- Sean Bean - Self
- Cameron Diaz - Self - Guest
- Drea de Matteo - Self - Guest
- Michelle Pfeiffer - Self - Guest
- Joe Pesci - Self - Guest
- Heather Locklear - Self
- James Spader - Self - Guest
- Vanna White - Self - Guest
- Louie Anderson - Self - Guest
- Jennifer Love Hewitt - Self
- Jennifer Aspen - Self
- Rosie Perez - Self - Guest
- Jessica Simpson - Self
- Kimberly Elise - Self - Guest
- Diane Keaton - Self - Guest
- Steve Zahn - Self
- Justin Hartley - Self - Guest
- Mandy Patinkin - Self - Guest
- Amanda Peet - Self
- Brad Garrett - Self
- Rihanna - Self - Guest
- Jonathan Taylor Thomas - Self
- Paula Deen - Self - Guest
- Debbie Gibson - Self
- Bob Barker - Self
- Simon Cowell - Self
- Joanna Gleason - Self
- Anna Faris - Self - Guest
- Dennis Quaid - Self - Guest
- Caroline Rhea - Self
- Katie Holmes - Self
- Charlize Theron - Self - Guest
- Meredith Vieira - Self
- Kirsten Dunst - Self - Guest
- Missi Pyle - Self
- Jason Hervey - Self
- Cathy Moriarty - Self
- Priscilla Presley - Self - Guest
- Ricky Schroder - Self
- Bobby Flay - Self
- Nelly - Self - Guest
- Yasmine Bleeth - Self
- Zach Braff - Self
- Marisa Tomei - Self - Guest
- Susan Lucci - Self
- Vanessa Williams - Self
- Debra Wilson - Self - Guest
- Jasmine Guy - Self - Guest
- Julia Roberts - Self
- Katey Sagal - Self - Guest
- Chevy Chase - Self - Guest
- Michael J. Fox - Self
- David Spade - Self
- Patrick Duffy - Self
- Stacy Keibler - Self - Guest
- Wayne Newton - Self
- Peri Gilpin - Self - Guest
- Heath Ledger - Self
- Paul Walker - Self
- Lori Loughlin - Self - Guest
- Eddie Murphy - Self
- Ethan Suplee - Self
- Jeff Corwin - Self
- Helen Hunt - Self - Guest
- Gwen Stefani - Self - Guest
- Scarlett Pomers - Self - Guest
- Denzel Washington - Self - Guest
- Whitney Houston - Self
- Jane Leeves - Self - Guest
- Natasha Richardson - Self
- Richard Dreyfuss - Self
- Ashton Kutcher - Self
- Bette Midler - Self - Guest
- Valerie Bertinelli - Self
- Constance Marie - Self - Guest
- Marlo Thomas - Self
- Hugh Laurie - Self
- Ryan Reynolds - Self
- Justin Timberlake - Self - Guest
- Fran Drescher - Self
- Victor Garber - Self
- Angelina Jolie - Self - Guest
- Robert De Niro - Self
- Jennifer Esposito - Self - Guest
- Owen Wilson - Self
- Danny Glover - Self
- Jane Lynch - Self
- Piper Perabo - Self - Guest
- Kevin Costner - Self - Guest
- Courteney Cox - Self
- Uma Thurman - Self - Guest
- Christina Applegate - Self - Guest
- Sarah Chalke - Self
- Debbie Matenopoulos - Self - Guest
- Patrick Dempsey - Self
- Penny Marshall - Self - Guest
- Brittany Murphy - Self - Guest
- Geena Davis - Self - Guest
- Reba McEntire - Self - Guest
- Paul Rudd - Self
- Candace Cameron Bure - Self
- Lisa Edelstein - Self
- Jon Cryer - Self
- Ricki Lake - Self
- Jason Ritter - Self
- Shania Twain - Self - Guest
- Gabrielle Union - Self
- Jensen Ackles - Self
- Will Ferrell - Self
- Luke Perry - Self - Guest
- Hugh Jackman - Self
- Will Smith - Self
- Bruce Willis - Self - Guest
- Ashanti - Self - Guest
- Lucy Lawless - Self
- Tom Welling - Self
- Kathy Griffin - Self - Guest
- Ben McKenzie - Self
- Jeffrey Tambor - Self - Guest
- Amanda Bynes - Self
- Patricia Heaton - Self
- Garry Marshall - Self
- Val Kilmer - Self
- Stephanie McMahon - Self
- Patrick Muldoon - Self - Guest
- Tom Bergeron - Self
- Katie Couric - Self
- Jane Fonda - Self
- Joely Fisher - Self
- Anjelica Huston - Self - Guest
- Burt Reynolds - Self - Guest
- Antonio Banderas - Self - Guest
- Jamie Oliver - Self
- Kelly Preston - Self - Guest
- Mario López - Self
- Jill Scott - Self
- Jennifer Tilly - Self - Guest
- Whoopi Goldberg - Self
- Kevin James - Self
- Patrick Swayze - Self
- Orlando Bloom - Self
- Alyson Hannigan - Self
- Laura Prepon - Self - Guest
- Holly Marie Combs - Self
- Joey Lawrence - Self
- Sean Penn - Self
- Howie Mandel - Self - Guest
- Deborah Norville - Self
- Mary-Louise Parker - Self
- Jamie Lee Curtis - Self - Guest
- Hilary Swank - Self
