- Morris Chestnut - Barrett Cain
- Melina Kanakaredes - Lane Hunter
- Moran Atias - Renata Morali
- Merrin Dungey - Claire Thorpe
- Andrew McCarthy - Ian Sullivan
- Kaley Ronayne - Kincaid Sullivan
- Violett Beane - Lily Kendall
- Michael Patrick Lane - Ross Evans
- Alexa Mansour - Chloe Goddard
- Coley Campany - Chloe's Mother
- Warren Christie - Jude Silva
- Jahi Di'Allo Winston - Trevor Conforth
- Vernee Watson-Johnson - Mary Phillips
- Erika Slezak - Eileen Jacoby
- Tzi Ma - Ted Zhou
- Chris Mayers - Steven Butler
- Lyman Chen - Bodyguard
- Matt Shively - TJ Chioffi
- Brooke Butler - Julie Guilford
- Michael O'Neill - Joshua Williams
- Jolene Purdy - Olivia Tan
- April Parker Jones - Jen Kars
- Barry Alan Levine - Russell Waters
- Patricia French - Lorraine Gleason
- Tara Jones - Angelica Barns
- Jade Fernandez - Ashley Garrity
- Charles Green - Leonard Langdon
- Al Mitchell - Wendal Mckee
- Hannah Alline - Alice Kirkton
- Roger Floyd - Anthony Ewen
- Stephen Ruffin - Hal Woods
- Rachel Harker - Joanne Jenkins
- Bill Kelly - Charles Jenkins
- Brooke Jaye Taylor - Mrs. Alderwood
- Emily Tosta - Joplin Bird
- Elia Monte-Brown - Natalie Ramirez
- Kevin Christy - Roger Stanley
- Joy Rovaris - Aubrey
- Dan Martin - Floyd Washington
- Melissa DuPrey - Marisol Garcia
- Ed Amatrudo - Ted Harris
- Victor Love - Carleton Ward
- Marianne Fraulo - Dina Basilico
- Tonia Jackson - Jane Diaz
- Tate Ellington - Jason Thoms
- Cyrina Fiallo - Rachel Bird
- Adrienne Whitney Papp - Melanie Thoms
- Yaani King Mondschein - Brianna Candelora
- Chris Myers - John Candelora
- Sonny Shroyer - Hugh Yokum
- Atkins Estimond - Casey Mitchell
- Colin Hay - Rhys Barrett
- Tanc Sade - Josh Robinson
- Malaya Rivera Drew - Naomi
- Emily Kuroda - Penny Oh
- Ravi Cabot-Conyers - Jasper Barnett
- Bailey Noble - Laurie Dante
- Emil Beheshti - Arthur Franklin
- Andy Milder - Stefan Kisic
- Linda Park - Janine Levasseur
- Joe Holt - Ernest Levasseur
- Zenobia Shroff - Himaya Pravesh
- Matt Malloy - Jake McCrary
- Harry Groener - Bartholomew McGainn
- Ellen Wroe - Rose Lapierre
- Dot-Marie Jones - Meg Mullins
- Michael Rady - Sam
- Sharon Omi - Florence Camden
- Ray Proscia - Terry Camden
- Carlos Lacámara - Andre
- Ron Simons - Otto
- Paul Skye Lehrman - Chet Aiken
- Shanley Caswell - Nora Mitchell
- Caroline Arapoglou - Noni Turner
- Alex Sgambati - Bella
- Amor Owens - Karin Cooper
- BettyLynn Allison - Gertie Burman
- Bethany Geaber - Isabel Sharp
- Sloane Warren - Social Worker
- Stephanie Wong - Meg Larue
- Satya Nikhil Polisetti - Sebastian Havis
- Lynn Whitfield - Josephine Okeke
- Josh Henry - Doug Bailey
- Susan McPhail - Nadine Lebas
- Sara Antonio - Miss Louise Lafleur
- Dan Lauria - Simon Ortiz
- Daniella Alonso - Zoey Barnett
- Evan Whitten - Henry Barnett
- Karly Rothenberg - Marilyn Spoelstra
- Rae Gray - Kay Spoelstra
- John Newberg - General Fulton
- Ian Gregg - Mason Buck
- Henry Haggard - Board Member #1
- Susan Macke Miller - Board Member #2
- Jay DeVon Johnson - Board Member
- Nicole Sellars - Connie Klein
- Grace McPhillips - QuoVadis Associate
- Shaun McMillan - QuoVadis Lawyer
- Akim Black - Security Guard #1
- Michael Weston - Gordon Page
- Omar Maskati - Evan Weston
- Kimmy Shields - Sydney Schroeder
- Jermaine Rivers - Agent Banks
- Jared Simon - Loomis
- Tony Bravado - FBI Agent
- Lauren Bonetti - Sally Dunhill
- Genneya Walton - Valerie
- April McCullough - Redhead
- Jamie Miles - Heavyset Man
- Peggy Sheffield - Sylvia Cooke
