy Samberg - Troy Bulletinboard
- Kurt Loder - Kurt Loder
- Savannah Paige Rae - Young Sarah
- Melanie Comarcho - Imaginary Partier
- Frankie Ray - Andre
- Chelsea Peretti - Becky
- Paul Rust - Customer
- Neil Campbell - Customer
- Azmyth Kaminski - Imaginary Partier
- Stephen Tobolowsky - Bill Fantastimart
- George Cheung - John
- Kulap Vilaysack - Carly
- Gregg Daniel - Manager
- Jeremy Vest - 'How's Your News?' Reporter
- Georgie Kidder - Ella Carroll - City Election Secretary
- Georgie Kidder - Jill
- Georgie Kidder - Miss Nightingale
- Georgie Kidder - Deirdre
- Georgie Kidder - Concert Fan
- Georgie Kidder - Jennifer
- Georgie Kidder - Lucy Quayle
- Georgie Kidder - Mrs. Giddon
- Georgie Kidder - Lynn - Orphanage Nurse
- Georgie Kidder - Georgie - Tap Dancing Trio
- Nancy Yee - Asian Prostitute
- Johanna Went - Clown
- Billy Crudup - Self
- Orson Bean - Mr. Myron
- Mary Gregory - Mrs. Myron
- John DiMaggio - Trent
- Joe Filippone - Roadie
- Nikky Smedley - Nikky McGuire
- Adam Scott - Agent Schroeder
- Keb' Mo' - Businessman
- Roy Gaines - Businessman
- Jake Vaughn - Baby-Man Jr.
- David Hartman - Older Engineer
- Ken Daly - Engineer
- Jennifer Flack - Monica
- Derek Mears - Captain Mears
- Buddy Sosthand - Swat
- Brian Avery - Swat
- Esteban Cueto - Swat
- David Anthony Buglione - Swat
- Randall Archer - Swat
- Tiffany Daniels - Trisha - Tap Dancing Trio
- Jessica Rotter - Jessie - Tap Dancing Trio
- Patton Oswalt - Vincent Van Guy
- Drew Droege - Seth
- Cade Dundish - Pee-Pee Kid
- Randy Gambill - Creepy Guy
- Doug Murray - Doctor
- Ed Asner - Commandant Von Reichenstein
- Michelle Lenhardt - Romanski's Waitress
- Scott Whyte - Percy
- Joseph Armillas - City Election Official
- Shelley Starrett - Vendor
- Bree Sanborn - Van Girl
- Doug Benson - Weird Nathan
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