- Alex Trebek - Self - Guest
- Josh Duhamel - Self
- Melissa McCarthy - Self - Guest
- Brenda Strong - Self
- Anthony Anderson - Self - Guest
- Robert Downey Jr. - Self
- Ashley Judd - Self
- Kelsey Grammer - Self - Guest
- Melissa Joan Hart - Self
- Miranda Lambert - Self
- Jason Priestley - Self - Guest
- Cristina Ferrare - Self
- Debra Messing - Self - Guest
- Frankie Muniz - Self
- Gwyneth Paltrow - Self - Guest
- Benjamin Bratt - Self - Guest
- Jada Pinkett Smith - Self
- Lou Diamond Phillips - Self
- Tara Reid - Self
- Paula Abdul - Self - Guest
- Roma Downey - Self
- Kimberley Locke - Self
- Joan Lunden - Self
- Ed O'Neill - Self
- Ellen Pompeo - Self
- Jennifer Aniston - Self - Guest
- Lauren Graham - Self - Guest
- Marie Osmond - Self
- Sarah Jessica Parker - Self - Guest
- Ray Romano - Self - Guest
- Aisha Tyler - Self
- William Baldwin - Self - Guest
- William Shatner - Self - Guest
- Courtney Thorne-Smith - Self
- Dustin Hoffman - Self
- Vanessa Marcil - Self
- Nadine Rajabi - Self - Comedian
- Vin Diesel - Self
- Sean Hayes - Self
- Ali Larter - Self
- Anne Hathaway - Self - Guest
- Lela Rochon - Self
- John Travolta - Self
- T'Keyah Crystal Keymáh - Self
- Lindsay Lohan - Self - Guest
- Jodie Sweetin - Self - Guest
- Sheryl Crow - Self
- Billy Joel - Self - Guest
- Matthew Perry - Self
- Rosa Blasi - Self
- Emilio Estevez - Self
- David Schwimmer - Self
- Linda Dano - Self
- Beverley Mitchell - Self
- Pam Tillis - Self
- Kathie Lee Gifford - Self
- Bonnie Hunt - Self
- Faith Ford - Self
- Jennie Garth - Self
- Barbara Mandrell - Self - Guest
- Cate Blanchett - Self - Guest
- Carmen Electra - Self - Guest
- Liv Tyler - Self
- Genevieve Gorder - Self - Guest
- Alyssa Milano - Self
- Nicollette Sheridan - Self
- Calista Flockhart - Self
- Jay Mohr - Self
- Jai Rodriguez - Self
- Alison Sweeney - Self
- Missy Elliott - Self
- Chris Rock - Self - Guest
- Kiefer Sutherland - Self
- Tim Allen - Self
- Gavin DeGraw - Self
- Doris Roberts - Self
- Della Reese - Self
- LeAnn Rimes - Self - Guest
- John Schneider - Self
- Barry Manilow - Self
- Rita Moreno - Self
- Queen Latifah - Self - Guest
- Neil Patrick Harris - Self - Guest
- Debbie Reynolds - Self - Guest
- Lisa Kudrow - Self
- Matthew Broderick - Self - Guest
- Adam Sandler - Self
- Harry Connick Jr. - Self
- Keira Knightley - Self
- Dana Carvey - Self
- Jessica Alba - Self - Guest
- Morgan Freeman - Self - Guest
- Randy Travis - Self
- Bill Engvall - Self
- Lucy Liu - Self
- David Boreanaz - Self
- Vince Vaughn - Self - Guest
- Susan Sarandon - Self - Guest
- Paris Hilton - Self - Guest
- Leah Remini - Self - Guest
- Lisa Ling - Self - Guest
- Jennifer Coolidge - Self - Guest
- Paula Jai Parker - Self
- Cindy Crawford - Self
- Denise Richards - Self
- Kirk Cameron - Self
- Bill Paxton - Self
- Cameron Mathison - Self
- Elisabeth Shue - Self - Guest
- Emily Deschanel - Self
- Tim Daly - Self
- Luke Wilson - Self
- JoAnna Garcia - Self
- Daisy Fuentes - Self
- Jackée Harry - Self
- Alicia Silverstone - Self - Guest
- Donald Faison - Self - Guest
- Mila Kunis - Self
- Gabrielle Carteris - Self
- Sean Astin - Self
- Kevin Sorbo - Self
- Joy Behar - Self
- Johnny Pacar - Self - Guest
- Cybill Shepherd - Self
- Bob Saget - Self
- Kelly Clarkson - Self - Guest
- Sarah Michelle Gellar - Self
- Mo Collins - Self - Guest
- Topher Grace - Self
- Roseanne Barr - Self
- Lisa Hartman - Self
- Donny Osmond - Self
- Carrie Havel
Bill Paxton interpreta a Self en la serie.
Sarah Jessica Parker hace el papel de Self - Guest.
Eddie Murphy interpreta a Self en la serie.
Michael J. Fox interpreta a Self en la serie.
Cybill Shepherd interpreta a Self en la serie.
Missi Pyle interpreta a Self en la serie.
Brad Garrett hace el papel de Self.
Heath Ledger interpreta a Self en la serie.
Diane Keaton hace el papel de Self - Guest.
Anne Hathaway interpreta a Self - Guest en la serie.
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