- Melissa Oulton Haas - Pathologist
- Shannon Wilcox - Donna Jackson
- Adam Irigoyen - Eric Teter
- Catherine Dyer - Alexis Stevens
- Peyton Jackson - Eli Garcia
- Walter Colson - Tony Garcia
- Nikki SooHoo - Bai Liu
- Nathan Anderson - Paramedic John
- Michael Goodwin - Bob Tuttle
- Dena Sodano - Paramedic Angie
- Kamal Angelo Bolden - Wade Davies
- Joel Johnstone - Gabriel Hendricks
- Vinessa Antoine - Lea Jordan
- John Billingsley - Dr. Stewart
- Crista Flanagan - Sharon Colby
- Paxton Singleton - Danny Hendricks
- Charlene Amoia - Bobbi Hendricks
- Mariana Novak - Entitled Mom
- Christopher B. Duncan - Brett Slater
- Bob Clendenin - William Harper
- Patrick Davis Alarcón - Fritz Rawlins
- Ashritha Kancharla - Tech
- Jibre Hordges - Monroe
- Riley Hough - Ralph
- Justin Randell Brooke - Receptionist
- Neva Howell - Sour Apple
- Miles Gaston Villanueva - Alec Shaw
- Sam Huntington - Taylor Emigh
- Al Calderon - Diego Herrera
- Andrea Laing - Coordinator
- Andrea Laing - Vanessa Luling
- Charmin Lee - Cardiologist
- John Noble - Elliot Festervan
- Daniel Augustin - Ricky
- Jordan Blair Mangold Brown - Paige the Waitress
- Julianna Guill - Jessie Nevin
- Stephanie Hunt - Shira Smook
- Gregory Itzin - Sunflower
- Scott Takeda - Xavier Lee
- Antwan Mills - Officer Dylan Marker
- Camile Ervin - Jolene Landis
- Joseph Castillo-Midyett - Trent
- Victoria Scala - Volunteer
- Annunziata Gianzero - Maya Turner
- Mary Shaw - Mary Bolton
- Mandy Levin - Wendy Jones
- Amber Wallace - Rosie
- Ric Reitz - Jim Deloach
- Jenny O'Hara - Shirley Harris
- Demi Castro - Alvarado
- Drew Waters - Bryce
- Chelsea Kurtz - Eloise Camden
- Cynthia Evans - Marie Albermerle
- Cole Eichenberger - Jonah Albermerle
- Kisa Willis - Fiona Gates
- Amanda Tavarez - Gallerista
- Claire Lanay - PICU Nurse
- Mike Pniewski - Abe Benedict
- Brandon Johnston - Reggie Watson
- Alimi Ballard - Al Raines
- Julia Campbell - Vivian Betournay
- Jonathan Lipnicki - Remy Necco
- Zach Appelman - Hades / Doug Atwater
- Samantha Boscarino - Bella
- Connor Paolo - Isaac Morgan
- David Alan Grier - Lamar Broome
- Adriane Lenox - Bonnie Broome
- Denise Dowse - Carol Austin
- Zach Cherry - Marcus Broome
- Trevor Long - Rob Spiro
- Kate Hodge - Lynette Hughes
- Karis Campbell - Dr. Jackie Lin
- Cayden Boyd - Tyler Warzel
- Radek Lord - Grayson Betournay
- Megyn Price - Eline Harris
- Skyler Day - Clara Rasmussen
- Marco Guerrero - Vince Artinian
- Brian Brightman - Scott Wilson
- Barry Piacente - Moore
- Erinn Westbrook - Adaku Eze
- Hal Ozsan - Nigel Sutton
- Chris Mason - Dax Ramsey
- Monica Garcia Bradley - Riley Jackson
- Charline St. Charles - Ingrid Nilsson
- Jessica Tuck - Becky Copple
- Wallace Langham - John Copple
- Geoffrey Cantor - Zip Betournay
- Devon Hales - Lisa Logan
- Scott Reeves - Vince McGill
- Jonathon Pawlowski - Joe Daniels
- Tim Russ - Tyrone Griffiths
- Steven Reddington - Bradley Jenkins
- Tenaya Cleveland - Georgetta Chenault
- Joseph C. Phillips - Dr. Jeffrey Pierce
- Lilli Birdsell - Publicist
- Zachary Gordon - Aaron Meuser
- Chloe Coleman - Lucy Williams
- Jaylen Moore - Raj Alizai
- Christina Marie Karis - Cynthia Fizdale
- Greg Pitts - Doug Corson
- Zane Stephens - Anesthesiologist
- Holly Morris - Female Nurse
- Aaron K Smalls - Male Nurse
- Robert Larriviere - Producer
- Regina Ting Chen - Scrub Nurse
- Mike Forbs - Transpo Worker Harold
- Tony Mirrcandani - King Jabbaar
- Rachael Thompson - VA Surgeon
- Rachael Thompson - Therapist Tammy
- Julie Zhan - Gemma Lin
- Missy Yager - Susan Lawson
- Connor Trinneer - Mark Lawson
- Molly Kunz - Mary Lawson
- Valerie Sue Love - Nurse Erica
- Ruth Reynolds - Assistant
- Joy Nash - Bianca
- Christie Lynn Smith - Joyce
- Karole Foreman - Adelaide Loggins
- Rick Holmes - Archer Loggins
- Kamran Shaikh - Robert
- Gunner Willis - Billy
- Kareem Lewis - Guy
- Savanna Renee - Teen Girl
- Alycia Cooper - Southern Lady
- Bridger Zadina - Finn Niver
- Lee Osorio - Odel De Silva
- Paden Fallis - Jake Winshine
- Richard Garner - Dr. Ed Langford
- Chris Ashworth - Reggie Perez
- Melanie Booth - Kimmy
- Jenna Kanell - Safety Coordinator
- Danielle Lyn - Jorani Wilson
- Candace West - Assistant
- Todd Sherry - Doll E. Wood / Joseph Kinney
- Rebecca Wisocky - Dr. Judith Brown
- Jesse Luken - Marcus Thompson
- Desiree Ross - Yvette Barnes
- Anita Sharma - Rupa Nour
- Shavonia Jones - Mom
- Elizabeth Faith Ludlow - Cara Ramirez
- Joanna Adler - Dawn Long
- Eli Gelb - Ezra Dreyfuss
- Matt Battaglia - Bill Landry
- Kwajalyn Brown - Sophia Marino
- Helen LeRoy - Maddie
- James Logan - Supervisor
- Michelle Rivera Huckaby - Respiratory Therapist
- Enya Flack - Cheryl Whickford
- Alicia Kelley - Phoebe Garrison
- Melinda Page Hamilton - Emma O'Neil
- Tucker Meek - Teen Boy (uncredited)
- Paul Schackman - Todd Eckart
- Joanne Kelly - Catherine Loy
- Michael Hogan - Albert Nolan
- Kearran Giovanni - Andrea Braydon
- Chelsea Gilligan - Molly Ingrams
- Andrew Ridings - Derek Ingrams
- Philip Anthony-Rodriguez - Miguel
- Kenneth Tigar - Henry Schultz
- Alex Hernandez - Ed Torres
- Aisha Kabia - Justine Hunt
- Moira Kelly - Annie Diamonte
- Scarlett Blum - Josie Ingrams
- Vince Pisani - Dr. Aaron Persopoulos
- Tasie Lawrence - Priya Nair
- Philip Covin - Ophthalmology Resident
- Patrick Walker - Micah Stevens
- Hannah Pniewski - Lab Tech Maria James
- Darla Delgado - Elena Olivera
- Darla Delgado - Hannah
- Jenna Dewan - Julian Booth
- Nick Arapoglou - Jason Brooks
- Camille Robinson - ND Nurse
- Jay Plyburn - Dale Holton
- Mala Bhattacharya - Administrator
- Rasool J'Han - Kara Andrews
- Brittney Level - Malia Long
- Aubriana Davis - Raylee
- Steven Serbones - Young Dad Borden
- Cory Scott Allen - Carter Wiggins
- Brittany Wilkerson - Doctor
- Alexis Auffray - Lady Guest
- Minnie Rajguru - Woman
- Rob Yang - Logan Kim
- Chido Nwokocha - James Carroll
- Victor McCay - Ben Mullins
- Evelyn Lorena - Bianca / Alicia
- Jennifer Patino - Yorn's Assistant
- Katie Parker - Eva Wolman
- Nathan Sutton - Darren Miller
- Don Stallings - Winston McCloud
- Isaiah Jarel - Emmett Mackey
- David Shae - Terry Berndahl
- Sarafina King - Ariana McCloud
- Glenn Magee - Agent Brooks
- Melissa Saint-Amand - Alicia Nelson
- Michael Christopher Rodney - Brandon Davis
- Kerr Smith - Jacob Yorn
- Anna Khaja - Himaya Pravesh
- Tijuana Ricks - Clementine Jolson
- Carlacia Grant - Trinity Jolson
- Taylor Rose - Fiona Myers
- Nichelle Hines - Nichelle Randall
- Jack Laufer - Norman Katz
- Roxanne Hart - Estelle Katz
- Whitney Goin - Denise
- Kenny Alfonso - Dr. Daniel Lamas
- Michael Rene Walton - Dr. Charles Aronson
- Leslie Sides - O.R. Tech
- Tim Griffin - Nate Hill
- Larry Herring - Anesthesiologist
- Lauren Halperin - Perfusionist
- Michael Aaron Milligan - Jay Pickering
- Daryn Kahn - Josko Novak
- Michelle Rose - Phlebotomist Lisa
- Eric Mendenhall - Seamus O'Reilly
- Renato Powell - Liz
- J. Barrett Cooper - Moises Knoll
- Mickey Cole Jr. - Male College Student
- Mickey Cole Jr. - Cleaning Tech George
- Kaleka - Volunteer
- Markelle Gay - Panda Bear
- Shazi Raja - Nadine Suheimat
- Meera Simhan - Myra Mattoo
- Maddie Nichols - Tina Miller
- Vince Foster - Paul Chu
- Mark Rowe - Richard Miller
- Kim Winter Mako - Mary Miller
- Darryl W. Handy - Officiant
- Alie Urquhart - Lisa McBride
- Carrie Walrond Hood - Patty McBride
- Elimu Nelson - Wes Gibson
- Adam Donshik - Ken Ackerman
- Tiffany Morgan - Gretchen Ackerman
- Robert Mello - Ted
- Gareth Williams - Pete Goldense
- Maurie A. Chandler - Cindy Washington
- Bill Murphey - Board Member
- Joshua Whichard - 20-ish Dude
- Cynthia Barrett - Dr. Wylie
- Michael Paul Chan - Yee Austin
- Cherise Boothe - Candace Oliver
- Miguel Pérez - Doug Johnson
- Anny Jules - Young Mother
- Ethan Corn - John Akerman
- Kelly Tippens - Linda Smith
- Jessica Miesel - Jessica Moore
- Tasso Feldman - Irving Feldman
- Glenn Morshower - Marshall Winthrop
- Brian George - Tejan Pravesh
- Cara Ricketts - Rose Williams
- Christopher J. Hanke - Gregg
- Summer Selby - Carol Austin
- Chris Perfetti - Phillip Bondman
- Chedi Chang - Sammie Ackerman
- Briana Venskus - Astrid Chavez
- Kim Estes - Roland Rawlins
- Allie McCulloch - Gabbi Johnson
- Maria Howell - Judge Lola Rawlins
- Corbin Bernsen - Kyle Nevin
- Caleb J. Avery - Young AJ
- Katie Gill - June Parks
- Tia L. Davis - Young Carol
- Teri Wyble - Sadie
- Conrad Ricamora - Jake Wong
- Carmela McNeal - Doreen
- Greyson Chadwick - ND Patient #1
- Ann Marie Gideon - Sylvie Pund
- Denitra Isler - Ellen Hundley
- Dean Cudworth - Mr. Hollister
- Andrew Dicostanzo - Young Man
- Aneesha Joshi - Padma Devi
- Jeena Yi - Jayci Lee
- Candy McLellan - Ciara Bullock
- Stephen Wallem - Winston Robards
- Kristina Arjona - ICU Nurse
- Kristina Arjona - Anesthesiologist
- Randy Gonzalez - Matias Alvarez
- Cosima Cabrera - Trini Alvarez
- Ana Mackenzie - Marion Clark
- Carlos Solórzano - Miguel Alvarez
- Suehyla El-Attar - Laura Graham
- Alison Ball - Meghan Greer
- Eliana Ghen - Anna
- Alain Uy - Albert Soriano
- Ashley Jones - Diana Anza
- Jeremy Thomas - Marco Anza
- Joe Herrera - Ted Lin
- Freddy Boyd - Lab Tech Morris
- Marc Farley - Jokey Patient
- Phil Buckman - Jimmy Miller
- Alexis Krause - Lola Miller
- Robert Diago DoQui - Jacob Garcia
- Aaron Gillespie - Security Guard
- Todd Faulkner - Aaron Crowe
- Anya Ruoss - Press
- Cynthia Youngblood - Miriam
- Joe Morelli - Sergeant
- Kate Kovach - ND Patient
- Jayne Taini - Teri Keene
- Jess Nurse - Naomi
- Charis Jeffers - Ashley Nelson
- Dave MacDonald - Todd Barker
- Tiffany Kyle - Phoebe Moffit
- Derek Russo - Taron Drakos
- Wes McGee - Scott
- Malena Cunningham Anderson - Press
- Malena Cunningham Anderson - Newscaster
- Jack Ha - Chatty Resident
- Danielle Liggens - Chatty Resident
- Jwaundace Candece - Driver
- Troy Rudeseal - Disheveled Doctor
- Sarah-Nicole Robles - Maya Nuñez
- Levi Meaden - Stewart Mayer
- Roberto 'Sanz' Sanchez - Enrique Mendez
- Troy Ruptash - Ben Richardson
- Melissa Pino - Aida Mendez
- Sailor Larocque - Emma
- Steven Anthony Washington - Officer Ruiz
- Steven Culp - Mark Betz
- Mick Szal - Janice Bonner
- Alexandre Bagot - Bryce Lonergan
- Crystal Rivers - Emily Benesch
- Jessi Case - Mia
- David de Vries - Frank Abernathy
- Africa Miranda - Kimberly Gund
- Andrea Frankle - Lori Mackey
- Leslie Martínez - Intern Kelsey
- Shanessa Sweeney - Janaya Purcell
- Alan Aisenberg - Zach Brooks
- Tequilla Whitfield - Cheryl Sullivan
- Tequilla Whitfield - Cheryl Poole
- Shirley Chen - Alicia Zhou
- Gary Perez - Bruno Camacho
- Elaine del Valle - Miranda Camacho
- Michael Tow - Nathan Zhou
- Bryan Gael Guzman - Max Camacho
- Jennica Hill - CRNA Diana
- Christopher Fisher - Eli Joe
- Omer Mughal - EMT Alex
- Jesse Gallegos - Eucalyptus
- Laura Holloway - Nurse Susan
- Megan Hayes - Pharmacist
- Ahmad Ghafouri - Pulmonary Doctor
- Kulani Kai - Scheduling Nurse
- Scott Deal - Anesthesiologist
- Anisa Nyell Johnson - Blood Bank Coordinator
- Moses Das - EMT
- Sharonne Lanier - Paramedic
- Sharonne Lanier - Paramedic #2
- Leigh Higginbotham - Blood Bank Coordinator
- Charlie Bodin - Spencer Shafer
- George Wyner - Arthur Kravitz
- Zsané Jhé - Gemma Nguyen
- Vicki Lawrence - Gloria Ortiz
- Tara Ochs - Sharon Hill
- Miles Fowler - Trevor Daniels
- Christina Brucato - Eliza Brockton
- Tobias Truvillion - Aaron Deering
- Andrea Powell - Leslie Malco
- Mike Masters - Bryan Pellington
- Leslie France - Dianne Elkins
- Ulisses Gonsalves - EMT
- Andre Lamar - Security Guard
- Michelle Krusiec - Grace Soriano
- Elizabeth Grullón - Mariana Gonzalez
- Lesa Wilson - Joyce Royal
- Scott Cohen - Robert Porter
- Raphael Sbarge - Lieutenant Governor Beaumont
- Danielle Lewis - Ramsey
- Spence Maughon - James
- Jeff Campanella - Male Executive
- Kim Matula - Scarlett Wexler
- Deanna Pak - Circulating Nurse #1
- Deanna Pak - VIP Nurse
- Deanna Pak - Scrub Nurse
- Rajeev Jacob - Rocco Pilkington (Paramedic)
- Rajeev Jacob - Paramedic Bill
- Jordyn Aurora Aquino - Charli Martinez
- Crystal Lo - Mother
- Xander Mateo - Daniel
- Lexi Simonsen - Ana
- Madison Johnson - Jane Doe / Scout
- Miguel A. Gaetan - Rashid
- Alec Adams - Hoodie Guy
- Landon Brooks - EMT
- Landon Brooks - Paramedic
- Ashlyn Moore - X-Ray Tech
- Randy Spence - Homeless Man
- Eden Lee - Dr. Dove
- Kiah Alexandria Clingman - Hannah Pierce
- Ted Johnson - Older Man
- Bonnie Johnson - Older Woman
- Peter Graham - Jerome Parker
- Nelcie Souffrant - Magdala
- Wes Jetton - McDonnell
- Kat Conner Sterling - Mindy
- Nysa Morris - Jill
- George Hampe - Wyatt Barnes
- Julia Cho - Brit Bennet
- Mark Evans - Dr. Radford
- Patrick Fleming - Anthony Lee
- Teresa L. Graves - Darcy
- Richard Kline - George Criforth
- Maya Stojan - Sofia Desoto
- Veronica Cartwright - Celeste Crisforth
- Dawn Halfkenny - Nurse Valerie
- Bryant Prince - Brent
- Karson Kern - Josh
- Gissette E. Valentin - Paramedic
- Viviana Chavez - Reena Reddy
- Viviana Chavez - ICU Nurse
- Anna George - Vineeta Devi
- Bernard White - Raj Devi
- Adam Cronan - Dan
- Robert Yatta - Kevin
- Paula Andrea Placido - Tamiko Rodriguez
- Christopher Redman - Jackson Tellenbaum
- Delmar Reyna - Tisha Cross
- Cara Mantella - Pharmacist Laura
- Malik McCall - Pharmacist Frank
- Koral Michaels - Grateful Woman
- Nasir Rahim - Officer Carr
- Selah Kimbro Jones - Ella
- Ross Crain - James Nye
- Troy Faruk - Cameraman
- Heather Mazur - Magdalena Axenberg
- Joshua Harto - Mike Jonah Rellie
- Duke Davis Roberts - Ethan Eriksten
- Erin Ownbey - Holly
- Ken Colquitt - Janitor Yancy
- Ken Colquitt - Yancy
- Emily Grace Dunn - Cat
- Jennifer Sears - Kietra
- Javier Vazquez Jr. - Zombie
- Gregg Henry - Aaron Kranepool
- Jason Douglas - Officer Winnaker
- Adam Poole - Officer Wright
- Lana Young - Mary Osder
- Lana Young - Marie Osder
- Marlene Forte - Cherry Sandoval
- Juan Carlos Cantu - Gabe Sandoval
- Cassidy Alexandra Kahler - Nic Photo Double
- Amy Hui - Santina
- Najah Bradley - Harvey
- Marnee Carpenter - Janey
- Raiany Silva - Female College Student
- David Christian Welborn - Jim Browner
- Darryl L. Dillard - Administrator
- Charito Mertz - Tina Chen
- Jeremy Anderson - State Trooper
- Chris McGarry - Ronan
- Lillian Ellen Jones - Esty
- Jody Whitehurst - Nurse
- John Crosby - Pissed Off Patient
- Zach Lazar Hoffman - Hacker
- Scotty Whitehurst - Hacker
- Lynn Andrews - Marty
- June Schreiner - Diana
- Ashlee Heath - Tabitha
- Sharon Mae Wang - OB Tech Duval
- Sharon Mae Wang - OB Tech Rebecca Duval
- Melanie J. Newby - Nurse Madison
- Melanie J. Newby - Lora Day
- Giovanni Antonio Rincón - Patient
- Jeff Benninghofen - Leo Bolton
- Sunkrish Bala - Raja Khoury
- Christopher Cousins - Marco
- Diany Rodriguez - Abigail
- Travon McEntyre - EMT
- Sundra Oakley - Tracy Laybourne
- Mila Davis-Kent - Max Laybourne
- Deborah Bowman - Wedding Planner
- Katelin Chesna - Pharmacist
- Andrew R. Shaw - Anesthesiologist
- Ian Anthony Dale - James Yamada
- Sekou Laidlow - Bobby Purcell
- Tori Danner - Claire
- Ashwin Gore - Aziz
- Landon Ashworth - Donald Killian
- Jim McKeny - Prison Doctor
- Mitch Johnston - Dale Watson
- Jordan Belfi - David Costican
- Lamont Thompson - Attorney
- Kylee Brown - Tally
- Kaycie Lee - Crying Girl
- Tyler Rainey - Amir Sheridan
- Marliss Amiea - Amir's Mother
- Sherod Morrison - Amir's Father
- Rich Hutchman - Cricket
- Ramón De Ocampo - Sam
- Susan Santiago - Tessa Perez
- Raquel Dominguez - Wendy
- William Mark McCullough - Wolf
- Arischa Conner - Genevieve
- Asha Etchison - EMT
- Beth Pilgreen - Jan Price
- Hailey Swartwout - Aimee
- Malone Thomas - Sue
- Erin Dangler - Doris Chambers
- Jozef Fahey - Lance Chambers
- Matthew Fahey - Fritz Chambers
- Anissa Matlock - Suni Jin
- Anissa Matlock - Raq
- Adrian Sparks - Leonard Perry
- Pamela Dunlap - Lilian Courtland
- Alexandra Grey - Thea Dwyer
- Kevin Jackson - Quentin Dwyer
- Jennifer Lafleur - Liv
- Janell Sexton - Jane Dwyer
- Rabon Hutcherson - EMT
- Joe Heath - Drag Show Patron (uncredited)
- Veanna Black - CT Tech Gail
- Veanna Black - MRI Tech
- Valerie Cruz - Renata Lopez
- Tom Nowicki - Lyle Hancock
- Danny Chung - Edmund Xu
- Anna Harriette Pittman - Chloe's Sister
- Karen Beyer - Mrs. Foster
- Timothy Batten - Nurse
- Justin Alvarez - Paramedic
- Daniel R. Hill - Chad Anderson
- Daniel R. Hill - Diabetic Patient
- Terri James - Upper Class Woman
- John Pirruccello - Mitch Kaplan
- Gregory Alan Williams - Dr. Peterson
- Kurt Yue - Fred Cho
- Lindsay Ayliffe - Trip Dunlap
- Kevin Patrick Murphy - Doobie
- Britt Rentschler - Sarah Cooper
- Matt Mercurio - Gene Lu
- Nichele Lambert - Megan King
- Valerie Jane Parker - Pretty Woman
- Jennifer Olympia Bentley - Porno Nurse
- Valyn Hall - Gloria
- Masey McLain - Daisy
- Taylor Polidore - Treena
- Eugene H. Russell IV - Singer
- Brandon O'Dell - Singer
- Ana Gray - Singer
- Kellee Stewart - Barb Olson
- Coral Peña - Louisa Rodriguez
- John Beasley - Mortimer Rosenthal
- Joe Massingill - Hank
- Lee Spencer - Jim Phillips
- James Moses Black - Stuart Green
- Frank Licari - Reynolds
- Michael Rubino - ICE Agent
- Emily Althaus - Nurse Tiffany
- Dakin Matthews - Howie Green
- Deke Anderson - Paul Robinson
- Blair Jasin - Erik
- Ryan D. Olson - Ian Robinson
- Seth Dousman - Sam Jones
- Joy Kigin - Paramedic Pat
- Chrystee Pharris - Allie Palmer
- Jackie Dallas - Nurse Jill
- Jennifer Van Horn - Cynthia
- Nick Caruso - Police Officer
- Evan Henderson - Jeremy Skinner
- Dustin Lewis - Radiologist
- Jacob Garcia - Brent Carter
- Jazmyn Simon - Christine Conforth
- Steve Rosen - York Evans
- Michael Trotter - Ed Brooks
- Jamie Gray Hyder - Grace Brooks
- Rebecca Tilney - Stacy Leonard
- Jason Turner - Dale Simich
- Keith Hudson - Augustus 'Gus' Spinelli
- Adrienne Johnson - Nurse
- Paul Ben-Victor - Edmund Carver
- Jocko Sims - Ben Wilmot
- Christian Barillas - Nigel Meahan
- Jacob Gibson - Atiba Jackson
- Angela Davis - Monique Jackson
- Dale Anthony Jennings - Torrance Jackson
- Shannon Mayers - Victoria Hewitt
- Andi Matheny - Kelly Whitley
- Rishik Patel - Jaime Frederick
- Lindsey Blackwell - Shalisha Curtis
- Samuel Smith - Ezekiel Curtis
- Kevin L. Johnson - Timothy Fleck
- Damon Dayoub - Bobby Singer
- Stephen McKinley Henderson - Darryl Phillips
- Matt Walton - Spalding Massero
- Jason Davis - Ed Rossi
- Joe Knezevich - Donald Cyrus
- Mark Cabus - Cameron Pressley
- India Batson - Blonde
- Meredith Parks - Redhead
- Janeen Michael - Anesthesiologist
- Brittany Inge - Kitchen Worker
- Kelsey Sanders - Woman
- Jennifer Landon - Jane Doe
- Rico Paris - Medical Assistant
- Rico Paris - Enrique Diaz
- Jai Rodriguez - Channing Brewster
- Geraldine Singer - Veronica Ravenscroft
- Michael Crider - Lawrence Ravenscroft
- Déjá Dee - Sandra Lindell
- Mark Oliver - Gavin Tennant
- Jon Briddell - Gordon
- Jo Perkins - Edna Hobart
- Andy Stahl - Buck Redger
- Erica Page - Anne Huntington
- Marc Gowan - Jerome Collins
- Henry Bazemore Jr. - Pharmacist
- Lenny Jacobson - Steve Berman
- R. Keith Harris - Delivery Man
- Tyler Patton - Derek Roberts
- Dana Ashbrook - Kevin Fell
- Kathleen Wilhoite - Claudia Webb
- Randee Heller - Yvonne Evans
- Ramses Jimenez - Felix
- Jock McKissic - Mambo
- Karen Labbe - Hospital Receptionist
- Greg Allan Martin - Adrian Hill
- Geordie White - Dana Walters
- Alan Heckner - Elias Everett
- Karen Wheeling Reynolds - Mrs. Florence Arby
- Greg Clarkson - Reporter One
- Mike Whaley - FBI One
- Jess Durham - FBI Two
- Kendrick Cross - Chief Medical Officer
- Ian Covell - Charles Simm
- Andrew Hunter - Radiologist Grayson Dees
- John Forbes - Mark Wilson
- Boo Arnold - Mr. Alderwood
- Joshua Brady - Gunner / Aaron Holt
- Jordan Patrick - Justin Arkman
- Derek Evans - Midtown Paramedic
- Mahdi Cocci - Airmed Paramedic
- Abigail Rose Cornell - Abby Arlen
- Tamara Whatley - Peyton
- Katherine Barber - Hooker
- Al-Jaleel Knox - Skateboard Bully
- Brannon Cross - Dispatcher
- Kermit Rolison - Rupert Warden
- Bayland Rippenkroeger - Biker
- Sara Torres - Stewardess
- Brian Childers - Kevin Finnerman / CEO
- Flint Beverage - Mr. Roman Price / CEO
- Annie Cook - Amber Curtis / CEO
- Gilbert Glenn Brown - Chastain Lawyer
- Deadra Moore - Betsy Chriss
- Rob Lawhon - Bearded Hipster
- LaNette Robinson - Grandma Janine Wendleton
- Drew Starkey - Young Lawyer
- Jason Burkey - Cody Coleman
- Tom Proctor - Sober Tony
- Darin Cooper - Timothy Buzzkirk
- Patrick Donohue - Ben Fitzgerald
- Ben VanderMey - Ken
- Tyner Rushing - Tilly Tyson
- Sean Michael Weber - Tarzan
- Adam Boyer - Frank Tanner
- Denise Santos - Mrs. Tanner
- Deep Rai - Lab Tech Ricky Vaskell
- Blane Crockarell - Young Conrad
- Ty Trumbo - John Losurdo
- Mayumi Roller - Adele
- Joshua Rivera - Mauricio
- Ryan King - Bookish Guy
- Alora Johnson - Ingrid Losurdo
- Victoria Ealy - Sarah Losurdo
- Maximillian McNamara - Carrot Guy
- Connor Hammond - Curly Resident
- Rona Benson - Resident One
- Scott Poythress - Wallace Troke
- Susan Shalhoub Larkin - Shelby Waverly
- Jim France - Tobias Waverly
- Arianne Martin - Chris Kimura
- Rob Demery - Security Guard
- Diahnna Nicole Baxter - Tracker
- David Marshall Silverman - Wayne Cutler / Deposition Lawyer
- Anjali Bhimani - Irena Simmons
- Drew Matthews - Investor Phil McCusker
- Kausar Mohammed - Bridesmaid
- Matt Lewis - Mark Truscott
- Todd Allen Durkin - Martin Blackmar
- Christina Bach - Christina Ruiz
- Mike Kopera - Ralph Difta
- Victor Turner - Wes Boysel
- Brook Todd - Charlie Plec
- Maia Moss-Fife - Gladys Meade
- Michael J. Ewing - New Patient
- Daniel Baldock - Scruffy
- Paul Brian Johnson - Officer Hancock
- Jordan Sherley - Woozy Teen
- Lindsey Shope - Exhausted Mother
- Boden Johnston - Son (Football Boy)
- Olivia D. Dawson - Jill Lombardo
- Dayna Beilenson - Darla Malhorta
- Jennifer A. Martin - Ingrid Belenky
- Arle Michel - ND Patient
- Don Hartman - Eric Basilico
- Roscoe Johnson - Officer Bailey
- Tracey Bonner - Officer Lenzer
- Victoria Patenaude - Judith Bigly
- Matt Burke - Everett Dobb
- Montel Williams - Self
- Brandi Huzzie - Woman Next to Bell
- Timothy J. Richardson - ND Patient
- Jeff Cole - Dr. Grisham
- Lily Knight - Mia Danvers
- Ben Taylor - Rick
- Alex Solowitz - Zeke Metcalfe
- Ashani Roberts - Sonya
- Jennifer Gatti - Nurse Nancy
- Gill Gayle - Electric Ed
- Randy Havens - Pharmacy Phil
- Cliff Weissman - Boone
- Kasey O'Barr - Security Guard
- Alexa Maria Huerta - ND Assistant
- Don Lake - Jerry Tolman
- Rebecca Field - Susan Mitchka
- Mary Jean Feton - Ellen Tolman
- Morgan Gao - Rufus Pressman
- Leslie Sheri - Airline Gate Attendant
- Michelle Civile - Screaming Woman
- Christopher Neiman - Jonesy
- Hugh Holub - Horace Dudley
- Lindsay Lamb - Deloach's Assistant
- Irene Ziegler - Henrietta Dudley
- Stella Pileggi - Lacy Shelton
- Rico Ball - General Surgeon Rory Stanton
- Linds Edwards - Steve Concado
- Sharon E. Smith - Jackie Davis
- Summer Rain Menkee - Leslie Davis
- Mark J.P. Hood - Camron Broome
- King Kedar - Delandre Harris
- Cooper Thornton - Ollie
- Adam Stephenson - Anthony Peterson
- David Alexander Kaplan - Ryan Peterson
- Michael Sokol - Harry Miller
- Autumn Monroe - June Miller
- Keith Brooks - Jay Smith
- Aven Lotz - Younger Jessie
- Izzy Herbert - Younger Nic
- Sumalee Montano - Trish Tintoc
- Anthony Azizi - Amir Yaheem
- Cuyle Carvin - Surgeon Josh Rudnick
- Angela Ray - Dallas Roberts
- Brandon Sutton - Gerard Shah
- Morganna Bridgers - Stephanie Sunderland
- Mark Jacobson - Jake Birch
- Samantha Worthen - Nurse
- Frances Mitchell - Janice
- Dan Bright - Brett Reynolds
- Kelly Collins Lintz - Neonatologist
- Ahmed Lucan - Ramesh Bajwa
- Dave Pileggi - Phil Thompson
- Orelon Sidney - Nurse Hicks
- Jon Michael Davis - Albert
- Brianna Quinn Lewis - Audience Member
- Jonathan Horne - Dr. Vincent
- Allison King - Piper Scott
- Marcia Harvey - Fellow
- Stephanie Hong - Fellow
- Wendell Scott - Jasper
- Ian Lyons - Wade
- Amy Holden Jones
John Noble hace el papel de Elliot Festervan.
Jenny O'Hara interpreta a Shirley Harris en la serie.
Connor Paolo interpreta a Isaac Morgan en la serie.
Cayden Boyd hace el papel de Tyler Warzel.
Gregg Henry interpreta a Aaron Kranepool en la serie.
Matt Czuchry hace el papel de Conrad Hawkins.
Manish Dayal interpreta a Devon Pravesh en la serie.
Malcolm-Jamal Warner interpreta a AJ Austin en la serie.
Jessica Lucas interpreta a Billie Sutton en la serie.
Bruce Greenwood interpreta a Randolph Bell en la serie.
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